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The map label for this gene is dfrA [H]

Identifier: 51893957

GI number: 51893957

Start: 3033348

End: 3034376

Strand: Reverse

Name: dfrA [H]

Synonym: STH2819

Alternate gene names: 51893957

Gene position: 3034376-3033348 (Counterclockwise)

Preceding gene: 51893958

Following gene: 51893956

Centisome position: 85.09

GC content: 71.91

Gene sequence:

>1029_bases
GTGGACCTGGTAACCGGCGCCACCGGCTTCATCGGCTCGCAGCTGGTGCCTCATCTGGTGGAGCAGGGGAGGCAGGTGCG
GATCCTCGTTCGTTCCCGGCAGAAGGCGGAAGCGGTTTTCGGCCCGCTCTGCGCGGCGCTGGAGGTGGCCGAGGGCGACC
TGGGGGACGAGGCCTCCCTGGCGCGGGCGGCCGCGGGCGTGGACCGGGTCTACCACCTGGCCTCGCGGATCAACTTCCAG
GGATCGCTTCGCCGGATGCGCGCCATCAACGTGGAGGGCACGCGGCGGTTGCTGGACGCCTGCGCGGCCGCGGGCGTGAA
GCGGGTGGTGCACATGTCCTCCATCGCGGCCGGGGGGCCGGCGGTGAAGGACGAAAACGGCCGCTACCGCGCCCGCACGG
AGGAGGACGAGGCTGCGCCCCTGCCCGATGCCTACGGGATTACCAAGCTGGAGCAGGAGCGGCTGGCGCTCTCTTACCAG
GAACGGGGGCTGGAGGTGGTCGTGGTCCGGCCCAGCGCGGTTTTCGGTCCGGGCGACCCCGACGGCATGAACACGCTGAT
CTGGATGGTGAAGAACGGCCGGTTGCCCTTCTACCTGGGGTCGGGGCAGGCGGTGGTCAACCTGGTCTTCGTGCGGGACG
TGGTGCGCGGCACGGTCGCGGCGATGGAGCGGGGGCGGCCGGGCGAGGTGTACCACCTGGTGGGGCCCAACCTGACCCAG
GAGCAGCTTTTCGGCCTCCTGGCGCAGGTGAGCGGCGGCCGCAGCCCCCGCTGGGCGATGCCGGTGCCGGTGCTGATGGG
CGCGGCGCGCCTGGCCACCATCGGCGCGCGCCTGACCTTCCGGCGGCGCTCGCTGGTCCATCCCCACGAGATCCGCAACT
GGACCGCCCCTTGGATCATGAGCGACGACAAAGCCCGCCGGGAGCTGGGGCTGGTGCCTACCGACACCGCGGCCGCCTTC
CGGGAGACCCTGCAGTGGCTGCAGGCGTACAAGGCACGCCAGGCGGAGGCGTCCCGGACCGGCAACTAG

Upstream 100 bases:

>100_bases
CGCTCGAAGAGCAGGCGCAGAAGTAAGGACGCCCCCCGCCGTAGGAACTGCGGCGGGGGCGTCTAATCTTTTCGGTAAAG
ATTGAAAGGAGGCGTGGCCC

Downstream 100 bases:

>100_bases
GTGGGGTCCAAAGGTGGCCAAGGGCCCTGGGCTTGTGCGCGGGCGGGCGCTCTGTGGTACACTCTGCCTATGAGCATGCA
GGAGACGCAGAAGCCCCCGG

Product: putative oxidoreductase

Products: NA

Alternate protein names: DFR; Dihydrokaempferol 4-reductase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MDLVTGATGFIGSQLVPHLVEQGRQVRILVRSRQKAEAVFGPLCAALEVAEGDLGDEASLARAAAGVDRVYHLASRINFQ
GSLRRMRAINVEGTRRLLDACAAAGVKRVVHMSSIAAGGPAVKDENGRYRARTEEDEAAPLPDAYGITKLEQERLALSYQ
ERGLEVVVVRPSAVFGPGDPDGMNTLIWMVKNGRLPFYLGSGQAVVNLVFVRDVVRGTVAAMERGRPGEVYHLVGPNLTQ
EQLFGLLAQVSGGRSPRWAMPVPVLMGAARLATIGARLTFRRRSLVHPHEIRNWTAPWIMSDDKARRELGLVPTDTAAAF
RETLQWLQAYKARQAEASRTGN

