Click here to switch to the map view.

The map label for this gene is yqjI [H]

Identifier: 52786305

GI number: 52786305

Start: 2485659

End: 2487068

Strand: Reverse

Name: yqjI [H]

Synonym: BLi02567

Alternate gene names: 52786305

Gene position: 2487068-2485659 (Counterclockwise)

Preceding gene: 52786306

Following gene: 52786304

Centisome position: 58.9

GC content: 47.87

Gene sequence:

>1410_bases
ATGGCAAAACAACAAATAGGTGTAGTTGGTTTAGCAGTAATGGGAAAAAACTTGGCTTTAAACATTGAAAGCCGCGGGTT
TTCAGTTTCTGTCTACAACAGATCAAGCGAGAAAACCGAAGAGTTTCTGAAAGAAGCCGAAGGCAAAAACGTTGTCGGTA
CATACAGCATTGAAGAGTTTGTTGAATCTCTTGAAAAACCGCGCAAAATTCTTTTAATGGTCAAAGCTGGAACACCGACA
GACGCAACGATTCAATCGCTTCTGCCTCATCTTGAAAAAGGCGACATTTTGATTGACGGCGGAAATACATATTATAAAGA
TACGCAGAGAAGAAACAGGGAGCTGGCCGAAAGCGGCATTCACTTCATCGGCACCGGCGTTTCCGGCGGTGAAGAAGGCG
CTCTGAAAGGGCCGTCTATCATGCCAGGCGGACAAAAGGAAGCCCATGAGCTTGTCAAGCCGATTCTTGAAGCTATTTCT
GCCAAGGTGGACGGCGAACCGTGTACGACATACATCGGTCCTGACGGCGCCGGCCATTATGTAAAAATGGTTCATAACGG
CATCGAATACGGCGATATGCAGCTGATCTCAGAATCCTACTTTATTTTGAAACACATTGTCGGTCTGTCATCAGATGAGC
TTCACGAAGTCTTTTCCGAGTGGAATAAGGGAGAGCTTGACAGCTATCTGATCGAAATCACGGCTGATATTTTCACGAAA
AAAGACGAGGAAACCGGCAAGCCGCTTGTTGACGTCATCCTCGATAAAGCAGGTCAAAAAGGCACAGGAAAATGGACAAG
CCAAAGCGCTCTTGACCTGGGCGTTCCGCTTCCAATCATTACGGAATCTGTTTTCGCCCGCTTCATCTCTTCCATGAAAG
AGGAGCGCGTCAAAGCGAGCAAGCTTCTGGCAGGACCTGAAGCGAAACCTGCCGCTGAGAACAAAGAAGAGCTGATCGAA
GCGGTCAGAAAAGCGCTCTTCATGAGCAAAATCTGTTCTTACGCCCAAGGCTTTGCTCAAATGAAAGCCGCATCAGAAGA
ATACGGCTGGGATTTGAAATACGGCGATATCGCGATGATTTTCCGCGGAGGATGCATCATCCGCGCGGCGTTCCTGCAAA
AAATCAAAGAAGCGTATGACCGCGATCCAGAGCTTGACAACCTGCTTCTTGACCCGTACTTCAAAAATATCGTTGAAAGC
TATCAGGGAGCCCTCCGCAAAACGATTTCTCTTGCGGTTGAACAAGGAATTCCTGTACCTTGCTTCTCAAGCGCTCTCGC
TTACTTTGACAGCTACCGCACTGCAACCCTGCCGGCCAACCTGATTCAGGCGCAGCGCGACTACTTTGGCGCCCATACGT
ATGAGCGTACAGATAAAGAAGGCATTTTCCACACTGAGTGGATGAAATAA

Upstream 100 bases:

>100_bases
GACAAGATCAATAGCTTGAAAATGTAGGTCAAAGTGTGGTAATTTCAATTTAAATAAAAATTAAACTATAATGCTAAACG
CTTTAGAAGGGACGTTAGAC

Downstream 100 bases:

