Click here to switch to the map view.

The map label for this gene is malA [H]

Identifier: 52784653

GI number: 52784653

Start: 874591

End: 875940

Strand: Direct

Name: malA [H]

Synonym: BLi00855

Alternate gene names: 52784653

Gene position: 874591-875940 (Clockwise)

Preceding gene: 52784651

Following gene: 52784654

Centisome position: 20.71

GC content: 48.37

Gene sequence:

>1350_bases
ATGGATAAAACGTATTCGATTGTCATTGCAGGCGGAGGAAGCACATTTACCCCGGGGATTGTATTGATGCTCTTGGACAA
TCTGGATGATTTCCCGATCCGACAGCTGAAATTGTATGACAATGATGGAGAGCGGCAAGACAAAATAGCCGGCGCCTGTG
AAGTGTTGGTTAAAGAAAGAGCTCCGCATATTCAATTTTTAGCGACGACCGATCCGGAAGAGGCGTTTTCCGATGTTGAT
TTCGTCATGGCTCATATCAGAGTCGGTAAATATGCAATGCGTGAGCTCGATGAAAAGATCCCTCTGAAATACGGAGTCGT
CGGCCAGGAGACGTGCGGACCCGGAGGGATTGCGTACGGAATGAGGTCGATTGGCGGCGTGCTTGAGCTCATTGATTATA
TGGAAACCTATTCGCCTGACGCGTGGATGCTGAACTATTCAAACCCGGCTGCAATCGTCGCCGAAGCGACAAGAAGGCTG
CGGCCGACATCAAAAGTGCTGAACATTTGCGATATGCCGATCGGTATCGAAGACAGGATGGCTCAGATTCTCGGACTGTC
TTCGCGGAAGGAGATGGTTGTCCGCTATTACGGCCTTAATCATTTTGGCTGGTGGACGTCAATTTGTGATAAAGACGGCA
ACGATCTGATGCCGGCGATCAAAGAGCATGTCAGGAGGTTCGGCTATATTCCGGAACAGGAGCATGAAAAGGCTGAGGCG
AGCTGGAATGACACGTTCAAAAAAGCGCGGGAAGTATTTGAACTCGATCCTGAGACGCTTCCAAATACGTATTTGCAATA
TTATTTTTATCCTGATGATATGGTGAAAAAATCAAACCCTGAATTTACCCGGGCGAACGAAGTAATGGAAGGGCGGGAGA
AATTCATTTTCGGCGAGTGTGAAAAAATCGCAAAAGCCCAATCCAGCGCCGGCAGCAAAATCGAAATTGATGATCATGCT
TCATATATTGTCGACCTTGCGCGCGCCCTTGCATTCAATACCGGTGAACGGATGCTTTTAATCGTTGAAAATAACGGAGC
GATCCAAAACTTCGATTCATCGGCGATGGTAGAGGTGCCTTGCATTGTCGGCAAGAACGGTCCGGAGCCGATCACAATCG
GCAAAATACCGCAGTTCCAAAAAGGGCTGATGGAACAGCAGGTGTCGGTTGAAAAGCTTGTCGTTGAAGCCTGGATTGAA
AAATCGTATCAAAAGCTTTGGCAGGCTCTGATTTTGTCGCGGACTGTGCCGAATGCACGAACAGCCAAACTGATTCTCGA
TGATCTGATTGAAGCGAACAAAGGCTATTGGCCGGAGCTCTCCGCGGAAAATCTTCAGCCGTCGCTTTAA

Upstream 100 bases:

>100_bases
ACAGAACGCGAGTATAGGAACTGTCTCCCCCGAACCTGTTGGAACGGCTCCTTCAGCATGATATAAGTAAATTGTAAACG
CTTATAAGGGGGCTTTAAAA

Downstream 100 bases:

>100_bases
GGATGAAAGCGCCTGGGGCTCCTGAGCCAGACCGCCAGCCCAGGCATATCCCCCCATTTATTCTCGTATTTTATATAATA
GAGACAGAGAATAAATGGGG

Product: MalA

Products: NA

Alternate protein names: 6-phospho-alpha-D-glucosidase; 6-phosphoryl-O-alpha-D-glucopyranosyl:phosphoglucohydrolase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MDKTYSIVIAGGGSTFTPGIVLMLLDNLDDFPIRQLKLYDNDGERQDKIAGACEVLVKERAPHIQFLATTDPEEAFSDVD
FVMAHIRVGKYAMRELDEKIPLKYGVVGQETCGPGGIAYGMRSIGGVLELIDYMETYSPDAWMLNYSNPAAIVAEATRRL
RPTSKVLNICDMPIGIEDRMAQILGLSSRKEMVVRYYGLNHFGWWTSICDKDGNDLMPAIKEHVRRFGYIPEQEHEKAEA
SWNDTFKKAREVFELDPETLPNTYLQYYFYPDDMVKKSNPEFTRANEVMEGREKFIFGECEKIAKAQSSAGSKIEIDDHA
SYIVDLARALAFNTGERMLLIVENNGAIQNFDSSAMVEVPCIVGKNGPEPITIGKIPQFQKGLMEQQVSVEKLVVEAWIE
KSYQKLWQALILSRTVPNARTAKLILDDLIEANKGYWPELSAENLQPSL

Sequences:

