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The map label for this gene is serS [H]

Identifier: 52783868

GI number: 52783868

Start: 20841

End: 22118

Strand: Direct

Name: serS [H]

Synonym: BLi00018

Alternate gene names: 52783868

Gene position: 20841-22118 (Clockwise)

Preceding gene: 52783867

Following gene: 52783876

Centisome position: 0.49

GC content: 47.42

Gene sequence:

>1278_bases
ATGCTTGATGTCAAACTGCTGCGGGCAAATTTTGAAGAAATCAAACAAAAGCTTGCCCACAGGGGAGAAGATTTATCAGA
TTTTGATCAATTTGAGGAATTGGATACAAAGAGAAGAGAATTGATCGTCAAAGTGGAAGAGCTGAAAGGGAAGCGCAATG
AGGTATCTCAGCAGGTTGCCGCTTTAAAGCGCGAGAAAAAAGATGCTGACCACCTCATTAAAGAAATGCGCGAAGTCGGT
GAAGACATTAAAAAACTTGATGAAGAGCTGAGAACGGTCGAGTCTTCGCTTGATAAAATCATGTTGTCTATCCCGAACAT
CCCCCACGAGTCTGTTCCGGTCGGTGAGACTGAAGACGACAACGTGGAAGTTCGCAAATGGGGCGAACTCCCTGAGTTTT
CGTTTGAGCCGAAGCCTCATTGGGATATTGCCGATCAATTGGATATTCTCGATTTTGAACGGGCCGGCAAGGTAACGGGA
AGCCGTTTCGTTTTCTATAAAGGGCTCGGCGCCAGACTTGAACGCGCATTGTATAACTTTATGCTTGATCTCCACGTAGA
CGAGTACGGCTATACGGAAGTCATCCCGCCGTACATGGTGAACCGCGCAAGCATGACAGGCACCGGACAGCTGCCGAAGT
TTGAGGAAGATGCTTTTAAGATCAGGGAAGAAGATTATTTCTTAATTCCGACGGCGGAAGTGCCGATTACGAACCTGCAT
CGCGATGAAATTTTGTCAGCTGACGAGCTGCCGATCAATTATGCGGCGTTCAGTGCGTGCTTCCGTTCAGAAGCAGGCTC
TGCCGGACGTGATACGCGCGGTTTGATTCGCCAGCACCAATTTAACAAGGTTGAACTGGTGAAATTTGTGAAGCCTGAGG
ATTCATATGAAGAGCTTGAAAAACTGACAAATCAAGCGGAGAAGGTTCTTCAGCTGCTTGAGCTTCCTTATCGGGTGATG
AGCATGTGTACGGGCGATCTGGGGTTTACCGCTGCGAAAAAATACGATATTGAAGTATGGATTCCAAGCCAAAACACATA
TCGCGAAATTTCATCATGCAGCAACTTTGAAGCTTTCCAGGCCAGACGGGCGAATATCAGATTCAGAAGGGAAGCAAAAG
GCAAGCCAGAGCATGTCCATACGCTAAACGGATCCGGCTTGGCAGTCGGCAGAACGGTTGCCGCATTATTGGAAAATTAT
CAGCAGGAGGACGGAAGCGTCATCATCCCTAAAGCGCTTCGTCCATACATGGGGAACAGAGACGTTATTCAACCATAA

Upstream 100 bases:

>100_bases
TGTTTTCAATCAGGGTGGCAACGCGAGAGCTCTCGTCCCTTTTATTTAGGGGACAAGGGCTCTTTTTTTCGGTCAAATCA
GTATAAAAGGAGCGAGGCAG

Downstream 100 bases:

>100_bases
AAAAGTGCGCGCCAATAGGCGCGCTTTTTTTATTCGAGTGACCAGACGGCGGCTACATTTCGCGCACAGCGCGTAAGATT
TGAACTTCCATCGGCAAGAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDVKLLRANFEEIKQKLAHRGEDLSDFDQFEELDTKRRELIVKVEELKGKRNEVSQQVAALKREKKDADHLIKEMREVG
EDIKKLDEELRTVESSLDKIMLSIPNIPHESVPVGETEDDNVEVRKWGELPEFSFEPKPHWDIADQLDILDFERAGKVTG
SRFVFYKGLGARLERALYNFMLDLHVDEYGYTEVIPPYMVNRASMTGTGQLPKFEEDAFKIREEDYFLIPTAEVPITNLH
RDEILSADELPINYAAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNQAEKVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWIPSQNTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRTVAALLENY
QQEDGSVIIPKALRPYMGNRDVIQP