>100_bases
GATGTAAAACCGCAAGCTGAAAAGCTTGCGGTTTTTTTGATTTTCGGAAGGATGCATGTTTAAGCGGTTGTGTGGAAACC
TACTCAAAAGTGAGTTTCAA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MAKQQIGVVGLAVMGKNLALNIESRGFSVSVYNRSSEKTEEFLKEAEGKNVVGTYSIEEFVESLEKPRKILLMVKAGTPT
DATIQSLLPHLEKGDILIDGGNTYYKDTQRRNRELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS
AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKHIVGLSSDELHEVFSEWNKGELDSYLIEITADIFTK
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISSMKEERVKASKLLAGPEAKPAAENKEELIE
AVRKALFMSKICSYAQGFAQMKAASEEYGWDLKYGDIAMIFRGGCIIRAAFLQKIKEAYDRDPELDNLLLDPYFKNIVES
YQGALRKTISLAVEQGIPVPCFSSALAYFDSYRTATLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK

Sequences:

>Translated_469_residues
MAKQQIGVVGLAVMGKNLALNIESRGFSVSVYNRSSEKTEEFLKEAEGKNVVGTYSIEEFVESLEKPRKILLMVKAGTPT
DATIQSLLPHLEKGDILIDGGNTYYKDTQRRNRELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS
AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKHIVGLSSDELHEVFSEWNKGELDSYLIEITADIFTK
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISSMKEERVKASKLLAGPEAKPAAENKEELIE
AVRKALFMSKICSYAQGFAQMKAASEEYGWDLKYGDIAMIFRGGCIIRAAFLQKIKEAYDRDPELDNLLLDPYFKNIVES
YQGALRKTISLAVEQGIPVPCFSSALAYFDSYRTATLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK
>Mature_468_residues
AKQQIGVVGLAVMGKNLALNIESRGFSVSVYNRSSEKTEEFLKEAEGKNVVGTYSIEEFVESLEKPRKILLMVKAGTPTD
ATIQSLLPHLEKGDILIDGGNTYYKDTQRRNRELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAISA
KVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKHIVGLSSDELHEVFSEWNKGELDSYLIEITADIFTKK
DEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISSMKEERVKASKLLAGPEAKPAAENKEELIEA
VRKALFMSKICSYAQGFAQMKAASEEYGWDLKYGDIAMIFRGGCIIRAAFLQKIKEAYDRDPELDNLLLDPYFKNIVESY
QGALRKTISLAVEQGIPVPCFSSALAYFDSYRTATLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=56.1702127659575, Blast_Score=528, Evalue=1e-150,
Organism=Escherichia coli, GI1788341, Length=469, Percent_Identity=70.5756929637527, Blast_Score=697, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=52.0169851380042, Blast_Score=525, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6321695, Length=452, Percent_Identity=56.1946902654867, Blast_Score=534, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=55.3097345132743, Blast_Score=511, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24639279, Length=465, Percent_Identity=54.6236559139785, Blast_Score=501, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51840; Mature: 51708

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQQIGVVGLAVMGKNLALNIESRGFSVSVYNRSSEKTEEFLKEAEGKNVVGTYSIEEF
CCCCHHHHEEHEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCEEEECCHHHH
VESLEKPRKILLMVKAGTPTDATIQSLLPHLEKGDILIDGGNTYYKDTQRRNRELAESGI
HHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
HFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAISAKVDGEPCTTYIGPDGAGHY
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHH
VKMVHNGIEYGDMQLISESYFILKHIVGLSSDELHEVFSEWNKGELDSYLIEITADIFTK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISSMKEERVKAS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KLLAGPEAKPAAENKEELIEAVRKALFMSKICSYAQGFAQMKAASEEYGWDLKYGDIAMI
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
FRGGCIIRAAFLQKIKEAYDRDPELDNLLLDPYFKNIVESYQGALRKTISLAVEQGIPVP
ECCCHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
CFSSALAYFDSYRTATLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKQQIGVVGLAVMGKNLALNIESRGFSVSVYNRSSEKTEEFLKEAEGKNVVGTYSIEEF
CCCHHHHEEHEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCEEEECCHHHH
VESLEKPRKILLMVKAGTPTDATIQSLLPHLEKGDILIDGGNTYYKDTQRRNRELAESGI
HHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
HFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAISAKVDGEPCTTYIGPDGAGHY
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHH
VKMVHNGIEYGDMQLISESYFILKHIVGLSSDELHEVFSEWNKGELDSYLIEITADIFTK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISSMKEERVKAS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KLLAGPEAKPAAENKEELIEAVRKALFMSKICSYAQGFAQMKAASEEYGWDLKYGDIAMI
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
FRGGCIIRAAFLQKIKEAYDRDPELDNLLLDPYFKNIVESYQGALRKTISLAVEQGIPVP
ECCCHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
CFSSALAYFDSYRTATLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]