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The map label for this gene is lysA [H]

Identifier: 52786225

GI number: 52786225

Start: 2418597

End: 2419916

Strand: Reverse

Name: lysA [H]

Synonym: BLi02486

Alternate gene names: 52786225

Gene position: 2419916-2418597 (Counterclockwise)

Preceding gene: 52786227

Following gene: 52786224

Centisome position: 57.31

GC content: 50.83

Gene sequence:

>1320_bases
TTGTTTTTACACGGTACTAGCAGACAAAATGAAAGAGGGCACCTCGAAATCGGCGGTGTCGATGTTCTATCATTGGCAGA
AAGATACGGAACACCTCTTTATGTATACGATGTCGCGCTGATTAGAGAGCGCGCCCGAAAATTCCAGAAGGCATTCAAGG
AAGCCGGTTTAAAAGCGCAGGTAGCGTATGCAAGCAAGGCGTTTTCATCGGTTGCCATGATTCAGCTTGCCGAACAAGAG
GGGCTGTCTCTGGATGTGGTATCGGGAGGAGAGCTTTTCACTGCGATCAAAGCAGGGTTCCCAGCTGAGCGGATTCATTT
TCACGGAAACAATAAGAGCCCTGAAGAACTAGCCATGGCGCTGGAGCATCAAATCGGCTGCATCGTGCTCGATAACTTTC
ACGAGATCGCCATTACAGAAGATCTTTGCAAGCGATCAGGACAAACTGTAGACGTTTTGCTCAGAATCACTCCGGGAGTT
GAAGCGCACACGCACGATTATATTACGACGGGGCAGGAAGATTCCAAATTCGGTTTTGATCTGCATAATGGACAGGTCGA
ACAAGCCATCGAACAAGTCCTCCGCTCGTCTGCGTTTAAGCTCCTCGGCGTGCACTGCCACATCGGTTCGCAAATTTTTG
ATACGGCAGGATTTGTCCTTGCAGCAGACAAGATTTTCGAGAAGCTTGCGGAATGGCGGGAGACTTACTCTTTCATTCCG
GAAGTGCTCAATCTTGGCGGGGGCTTCGGCATCCGCTATACAAAAGACGACGAGCCGCTTGCAGCTGATGTTTATGTTGA
AAAAATCATCGAGGCGGTCAAAGCAAATGCCGAGCATTTCGGCTTTGACATCCCTGAGATTTGGATCGAACCAGGCCGGT
CTCTCGTCGGTGATGCGGGGACTACGCTGTACACGATCGGTTCTCAAAAAGAGGTGCCGGGCATTCGCAAATATGTAGCC
ATCGACGGCGGCATGAGCGATAATATCAGGCCGGCGCTTTATGAGGCAAAATATGAAGCAGCCGTCGCCAACAGGATGAA
CGATGCTTGTCATGATACCGCATCAATCGCAGGAAAATGCTGCGAAAGCGGAGATATGCTGATTTGGGATTTGGAAATCC
CCGAAGTTCGCGACGGAGATGTGCTCGCCGTTTTCTGCACCGGTGCGTACGGCTACAGCATGGCCAACAACTACAACCGC
ATTCCGCGCCCGGCCGTCGTCTTTGTCGAGGACGGGGAAGCGCAGCTCGTCATTCAGAGAGAGACGTATGAGGATATCGT
CAAGCTGGATCTGCCGCTGAAATCGAAAGTCAAACAATAA

Upstream 100 bases:

>100_bases
TACAACATAAGAATCGCACTATCATGAAGCCGGAAGATGCATCGGGCAGCAACCGGAGCGCCCCTTGCACCTTTGTCGAT
AGAGAAAGAGGGAATGACAA

Downstream 100 bases:

>100_bases
AAAAATGGAGATTCCCTAAGAGGGGGGTCTCCATTTTTAATTCAAGCACGAAAAACACTTCCCGGTGATCGGGAGGTGTT
TTTTGTTAAAAAGATCATGA

Product: hypothetical protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MFLHGTSRQNERGHLEIGGVDVLSLAERYGTPLYVYDVALIRERARKFQKAFKEAGLKAQVAYASKAFSSVAMIQLAEQE
GLSLDVVSGGELFTAIKAGFPAERIHFHGNNKSPEELAMALEHQIGCIVLDNFHEIAITEDLCKRSGQTVDVLLRITPGV
EAHTHDYITTGQEDSKFGFDLHNGQVEQAIEQVLRSSAFKLLGVHCHIGSQIFDTAGFVLAADKIFEKLAEWRETYSFIP
EVLNLGGGFGIRYTKDDEPLAADVYVEKIIEAVKANAEHFGFDIPEIWIEPGRSLVGDAGTTLYTIGSQKEVPGIRKYVA
IDGGMSDNIRPALYEAKYEAAVANRMNDACHDTASIAGKCCESGDMLIWDLEIPEVRDGDVLAVFCTGAYGYSMANNYNR
IPRPAVVFVEDGEAQLVIQRETYEDIVKLDLPLKSKVKQ

Sequences:

>Translated_439_residues
MFLHGTSRQNERGHLEIGGVDVLSLAERYGTPLYVYDVALIRERARKFQKAFKEAGLKAQVAYASKAFSSVAMIQLAEQE
GLSLDVVSGGELFTAIKAGFPAERIHFHGNNKSPEELAMALEHQIGCIVLDNFHEIAITEDLCKRSGQTVDVLLRITPGV
EAHTHDYITTGQEDSKFGFDLHNGQVEQAIEQVLRSSAFKLLGVHCHIGSQIFDTAGFVLAADKIFEKLAEWRETYSFIP
EVLNLGGGFGIRYTKDDEPLAADVYVEKIIEAVKANAEHFGFDIPEIWIEPGRSLVGDAGTTLYTIGSQKEVPGIRKYVA
IDGGMSDNIRPALYEAKYEAAVANRMNDACHDTASIAGKCCESGDMLIWDLEIPEVRDGDVLAVFCTGAYGYSMANNYNR
IPRPAVVFVEDGEAQLVIQRETYEDIVKLDLPLKSKVKQ
>Mature_439_residues
MFLHGTSRQNERGHLEIGGVDVLSLAERYGTPLYVYDVALIRERARKFQKAFKEAGLKAQVAYASKAFSSVAMIQLAEQE
GLSLDVVSGGELFTAIKAGFPAERIHFHGNNKSPEELAMALEHQIGCIVLDNFHEIAITEDLCKRSGQTVDVLLRITPGV
EAHTHDYITTGQEDSKFGFDLHNGQVEQAIEQVLRSSAFKLLGVHCHIGSQIFDTAGFVLAADKIFEKLAEWRETYSFIP
EVLNLGGGFGIRYTKDDEPLAADVYVEKIIEAVKANAEHFGFDIPEIWIEPGRSLVGDAGTTLYTIGSQKEVPGIRKYVA
IDGGMSDNIRPALYEAKYEAAVANRMNDACHDTASIAGKCCESGDMLIWDLEIPEVRDGDVLAVFCTGAYGYSMANNYNR
IPRPAVVFVEDGEAQLVIQRETYEDIVKLDLPLKSKVKQ

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=425, Percent_Identity=29.4117647058824, Blast_Score=151, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48443; Mature: 48443

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2 ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLHGTSRQNERGHLEIGGVDVLSLAERYGTPLYVYDVALIRERARKFQKAFKEAGLKAQ
CCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEE
VAYASKAFSSVAMIQLAEQEGLSLDVVSGGELFTAIKAGFPAERIHFHGNNKSPEELAMA
EHHHHHHHHHHHHEEEHHHCCCEEEEECCCHHHHHHHCCCCHHEEEEECCCCCHHHHHHH
LEHQIGCIVLDNFHEIAITEDLCKRSGQTVDVLLRITPGVEAHTHDYITTGQEDSKFGFD
HHHCCCEEEECCCCCEEECHHHHHCCCCEEEEEEEECCCCCCCCCCCEECCCCCCCCCCC
LHNGQVEQAIEQVLRSSAFKLLGVHCHIGSQIFDTAGFVLAADKIFEKLAEWRETYSFIP
CCCCHHHHHHHHHHHHCHHHEEEEEEECCCHHHHHCCHHEEHHHHHHHHHHHHHHHHHHH
EVLNLGGGFGIRYTKDDEPLAADVYVEKIIEAVKANAEHFGFDIPEIWIEPGRSLVGDAG
HHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCCCHHCCCCC
TTLYTIGSQKEVPGIRKYVAIDGGMSDNIRPALYEAKYEAAVANRMNDACHDTASIAGKC
CEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CESGDMLIWDLEIPEVRDGDVLAVFCTGAYGYSMANNYNRIPRPAVVFVEDGEAQLVIQR
CCCCCEEEEEECCCCCCCCCEEEEEEECCCCHHHCCCCCCCCCCEEEEEECCCEEEEEEE
ETYEDIVKLDLPLKSKVKQ
CCHHHHHEECCCHHHHCCC
>Mature Secondary Structure
MFLHGTSRQNERGHLEIGGVDVLSLAERYGTPLYVYDVALIRERARKFQKAFKEAGLKAQ
CCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEE
VAYASKAFSSVAMIQLAEQEGLSLDVVSGGELFTAIKAGFPAERIHFHGNNKSPEELAMA
EHHHHHHHHHHHHEEEHHHCCCEEEEECCCHHHHHHHCCCCHHEEEEECCCCCHHHHHHH
LEHQIGCIVLDNFHEIAITEDLCKRSGQTVDVLLRITPGVEAHTHDYITTGQEDSKFGFD
HHHCCCEEEECCCCCEEECHHHHHCCCCEEEEEEEECCCCCCCCCCCEECCCCCCCCCCC
LHNGQVEQAIEQVLRSSAFKLLGVHCHIGSQIFDTAGFVLAADKIFEKLAEWRETYSFIP
CCCCHHHHHHHHHHHHCHHHEEEEEEECCCHHHHHCCHHEEHHHHHHHHHHHHHHHHHHH
EVLNLGGGFGIRYTKDDEPLAADVYVEKIIEAVKANAEHFGFDIPEIWIEPGRSLVGDAG
HHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCCCHHCCCCC
TTLYTIGSQKEVPGIRKYVAIDGGMSDNIRPALYEAKYEAAVANRMNDACHDTASIAGKC
CEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CESGDMLIWDLEIPEVRDGDVLAVFCTGAYGYSMANNYNRIPRPAVVFVEDGEAQLVIQR
CCCCCEEEEEECCCCCCCCCEEEEEEECCCCHHHCCCCCCCCCCEEEEEECCCEEEEEEE
ETYEDIVKLDLPLKSKVKQ
CCHHHHHEECCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]