Click here to switch to the map view.

The map label for this gene is yngG [H]

Identifier: 52785892

GI number: 52785892

Start: 2089920

End: 2090831

Strand: Reverse

Name: yngG [H]

Synonym: BLi02141

Alternate gene names: 52785892

Gene position: 2090831-2089920 (Counterclockwise)

Preceding gene: 52785893

Following gene: 52785891

Centisome position: 49.51

GC content: 50.88

Gene sequence:

>912_bases
ATGGACGTACCGAAGAACATTTTCATTAAAGAAGTCGGGCCGCGCGACGGTCTGCAAAATGAACAAACCGCACTTTCGAC
AGCTGATAAAATTACCTGGATCGACATGCTTTCTGCCACAGGGCTTTCGTATATCGAAATCACTTCATTCGTCCATCCTA
AGTGGATTCCTGCACTGTCTGATGCCCTTGATGTCGCCAAAGGGATCAACCGGAAGCCGGGCGTCACCTACGCAGCCCTG
ATTCCGAACCGAAAAGGGCTGGAACGGGCTCTCGAAGGAGGGATCGATGAAGCTTCTGTTTTCATGTCGGCAAGCGAGAC
ACACAACCGGAAAAATATTAACAAATCGATCGGGGAAACGCTTCCCGTCCTGAAGGAAGTCATCGGAGCGGCAAAACAAG
CGGGCCTCACCGCCAGAGCATACCTGTCCACAGTATTTGGCTGTCCTTATGAACATCACGTGCCATTGGAACAAATTATA
CGGACATCTGAAACGCTGTTCGACATGGGGATCAACGAACTTTCCCTCGGAGATACGATCGGCGCAGCAAATCCCGTACA
GGTTCAAAGGGTGCTTGAAGTCCTCTTAAAGCGCTTTCCAAAAGAGAATATCGCCCTTCATTTTCATGATACGAGAGGGA
TGGCGCTCGCCAACATGATCGCAGCGATGGACATGGGAATCACCGTATTTGACTCATCATGCGGCGGGCTGGGCGGCTGT
CCTTACGCACCGGGAGCCACGGGGAATGCGGCAACTGATGATTTGATCTACATGTGCGCCCAGATGGGCATCGAAACCGG
AGTTGATCTCAGCAAGCTGCTTTCAGCTGCTAAATGGATCGAAGACAAAACCGGAAGAGAGCTGCCAAGCCGAAATTTGC
AGGCGGCTAAATCAAAGAACTGTTTTCATTGA

Upstream 100 bases:

>100_bases
AAACGGCCGGAACAGTCAAAACCGTCAGAAAGAACGAAGGTGATTTTGCCGATGAAGGGGATGTCTTATTGGAGCTTCAA
TAAGGTCTGGAGGATGGCAA

Downstream 100 bases:

>100_bases
TGAAGAGGAGGAAGACCGAATGGAGCCCAATGTTCTTTATTCCATAAACGAGCAGTCGGTCGCCGTGTTGACGCTGAACA
GGCCGCAGGCTGCAAATGCC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MDVPKNIFIKEVGPRDGLQNEQTALSTADKITWIDMLSATGLSYIEITSFVHPKWIPALSDALDVAKGINRKPGVTYAAL
IPNRKGLERALEGGIDEASVFMSASETHNRKNINKSIGETLPVLKEVIGAAKQAGLTARAYLSTVFGCPYEHHVPLEQII
RTSETLFDMGINELSLGDTIGAANPVQVQRVLEVLLKRFPKENIALHFHDTRGMALANMIAAMDMGITVFDSSCGGLGGC
PYAPGATGNAATDDLIYMCAQMGIETGVDLSKLLSAAKWIEDKTGRELPSRNLQAAKSKNCFH

Sequences:

>Translated_303_residues
MDVPKNIFIKEVGPRDGLQNEQTALSTADKITWIDMLSATGLSYIEITSFVHPKWIPALSDALDVAKGINRKPGVTYAAL
IPNRKGLERALEGGIDEASVFMSASETHNRKNINKSIGETLPVLKEVIGAAKQAGLTARAYLSTVFGCPYEHHVPLEQII
RTSETLFDMGINELSLGDTIGAANPVQVQRVLEVLLKRFPKENIALHFHDTRGMALANMIAAMDMGITVFDSSCGGLGGC
PYAPGATGNAATDDLIYMCAQMGIETGVDLSKLLSAAKWIEDKTGRELPSRNLQAAKSKNCFH
>Mature_303_residues
MDVPKNIFIKEVGPRDGLQNEQTALSTADKITWIDMLSATGLSYIEITSFVHPKWIPALSDALDVAKGINRKPGVTYAAL
IPNRKGLERALEGGIDEASVFMSASETHNRKNINKSIGETLPVLKEVIGAAKQAGLTARAYLSTVFGCPYEHHVPLEQII
RTSETLFDMGINELSLGDTIGAANPVQVQRVLEVLLKRFPKENIALHFHDTRGMALANMIAAMDMGITVFDSSCGGLGGC
PYAPGATGNAATDDLIYMCAQMGIETGVDLSKLLSAAKWIEDKTGRELPSRNLQAAKSKNCFH

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=293, Percent_Identity=47.098976109215, Blast_Score=283, Evalue=1e-76,
Organism=Homo sapiens, GI109150422, Length=294, Percent_Identity=46.5986394557823, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI109150427, Length=294, Percent_Identity=46.5986394557823, Blast_Score=281, Evalue=3e-76,
Organism=Homo sapiens, GI260654708, Length=133, Percent_Identity=47.3684210526316, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17510563, Length=297, Percent_Identity=44.7811447811448, Blast_Score=258, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6320071, Length=237, Percent_Identity=26.5822784810127, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320019, Length=227, Percent_Identity=26.8722466960352, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24582381, Length=292, Percent_Identity=46.9178082191781, Blast_Score=278, Evalue=4e-75,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32714; Mature: 32714

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVPKNIFIKEVGPRDGLQNEQTALSTADKITWIDMLSATGLSYIEITSFVHPKWIPALS
CCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHH
DALDVAKGINRKPGVTYAALIPNRKGLERALEGGIDEASVFMSASETHNRKNINKSIGET
HHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LPVLKEVIGAAKQAGLTARAYLSTVFGCPYEHHVPLEQIIRTSETLFDMGINELSLGDTI
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCC
GAANPVQVQRVLEVLLKRFPKENIALHFHDTRGMALANMIAAMDMGITVFDSSCGGLGGC
CCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEECCCCCCCCC
PYAPGATGNAATDDLIYMCAQMGIETGVDLSKLLSAAKWIEDKTGRELPSRNLQAAKSKN
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCC
CFH
CCC
>Mature Secondary Structure
MDVPKNIFIKEVGPRDGLQNEQTALSTADKITWIDMLSATGLSYIEITSFVHPKWIPALS
CCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHH
DALDVAKGINRKPGVTYAALIPNRKGLERALEGGIDEASVFMSASETHNRKNINKSIGET
HHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LPVLKEVIGAAKQAGLTARAYLSTVFGCPYEHHVPLEQIIRTSETLFDMGINELSLGDTI
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCC
GAANPVQVQRVLEVLLKRFPKENIALHFHDTRGMALANMIAAMDMGITVFDSSCGGLGGC
CCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEECCCCCCCCC
PYAPGATGNAATDDLIYMCAQMGIETGVDLSKLLSAAKWIEDKTGRELPSRNLQAAKSKN
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCC
CFH
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]