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The map label for this gene is bcd [H]

Identifier: 52142954

GI number: 52142954

Start: 2423004

End: 2424149

Strand: Direct

Name: bcd [H]

Synonym: BCZK2285

Alternate gene names: 52142954

Gene position: 2423004-2424149 (Clockwise)

Preceding gene: 52142955

Following gene: 52142953

Centisome position: 45.71

GC content: 38.66

Gene sequence:

>1146_bases
ATGGAATTTACTCTAACTCGCGAAAAACAAATGATTAAAGAAATGGTACGTGACTTTGCTGAAAAGGAAATCGCACCGAA
AGCTGTATATTATGACAAAACTGCGGAATTTCCATATGAAACATTTCAAAAAATGGGCGAACTAGGATTATTAGGCATCC
CATTCCCTGAAGAGTATGGAGGTTCAGGTGGCGATACAGTATCGTACGCGTTAGCAGTTGAAGAAATTGGTCGTGCTTGT
GGTGGGACAGGATTAAGTTACGCTGCAACAATTTCATTAGGTGCTTCTCCAATTTATTATTTCGGTACAGAAGAACAAAA
ACAGAAATATTTAGTTCCAATGGCATCAGGCAAAACTTTAGGTGCTTTCGGATTAACGGAGCCGAATGCTGGATCTGATG
CAGGTGGCACACAAACGAAAGCTATATTAGATGGAGACGAGTATGTTATTAGTGGTGAGAAGTGTTGGATTACAAATGCT
GAGTATGCAAATACAATTATTGTAACCGCTGTCAATGGTGTGGAAGAGAATGGTAGAAAACGTATTTCTGCATTTATCGT
ACCGACTACTAGTGAAGGGTTAACGATTTCAAGCCCTTACGATAAGATGGGCGTACGTGCTTCTAATACTTGTGAAATCG
TACTTGATGGTGTACGTGTACCGAAAGAAAATATTCTTGGTGATGTAAATAAAGGATTTAAACAATTCTTATATACACTT
GATGGAGGACGTATTTCAATCGCAGCATTAGCTGTTGGTATTGCGCAATCTGCATTTGAACGTGCATTGCAATATGCGAA
AGAACGTCAACAATTTGGAAAGTCAATTTCTAATTTCCAAGCGATTCAATTTAAATTAGCTGATATGGCGACTGAAGTAG
AGCTAGCGCGTAATTTAGTACATAAAGCAGCTTGGTTAAAAGATAACGATAAACCTTTCGGTAAAGAAGCGGCTATGGCA
AAACTTTTCGCATCTGAGGCTGCTAGTCGTATTGCAAATCAAGCGGTACAAATTCACGGTGGATACGGCTATATGCGTGA
ATATGAAGTAGAACGACATATTCGTGATGCAAAACTATTAGAAATTGGTGAAGGAACTTCTGAAATTCAACGTCTCGTAA
TTGCTAGACATTTAGGATGTAGATAA

Upstream 100 bases:

>100_bases
CAATTATCTAACTAATGTTCTTGTCTTTTCATTCGTAATGTTTGTAGTAGAAACTCGCACGCTGTCGAAACTCAATATTC
GATAAGGGGTGTGTAGCGGA

Downstream 100 bases:

>100_bases
AAAGGAGGAATCACTATGTTTCAAAAAATATTAATTGCTAATCGCGGGGAAATCGCAGTTCGTATTATGAAAACTTGTCA
AAAACTTGGCATTCGTACTG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKMGELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRAC
GGTGLSYAATISLGASPIYYFGTEEQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNA
EYANTIIVTAVNGVEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPKENILGDVNKGFKQFLYTL
DGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQAIQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMA
KLFASEAASRIANQAVQIHGGYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR

Sequences:

>Translated_381_residues
MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKMGELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRAC
GGTGLSYAATISLGASPIYYFGTEEQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNA
EYANTIIVTAVNGVEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPKENILGDVNKGFKQFLYTL
DGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQAIQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMA
KLFASEAASRIANQAVQIHGGYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR
>Mature_381_residues
MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKMGELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRAC
GGTGLSYAATISLGASPIYYFGTEEQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNA
EYANTIIVTAVNGVEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPKENILGDVNKGFKQFLYTL
DGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQAIQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMA
KLFASEAASRIANQAVQIHGGYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=50.6666666666667, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=40.5333333333333, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=42.2872340425532, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=42.2872340425532, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=38.6666666666667, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=39.9408284023669, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=40.0544959128065, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI4557235, Length=379, Percent_Identity=38.5224274406332, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI76496475, Length=379, Percent_Identity=38.5224274406332, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=34.8404255319149, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=33.3333333333333, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=35.4497354497354, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI7669494, Length=355, Percent_Identity=36.056338028169, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI48976061, Length=335, Percent_Identity=28.3582089552239, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI211971008, Length=335, Percent_Identity=28.3582089552239, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI38505218, Length=396, Percent_Identity=28.030303030303, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI218563752, Length=238, Percent_Identity=30.672268907563, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=32.2834645669291, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1786223, Length=379, Percent_Identity=29.5514511873351, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI87081702, Length=335, Percent_Identity=25.6716417910448, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87082384, Length=318, Percent_Identity=24.5283018867925, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=40.5759162303665, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=40.3141361256544, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17570075, Length=383, Percent_Identity=40.2088772845953, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=40.5913978494624, Blast_Score=267, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17506239, Length=372, Percent_Identity=40.0537634408602, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=38.6842105263158, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=35.7333333333333, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI71990804, Length=307, Percent_Identity=42.3452768729642, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17534353, Length=374, Percent_Identity=34.4919786096257, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI71985184, Length=381, Percent_Identity=35.4330708661417, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17551932, Length=359, Percent_Identity=30.08356545961, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17505929, Length=358, Percent_Identity=29.608938547486, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=40.5172413793103, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71985192, Length=328, Percent_Identity=33.8414634146341, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=36.0294117647059, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=34.4398340248963, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17562446, Length=330, Percent_Identity=30.6060606060606, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17531913, Length=178, Percent_Identity=34.2696629213483, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=273, Percent_Identity=27.4725274725275, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=273, Percent_Identity=27.4725274725275, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=47.4393530997305, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI24646207, Length=385, Percent_Identity=45.7142857142857, Blast_Score=326, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=42.0634920634921, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=40.6824146981627, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=41.3978494623656, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI281363737, Length=380, Percent_Identity=35.2631578947368, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=35.3403141361257, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI221473076, Length=226, Percent_Identity=27.8761061946903, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550141, Length=226, Percent_Identity=27.8761061946903, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41607; Mature: 41607

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKMGELGLLGIPFPEEYG
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCEEECCCCHHHC
GSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTEEQKQKYLVPMASGKTL
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCCEEEEEECCCCEE
GAFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNAEYANTIIVTAVNGVEENGRK
EECCCCCCCCCCCCCCCCEEEEECCCCEEEECCEEEEECCCCCCEEEEEEECCCCCCCCE
RISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPKENILGDVNKGFKQFLYTL
EEEEEEEEECCCCEEEECCHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
DGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQAIQFKLADMATEVELARNLV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHGGYGYMREYEVERHIRDAKLL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHCCCCEE
EIGEGTSEIQRLVIARHLGCR
EECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKMGELGLLGIPFPEEYG
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCEEECCCCHHHC
GSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTEEQKQKYLVPMASGKTL
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCCEEEEEECCCCEE
GAFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNAEYANTIIVTAVNGVEENGRK
EECCCCCCCCCCCCCCCCEEEEECCCCEEEECCEEEEECCCCCCEEEEEEECCCCCCCCE
RISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPKENILGDVNKGFKQFLYTL
EEEEEEEEECCCCEEEECCHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
DGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQAIQFKLADMATEVELARNLV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHGGYGYMREYEVERHIRDAKLL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHCCCCEE
EIGEGTSEIQRLVIARHLGCR
EECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]