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The map label for this gene is yngE [H]

Identifier: 52785890

GI number: 52785890

Start: 2087568

End: 2089097

Strand: Reverse

Name: yngE [H]

Synonym: BLi02139

Alternate gene names: 52785890

Gene position: 2089097-2087568 (Counterclockwise)

Preceding gene: 52785891

Following gene: 52785889

Centisome position: 49.47

GC content: 50.72

Gene sequence:

>1530_bases
ATGCCGGCCGAAAAGGAATTGTATGAACGCATCCGCCGGATTCAGGAGGGCGGCGCGGAGAAATACCATGAAGCTAATAA
GAAAAAAGGGAAATTATTTGTCAGAGACCGATTAAAGCTGCTGCTTGACGAAGGACTCGACCTAGAGGACGCGTTTTTTG
CCAATTGCATGGCTGACGGGCTACCGGCAGATGGAGTCGTCACTGGAATCGGAAAAATCGGCGGGCGAACCGTTTGCGTC
ATGGCCAATGATTCAACTGTCAAAGCAGGATCATGGGGAGCGAGAACCGTTGAAAAAATCATCCGCATCCAGGAAACAGC
CGAAAAACTGAATTGCCCGCTTCTTTATTTGGTCGATTCGGCAGGCGCAAGGATTACGGATCAAGTTGACATGTTTCCGG
GGCGAAGAGGAGCGGGGCGGATTTTTTATCAGCAAGTCAAATTATCCGGGCGCATCCCGCAAATCTGTCTCTTGTTCGGG
CCTTCAGCGGCAGGAGGCGCCTACATACCGGCTTTTTGCGACATCGTCATTATGGTCGAAGGTAACGCCTCGATGTATTT
AGGCTCGCCGCGCATGGCGGAAATGGTGATCGGCGAAAAAGTATCGCTTGAAGAAATGGGCGGCGCGAGAATGCACTGTT
CTGTTTCAGGCTGCGGAGACATTCTTGCCGACACGGAAGAAGATGCGATCAAGTCGGCGCGCCGGTATCTTTCCTACTTT
CCGTCGAACTACACCGAAAAAGCGCCTGTCATTGAAGCAAAATCCGCCCGTCCGTTTGACCGGTCATTGGAGGACATCAT
TCCGAAAAACCAAAACGCTCCGTTTCAGATGATGGATTTAATCGATCGGATCATTGATGAAGCGTCTTTTTATGAGATCA
AAAAATTGTTCGCGCCAGAGCTGATTACCGGTTTGGCAAGGATTCACGGGCAGCCTGTCGGCATCATTGCCAATCAGCCG
CGGGTCAAAGGCGGTGTTTTGTTCCACGATTCGGCAGACAAGGCCGCAAAGTTTATCAATTTGTGTGATGCCTATCATAT
CCCGCTGCTGTTTCTGGCTGACATCCCCGGTTTTATGATCGGAACGAAAGTCGAGAGGGCGGGTATCATCAGACACGGTG
CGAAAATGATTTCAGCGATGGCCGAAGCAACCGTACCGAAAATATCCGTCATCGTCAGGAAAGCTTATGGTGCAGGCTTG
TATGCGATGGCCGGTCCGGCCTTTGAACCTGACTGCTGTCTGGCGCTGCCGACGGCGCAAATTGCCGTCATGGGCCCGGA
AGCAGCGGTAAATGCCGTTTACGCTAAAAAAATCGCAGAATTGCCTGAAGAAGAACGGTCCGCATTCATCGCCGAAAAAC
GGAAAGAGTACCAAAAAGACATAGACATTTACCGGCTTGCTTCAGAAATGATTGTCGACGGGATCATTCCGGCCGACTCG
CTGCGAACGGAACTCATCAAACGGCTGAATGCATATATGACCAAATACATGACATTTACGGAACGGAAGCATCCTGTTTA
TCCCGTCTAA

Upstream 100 bases:

>100_bases
TGACGATTCCGACGAAAGACAGGACAGAAGGGCTGAAAGCTTTTGCAGAAAAGCGGAAGCCGGATTATACGGGAGAATAA
AACGAACGGAGGGACAGCCG

Downstream 100 bases:

>100_bases
AGGCCAATGAAACGAAAAGGAGGAAACGGCATGGGCGAAAAAGCGGTTTGGCAGCCTGATCCGGAATTTGTAAAAACAAC
CCGGCTGTTTCAATGGATGA

Product: YngE

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MPAEKELYERIRRIQEGGAEKYHEANKKKGKLFVRDRLKLLLDEGLDLEDAFFANCMADGLPADGVVTGIGKIGGRTVCV
MANDSTVKAGSWGARTVEKIIRIQETAEKLNCPLLYLVDSAGARITDQVDMFPGRRGAGRIFYQQVKLSGRIPQICLLFG
PSAAGGAYIPAFCDIVIMVEGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSVSGCGDILADTEEDAIKSARRYLSYF
PSNYTEKAPVIEAKSARPFDRSLEDIIPKNQNAPFQMMDLIDRIIDEASFYEIKKLFAPELITGLARIHGQPVGIIANQP
RVKGGVLFHDSADKAAKFINLCDAYHIPLLFLADIPGFMIGTKVERAGIIRHGAKMISAMAEATVPKISVIVRKAYGAGL
YAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERSAFIAEKRKEYQKDIDIYRLASEMIVDGIIPADS
LRTELIKRLNAYMTKYMTFTERKHPVYPV

Sequences:

