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The map label for this gene is comEC [H]

Identifier: 52142711

GI number: 52142711

Start: 2655200

End: 2656585

Strand: Direct

Name: comEC [H]

Synonym: BCZK2530

Alternate gene names: 52142711

Gene position: 2655200-2656585 (Clockwise)

Preceding gene: 52142719

Following gene: 52142708

Centisome position: 50.09

GC content: 35.06

Gene sequence:

>1386_bases
TTGAAAAAGTTTAGTTTATTATTAACAGCATTTGTCATGATTTTAACATTGTTCATTCCAAATCTTACAAGTGCTAAATC
TTTCCCTGATGTCCAAGCTAATCATTGGGCAATTAAAGAAATTAACTATTTATCGGATAAAGGTATCATTAATGGTACGC
CAGAAGGAACTTTTAAACCGAGTGATCATGTAACTCGTGGACAAATGGCCTTAATGCTAGATTTATCATTAAAATTAGAA
AAACCATCTAACTATAATCATATTTTTTCCGATGTAGCCAAAGGTGTCTATTACTATGATTCTGTACATAAGTTAGCACA
TAACAATATTGTACAACGTGAAACAAACTACTTCCCTGACCGCTCATTAACTCGTGCAGAAATGGCAGTAGTACTAGTTA
AAACTTTTAATTTGAAACCTACAGGTGCTGACGTCAATTTCCCTGATGTTCCATCTAATCATTGGGGTTACAATTATGTC
AAAATTTTAGCCCAAAATAATATTACAGCTGGATTTCCTGATGGTACATTTGGTCCAGATGTAAAAGTAACTCGTGAACA
GTTCGCTGCATTCTTAGCAAGAGTATTAGAACCAAGTTTCCGTCCAGGTCTTCCTAAGCCTAAAGGAGAGTTAGAAGTCC
ATTATATAAATGTCGGACAAGGTGATGCTACATTTATTAAATCTCCAAGTGGAGAAACGATCCTTATTGATGGCGGAAAT
AACGGAAAAGGTAAAGTTGTAGCAAATTATTTAAAAGGATTAGGATTCCAAACTATCGATTATATGATTGCCACTCATCC
TGATGCCGATCATGTAGGCGGATTGGATGAAGTACTTTATGCTATGAATGTAAAAAACGTTTACGCACCTAAAGTAAGTC
ATACAACACAAACGTTTAAGGACTTTTTAACTGCAGTAGCTAACAAAGGATTGACTATTAAAGAAGCGAAATCTGGAGTA
ACTTTACCAATCAATGGTTTAAACTCACAATTTTTAGCTCCTGTTAAAGAATACGGTAACGATTTAAATGAGTGGAGTGC
TGTATTAAAAGTAACACATGGCAGCAAATCTTTCTTATTTACTGGTGATGCTGAATCTAAAAGTGAAAAAGATATGGTTG
CAACGTATGGTTCCGGCCTAAAATCCGATGTATTAAAACCTGGTCATCACGGAAGTAAGACATCTTCTTCTCAGCCATTT
TTAGATGCAGTGAAACCAAGTATCGCTGTAATCAGTGCAGGTGCAGGTAACCGATATGGCCATCCTACTCAGAAAACTTT
AGCAAAGTTAAATGCAATGTCTGTTAAGGTATATAGAACTGATTTAAATGGAACTGTAATTATTAATAGTGATGGTTCTA
ACATTTCTGTAAGAACGGAGAGATAA

Upstream 100 bases:

>100_bases
TACAAAACAACTAATAAAATATTTACCTATTAAACTTTGAATCACTTGTAAGAAATGGTAAAGTTAATAAGGTAAAAAAT
ACATTAAGTGAGGCGATTTT

Downstream 100 bases:

>100_bases
TTATGAAGAGAGGTATTATTGACCGTTTTGAAGGCAAACTAGCAGTTATTGAAGTGAATAACGTAACAATTGATGTACCT
AAGTCCAAACTCCCTTCCAC

Product: S-layer protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MKKFSLLLTAFVMILTLFIPNLTSAKSFPDVQANHWAIKEINYLSDKGIINGTPEGTFKPSDHVTRGQMALMLDLSLKLE
KPSNYNHIFSDVAKGVYYYDSVHKLAHNNIVQRETNYFPDRSLTRAEMAVVLVKTFNLKPTGADVNFPDVPSNHWGYNYV
KILAQNNITAGFPDGTFGPDVKVTREQFAAFLARVLEPSFRPGLPKPKGELEVHYINVGQGDATFIKSPSGETILIDGGN
NGKGKVVANYLKGLGFQTIDYMIATHPDADHVGGLDEVLYAMNVKNVYAPKVSHTTQTFKDFLTAVANKGLTIKEAKSGV
TLPINGLNSQFLAPVKEYGNDLNEWSAVLKVTHGSKSFLFTGDAESKSEKDMVATYGSGLKSDVLKPGHHGSKTSSSQPF
LDAVKPSIAVISAGAGNRYGHPTQKTLAKLNAMSVKVYRTDLNGTVIINSDGSNISVRTER

Sequences:

>Translated_461_residues
MKKFSLLLTAFVMILTLFIPNLTSAKSFPDVQANHWAIKEINYLSDKGIINGTPEGTFKPSDHVTRGQMALMLDLSLKLE
KPSNYNHIFSDVAKGVYYYDSVHKLAHNNIVQRETNYFPDRSLTRAEMAVVLVKTFNLKPTGADVNFPDVPSNHWGYNYV
KILAQNNITAGFPDGTFGPDVKVTREQFAAFLARVLEPSFRPGLPKPKGELEVHYINVGQGDATFIKSPSGETILIDGGN
NGKGKVVANYLKGLGFQTIDYMIATHPDADHVGGLDEVLYAMNVKNVYAPKVSHTTQTFKDFLTAVANKGLTIKEAKSGV
TLPINGLNSQFLAPVKEYGNDLNEWSAVLKVTHGSKSFLFTGDAESKSEKDMVATYGSGLKSDVLKPGHHGSKTSSSQPF
LDAVKPSIAVISAGAGNRYGHPTQKTLAKLNAMSVKVYRTDLNGTVIINSDGSNISVRTER
>Mature_461_residues
MKKFSLLLTAFVMILTLFIPNLTSAKSFPDVQANHWAIKEINYLSDKGIINGTPEGTFKPSDHVTRGQMALMLDLSLKLE
KPSNYNHIFSDVAKGVYYYDSVHKLAHNNIVQRETNYFPDRSLTRAEMAVVLVKTFNLKPTGADVNFPDVPSNHWGYNYV
KILAQNNITAGFPDGTFGPDVKVTREQFAAFLARVLEPSFRPGLPKPKGELEVHYINVGQGDATFIKSPSGETILIDGGN
NGKGKVVANYLKGLGFQTIDYMIATHPDADHVGGLDEVLYAMNVKNVYAPKVSHTTQTFKDFLTAVANKGLTIKEAKSGV
TLPINGLNSQFLAPVKEYGNDLNEWSAVLKVTHGSKSFLFTGDAESKSEKDMVATYGSGLKSDVLKPGHHGSKTSSSQPF
LDAVKPSIAVISAGAGNRYGHPTQKTLAKLNAMSVKVYRTDLNGTVIINSDGSNISVRTER

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=265, Percent_Identity=26.4150943396226, Blast_Score=85, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 50305; Mature: 50305

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS01072 SLH_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFSLLLTAFVMILTLFIPNLTSAKSFPDVQANHWAIKEINYLSDKGIINGTPEGTFKP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCC
SDHVTRGQMALMLDLSLKLEKPSNYNHIFSDVAKGVYYYDSVHKLAHNNIVQRETNYFPD
CCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCC
RSLTRAEMAVVLVKTFNLKPTGADVNFPDVPSNHWGYNYVKILAQNNITAGFPDGTFGPD
CCCCHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEECCCCCCCCCC
VKVTREQFAAFLARVLEPSFRPGLPKPKGELEVHYINVGQGDATFIKSPSGETILIDGGN
CEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCEEEEECCC
NGKGKVVANYLKGLGFQTIDYMIATHPDADHVGGLDEVLYAMNVKNVYAPKVSHTTQTFK
CCCCHHHHHHHHCCCCCEEEEEEEECCCCHHCCCHHHHHHHHCCCHHCCCCCCHHHHHHH
DFLTAVANKGLTIKEAKSGVTLPINGLNSQFLAPVKEYGNDLNEWSAVLKVTHGSKSFLF
HHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHCCCHHHHEEEEEEECCCCEEEE
TGDAESKSEKDMVATYGSGLKSDVLKPGHHGSKTSSSQPFLDAVKPSIAVISAGAGNRYG
ECCCCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCCCCCCC
HPTQKTLAKLNAMSVKVYRTDLNGTVIINSDGSNISVRTER
CCHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEEEECC
>Mature Secondary Structure
MKKFSLLLTAFVMILTLFIPNLTSAKSFPDVQANHWAIKEINYLSDKGIINGTPEGTFKP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCC
SDHVTRGQMALMLDLSLKLEKPSNYNHIFSDVAKGVYYYDSVHKLAHNNIVQRETNYFPD
CCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCC
RSLTRAEMAVVLVKTFNLKPTGADVNFPDVPSNHWGYNYVKILAQNNITAGFPDGTFGPD
CCCCHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEECCCCCCCCCC
VKVTREQFAAFLARVLEPSFRPGLPKPKGELEVHYINVGQGDATFIKSPSGETILIDGGN
CEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCEEEEECCC
NGKGKVVANYLKGLGFQTIDYMIATHPDADHVGGLDEVLYAMNVKNVYAPKVSHTTQTFK
CCCCHHHHHHHHCCCCCEEEEEEEECCCCHHCCCHHHHHHHHCCCHHCCCCCCHHHHHHH
DFLTAVANKGLTIKEAKSGVTLPINGLNSQFLAPVKEYGNDLNEWSAVLKVTHGSKSFLF
HHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHCCCHHHHEEEEEEECCCCEEEE
TGDAESKSEKDMVATYGSGLKSDVLKPGHHGSKTSSSQPFLDAVKPSIAVISAGAGNRYG
ECCCCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCCCCCCC
HPTQKTLAKLNAMSVKVYRTDLNGTVIINSDGSNISVRTER
CCHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]