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The map label for this gene is ygcA [C]

Identifier: 51893956

GI number: 51893956

Start: 3031893

End: 3033272

Strand: Reverse

Name: ygcA [C]

Synonym: STH2818

Alternate gene names: 51893956

Gene position: 3033272-3031893 (Counterclockwise)

Preceding gene: 51893957

Following gene: 51893953

Centisome position: 85.06

GC content: 72.1

Gene sequence:

>1380_bases
ATGCAGGAGACGCAGAAGCCCCCGGTTCGCCCGGGGCAGGAGATCGAGGTGACGGTCCACGGCCTCGGCAGCAGCGGCGA
GGGCGTGGCCCGCTATGAGGGACTGACCGTATTTATCCCCGGCGGCGCCCCCGGCGACCGCCTGTCCGCGCGCGTGCAGG
AGGTGAAGCGGAACTACGCCCGGGCGGCGCTGGTGCGGGTGGAGGAGCCGTCGCCGGACCGGGTGGCTCCGCCCTGCCCG
GTGGTGGGGAAGTGCGGCGGGTGCCAGCTGCAGCACATCGCCTACGAGGCGCAGCTCGGGCTGAAGCGGCAGCAGGTGGT
CGACGCCGTGGAGCGGCTGGGGAGGCTGAGTGGGGTGACGGTGCACCCGACCCTGGGCATGGCGGATCCCTGGGGGTACC
GCAACAAGGCGCAGTTCCCGGTGGGACGGCGCTCCGGCCGGGTGATCGCCGGTTTCTTCGCCCCGGGCAGCCACCGCATC
GTGGACATCGAGCGGTGCGCCATCCAGCACCCGCTGGCCAACCGGATCATGGCCGAGGTGAAGGAGCTGGCCGGGCGGTT
CGGCGTGCCGATCTACGATGAGCGCAGCCACACCGGCGTCCTGCGCCACGTGCTCGCACGGGTGGGCCGGGGGACCGGCG
AGGCGATGGCGGTGCTGGTGACCAACGGCCCGCATCTGCCCCGCGGCAAGGACATCGCCCGGGAGCTGATGACCCGCATC
CCCGAGCTGGTCAGCGTGGTGCAGAACATCAACCCGGCCCGCACCAACGTGGTGCTGGGCCGGGAGAGCCGCGTGCTCGC
GGGGCGGGATGCGATCACCGACTACATCGGCGACCTGCAGTTCAGCATCTCCCCCGTCTCCTTCTTCCAGGTGAACCCGG
CGCAGACCGAGGTGCTGTACGACAAGGCCCTGGAGTACGCCGGCCTCACCGGTTCGGAGACGGTGATCGACCTCTACTGC
GGCATCGGCACGATCTCGCTGTTCCTGGCGCGCCGGTGCCGGGAGGTCGTCGGCATCGAGTGGGTGGAGGAGGCGGTGGC
GGACGCCCGGGAGAACGCGGCCCGCAATGGCATCGGGAACGTGCGGTTCATCGCCGGCGACGCGGCGGTGGAGATGCCCC
GGCTGGCGGCGGAGGGGGTGCGGGCGGACGTGATCGTGCTGGACCCGCCCCGCAAGGGCTGCGACGGGCCGGTGCTGGAG
GCGATCGCGCAGGTGGCGCCGCGGCGGGTGGTCTACGTGTCGTGCAACCCCGCCAGCCTCGCCCGGGACCTGGGCCGGCT
GGCGGAGATGGGGTACCGCACCGTCGAGGTGCAGCCGGTGGATATGTTCCCGCACACGGCGCACGTGGAGTGCGTCGCGC
GGGTGGAGAGGGAGGGATAG

Upstream 100 bases:

>100_bases
GGAGGCGTCCCGGACCGGCAACTAGGTGGGGTCCAAAGGTGGCCAAGGGCCCTGGGCTTGTGCGCGGGCGGGCGCTCTGT
GGTACACTCTGCCTATGAGC

Downstream 100 bases:

>100_bases
CCCCCCTGTGCCCTGCCAAGGCGCCGAGACACGATCGCTTGTTCATGCTCACGTAGCACCGCGTTCACCTGCGCAGACGT
CTGCGCCGGCACGCCCTGGT

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MQETQKPPVRPGQEIEVTVHGLGSSGEGVARYEGLTVFIPGGAPGDRLSARVQEVKRNYARAALVRVEEPSPDRVAPPCP
VVGKCGGCQLQHIAYEAQLGLKRQQVVDAVERLGRLSGVTVHPTLGMADPWGYRNKAQFPVGRRSGRVIAGFFAPGSHRI
VDIERCAIQHPLANRIMAEVKELAGRFGVPIYDERSHTGVLRHVLARVGRGTGEAMAVLVTNGPHLPRGKDIARELMTRI
PELVSVVQNINPARTNVVLGRESRVLAGRDAITDYIGDLQFSISPVSFFQVNPAQTEVLYDKALEYAGLTGSETVIDLYC
GIGTISLFLARRCREVVGIEWVEEAVADARENAARNGIGNVRFIAGDAAVEMPRLAAEGVRADVIVLDPPRKGCDGPVLE
AIAQVAPRRVVYVSCNPASLARDLGRLAEMGYRTVEVQPVDMFPHTAHVECVARVEREG

Sequences:

