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The map label for this gene is bla [H]

Identifier: 52142992

GI number: 52142992

Start: 2376585

End: 2377514

Strand: Direct

Name: bla [H]

Synonym: BCZK2247

Alternate gene names: 52142992

Gene position: 2376585-2377514 (Clockwise)

Preceding gene: 52142993

Following gene: 52142990

Centisome position: 44.83

GC content: 38.71

Gene sequence:

>930_bases
ATGATGATTTTGAAAAACAAGAAAATGCTAAAAATAGGGATGTGCGTTGGTATATTAGGTTTAAGTTTTACAAGCCTCGA
AGCTTTTACAGGAGGACCATTGCAAGTTGAAGCGAAAGAAAAGAAAGGGCAAATAAAACATAAAAAGCAGGCGACGCATA
AAGAGTTTTCTCAACTTGAGAAAAAATTTGATGCTCAATTAGGTGTATATGCGATTGATACTGGTTCAAATCAGACAATC
GCTTATCGACCTAACGAAAGGTTTGCCTTTGCATCAACTTACAAGGCTTTAGCGGCAGGGGTATTACTGCAACAGAACTC
TACTAAGAAATTAGATGAAGTTATTACTTATACGAAAGAAGACTTAGTGGATTATTCACCTGTTACAGAGAAACATGTAG
ATACTGGAATGACACTAGGAGAAATTGCGGAGGCTGCTGTTCGTTACAGTGATAATACTGCAGGGAATATTTTATTTAAC
AAAATAGGTGGACCGAAAGGATATGAAAAAGCGCTTAGAAAAATGGGGGATCGAATTACTATGTCTGATCGCCTTGAAAC
GGAATTAAACGAGGCTATTCCAGGGGATATTCGTGACACTAGTACAGCGAAAGCAGTTGCTATGAATCTTAAAGCTTTTA
CGGCCGGAAATGCGCTTCCAAATCATAAACGTAACATTCTTACAGAATGGATGAAAGGAAATGCTACAGGAGACAAACTT
ATTCGTGCAGGTGTGCCAACTGATTGGGTAGTTGCAGATAAATCAGGTGCAGGAAGTTACGGGACACGAAATGATATTGC
GATCGTTTGGCCACCAAATAGAGCACCTATTATCATCGCAATTTTATCTAGTAAAGATGAGAAAGAGGCTACCTATGATA
ATCAACTCATTGCAGAGGCGGCTGAAGTTGTCGTTAATGCTTTTAAGTGA

Upstream 100 bases:

>100_bases
TGTGATACGAGCGATAAAATTTTTAAAGTTTATGGAACAAACTTGTTTCGATGATTGTCTATTATATGTAAGTAAAAAAA
GTGTTAAGAACTTGAAAGGG

Downstream 100 bases:

>100_bases
TAATCTCTCAATTCTTTATGTAATGTAATTGAAAATATGAACTTGGAAAGCGATTCTTTTTAATGTGAAAAGAATCGCTT
TTTTGTATTCCTAATACATT

Product: beta-lactamase

Products: NA

Alternate protein names: Beta-lactamase I; Penicillinase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MMILKNKKMLKIGMCVGILGLSFTSLEAFTGGPLQVEAKEKKGQIKHKKQATHKEFSQLEKKFDAQLGVYAIDTGSNQTI
AYRPNERFAFASTYKALAAGVLLQQNSTKKLDEVITYTKEDLVDYSPVTEKHVDTGMTLGEIAEAAVRYSDNTAGNILFN
KIGGPKGYEKALRKMGDRITMSDRLETELNEAIPGDIRDTSTAKAVAMNLKAFTAGNALPNHKRNILTEWMKGNATGDKL
IRAGVPTDWVVADKSGAGSYGTRNDIAIVWPPNRAPIIIAILSSKDEKEATYDNQLIAEAAEVVVNAFK

Sequences:

>Translated_309_residues
MMILKNKKMLKIGMCVGILGLSFTSLEAFTGGPLQVEAKEKKGQIKHKKQATHKEFSQLEKKFDAQLGVYAIDTGSNQTI
AYRPNERFAFASTYKALAAGVLLQQNSTKKLDEVITYTKEDLVDYSPVTEKHVDTGMTLGEIAEAAVRYSDNTAGNILFN
KIGGPKGYEKALRKMGDRITMSDRLETELNEAIPGDIRDTSTAKAVAMNLKAFTAGNALPNHKRNILTEWMKGNATGDKL
IRAGVPTDWVVADKSGAGSYGTRNDIAIVWPPNRAPIIIAILSSKDEKEATYDNQLIAEAAEVVVNAFK
>Mature_309_residues
MMILKNKKMLKIGMCVGILGLSFTSLEAFTGGPLQVEAKEKKGQIKHKKQATHKEFSQLEKKFDAQLGVYAIDTGSNQTI
AYRPNERFAFASTYKALAAGVLLQQNSTKKLDEVITYTKEDLVDYSPVTEKHVDTGMTLGEIAEAAVRYSDNTAGNILFN
KIGGPKGYEKALRKMGDRITMSDRLETELNEAIPGDIRDTSTAKAVAMNLKAFTAGNALPNHKRNILTEWMKGNATGDKL
IRAGVPTDWVVADKSGAGSYGTRNDIAIVWPPNRAPIIIAILSSKDEKEATYDNQLIAEAAEVVVNAFK

Specific function: Acts preferentially on penicillins [H]

COG id: COG2367

COG function: function code V; Beta-lactamase class A

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-A beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR000871 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 33789; Mature: 33789

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMILKNKKMLKIGMCVGILGLSFTSLEAFTGGPLQVEAKEKKGQIKHKKQATHKEFSQLE
CEEECCCCEEEHHHHHHHHHCCHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHH
KKFDAQLGVYAIDTGSNQTIAYRPNERFAFASTYKALAAGVLLQQNSTKKLDEVITYTKE
HHHCCCCCEEEEECCCCCEEEECCCCCEEHHHHHHHHHHHHHEECCCHHHHHHHHHHHHH
DLVDYSPVTEKHVDTGMTLGEIAEAAVRYSDNTAGNILFNKIGGPKGYEKALRKMGDRIT
HHCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCC
MSDRLETELNEAIPGDIRDTSTAKAVAMNLKAFTAGNALPNHKRNILTEWMKGNATGDKL
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCCCHHHH
IRAGVPTDWVVADKSGAGSYGTRNDIAIVWPPNRAPIIIAILSSKDEKEATYDNQLIAEA
EECCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHH
AEVVVNAFK
HHHHHHHCC
>Mature Secondary Structure
MMILKNKKMLKIGMCVGILGLSFTSLEAFTGGPLQVEAKEKKGQIKHKKQATHKEFSQLE
CEEECCCCEEEHHHHHHHHHCCHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHH
KKFDAQLGVYAIDTGSNQTIAYRPNERFAFASTYKALAAGVLLQQNSTKKLDEVITYTKE
HHHCCCCCEEEEECCCCCEEEECCCCCEEHHHHHHHHHHHHHEECCCHHHHHHHHHHHHH
DLVDYSPVTEKHVDTGMTLGEIAEAAVRYSDNTAGNILFNKIGGPKGYEKALRKMGDRIT
HHCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCC
MSDRLETELNEAIPGDIRDTSTAKAVAMNLKAFTAGNALPNHKRNILTEWMKGNATGDKL
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCCCHHHH
IRAGVPTDWVVADKSGAGSYGTRNDIAIVWPPNRAPIIIAILSSKDEKEATYDNQLIAEA
EECCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHH
AEVVVNAFK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2991192 [H]