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The map label for this gene is pcc [H]

Identifier: 52142953

GI number: 52142953

Start: 2424165

End: 2425502

Strand: Direct

Name: pcc [H]

Synonym: BCZK2286

Alternate gene names: 52142953

Gene position: 2424165-2425502 (Clockwise)

Preceding gene: 52142954

Following gene: 52142951

Centisome position: 45.73

GC content: 37.29

Gene sequence:

>1338_bases
ATGTTTCAAAAAATATTAATTGCTAATCGCGGGGAAATCGCAGTTCGTATTATGAAAACTTGTCAAAAACTTGGCATTCG
TACTGTTGCTATTTATTCTGAGGCAGATGAAAATGCCTTACATGTAAAAATGGCAAATGAAGCTTACTTAGTGGGTGGGC
CGCGTGTCCAAGAAAGCTATTTAAACCTTGAGAAAATAATTGAAATAGCGAAGAAGACAAATGCCGAAGCAATCCATCCG
GGATATGGATTATTATCTGAGAATCCATCTTTCCCAGTACGTTGTAAAGAAGAAGGAATCGTATTTATCGGTCCATCAGA
AGAAATCATTACGAAGATGGGAAGTAAAATTGAATCACGTATTGCAATGCAAGCTGCAGATGTCCCAGTAGTTCCAGGTA
TTACTACAAATATTGAAACTGCTGAAGAAGCAATTGAAATTGCGAAACAAATTGGTTATCCATTAATGTTGAAGGCATCC
GCAGGAGGCGGAGGCATTGGAATGCAGTTGATGGAAACTGAGCAAACGCTCACCAAAGCATTTGAAAGCAACAAAACAAG
AGCACAAAACTTCTTCGGTAATGGAGAAATGTATTTAGAGCGCTATATAGCAGACGCGCATCATATTGAAATTCAGCTTT
TAGCAGATACACATGGTAACACGGTGTATTTATGGGAGCGTGAATGTTCAGTGCAGCGCCGAAATCAAAAAGTGATTGAA
GAAGCCCCTTCACCATTTTTAGATGAAGGTACACGAAAAGCGATGGGTGAAGTTGCTGTACAAGCTGCCAAAGCTTTAGG
ATATACGAATGCTGGTACAGTTGAGTTTCTTGTAGATGATCAGAAGAACTTCTATTTCTTAGAGATGAATACGAGATTAC
AAGTAGAGCATCCAGTTACAGAAGAAATTACTGGTTTAGATCTTGTAGAACAACAACTTCTAATTGCATATGGTGAGAAA
TTATCTTTTACACAAGATGATATAAAACGTAGTGGTCATGCCATTGAGGCACGTATTTATGCAGAAGATCCGAAAACTTT
CTTCCCATCACCTGGGAAAATTACAGATTTAACGCTTCCAACAAATGTACGTATTGATCACTTTTTAGAGAATCAAGTAA
CGATTACACCTTTCTATGATCCAATGATTGCGAAAGTCATTGCTCATGGTGAGACTCGTGAAGAAGCAATTTCAAAATTA
CATGATGCTTTAGAAGAATTAAAAGTAGAAGGTATTAAAACAAACACGCCAATGCTACTTCAAGTATTGGAAGATGATGT
GTTCAAAAGTGGTATTTATACAACGGGTTTTGTAACGAAACAACTTGTTAAAAAATAA

Upstream 100 bases:

>100_bases
TCGTGATGCAAAACTATTAGAAATTGGTGAAGGAACTTCTGAAATTCAACGTCTCGTAATTGCTAGACATTTAGGATGTA
GATAAAAAGGAGGAATCACT

Downstream 100 bases:

>100_bases
GATTTAAAAATACTAAGGGGGAAAAAATGATGACGAAAGTATATGCATCGATGGCAGGAAATGTATGGAAGATTGTTGTA
GGAGTAGGAGATACAGTAGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 2; ACC 2 [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMANEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHP
GYGLLSENPSFPVRCKEEGIVFIGPSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKAS
AGGGGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTVYLWERECSVQRRNQKVIE
EAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQKNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEK
LSFTQDDIKRSGHAIEARIYAEDPKTFFPSPGKITDLTLPTNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISKL
HDALEELKVEGIKTNTPMLLQVLEDDVFKSGIYTTGFVTKQLVKK

