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The map label for this gene is degA [H]

Identifier: 52142990

GI number: 52142990

Start: 2378335

End: 2379336

Strand: Direct

Name: degA [H]

Synonym: BCZK2249

Alternate gene names: 52142990

Gene position: 2378335-2379336 (Clockwise)

Preceding gene: 52142992

Following gene: 52142988

Centisome position: 44.87

GC content: 36.63

Gene sequence:

>1002_bases
GTGAAACCAACAATTTATGATGTTGCGGAAAAAGCAGGTGTATCAATAGCGACTGTATCCAAGGTAATTAATCAAACTGG
ACGTATTAGTGAAAAAACAATAAACAAAGTAAATCAGGTAATGGATGAACTAGATTACCAGCCAAGTAGTGTAGCGGCAG
CGTTAACAGGTAAAAAAACATATACGATTGGGGTACTTGTCCCAGATATCTCAAACCCTTTTTTTGCAGAAGTAGCAAGA
GCATTTGAAAATAGTGCACGAGAATCAGGGTATACACTCATTCTATGTAGTACAGACCATCAAACAAAACGTGAACACGA
GTACATTGATCTATTATTTAAAAAGCAAGTAGATGGCATTATTATTGCAACGGAGCTAAATGATTATAAGCTTGTAAAAA
AAATTGTAAATCGAGATTTGCCACTAGTATTATTCACTGTAGATCATTCTTCCATCACGACTCATGTTGTGACAACTGAT
GATATGAGGGGAGGCTACCTAGCTGGAAGTTATCTAACGCAAAAAGGCCATACATCTTTAACGATTATGATGGAGAAGGA
TAGAAAAAGTAGCTTAGGCAGATTGAATGGTTTCAAACAAGCGCTAACGGATTCAGGGATCCCGTTAGATGATGAGGCTA
TTATTAGTTGCTATTCGACAGTGGAAGATAGCAAACGTGCAAGTAAAGAGTTACTTAATTTACCTAACAGACCTACAGCG
GTTTTTGCTTGTACAGATTTGATTGCTATTTGCCTTATGAATGAAGCAAGAAAACAAGGGCTTTCAATTCCGGAAGATTT
ATCAATTATAGGATTTGATAATACAATCTATGCTGAGATTGCAGATCCAGGGTTAACAACAATTGAACAGCCAATTAAAC
AAATGGCAGCCTGTACGTTTGAACAACTGCTAAAAACGATGGAAATGAAGGAGCATGCTAAGCAAAAAATTACAATTATT
CCTCAGTTAGTAGAGCGATCCTCAGTAAAGGATATTACATGA

Upstream 100 bases:

>100_bases
AAATACTTACAAATTTTAAAAGAATTCCTTTTGTGTACCAAGAAGTAAAATATTTTTATGATAAAATATAGAAAAAGATG
ATTAAGAAGGGATAATTAAA

Downstream 100 bases:

>100_bases
TAGATTTTTTATAAGCCTATTTGAATGTAACAAAAGAAGGTCATCGTAACTAAATATAGTTAGGATGACCTTCTTTTATA
TTTAGGATTTATACTGAGAA

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Degradation activator [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKPTIYDVAEKAGVSIATVSKVINQTGRISEKTINKVNQVMDELDYQPSSVAAALTGKKTYTIGVLVPDISNPFFAEVAR
AFENSARESGYTLILCSTDHQTKREHEYIDLLFKKQVDGIIIATELNDYKLVKKIVNRDLPLVLFTVDHSSITTHVVTTD
DMRGGYLAGSYLTQKGHTSLTIMMEKDRKSSLGRLNGFKQALTDSGIPLDDEAIISCYSTVEDSKRASKELLNLPNRPTA
VFACTDLIAICLMNEARKQGLSIPEDLSIIGFDNTIYAEIADPGLTTIEQPIKQMAACTFEQLLKTMEMKEHAKQKITII
PQLVERSSVKDIT

Sequences:

>Translated_333_residues
MKPTIYDVAEKAGVSIATVSKVINQTGRISEKTINKVNQVMDELDYQPSSVAAALTGKKTYTIGVLVPDISNPFFAEVAR
AFENSARESGYTLILCSTDHQTKREHEYIDLLFKKQVDGIIIATELNDYKLVKKIVNRDLPLVLFTVDHSSITTHVVTTD
DMRGGYLAGSYLTQKGHTSLTIMMEKDRKSSLGRLNGFKQALTDSGIPLDDEAIISCYSTVEDSKRASKELLNLPNRPTA
VFACTDLIAICLMNEARKQGLSIPEDLSIIGFDNTIYAEIADPGLTTIEQPIKQMAACTFEQLLKTMEMKEHAKQKITII
PQLVERSSVKDIT
>Mature_333_residues
MKPTIYDVAEKAGVSIATVSKVINQTGRISEKTINKVNQVMDELDYQPSSVAAALTGKKTYTIGVLVPDISNPFFAEVAR
AFENSARESGYTLILCSTDHQTKREHEYIDLLFKKQVDGIIIATELNDYKLVKKIVNRDLPLVLFTVDHSSITTHVVTTD
DMRGGYLAGSYLTQKGHTSLTIMMEKDRKSSLGRLNGFKQALTDSGIPLDDEAIISCYSTVEDSKRASKELLNLPNRPTA
VFACTDLIAICLMNEARKQGLSIPEDLSIIGFDNTIYAEIADPGLTTIEQPIKQMAACTFEQLLKTMEMKEHAKQKITII
PQLVERSSVKDIT

Specific function: Involved in the control of degradation of B.subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=331, Percent_Identity=35.0453172205438, Blast_Score=204, Evalue=9e-54,
Organism=Escherichia coli, GI1790369, Length=308, Percent_Identity=34.7402597402597, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1790194, Length=329, Percent_Identity=32.2188449848024, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1789202, Length=336, Percent_Identity=30.6547619047619, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1787580, Length=326, Percent_Identity=29.7546012269939, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788474, Length=334, Percent_Identity=31.1377245508982, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789068, Length=333, Percent_Identity=27.3273273273273, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI48994940, Length=306, Percent_Identity=25.4901960784314, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1786540, Length=312, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786268, Length=333, Percent_Identity=27.6276276276276, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787906, Length=336, Percent_Identity=25, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790715, Length=330, Percent_Identity=23.3333333333333, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36871; Mature: 36871

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTIYDVAEKAGVSIATVSKVINQTGRISEKTINKVNQVMDELDYQPSSVAAALTGKKT
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHEECCCCE
YTIGVLVPDISNPFFAEVARAFENSARESGYTLILCSTDHQTKREHEYIDLLFKKQVDGI
EEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCE
IIATELNDYKLVKKIVNRDLPLVLFTVDHSSITTHVVTTDDMRGGYLAGSYLTQKGHTSL
EEEEECCHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCEEECHHHHCCCCCEE
TIMMEKDRKSSLGRLNGFKQALTDSGIPLDDEAIISCYSTVEDSKRASKELLNLPNRPTA
EEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
VFACTDLIAICLMNEARKQGLSIPEDLSIIGFDNTIYAEIADPGLTTIEQPIKQMAACTF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHH
EQLLKTMEMKEHAKQKITIIPQLVERSSVKDIT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKPTIYDVAEKAGVSIATVSKVINQTGRISEKTINKVNQVMDELDYQPSSVAAALTGKKT
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHEECCCCE
YTIGVLVPDISNPFFAEVARAFENSARESGYTLILCSTDHQTKREHEYIDLLFKKQVDGI
EEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCE
IIATELNDYKLVKKIVNRDLPLVLFTVDHSSITTHVVTTDDMRGGYLAGSYLTQKGHTSL
EEEEECCHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCEEECHHHHCCCCCEE
TIMMEKDRKSSLGRLNGFKQALTDSGIPLDDEAIISCYSTVEDSKRASKELLNLPNRPTA
EEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
VFACTDLIAICLMNEARKQGLSIPEDLSIIGFDNTIYAEIADPGLTTIEQPIKQMAACTF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHH
EQLLKTMEMKEHAKQKITIIPQLVERSSVKDIT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407808; 9353932; 9384377 [H]