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The map label for this gene is fba [H]

Identifier: 52142984

GI number: 52142984

Start: 2388103

End: 2388948

Strand: Direct

Name: fba [H]

Synonym: BCZK2256

Alternate gene names: 52142984

Gene position: 2388103-2388948 (Clockwise)

Preceding gene: 52142983

Following gene: 52142982

Centisome position: 45.05

GC content: 39.6

Gene sequence:

>846_bases
ATGCCAATAGTTCAAATGAAAGATATCTTAATAAAAGCAAATCAAGAGAATTATGGGGTTGGGGCTTTCAGTGTCGCTAA
TATGGAAATGGTCATGGGAGCTATCAAAGCAGCTGAAGAGTTAAGTTCGCCGCTTATTCTACAAATTGCAGAAGTTCGTT
TGAATCATTCGCCAATTCATATGATTGGTCCGTTGATGGTAGCTGCAGCGAAAAAAGCAACTGTTCCAGTTGTAGTTCAC
TTTGATCATGGGATGACATTTGAAAAGATTCAAGAGACGTTAGAAATTGGTTTTAGTTCGGTTATGTTTGATGGCTCTCA
CTATCCGTTAGAAGAAAATATACAAAAGACAAAAGAAATTGTAGAGCTTGCCAAACAGTACGGTGCGACGGTAGAGGCTG
AGATTGGCAGAGTTGGTGGTAGTGAGGACGGATCAGAAGATATTGAAATGTTGCTGACAAGCACTACAGAAGCAAAACGA
TTTGCAGAAGAAACAGGCGTAGATGTGTTAGCTGTTGCAATTGGAAATGCGCATGGTATGTACAATGGCGATCCTAATTT
ACGATTAGACCGCCTACAAGAGATTAATGAGGTAGTCCATATCCCACTCGTTTTACATGGTGGCTCTGGCATTAGTCCAG
AGGATTTTAAGCAATGTATTCAACATGGTGTTCGAAAAATTAATGTAGCAACAGCCACATTTCAGAATGTAATTACTGCA
GTTAACACTGCCGTCCTAAATACTCCGTATGCAGATTACTTTACGTACCACCAGGATGTTATTAAGGCTGCATACGAAAA
CGTTAAAAGTCATATGCAAATATTCGGAAGTGAAAACAGAGCATAA

Upstream 100 bases:

>100_bases
AATGATTGGGCAATCAAAAGGTCTTCTTACAAAAGGAGTAAAAAGACAGAGACGGTTGATTCTATATTAAATAAATAATT
TTGAAATAGGTGAATATGTA

Downstream 100 bases:

>100_bases
TCAGAAAAGCTTTCTTCATTGATAGTTAGAAGAAACTCAGAATGTAGTGAACTGACAAAAGTAGAGAATGATTGAGTAGT
TATTTTATAAAAGGAGGAGA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MPIVQMKDILIKANQENYGVGAFSVANMEMVMGAIKAAEELSSPLILQIAEVRLNHSPIHMIGPLMVAAAKKATVPVVVH
FDHGMTFEKIQETLEIGFSSVMFDGSHYPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSEDGSEDIEMLLTSTTEAKR
FAEETGVDVLAVAIGNAHGMYNGDPNLRLDRLQEINEVVHIPLVLHGGSGISPEDFKQCIQHGVRKINVATATFQNVITA
VNTAVLNTPYADYFTYHQDVIKAAYENVKSHMQIFGSENRA

Sequences:

>Translated_281_residues
MPIVQMKDILIKANQENYGVGAFSVANMEMVMGAIKAAEELSSPLILQIAEVRLNHSPIHMIGPLMVAAAKKATVPVVVH
FDHGMTFEKIQETLEIGFSSVMFDGSHYPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSEDGSEDIEMLLTSTTEAKR
FAEETGVDVLAVAIGNAHGMYNGDPNLRLDRLQEINEVVHIPLVLHGGSGISPEDFKQCIQHGVRKINVATATFQNVITA
VNTAVLNTPYADYFTYHQDVIKAAYENVKSHMQIFGSENRA
>Mature_280_residues
PIVQMKDILIKANQENYGVGAFSVANMEMVMGAIKAAEELSSPLILQIAEVRLNHSPIHMIGPLMVAAAKKATVPVVVHF
DHGMTFEKIQETLEIGFSSVMFDGSHYPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSEDGSEDIEMLLTSTTEAKRF
AEETGVDVLAVAIGNAHGMYNGDPNLRLDRLQEINEVVHIPLVLHGGSGISPEDFKQCIQHGVRKINVATATFQNVITAV
NTAVLNTPYADYFTYHQDVIKAAYENVKSHMQIFGSENRA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=283, Percent_Identity=38.1625441696113, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI87082041, Length=284, Percent_Identity=36.9718309859155, Blast_Score=183, Evalue=8e-48,
Organism=Escherichia coli, GI1788072, Length=270, Percent_Identity=38.5185185185185, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1789293, Length=206, Percent_Identity=28.6407766990291, Blast_Score=71, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322790, Length=293, Percent_Identity=27.6450511945392, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30753; Mature: 30621

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVQMKDILIKANQENYGVGAFSVANMEMVMGAIKAAEELSSPLILQIAEVRLNHSPIH
CCCCCEEHHHEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHH
MIGPLMVAAAKKATVPVVVHFDHGMTFEKIQETLEIGFSSVMFDGSHYPLEENIQKTKEI
HHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCHHHEEECCCCCCHHHHHHHHHHH
VELAKQYGATVEAEIGRVGGSEDGSEDIEMLLTSTTEAKRFAEETGVDVLAVAIGNAHGM
HHHHHHHCCEEEEHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEEECCCCCC
YNGDPNLRLDRLQEINEVVHIPLVLHGGSGISPEDFKQCIQHGVRKINVATATFQNVITA
CCCCCCCCHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHEEHHHHHHHHHHHHH
VNTAVLNTPYADYFTYHQDVIKAAYENVKSHMQIFGSENRA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PIVQMKDILIKANQENYGVGAFSVANMEMVMGAIKAAEELSSPLILQIAEVRLNHSPIH
CCCCEEHHHEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHH
MIGPLMVAAAKKATVPVVVHFDHGMTFEKIQETLEIGFSSVMFDGSHYPLEENIQKTKEI
HHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCHHHEEECCCCCCHHHHHHHHHHH
VELAKQYGATVEAEIGRVGGSEDGSEDIEMLLTSTTEAKRFAEETGVDVLAVAIGNAHGM
HHHHHHHCCEEEEHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEEECCCCCC
YNGDPNLRLDRLQEINEVVHIPLVLHGGSGISPEDFKQCIQHGVRKINVATATFQNVITA
CCCCCCCCHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHEEHHHHHHHHHHHHH
VNTAVLNTPYADYFTYHQDVIKAAYENVKSHMQIFGSENRA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2457578; 1640835; 9353933; 9384377; 1556067 [H]