Sequences:

>Translated_445_residues
MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMANEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHP
GYGLLSENPSFPVRCKEEGIVFIGPSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKAS
AGGGGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTVYLWERECSVQRRNQKVIE
EAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQKNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEK
LSFTQDDIKRSGHAIEARIYAEDPKTFFPSPGKITDLTLPTNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISKL
HDALEELKVEGIKTNTPMLLQVLEDDVFKSGIYTTGFVTKQLVKK
>Mature_445_residues
MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMANEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHP
GYGLLSENPSFPVRCKEEGIVFIGPSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKAS
AGGGGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTVYLWERECSVQRRNQKVIE
EAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQKNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEK
LSFTQDDIKRSGHAIEARIYAEDPKTFFPSPGKITDLTLPTNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISKL
HDALEELKVEGIKTNTPMLLQVLEDDVFKSGIYTTGFVTKQLVKK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=444, Percent_Identity=50.4504504504504, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=50.4504504504504, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=50.4504504504504, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=49.2170022371365, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=44.3693693693694, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=44.3693693693694, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=44.3693693693694, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=32.2834645669291, Blast_Score=258, Evalue=7e-69,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=32.2834645669291, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=32.2834645669291, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=32.2834645669291, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=32.2834645669291, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=32.9411764705882, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=46.2921348314607, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=47.0588235294118, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71987519, Length=438, Percent_Identity=47.7168949771689, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17562816, Length=445, Percent_Identity=45.8426966292135, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=31.9105691056911, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=30.1369863013699, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=30.1369863013699, Blast_Score=214, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6319685, Length=440, Percent_Identity=47.7272727272727, Blast_Score=419, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319695, Length=454, Percent_Identity=44.7136563876652, Blast_Score=354, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=456, Percent_Identity=44.9561403508772, Blast_Score=342, Evalue=8e-95,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=32.3643410852713, Blast_Score=253, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6323863, Length=459, Percent_Identity=33.1154684095861, Blast_Score=248, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=47.2972972972973, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=46.078431372549, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI161076407, Length=499, Percent_Identity=32.064128256513, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24586460, Length=499, Percent_Identity=32.064128256513, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24586458, Length=499, Percent_Identity=32.064128256513, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI161076409, Length=499, Percent_Identity=32.064128256513, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49629; Mature: 49629

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMANEAYLVGGPRVQESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCHHHHH
LNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIGPSEEIITKMGSKIESR
CCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHH
IAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGGGGIGMQLMETEQTLTKA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEHHHHHHHHH
FESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTVYLWERECSVQRRNQKVIE
HHCCCHHHHHCCCCCHHHHHHHHCCCEEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHH
EAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQKNFYFLEMNTRLQVEHPVT
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEITGLDLVEQQLLIAYGEKLSFTQDDIKRSGHAIEARIYAEDPKTFFPSPGKITDLTLP
HHHCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCCCCCCEEEEECC
TNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISKLHDALEELKVEGIKTNTPMLL
CCCEEHEECCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHH
QVLEDDVFKSGIYTTGFVTKQLVKK
HHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMANEAYLVGGPRVQESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCHHHHH
LNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIGPSEEIITKMGSKIESR
CCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHH
IAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGGGGIGMQLMETEQTLTKA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEHHHHHHHHH
FESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTVYLWERECSVQRRNQKVIE
HHCCCHHHHHCCCCCHHHHHHHHCCCEEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHH
EAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQKNFYFLEMNTRLQVEHPVT
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEITGLDLVEQQLLIAYGEKLSFTQDDIKRSGHAIEARIYAEDPKTFFPSPGKITDLTLP
HHHCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCCCCCCEEEEECC
TNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISKLHDALEELKVEGIKTNTPMLL
CCCEEHEECCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHH
QVLEDDVFKSGIYTTGFVTKQLVKK
HHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]