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The map label for this gene is ycgH [H]

Identifier: 52784191

GI number: 52784191

Start: 345650

End: 346984

Strand: Reverse

Name: ycgH [H]

Synonym: BLi00369

Alternate gene names: 52784191

Gene position: 346984-345650 (Counterclockwise)

Preceding gene: 52784199

Following gene: 52784187

Centisome position: 8.22

GC content: 48.24

Gene sequence:

>1335_bases
ATGAAACGACAAGCGAAAAAAGGAGATTTAAAATGGTGGCAGCTGTCCATGATCGGGGTCGGCTGCACAATTGGAACGGG
GTTTTTCCTCGGCTCAAGCATCGCGATTAAGAAAAGCGGCTTTTCCGTATTAGCCGCCTTTCTTCTTGCTGCCCTTGGCA
CTTTTCTTGTTTTTCAGCAGCTGGCGAAATTAACGGCAGATCATCCTGTTGAAGGGTCTTTTTGTTCTTACGCCAGAGAG
GCCTTCGGCAATTGGGCGGGGTTTAGCAATGGCTGGGTCTACTGGTCATCGGAAATGCTGATCATCGGGAGCCAGTTGAC
AGCGATTTCCCTGTTTACGCGCCATTGGTTTAACGAGATTCCGCTGTGGGTGTTCGCCTCTATTTATGCGATTCTCGGAT
TGATCGTCATTTTCACAGGGCGCAGCAGCTTTGAAAAAACGGAAAACATATTGGCCGTGTTGAAAACGGCGGCCATTTTA
ATGTTTATCATCATCGCTGTCTTGGCATTGTGCGGGCTGCTGCCTGGAAAAACGCCTGAAGTGCAGTTCCCTGACCGGGT
TCACGAATTGTTTCCTTTCGGCTTTATGGGATTGTGGACGGGGTTGATTTATACATTTTACGCTTATGGAGGAATCGAAG
TCATGGGTCTGATGGCGATTCACTTAAAAGACCCGAAGGATTCATCAAAGTCAGGCAGCCTGATGCTCATAACCCTTGCT
GTGGTCTACGTCGTATCGATCGGGCTGGCCATGCTCCTTGTACCACGCGGAACATTCACCGAACAGAACAGCCCGTTTAT
TACGTCATTAAAAGACTTTCATCTCGATTTGATCATGGATATTTTCAACGGCATTTTTATTATTGCCGGTTTTTCAACGC
TGACCGCTTCCCTGTTCGCCGTCACCACACTGATGGGAACAATGGCGAAAAACGGGGATGCACCGGCCTGCTTTGCCAAA
AAAGAAAAGGCGAAAGTATCGTGGCCGGCACTCGGCCTGACAGTGCTCGTTCTCGCTGCTTCCATCGTCTTGTCGCTCAT
TTTGCCGAAGCAGCTTTATGAACACATGACGACGGCCGCCAGCTTGATGCTGCTCTATAACTGGATGTTTATCCTGCTTT
CCAGCAAAAAGCTCACAAAACCGAAAATGAAAGGGAATGTCCAGATTGTCACAGCGCTCGTCCTGATTTTGTTCGCCGTT
TCGGGTACGTTATTTGAAAAAAACAGCAGACCCGGTTTTTTTGTGAGCCTTCTCTTTCTTGCCGTTATTGCTGCTGTGAC
GATGCTCATGAAAAAAAAGTGGGCGGATCAGGAAGAGAAAAACGGGCAGACATGA

Upstream 100 bases:

>100_bases
ATTTCAAAGTGAATATTGAGGTGCGCAAAGAACCTCCCCCTTTGCGAATAAAAACGGAGCCCCCTGGCAAAATAACAAGA
AGATTAGAGGGGTTGAAACG

Downstream 100 bases:

>100_bases
TCAGCGCCCCGCCTGCAGCAGTTCGAGAATTCCCTGATAGCCGAAGTAGCATCCAAATACGATCAGACTGATGCCCGCGA
GCCAAGTCGTTCCCTGGATC

Product: YcgH

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MKRQAKKGDLKWWQLSMIGVGCTIGTGFFLGSSIAIKKSGFSVLAAFLLAALGTFLVFQQLAKLTADHPVEGSFCSYARE
AFGNWAGFSNGWVYWSSEMLIIGSQLTAISLFTRHWFNEIPLWVFASIYAILGLIVIFTGRSSFEKTENILAVLKTAAIL
MFIIIAVLALCGLLPGKTPEVQFPDRVHELFPFGFMGLWTGLIYTFYAYGGIEVMGLMAIHLKDPKDSSKSGSLMLITLA
VVYVVSIGLAMLLVPRGTFTEQNSPFITSLKDFHLDLIMDIFNGIFIIAGFSTLTASLFAVTTLMGTMAKNGDAPACFAK
KEKAKVSWPALGLTVLVLAASIVLSLILPKQLYEHMTTAASLMLLYNWMFILLSSKKLTKPKMKGNVQIVTALVLILFAV
SGTLFEKNSRPGFFVSLLFLAVIAAVTMLMKKKWADQEEKNGQT

Sequences:

