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The map label for this gene is gabR [H]

Identifier: 52784293

GI number: 52784293

Start: 474779

End: 476209

Strand: Reverse

Name: gabR [H]

Synonym: BLi00473

Alternate gene names: 52784293

Gene position: 476209-474779 (Counterclockwise)

Preceding gene: 52784297

Following gene: 52784291

Centisome position: 11.28

GC content: 48.85

Gene sequence:

>1431_bases
ATGATCACAATACCGATTGACCGCTCCAAGGGCGCGGAATATATTTATCACCAAATCTATCAACGGATTAAAGAAGAAAT
TTTCAGCCGCAACCTTTTGCCGGGGAAAAAGCTCCCATCCAAGCGAGAGCTCGCCGAAACATTGAACGTCAGCATCAATT
CGGTCAACGCCGCCTACCAGCAGCTTCTGGCAGAAGGTTATCTTTATTCGCGTGAAAGAAAAGGCTTTTTTGTAGAGCAG
ATCGAAACGTTCCACGCCAGCCGTCACCCCGGTCCCCTTCAATTGGAAAAAGAACTGGTTGAAGAGCCTGAAAGCAAAGA
CGGCTGGATCTCGTTTTCCCATATGAGCGTCGATACGGCGCATTTTCCGTTTAAAACATGGCTTCGCTGCGAACAGAAAG
CGGTTTCTTCACATGTTGACGAACTCGGAGAAATGACGCACCCGCAAGGCGTCTACGAAGTGCGCCAAACGATCGCACGC
TTTATCGCTTTAACGAGAGGCGTCAAATGTCTCCCCGAACAAATCGTGATCAGCGCAGGGACGCAGTCCTTAATTCACAC
GCTCCAGGACCTTCTCCCCGCCTCAGCCGTCTATGCGATGGAGGAGCCGGGATACAGCCGCATTTATCGACTGCTGAAAA
ATGAAGGAAAAGAAGTCGCCACGATTCAGCTCGACCATAAAGGAATGCGGATCAGCGAGATTCACCGTCTGAATCCGGAC
GTTTTATTTGTCACGCCTTCACACCAGTTTCCAACAGGAATCATTATGCCGGTATCGAGGAGGATTCAGCTTTTAAACTG
GGTTTCCGACGGGGCAAACCGCTATATTGTGGAAGACGATTATGACAGCGAATTTAAATACGGGAGCGATACGATCCCCG
CCCTGCAAAGCCTTGACCGCTCTGAAAAAGTCATCTACATCGGCACTTTTTCAAAATCGCTTCTTCCGGGCCTGAGAATC
AGCTATATGGTACTGCCGCAAAAGCTGCTGAAGCGATACAGAAAAAGGCACCATTTCTCGATTCAATCGAGCAGCGTCTT
AACGCAGCTCGCCCTGCAGGAACTGATCGAATCGGGGGAGTACCAAAAGCACATTAAGAAAATGAACCAGATTTACGAAA
AAAAGCGGACAAGGCTGATCGGAAGCCTTGTCAAACACTTTAACGGCCGGGTCAAAATTAAAGGCGAGAGCGCAGGCCTT
CACTTTGTGGCCGATTTTGAAACGGATAGAAGTGAAGAAGAGGTTTTATTAAGAGCAAAGGAAAGGCGGGTCGAGGTTTA
CGGCATGAGTCGGTTTACGTTAAAGAAAGAGCAGACAAAACATGAAGGAACGGTATCGCTCGTGCTCGGATTCGCCAAAA
TCGCTGCCGATCAGATCGACGAAGGGACTGCCAAGCTTTATGAAGCGGTATGCGGTGATGAGAAGCTTTAA

Upstream 100 bases:

>100_bases
AAAATCTCTCCCCCACTTTTATTTCTTATAATTCTGAATATTTTTTGGTATGATGAAAAGTACCAATCATTAATTTTTGA
TGGTACCAGAGGGAGGCGCT

Downstream 100 bases:

>100_bases
AAATACCGGCAGGTTCTTTCCTGCCGGTATCAGCCTGGCTTTAAAAAGCCGACATCTGGTCCGTTTACCACCGTTCCTTT
TCTACCTTGAGAACCGCCTC

Product: GabR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MITIPIDRSKGAEYIYHQIYQRIKEEIFSRNLLPGKKLPSKRELAETLNVSINSVNAAYQQLLAEGYLYSRERKGFFVEQ
IETFHASRHPGPLQLEKELVEEPESKDGWISFSHMSVDTAHFPFKTWLRCEQKAVSSHVDELGEMTHPQGVYEVRQTIAR
FIALTRGVKCLPEQIVISAGTQSLIHTLQDLLPASAVYAMEEPGYSRIYRLLKNEGKEVATIQLDHKGMRISEIHRLNPD
VLFVTPSHQFPTGIIMPVSRRIQLLNWVSDGANRYIVEDDYDSEFKYGSDTIPALQSLDRSEKVIYIGTFSKSLLPGLRI
SYMVLPQKLLKRYRKRHHFSIQSSSVLTQLALQELIESGEYQKHIKKMNQIYEKKRTRLIGSLVKHFNGRVKIKGESAGL
HFVADFETDRSEEEVLLRAKERRVEVYGMSRFTLKKEQTKHEGTVSLVLGFAKIAADQIDEGTAKLYEAVCGDEKL

Sequences:

>Translated_476_residues
MITIPIDRSKGAEYIYHQIYQRIKEEIFSRNLLPGKKLPSKRELAETLNVSINSVNAAYQQLLAEGYLYSRERKGFFVEQ
IETFHASRHPGPLQLEKELVEEPESKDGWISFSHMSVDTAHFPFKTWLRCEQKAVSSHVDELGEMTHPQGVYEVRQTIAR
FIALTRGVKCLPEQIVISAGTQSLIHTLQDLLPASAVYAMEEPGYSRIYRLLKNEGKEVATIQLDHKGMRISEIHRLNPD
VLFVTPSHQFPTGIIMPVSRRIQLLNWVSDGANRYIVEDDYDSEFKYGSDTIPALQSLDRSEKVIYIGTFSKSLLPGLRI
SYMVLPQKLLKRYRKRHHFSIQSSSVLTQLALQELIESGEYQKHIKKMNQIYEKKRTRLIGSLVKHFNGRVKIKGESAGL
HFVADFETDRSEEEVLLRAKERRVEVYGMSRFTLKKEQTKHEGTVSLVLGFAKIAADQIDEGTAKLYEAVCGDEKL
>Mature_476_residues
MITIPIDRSKGAEYIYHQIYQRIKEEIFSRNLLPGKKLPSKRELAETLNVSINSVNAAYQQLLAEGYLYSRERKGFFVEQ
IETFHASRHPGPLQLEKELVEEPESKDGWISFSHMSVDTAHFPFKTWLRCEQKAVSSHVDELGEMTHPQGVYEVRQTIAR
FIALTRGVKCLPEQIVISAGTQSLIHTLQDLLPASAVYAMEEPGYSRIYRLLKNEGKEVATIQLDHKGMRISEIHRLNPD
VLFVTPSHQFPTGIIMPVSRRIQLLNWVSDGANRYIVEDDYDSEFKYGSDTIPALQSLDRSEKVIYIGTFSKSLLPGLRI
SYMVLPQKLLKRYRKRHHFSIQSSSVLTQLALQELIESGEYQKHIKKMNQIYEKKRTRLIGSLVKHFNGRVKIKGESAGL
HFVADFETDRSEEEVLLRAKERRVEVYGMSRFTLKKEQTKHEGTVSLVLGFAKIAADQIDEGTAKLYEAVCGDEKL

Specific function: Activates the transcription of the gabTD operon. Is also a repressor of its own expression, both in the presence and absence of GABA. Binds specifically to the DNA region overlapping the -35 region of the gabT promoter and the -10 and +1 regions of the ga

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787710, Length=400, Percent_Identity=24.5, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790797, Length=389, Percent_Identity=24.9357326478149, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000524
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 54572; Mature: 54572

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIPIDRSKGAEYIYHQIYQRIKEEIFSRNLLPGKKLPSKRELAETLNVSINSVNAAYQ
CEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHH
QLLAEGYLYSRERKGFFVEQIETFHASRHPGPLQLEKELVEEPESKDGWISFSHMSVDTA
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEEEEEEECCC
HFPFKTWLRCEQKAVSSHVDELGEMTHPQGVYEVRQTIARFIALTRGVKCLPEQIVISAG
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHCCHHHHHHCC
TQSLIHTLQDLLPASAVYAMEEPGYSRIYRLLKNEGKEVATIQLDHKGMRISEIHRLNPD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCCC
VLFVTPSHQFPTGIIMPVSRRIQLLNWVSDGANRYIVEDDYDSEFKYGSDTIPALQSLDR
EEEEECCCCCCCCEEECHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHCCC
SEKVIYIGTFSKSLLPGLRISYMVLPQKLLKRYRKRHHFSIQSSSVLTQLALQELIESGE
CCCEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
YQKHIKKMNQIYEKKRTRLIGSLVKHFNGRVKIKGESAGLHFVADFETDRSEEEVLLRAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHH
ERRVEVYGMSRFTLKKEQTKHEGTVSLVLGFAKIAADQIDEGTAKLYEAVCGDEKL
HCEEEEEECCHHEECHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MITIPIDRSKGAEYIYHQIYQRIKEEIFSRNLLPGKKLPSKRELAETLNVSINSVNAAYQ
CEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHH
QLLAEGYLYSRERKGFFVEQIETFHASRHPGPLQLEKELVEEPESKDGWISFSHMSVDTA
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEEEEEEECCC
HFPFKTWLRCEQKAVSSHVDELGEMTHPQGVYEVRQTIARFIALTRGVKCLPEQIVISAG
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHCCHHHHHHCC
TQSLIHTLQDLLPASAVYAMEEPGYSRIYRLLKNEGKEVATIQLDHKGMRISEIHRLNPD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCCC
VLFVTPSHQFPTGIIMPVSRRIQLLNWVSDGANRYIVEDDYDSEFKYGSDTIPALQSLDR
EEEEECCCCCCCCEEECHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHCCC
SEKVIYIGTFSKSLLPGLRISYMVLPQKLLKRYRKRHHFSIQSSSVLTQLALQELIESGE
CCCEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
YQKHIKKMNQIYEKKRTRLIGSLVKHFNGRVKIKGESAGLHFVADFETDRSEEEVLLRAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHH
ERRVEVYGMSRFTLKKEQTKHEGTVSLVLGFAKIAADQIDEGTAKLYEAVCGDEKL
HCEEEEEECCHHEECHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]