>Translated_449_residues
MDKTYSIVIAGGGSTFTPGIVLMLLDNLDDFPIRQLKLYDNDGERQDKIAGACEVLVKERAPHIQFLATTDPEEAFSDVD
FVMAHIRVGKYAMRELDEKIPLKYGVVGQETCGPGGIAYGMRSIGGVLELIDYMETYSPDAWMLNYSNPAAIVAEATRRL
RPTSKVLNICDMPIGIEDRMAQILGLSSRKEMVVRYYGLNHFGWWTSICDKDGNDLMPAIKEHVRRFGYIPEQEHEKAEA
SWNDTFKKAREVFELDPETLPNTYLQYYFYPDDMVKKSNPEFTRANEVMEGREKFIFGECEKIAKAQSSAGSKIEIDDHA
SYIVDLARALAFNTGERMLLIVENNGAIQNFDSSAMVEVPCIVGKNGPEPITIGKIPQFQKGLMEQQVSVEKLVVEAWIE
KSYQKLWQALILSRTVPNARTAKLILDDLIEANKGYWPELSAENLQPSL
>Mature_449_residues
MDKTYSIVIAGGGSTFTPGIVLMLLDNLDDFPIRQLKLYDNDGERQDKIAGACEVLVKERAPHIQFLATTDPEEAFSDVD
FVMAHIRVGKYAMRELDEKIPLKYGVVGQETCGPGGIAYGMRSIGGVLELIDYMETYSPDAWMLNYSNPAAIVAEATRRL
RPTSKVLNICDMPIGIEDRMAQILGLSSRKEMVVRYYGLNHFGWWTSICDKDGNDLMPAIKEHVRRFGYIPEQEHEKAEA
SWNDTFKKAREVFELDPETLPNTYLQYYFYPDDMVKKSNPEFTRANEVMEGREKFIFGECEKIAKAQSSAGSKIEIDDHA
SYIVDLARALAFNTGERMLLIVENNGAIQNFDSSAMVEVPCIVGKNGPEPITIGKIPQFQKGLMEQQVSVEKLVVEAWIE
KSYQKLWQALILSRTVPNARTAKLILDDLIEANKGYWPELSAENLQPSL

Specific function: Hydrolyzes maltose-6'-phosphate and trehalose-6'- phosphate. Is involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent maltose phosphotransferase system (PEP-PTS). Is also able to significantly catalyze the hydrolys

COG id: COG1486

COG function: function code G; Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 4 family [H]

Homologues:

Organism=Escherichia coli, GI1788029, Length=461, Percent_Identity=25.5965292841649, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI1790560, Length=454, Percent_Identity=24.4493392070485, Blast_Score=102, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019802
- InterPro:   IPR001088
- InterPro:   IPR022616
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02056 Glyco_hydro_4; PF11975 Glyco_hydro_4C [H]

EC number: =3.2.1.122 [H]

Molecular weight: Translated: 50622; Mature: 50622

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS01324 GLYCOSYL_HYDROL_F4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTYSIVIAGGGSTFTPGIVLMLLDNLDDFPIRQLKLYDNDGERQDKIAGACEVLVKER
CCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCC
APHIQFLATTDPEEAFSDVDFVMAHIRVGKYAMRELDEKIPLKYGVVGQETCGPGGIAYG
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHH
MRSIGGVLELIDYMETYSPDAWMLNYSNPAAIVAEATRRLRPTSKVLNICDMPIGIEDRM
HHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHH
AQILGLSSRKEMVVRYYGLNHFGWWTSICDKDGNDLMPAIKEHVRRFGYIPEQEHEKAEA
HHHHCCCCCHHHHHHEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHC
SWNDTFKKAREVFELDPETLPNTYLQYYFYPDDMVKKSNPEFTRANEVMEGREKFIFGEC
CHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EKIAKAQSSAGSKIEIDDHASYIVDLARALAFNTGERMLLIVENNGAIQNFDSSAMVEVP
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEE
CIVGKNGPEPITIGKIPQFQKGLMEQQVSVEKLVVEAWIEKSYQKLWQALILSRTVPNAR
EEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
TAKLILDDLIEANKGYWPELSAENLQPSL
HHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDKTYSIVIAGGGSTFTPGIVLMLLDNLDDFPIRQLKLYDNDGERQDKIAGACEVLVKER
CCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCC
APHIQFLATTDPEEAFSDVDFVMAHIRVGKYAMRELDEKIPLKYGVVGQETCGPGGIAYG
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHH
MRSIGGVLELIDYMETYSPDAWMLNYSNPAAIVAEATRRLRPTSKVLNICDMPIGIEDRM
HHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHH
AQILGLSSRKEMVVRYYGLNHFGWWTSICDKDGNDLMPAIKEHVRRFGYIPEQEHEKAEA
HHHHCCCCCHHHHHHEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHC
SWNDTFKKAREVFELDPETLPNTYLQYYFYPDDMVKKSNPEFTRANEVMEGREKFIFGEC
CHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EKIAKAQSSAGSKIEIDDHASYIVDLARALAFNTGERMLLIVENNGAIQNFDSSAMVEVP
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEE
CIVGKNGPEPITIGKIPQFQKGLMEQQVSVEKLVVEAWIEKSYQKLWQALILSRTVPNAR
EEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
TAKLILDDLIEANKGYWPELSAENLQPSL
HHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8704981; 9384377; 9765262; 11489864; 10329789 [H]