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The map label for this gene is folK [H]

Identifier: 52783936

GI number: 52783936

Start: 91585

End: 92085

Strand: Direct

Name: folK [H]

Synonym: BLi00095

Alternate gene names: 52783936

Gene position: 91585-92085 (Clockwise)

Preceding gene: 52783935

Following gene: 52783937

Centisome position: 2.17

GC content: 43.51

Gene sequence:

>501_bases
ATGAACAACACGGCATATATAGCGCTCGGCTCGAATATCGGCCGGCGGGAAGAATATTTAAAAAAAGCTGTCTCTCTCCT
CCATCAACATCCGTCTGTAGAGGTGACAGACATCTCGTCAATTTACGAAACTGATCCTGTCGGTTATACAGACCAAGATC
TATTTTTAAACATGGCTGCAGCTGTTAAAACATCTCTTTCACCGTTTGAATTGCTCGATTTGACTCAGCGTATTGAAAAA
GAACTCGGCCGCAAACGCGACATTAGATGGGGGCCGAGGACTGCAGACCTTGACATTTTGTTGTATAATCGTGAAAATAT
TGAGACAGAGCAACTTATCGTTCCTCATCCTAGAATGCATGAACGTTTGTTTGTACTCATCCCGCTGCTGGAGATTTATC
CGGATCTTGAGGGAGCTGTCAATCATGCAAAAAATCAAGAAGGTGTAAGAGTATGGAAGCAGAAATCTGGGGTAGACGAA
TTCGTGCATATCGAAAGCTGA

Upstream 100 bases:

>100_bases
TTGAAGCGGTTCAGGAATGTACGGTTAAAGTCGTCAAGCCTGATCCTCCTATACCTGGGCACTATAAATCGGTGGCCATC
GAGATGACGAGAAAGCGAAA

Downstream 100 bases:

>100_bases
AGGGTTATACTCAAGAAGGGTTTGCCAAAGCATTGGGTATATCCGTTTCTGTGCTTGGTGAAGTAGAACGCGGGAATCGT
ATGCCGACGGAGAGCATGCT

Product: hypothetical protein

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MNNTAYIALGSNIGRREEYLKKAVSLLHQHPSVEVTDISSIYETDPVGYTDQDLFLNMAAAVKTSLSPFELLDLTQRIEK
ELGRKRDIRWGPRTADLDILLYNRENIETEQLIVPHPRMHERLFVLIPLLEIYPDLEGAVNHAKNQEGVRVWKQKSGVDE
FVHIES

Sequences:

>Translated_166_residues
MNNTAYIALGSNIGRREEYLKKAVSLLHQHPSVEVTDISSIYETDPVGYTDQDLFLNMAAAVKTSLSPFELLDLTQRIEK
ELGRKRDIRWGPRTADLDILLYNRENIETEQLIVPHPRMHERLFVLIPLLEIYPDLEGAVNHAKNQEGVRVWKQKSGVDE
FVHIES
>Mature_166_residues
MNNTAYIALGSNIGRREEYLKKAVSLLHQHPSVEVTDISSIYETDPVGYTDQDLFLNMAAAVKTSLSPFELLDLTQRIEK
ELGRKRDIRWGPRTADLDILLYNRENIETEQLIVPHPRMHERLFVLIPLLEIYPDLEGAVNHAKNQEGVRVWKQKSGVDE
FVHIES

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=135, Percent_Identity=49.6296296296296, Blast_Score=122, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324073, Length=136, Percent_Identity=44.1176470588235, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19093; Mature: 19093

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTAYIALGSNIGRREEYLKKAVSLLHQHPSVEVTDISSIYETDPVGYTDQDLFLNMAA
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCCCCHHHHHHHHH
AVKTSLSPFELLDLTQRIEKELGRKRDIRWGPRTADLDILLYNRENIETEQLIVPHPRMH
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCHH
ERLFVLIPLLEIYPDLEGAVNHAKNQEGVRVWKQKSGVDEFVHIES
HHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MNNTAYIALGSNIGRREEYLKKAVSLLHQHPSVEVTDISSIYETDPVGYTDQDLFLNMAA
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCCCCHHHHHHHHH
AVKTSLSPFELLDLTQRIEKELGRKRDIRWGPRTADLDILLYNRENIETEQLIVPHPRMH
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCHH
ERLFVLIPLLEIYPDLEGAVNHAKNQEGVRVWKQKSGVDEFVHIES
HHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]