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The map label for this gene is nupC [H]

Identifier: 52142533

GI number: 52142533

Start: 2826535

End: 2827728

Strand: Direct

Name: nupC [H]

Synonym: BCZK2710

Alternate gene names: 52142533

Gene position: 2826535-2827728 (Clockwise)

Preceding gene: 52142532

Following gene: 52142529

Centisome position: 53.32

GC content: 33.17

Gene sequence:

>1194_bases
ATGTATTTCATATTGAATATGTTAGGGATTTTCGTTGTCATATTAATTGTTTACTTATGTTCACCTAATAAAAAACATAT
AAAATGGAGACCAATTGTAATTCTCATCATATTGGAGCTTTTTATTACGTGGTTTATGTTAGGCACAAAGCTAGGCAGTA
TTATCATTAATAAAATTGCTTCATTTTTCAGTTGGCTACTGGCATGTGCAAATGAAGGAATTCGATTTGCATTTCCTTCT
GCTATGGAAAATCAAACAATTGATTTCTTCTTTAGCGCATTACTTCCTATCATTTTTGTTATCACGTTCTTTGATATTCT
TTCTTACTTTGGAATCTTAACTTGGATTATTGATAAAGTAGGTGCAATTATTTCAAAGATTTCTCGTTTACCAAAGTTAG
AAAGCTTCTTTTCGATTCAAATGATGTTTTTAGGGAACACCGAAGCGCTTGCTGTTGTTCGGGATCAATTATCTGTTTTA
AAAGAAAATCGTCTGCTGACTTTTGGAATTATGAGTATGAGTAGCGTCAGCGGATCCATTCTTGGTGCTTATTTATCAAT
GGTTCCAGCAACATATATTTTCAGCGCAATCCCATTAAATTGTATTAACGCATTAATTTTAGCCAATGTATTAAATCCTG
TGGAAGTTTCGAAAGAAGAAGATGTTGTTTACACACCTTCCAAACATGAAAAAAAGGATTTCTTTTCTACTATTTCAAAC
AGCATGTTAGTCGGGATGAATATGGTTATCGTTATTTTAGCTATGGTAATTGGTTATGTAGCTTTAACTGCATGTTTAAA
TGGGATTTTAGGATTTTTTGTAACGGGGTTAACAATTCAAAAAATCTTCTCCATTATCTTTAGTCCTTTCGCTTTTTTAC
TCGGTTTATCGGGCAGTGATGCTATGTATGTAGCTGAATTAATGGGGATCAAAATAACGACGAATGAATTTGTTGCAATG
ATGGATTTAAAATCAAACTTAAAGTCTTTACAACCGCATACGGTTGCGGTTGCCACAACATTTCTAGCTTCTTTTGCTAA
CTTTAGTACAGTAGGTATGATTTATGGAACTTACAATTCATTATTTGGTGACGAAAAATCATCAGTCATCGGTAAAAATG
TTTGGAAGCTTCTTGTGAGCGGAATGGCTGTTTCCTTATTAAGTGCTATGCTTGTTGGGCTTTTTGTATGGTAA

Upstream 100 bases:

>100_bases
AAACATCATTCACATGCTTCATAACTTCTGATCATAATCCAAATTTGGAAGAATAGAGGCTTTTTTATATACAAATAATA
AGCCTCAAGGAGTTGTTGAC

Downstream 100 bases:

>100_bases
ATAATTTTTAAAATAAAAGACACCCAAACGAATTGAGTGTCTTTTATTTTTATTTTCGAATTTGTCCATTTCCACGAATG
ACGTATTTTATAGAAGTTAA

Product: nucleoside transporter

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MYFILNMLGIFVVILIVYLCSPNKKHIKWRPIVILIILELFITWFMLGTKLGSIIINKIASFFSWLLACANEGIRFAFPS
AMENQTIDFFFSALLPIIFVITFFDILSYFGILTWIIDKVGAIISKISRLPKLESFFSIQMMFLGNTEALAVVRDQLSVL
KENRLLTFGIMSMSSVSGSILGAYLSMVPATYIFSAIPLNCINALILANVLNPVEVSKEEDVVYTPSKHEKKDFFSTISN
SMLVGMNMVIVILAMVIGYVALTACLNGILGFFVTGLTIQKIFSIIFSPFAFLLGLSGSDAMYVAELMGIKITTNEFVAM
MDLKSNLKSLQPHTVAVATTFLASFANFSTVGMIYGTYNSLFGDEKSSVIGKNVWKLLVSGMAVSLLSAMLVGLFVW

Sequences:

>Translated_397_residues
MYFILNMLGIFVVILIVYLCSPNKKHIKWRPIVILIILELFITWFMLGTKLGSIIINKIASFFSWLLACANEGIRFAFPS
AMENQTIDFFFSALLPIIFVITFFDILSYFGILTWIIDKVGAIISKISRLPKLESFFSIQMMFLGNTEALAVVRDQLSVL
KENRLLTFGIMSMSSVSGSILGAYLSMVPATYIFSAIPLNCINALILANVLNPVEVSKEEDVVYTPSKHEKKDFFSTISN
SMLVGMNMVIVILAMVIGYVALTACLNGILGFFVTGLTIQKIFSIIFSPFAFLLGLSGSDAMYVAELMGIKITTNEFVAM
MDLKSNLKSLQPHTVAVATTFLASFANFSTVGMIYGTYNSLFGDEKSSVIGKNVWKLLVSGMAVSLLSAMLVGLFVW
>Mature_397_residues
MYFILNMLGIFVVILIVYLCSPNKKHIKWRPIVILIILELFITWFMLGTKLGSIIINKIASFFSWLLACANEGIRFAFPS
AMENQTIDFFFSALLPIIFVITFFDILSYFGILTWIIDKVGAIISKISRLPKLESFFSIQMMFLGNTEALAVVRDQLSVL
KENRLLTFGIMSMSSVSGSILGAYLSMVPATYIFSAIPLNCINALILANVLNPVEVSKEEDVVYTPSKHEKKDFFSTISN
SMLVGMNMVIVILAMVIGYVALTACLNGILGFFVTGLTIQKIFSIIFSPFAFLLGLSGSDAMYVAELMGIKITTNEFVAM
MDLKSNLKSLQPHTVAVATTFLASFANFSTVGMIYGTYNSLFGDEKSSVIGKNVWKLLVSGMAVSLLSAMLVGLFVW

Specific function: Involved in the uptake of the purine ribonucleosides inosine and guanosine [H]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI42542381, Length=412, Percent_Identity=27.9126213592233, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI227116277, Length=410, Percent_Identity=27.3170731707317, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI11545853, Length=411, Percent_Identity=26.7639902676399, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1788737, Length=393, Percent_Identity=34.6055979643766, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1788485, Length=416, Percent_Identity=26.6826923076923, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788488, Length=417, Percent_Identity=26.8585131894484, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17560276, Length=396, Percent_Identity=25.7575757575758, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71991794, Length=397, Percent_Identity=24.9370277078086, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI45552519, Length=397, Percent_Identity=25.6926952141058, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45552517, Length=397, Percent_Identity=25.6926952141058, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19921868, Length=397, Percent_Identity=25.6926952141058, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281360430, Length=407, Percent_Identity=23.5872235872236, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 43909; Mature: 43909

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFILNMLGIFVVILIVYLCSPNKKHIKWRPIVILIILELFITWFMLGTKLGSIIINKIA
CHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFFSWLLACANEGIRFAFPSAMENQTIDFFFSALLPIIFVITFFDILSYFGILTWIIDKV
HHHHHHHHHHCCCCEEECCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAIISKISRLPKLESFFSIQMMFLGNTEALAVVRDQLSVLKENRLLTFGIMSMSSVSGSI
HHHHHHHHHCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHH
LGAYLSMVPATYIFSAIPLNCINALILANVLNPVEVSKEEDVVYTPSKHEKKDFFSTISN
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHCCCCCCEEECCCCCHHHHHHHHHHH
SMLVGMNMVIVILAMVIGYVALTACLNGILGFFVTGLTIQKIFSIIFSPFAFLLGLSGSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AMYVAELMGIKITTNEFVAMMDLKSNLKSLQPHTVAVATTFLASFANFSTVGMIYGTYNS
HHHHHHHHCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LFGDEKSSVIGKNVWKLLVSGMAVSLLSAMLVGLFVW
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYFILNMLGIFVVILIVYLCSPNKKHIKWRPIVILIILELFITWFMLGTKLGSIIINKIA
CHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFFSWLLACANEGIRFAFPSAMENQTIDFFFSALLPIIFVITFFDILSYFGILTWIIDKV
HHHHHHHHHHCCCCEEECCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAIISKISRLPKLESFFSIQMMFLGNTEALAVVRDQLSVLKENRLLTFGIMSMSSVSGSI
HHHHHHHHHCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHH
LGAYLSMVPATYIFSAIPLNCINALILANVLNPVEVSKEEDVVYTPSKHEKKDFFSTISN
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHCCCCCCEEECCCCCHHHHHHHHHHH
SMLVGMNMVIVILAMVIGYVALTACLNGILGFFVTGLTIQKIFSIIFSPFAFLLGLSGSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AMYVAELMGIKITTNEFVAMMDLKSNLKSLQPHTVAVATTFLASFANFSTVGMIYGTYNS
HHHHHHHHCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LFGDEKSSVIGKNVWKLLVSGMAVSLLSAMLVGLFVW
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969509; 9384377 [H]