Sequences:

>Translated_425_residues
MLDVKLLRANFEEIKQKLAHRGEDLSDFDQFEELDTKRRELIVKVEELKGKRNEVSQQVAALKREKKDADHLIKEMREVG
EDIKKLDEELRTVESSLDKIMLSIPNIPHESVPVGETEDDNVEVRKWGELPEFSFEPKPHWDIADQLDILDFERAGKVTG
SRFVFYKGLGARLERALYNFMLDLHVDEYGYTEVIPPYMVNRASMTGTGQLPKFEEDAFKIREEDYFLIPTAEVPITNLH
RDEILSADELPINYAAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNQAEKVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWIPSQNTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRTVAALLENY
QQEDGSVIIPKALRPYMGNRDVIQP
>Mature_425_residues
MLDVKLLRANFEEIKQKLAHRGEDLSDFDQFEELDTKRRELIVKVEELKGKRNEVSQQVAALKREKKDADHLIKEMREVG
EDIKKLDEELRTVESSLDKIMLSIPNIPHESVPVGETEDDNVEVRKWGELPEFSFEPKPHWDIADQLDILDFERAGKVTG
SRFVFYKGLGARLERALYNFMLDLHVDEYGYTEVIPPYMVNRASMTGTGQLPKFEEDAFKIREEDYFLIPTAEVPITNLH
RDEILSADELPINYAAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNQAEKVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWIPSQNTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRTVAALLENY
QQEDGSVIIPKALRPYMGNRDVIQP

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=362, Percent_Identity=37.5690607734807, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI8923421, Length=440, Percent_Identity=32.5, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI225579074, Length=330, Percent_Identity=35.7575757575758, Blast_Score=202, Evalue=5e-52,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=52.3255813953488, Blast_Score=442, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17539260, Length=463, Percent_Identity=31.317494600432, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=323, Percent_Identity=30.6501547987616, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320226, Length=389, Percent_Identity=35.73264781491, Blast_Score=242, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6321799, Length=415, Percent_Identity=31.8072289156626, Blast_Score=216, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24581334, Length=361, Percent_Identity=35.1800554016621, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17737985, Length=349, Percent_Identity=32.9512893982808, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48877; Mature: 48877

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVKLLRANFEEIKQKLAHRGEDLSDFDQFEELDTKRRELIVKVEELKGKRNEVSQQVA
CCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ALKREKKDADHLIKEMREVGEDIKKLDEELRTVESSLDKIMLSIPNIPHESVPVGETEDD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEVRKWGELPEFSFEPKPHWDIADQLDILDFERAGKVTGSRFVFYKGLGARLERALYNF
CEEHEECCCCCCCCCCCCCCCCCHHCCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHH
MLDLHVDEYGYTEVIPPYMVNRASMTGTGQLPKFEEDAFKIREEDYFLIPTAEVPITNLH
HHHEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCCC
RDEILSADELPINYAAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELE
HHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
KLTNQAEKVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWIPSQNTYREISSCSNFEAFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCHHHHHHHCCCCHHHHH
ARRANIRFRREAKGKPEHVHTLNGSGLAVGRTVAALLENYQQEDGSVIIPKALRPYMGNR
HHHCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECHHHCCCCCCC
DVIQP
CCCCC
>Mature Secondary Structure
MLDVKLLRANFEEIKQKLAHRGEDLSDFDQFEELDTKRRELIVKVEELKGKRNEVSQQVA
CCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ALKREKKDADHLIKEMREVGEDIKKLDEELRTVESSLDKIMLSIPNIPHESVPVGETEDD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEVRKWGELPEFSFEPKPHWDIADQLDILDFERAGKVTGSRFVFYKGLGARLERALYNF
CEEHEECCCCCCCCCCCCCCCCCHHCCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHH
MLDLHVDEYGYTEVIPPYMVNRASMTGTGQLPKFEEDAFKIREEDYFLIPTAEVPITNLH
HHHEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCCC
RDEILSADELPINYAAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELE
HHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
KLTNQAEKVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWIPSQNTYREISSCSNFEAFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCHHHHHHHCCCCHHHHH
ARRANIRFRREAKGKPEHVHTLNGSGLAVGRTVAALLENYQQEDGSVIIPKALRPYMGNR
HHHCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECHHHCCCCCCC
DVIQP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA