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The map label for this gene is proC [H]

Identifier: 52142529

GI number: 52142529

Start: 2830857

End: 2831675

Strand: Direct

Name: proC [H]

Synonym: BCZK2713

Alternate gene names: 52142529

Gene position: 2830857-2831675 (Clockwise)

Preceding gene: 52142533

Following gene: 52142526

Centisome position: 53.4

GC content: 35.41

Gene sequence:

>819_bases
ATGGATAAACAAATTGGATTCATTGGATGCGGAAATATGGGGATGGCTATAGTTGGTGGGATGCTAAATAAAAAGATAGT
GTCTTCAAATAAAATCATGTGTTCAGATTTAAACACGACGAATTTAGAAAATGCTAGTGAAAAGTACGGAATATCTATAA
CTACTGACAACAAGAAAGTCGCTAAAAATGCTGATATTTTAATTTTATCAATTAAGCCAGACTTATACACCGCAGTAATT
AACGAAATTAAAGAAGTGATAAAAAACGATGCTATCATCGTTACGATCGCTGCTGGTAAAAGTATTGAAAGTACTGAAAA
TGCCTTTAATCAAAAATTAAAAGTTGTAAGAGTAATGCCTAATACTCCTGCTCTTGTTGGAGAAGGAATGTCTGCATTAT
GCCCGAATGAAATGGTGACAGAAAAAGATTTAGAAGAAGTGCTAAACATTTTCAATAGTTTTGGTCAATCAGAGATTGTA
AGTGAAAAGTTAATGGATGTTGTAACATCTGTAAGTGGTTCTTCACCAGCATACGTATATATGATTATAGAAGCGATGGC
AGATGCTGCTGTACTAGATGGTATGCCAAGAAATCAAGCATATAAATTCGCTGCTCAAGCAGTATTAGGCTCTGCAAAAA
TGGTACTAGAAACAGGAATACATCCAGGTGAATTGAAAGATATGGTTTGTTCTCCTGGCGGAACAACGATAGAAGCTGTA
GCAACTTTAGAGGAAAAAGGCTTACGAACAGCCATCATTTCAGCTATGCAACGTTGTACACAAAAGTCTGTCGAACTATC
TGGTCAAACGAAAAAGTAA

Upstream 100 bases:

>100_bases
TAGAATGTTTCTTTATATTGCATGGAGATGTTATTGTTATTTTAAGATAACAATTTCAAAATGATATAATTTTTTAAAAA
AGGAGCAAGATTGAATTATT

Downstream 100 bases:

>100_bases
AACTATAAATTCACATGAATGTAATTAGAAATGCACTACATGATAAACGGCCAAACTCGAATTTACTTGAGTTTGGCCGT
TTTAGTTGTTAATTATATTA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MDKQIGFIGCGNMGMAIVGGMLNKKIVSSNKIMCSDLNTTNLENASEKYGISITTDNKKVAKNADILILSIKPDLYTAVI
NEIKEVIKNDAIIVTIAAGKSIESTENAFNQKLKVVRVMPNTPALVGEGMSALCPNEMVTEKDLEEVLNIFNSFGQSEIV
SEKLMDVVTSVSGSSPAYVYMIIEAMADAAVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
ATLEEKGLRTAIISAMQRCTQKSVELSGQTKK

Sequences:

>Translated_272_residues
MDKQIGFIGCGNMGMAIVGGMLNKKIVSSNKIMCSDLNTTNLENASEKYGISITTDNKKVAKNADILILSIKPDLYTAVI
NEIKEVIKNDAIIVTIAAGKSIESTENAFNQKLKVVRVMPNTPALVGEGMSALCPNEMVTEKDLEEVLNIFNSFGQSEIV
SEKLMDVVTSVSGSSPAYVYMIIEAMADAAVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
ATLEEKGLRTAIISAMQRCTQKSVELSGQTKK
>Mature_272_residues
MDKQIGFIGCGNMGMAIVGGMLNKKIVSSNKIMCSDLNTTNLENASEKYGISITTDNKKVAKNADILILSIKPDLYTAVI
NEIKEVIKNDAIIVTIAAGKSIESTENAFNQKLKVVRVMPNTPALVGEGMSALCPNEMVTEKDLEEVLNIFNSFGQSEIV
SEKLMDVVTSVSGSSPAYVYMIIEAMADAAVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
ATLEEKGLRTAIISAMQRCTQKSVELSGQTKK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=38.2022471910112, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=37.546468401487, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=37.546468401487, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=35.4716981132075, Blast_Score=177, Evalue=6e-45,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=53.1835205992509, Blast_Score=298, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI17569021, Length=261, Percent_Identity=37.9310344827586, Blast_Score=184, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17540664, Length=285, Percent_Identity=32.9824561403509, Blast_Score=140, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6320861, Length=291, Percent_Identity=29.553264604811, Blast_Score=124, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=40.7272727272727, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=37.1747211895911, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24647700, Length=173, Percent_Identity=43.3526011560694, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29078; Mature: 29078

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKQIGFIGCGNMGMAIVGGMLNKKIVSSNKIMCSDLNTTNLENASEKYGISITTDNKKV
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHCCEEEEECCCHH
AKNADILILSIKPDLYTAVINEIKEVIKNDAIIVTIAAGKSIESTENAFNQKLKVVRVMP
HCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCEEEEEECC
NTPALVGEGMSALCPNEMVTEKDLEEVLNIFNSFGQSEIVSEKLMDVVTSVSGSSPAYVY
CCCHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEE
MIIEAMADAAVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHH
ATLEEKGLRTAIISAMQRCTQKSVELSGQTKK
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDKQIGFIGCGNMGMAIVGGMLNKKIVSSNKIMCSDLNTTNLENASEKYGISITTDNKKV
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHCCEEEEECCCHH
AKNADILILSIKPDLYTAVINEIKEVIKNDAIIVTIAAGKSIESTENAFNQKLKVVRVMP
HCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCEEEEEECC
NTPALVGEGMSALCPNEMVTEKDLEEVLNIFNSFGQSEIVSEKLMDVVTSVSGSSPAYVY
CCCHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEE
MIIEAMADAAVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHH
ATLEEKGLRTAIISAMQRCTQKSVELSGQTKK
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]