>Translated_509_residues
MPAEKELYERIRRIQEGGAEKYHEANKKKGKLFVRDRLKLLLDEGLDLEDAFFANCMADGLPADGVVTGIGKIGGRTVCV
MANDSTVKAGSWGARTVEKIIRIQETAEKLNCPLLYLVDSAGARITDQVDMFPGRRGAGRIFYQQVKLSGRIPQICLLFG
PSAAGGAYIPAFCDIVIMVEGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSVSGCGDILADTEEDAIKSARRYLSYF
PSNYTEKAPVIEAKSARPFDRSLEDIIPKNQNAPFQMMDLIDRIIDEASFYEIKKLFAPELITGLARIHGQPVGIIANQP
RVKGGVLFHDSADKAAKFINLCDAYHIPLLFLADIPGFMIGTKVERAGIIRHGAKMISAMAEATVPKISVIVRKAYGAGL
YAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERSAFIAEKRKEYQKDIDIYRLASEMIVDGIIPADS
LRTELIKRLNAYMTKYMTFTERKHPVYPV
>Mature_508_residues
PAEKELYERIRRIQEGGAEKYHEANKKKGKLFVRDRLKLLLDEGLDLEDAFFANCMADGLPADGVVTGIGKIGGRTVCVM
ANDSTVKAGSWGARTVEKIIRIQETAEKLNCPLLYLVDSAGARITDQVDMFPGRRGAGRIFYQQVKLSGRIPQICLLFGP
SAAGGAYIPAFCDIVIMVEGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSVSGCGDILADTEEDAIKSARRYLSYFP
SNYTEKAPVIEAKSARPFDRSLEDIIPKNQNAPFQMMDLIDRIIDEASFYEIKKLFAPELITGLARIHGQPVGIIANQPR
VKGGVLFHDSADKAAKFINLCDAYHIPLLFLADIPGFMIGTKVERAGIIRHGAKMISAMAEATVPKISVIVRKAYGAGLY
AMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERSAFIAEKRKEYQKDIDIYRLASEMIVDGIIPADSL
RTELIKRLNAYMTKYMTFTERKHPVYPV

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=505, Percent_Identity=37.8217821782178, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI295821216, Length=525, Percent_Identity=36.5714285714286, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI11545863, Length=491, Percent_Identity=37.8818737270876, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI134142062, Length=339, Percent_Identity=25.0737463126844, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI38679974, Length=345, Percent_Identity=24.0579710144928, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679971, Length=345, Percent_Identity=24.0579710144928, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679960, Length=345, Percent_Identity=24.0579710144928, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679977, Length=345, Percent_Identity=24.0579710144928, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679967, Length=345, Percent_Identity=24.0579710144928, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=505, Percent_Identity=36.8316831683168, Blast_Score=317, Evalue=9e-87,
Organism=Caenorhabditis elegans, GI25147359, Length=505, Percent_Identity=36.8316831683168, Blast_Score=317, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI17552936, Length=493, Percent_Identity=35.2941176470588, Blast_Score=307, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI71997163, Length=289, Percent_Identity=24.5674740484429, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24586065, Length=504, Percent_Identity=37.3015873015873, Blast_Score=304, Evalue=1e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 55963; Mature: 55832

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAEKELYERIRRIQEGGAEKYHEANKKKGKLFVRDRLKLLLDEGLDLEDAFFANCMADG
CCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LPADGVVTGIGKIGGRTVCVMANDSTVKAGSWGARTVEKIIRIQETAEKLNCPLLYLVDS
CCCCCHHEHHHCCCCEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEC
AGARITDQVDMFPGRRGAGRIFYQQVKLSGRIPQICLLFGPSAAGGAYIPAFCDIVIMVE
CCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEE
GNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSVSGCGDILADTEEDAIKSARRYLSYF
CCCEEEECCCHHHHHHHCCCCCHHHCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHHC
PSNYTEKAPVIEAKSARPFDRSLEDIIPKNQNAPFQMMDLIDRIIDEASFYEIKKLFAPE
CCCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
LITGLARIHGQPVGIIANQPRVKGGVLFHDSADKAAKFINLCDAYHIPLLFLADIPGFMI
HHHHHHHHCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHCHHHHHHCCCCHHH
GTKVERAGIIRHGAKMISAMAEATVPKISVIVRKAYGAGLYAMAGPAFEPDCCLALPTAQ
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCCCCCCCEEECCCCE
IAVMGPEAAVNAVYAKKIAELPEEERSAFIAEKRKEYQKDIDIYRLASEMIVDGIIPADS
EEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LRTELIKRLNAYMTKYMTFTERKHPVYPV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PAEKELYERIRRIQEGGAEKYHEANKKKGKLFVRDRLKLLLDEGLDLEDAFFANCMADG
CCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LPADGVVTGIGKIGGRTVCVMANDSTVKAGSWGARTVEKIIRIQETAEKLNCPLLYLVDS
CCCCCHHEHHHCCCCEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEC
AGARITDQVDMFPGRRGAGRIFYQQVKLSGRIPQICLLFGPSAAGGAYIPAFCDIVIMVE
CCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEE
GNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSVSGCGDILADTEEDAIKSARRYLSYF
CCCEEEECCCHHHHHHHCCCCCHHHCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHHC
PSNYTEKAPVIEAKSARPFDRSLEDIIPKNQNAPFQMMDLIDRIIDEASFYEIKKLFAPE
CCCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
LITGLARIHGQPVGIIANQPRVKGGVLFHDSADKAAKFINLCDAYHIPLLFLADIPGFMI
HHHHHHHHCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHCHHHHHHCCCCHHH
GTKVERAGIIRHGAKMISAMAEATVPKISVIVRKAYGAGLYAMAGPAFEPDCCLALPTAQ
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCCCCCCCEEECCCCE
IAVMGPEAAVNAVYAKKIAELPEEERSAFIAEKRKEYQKDIDIYRLASEMIVDGIIPADS
EEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LRTELIKRLNAYMTKYMTFTERKHPVYPV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]