>Translated_444_residues
MKRQAKKGDLKWWQLSMIGVGCTIGTGFFLGSSIAIKKSGFSVLAAFLLAALGTFLVFQQLAKLTADHPVEGSFCSYARE
AFGNWAGFSNGWVYWSSEMLIIGSQLTAISLFTRHWFNEIPLWVFASIYAILGLIVIFTGRSSFEKTENILAVLKTAAIL
MFIIIAVLALCGLLPGKTPEVQFPDRVHELFPFGFMGLWTGLIYTFYAYGGIEVMGLMAIHLKDPKDSSKSGSLMLITLA
VVYVVSIGLAMLLVPRGTFTEQNSPFITSLKDFHLDLIMDIFNGIFIIAGFSTLTASLFAVTTLMGTMAKNGDAPACFAK
KEKAKVSWPALGLTVLVLAASIVLSLILPKQLYEHMTTAASLMLLYNWMFILLSSKKLTKPKMKGNVQIVTALVLILFAV
SGTLFEKNSRPGFFVSLLFLAVIAAVTMLMKKKWADQEEKNGQT
>Mature_444_residues
MKRQAKKGDLKWWQLSMIGVGCTIGTGFFLGSSIAIKKSGFSVLAAFLLAALGTFLVFQQLAKLTADHPVEGSFCSYARE
AFGNWAGFSNGWVYWSSEMLIIGSQLTAISLFTRHWFNEIPLWVFASIYAILGLIVIFTGRSSFEKTENILAVLKTAAIL
MFIIIAVLALCGLLPGKTPEVQFPDRVHELFPFGFMGLWTGLIYTFYAYGGIEVMGLMAIHLKDPKDSSKSGSLMLITLA
VVYVVSIGLAMLLVPRGTFTEQNSPFITSLKDFHLDLIMDIFNGIFIIAGFSTLTASLFAVTTLMGTMAKNGDAPACFAK
KEKAKVSWPALGLTVLVLAASIVLSLILPKQLYEHMTTAASLMLLYNWMFILLSSKKLTKPKMKGNVQIVTALVLILFAV
SGTLFEKNSRPGFFVSLLFLAVIAAVTMLMKKKWADQEEKNGQT

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=429, Percent_Identity=26.3403263403263, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87081915, Length=384, Percent_Identity=27.8645833333333, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786789, Length=365, Percent_Identity=25.2054794520548, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1786602, Length=459, Percent_Identity=24.400871459695, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI87081708, Length=461, Percent_Identity=25.1626898047722, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1789017, Length=392, Percent_Identity=25.5102040816327, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI48994972, Length=444, Percent_Identity=23.1981981981982, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1790653, Length=457, Percent_Identity=23.6323851203501, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1788480, Length=388, Percent_Identity=24.2268041237113, Blast_Score=121, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6324061, Length=402, Percent_Identity=23.3830845771144, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320772, Length=400, Percent_Identity=23.25, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324553, Length=331, Percent_Identity=26.8882175226586, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320251, Length=404, Percent_Identity=22.029702970297, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324990, Length=398, Percent_Identity=23.1155778894472, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321629, Length=447, Percent_Identity=23.7136465324385, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322967, Length=337, Percent_Identity=24.3323442136499, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324924, Length=362, Percent_Identity=22.9281767955801, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324059, Length=304, Percent_Identity=22.6973684210526, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322892, Length=362, Percent_Identity=21.2707182320442, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320717, Length=412, Percent_Identity=20.1456310679612, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319543, Length=396, Percent_Identity=22.4747474747475, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324981, Length=416, Percent_Identity=20.6730769230769, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321053, Length=340, Percent_Identity=22.3529411764706, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319824, Length=410, Percent_Identity=18.5365853658537, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48713; Mature: 48713

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRQAKKGDLKWWQLSMIGVGCTIGTGFFLGSSIAIKKSGFSVLAAFLLAALGTFLVFQQ
CCCCCCCCCCCEEEEEEEECCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LAKLTADHPVEGSFCSYAREAFGNWAGFSNGWVYWSSEMLIIGSQLTAISLFTRHWFNEI
HHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCEEEEECHHHHHHHHHHHHHHHC
PLWVFASIYAILGLIVIFTGRSSFEKTENILAVLKTAAILMFIIIAVLALCGLLPGKTPE
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
VQFPDRVHELFPFGFMGLWTGLIYTFYAYGGIEVMGLMAIHLKDPKDSSKSGSLMLITLA
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHEEEECCCCCCCCCCCCHHHHHH
VVYVVSIGLAMLLVPRGTFTEQNSPFITSLKDFHLDLIMDIFNGIFIIAGFSTLTASLFA
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHH
VTTLMGTMAKNGDAPACFAKKEKAKVSWPALGLTVLVLAASIVLSLILPKQLYEHMTTAA
HHHHHHHHHCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLMLLYNWMFILLSSKKLTKPKMKGNVQIVTALVLILFAVSGTLFEKNSRPGFFVSLLFL
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHH
AVIAAVTMLMKKKWADQEEKNGQT
HHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKRQAKKGDLKWWQLSMIGVGCTIGTGFFLGSSIAIKKSGFSVLAAFLLAALGTFLVFQQ
CCCCCCCCCCCEEEEEEEECCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LAKLTADHPVEGSFCSYAREAFGNWAGFSNGWVYWSSEMLIIGSQLTAISLFTRHWFNEI
HHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCEEEEECHHHHHHHHHHHHHHHC
PLWVFASIYAILGLIVIFTGRSSFEKTENILAVLKTAAILMFIIIAVLALCGLLPGKTPE
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
VQFPDRVHELFPFGFMGLWTGLIYTFYAYGGIEVMGLMAIHLKDPKDSSKSGSLMLITLA
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHEEEECCCCCCCCCCCCHHHHHH
VVYVVSIGLAMLLVPRGTFTEQNSPFITSLKDFHLDLIMDIFNGIFIIAGFSTLTASLFA
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHH
VTTLMGTMAKNGDAPACFAKKEKAKVSWPALGLTVLVLAASIVLSLILPKQLYEHMTTAA
HHHHHHHHHCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLMLLYNWMFILLSSKKLTKPKMKGNVQIVTALVLILFAVSGTLFEKNSRPGFFVSLLFL
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHH
AVIAAVTMLMKKKWADQEEKNGQT
HHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]