>Translated_459_residues
MQETQKPPVRPGQEIEVTVHGLGSSGEGVARYEGLTVFIPGGAPGDRLSARVQEVKRNYARAALVRVEEPSPDRVAPPCP
VVGKCGGCQLQHIAYEAQLGLKRQQVVDAVERLGRLSGVTVHPTLGMADPWGYRNKAQFPVGRRSGRVIAGFFAPGSHRI
VDIERCAIQHPLANRIMAEVKELAGRFGVPIYDERSHTGVLRHVLARVGRGTGEAMAVLVTNGPHLPRGKDIARELMTRI
PELVSVVQNINPARTNVVLGRESRVLAGRDAITDYIGDLQFSISPVSFFQVNPAQTEVLYDKALEYAGLTGSETVIDLYC
GIGTISLFLARRCREVVGIEWVEEAVADARENAARNGIGNVRFIAGDAAVEMPRLAAEGVRADVIVLDPPRKGCDGPVLE
AIAQVAPRRVVYVSCNPASLARDLGRLAEMGYRTVEVQPVDMFPHTAHVECVARVEREG
>Mature_459_residues
MQETQKPPVRPGQEIEVTVHGLGSSGEGVARYEGLTVFIPGGAPGDRLSARVQEVKRNYARAALVRVEEPSPDRVAPPCP
VVGKCGGCQLQHIAYEAQLGLKRQQVVDAVERLGRLSGVTVHPTLGMADPWGYRNKAQFPVGRRSGRVIAGFFAPGSHRI
VDIERCAIQHPLANRIMAEVKELAGRFGVPIYDERSHTGVLRHVLARVGRGTGEAMAVLVTNGPHLPRGKDIARELMTRI
PELVSVVQNINPARTNVVLGRESRVLAGRDAITDYIGDLQFSISPVSFFQVNPAQTEVLYDKALEYAGLTGSETVIDLYC
GIGTISLFLARRCREVVGIEWVEEAVADARENAARNGIGNVRFIAGDAAVEMPRLAAEGVRADVIVLDPPRKGCDGPVLE
AIAQVAPRRVVYVSCNPASLARDLGRLAEMGYRTVEVQPVDMFPHTAHVECVARVEREG

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=373, Percent_Identity=30.2949061662198, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI51173878, Length=373, Percent_Identity=30.2949061662198, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI269784680, Length=421, Percent_Identity=28.2660332541568, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI269784676, Length=421, Percent_Identity=28.2660332541568, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI20149688, Length=421, Percent_Identity=28.2660332541568, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI269784678, Length=394, Percent_Identity=28.6802030456853, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1789148, Length=451, Percent_Identity=33.2594235033259, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1787083, Length=331, Percent_Identity=28.7009063444109, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790403, Length=380, Percent_Identity=26.5789473684211, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71997438, Length=165, Percent_Identity=32.7272727272727, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322909, Length=438, Percent_Identity=27.3972602739726, Blast_Score=113, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24666579, Length=417, Percent_Identity=30.4556354916067, Blast_Score=178, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 49753; Mature: 49753

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS50926 TRAM ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETQKPPVRPGQEIEVTVHGLGSSGEGVARYEGLTVFIPGGAPGDRLSARVQEVKRNYA
CCCCCCCCCCCCCEEEEEEEECCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHH
RAALVRVEEPSPDRVAPPCPVVGKCGGCQLQHIAYEAQLGLKRQQVVDAVERLGRLSGVT
HEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCEE
VHPTLGMADPWGYRNKAQFPVGRRSGRVIAGFFAPGSHRIVDIERCAIQHPLANRIMAEV
ECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHCHHHHHHHHHH
KELAGRFGVPIYDERSHTGVLRHVLARVGRGTGEAMAVLVTNGPHLPRGKDIARELMTRI
HHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHH
PELVSVVQNINPARTNVVLGRESRVLAGRDAITDYIGDLQFSISPVSFFQVNPAQTEVLY
HHHHHHHHCCCCCCCEEEECCCCCEEECHHHHHHHHCCCEEEECCEEEEEECCHHHHHHH
DKALEYAGLTGSETVIDLYCGIGTISLFLARRCREVVGIEWVEEAVADARENAARNGIGN
HHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VRFIAGDAAVEMPRLAAEGVRADVIVLDPPRKGCDGPVLEAIAQVAPRRVVYVSCNPASL
EEEEECCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCHHHH
ARDLGRLAEMGYRTVEVQPVDMFPHTAHVECVARVEREG
HHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MQETQKPPVRPGQEIEVTVHGLGSSGEGVARYEGLTVFIPGGAPGDRLSARVQEVKRNYA
CCCCCCCCCCCCCEEEEEEEECCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHH
RAALVRVEEPSPDRVAPPCPVVGKCGGCQLQHIAYEAQLGLKRQQVVDAVERLGRLSGVT
HEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCEE
VHPTLGMADPWGYRNKAQFPVGRRSGRVIAGFFAPGSHRIVDIERCAIQHPLANRIMAEV
ECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHCHHHHHHHHHH
KELAGRFGVPIYDERSHTGVLRHVLARVGRGTGEAMAVLVTNGPHLPRGKDIARELMTRI
HHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHH
PELVSVVQNINPARTNVVLGRESRVLAGRDAITDYIGDLQFSISPVSFFQVNPAQTEVLY
HHHHHHHHCCCCCCCEEEECCCCCEEECHHHHHHHHCCCEEEECCEEEEEECCHHHHHHH
DKALEYAGLTGSETVIDLYCGIGTISLFLARRCREVVGIEWVEEAVADARENAARNGIGN
HHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VRFIAGDAAVEMPRLAAEGVRADVIVLDPPRKGCDGPVLEAIAQVAPRRVVYVSCNPASL
EEEEECCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCHHHH
ARDLGRLAEMGYRTVEVQPVDMFPHTAHVECVARVEREG
HHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]