Sequences:

>Translated_342_residues
MDLVTGATGFIGSQLVPHLVEQGRQVRILVRSRQKAEAVFGPLCAALEVAEGDLGDEASLARAAAGVDRVYHLASRINFQ
GSLRRMRAINVEGTRRLLDACAAAGVKRVVHMSSIAAGGPAVKDENGRYRARTEEDEAAPLPDAYGITKLEQERLALSYQ
ERGLEVVVVRPSAVFGPGDPDGMNTLIWMVKNGRLPFYLGSGQAVVNLVFVRDVVRGTVAAMERGRPGEVYHLVGPNLTQ
EQLFGLLAQVSGGRSPRWAMPVPVLMGAARLATIGARLTFRRRSLVHPHEIRNWTAPWIMSDDKARRELGLVPTDTAAAF
RETLQWLQAYKARQAEASRTGN
>Mature_342_residues
MDLVTGATGFIGSQLVPHLVEQGRQVRILVRSRQKAEAVFGPLCAALEVAEGDLGDEASLARAAAGVDRVYHLASRINFQ
GSLRRMRAINVEGTRRLLDACAAAGVKRVVHMSSIAAGGPAVKDENGRYRARTEEDEAAPLPDAYGITKLEQERLALSYQ
ERGLEVVVVRPSAVFGPGDPDGMNTLIWMVKNGRLPFYLGSGQAVVNLVFVRDVVRGTVAAMERGRPGEVYHLVGPNLTQ
EQLFGLLAQVSGGRSPRWAMPVPVLMGAARLATIGARLTFRRRSLVHPHEIRNWTAPWIMSDDKARRELGLVPTDTAAAF
RETLQWLQAYKARQAEASRTGN

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroflavonol-4-reductase family [H]

Homologues:

Organism=Homo sapiens, GI193211614, Length=224, Percent_Identity=30.3571428571429, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI8393516, Length=224, Percent_Identity=30.3571428571429, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI260763931, Length=369, Percent_Identity=26.8292682926829, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4504509, Length=369, Percent_Identity=26.8292682926829, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4504507, Length=374, Percent_Identity=25.9358288770053, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI239745448, Length=238, Percent_Identity=29.8319327731092, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI310132178, Length=238, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI310113012, Length=238, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI7657641, Length=258, Percent_Identity=27.1317829457364, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI116268111, Length=371, Percent_Identity=24.7978436657682, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI87081792, Length=340, Percent_Identity=24.1176470588235, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17570557, Length=346, Percent_Identity=23.9884393063584, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71987463, Length=236, Percent_Identity=30.9322033898305, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322972, Length=236, Percent_Identity=27.9661016949153, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR017829
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.219 [H]

Molecular weight: Translated: 37279; Mature: 37279

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLVTGATGFIGSQLVPHLVEQGRQVRILVRSRQKAEAVFGPLCAALEVAEGDLGDEASL
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
ARAAAGVDRVYHLASRINFQGSLRRMRAINVEGTRRLLDACAAAGVKRVVHMSSIAAGGP
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVKDENGRYRARTEEDEAAPLPDAYGITKLEQERLALSYQERGLEVVVVRPSAVFGPGDP
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCC
DGMNTLIWMVKNGRLPFYLGSGQAVVNLVFVRDVVRGTVAAMERGRPGEVYHLVGPNLTQ
CCCCEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCH
EQLFGLLAQVSGGRSPRWAMPVPVLMGAARLATIGARLTFRRRSLVHPHEIRNWTAPWIM
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEE
SDDKARRELGLVPTDTAAAFRETLQWLQAYKARQAEASRTGN
CCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLVTGATGFIGSQLVPHLVEQGRQVRILVRSRQKAEAVFGPLCAALEVAEGDLGDEASL
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
ARAAAGVDRVYHLASRINFQGSLRRMRAINVEGTRRLLDACAAAGVKRVVHMSSIAAGGP
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVKDENGRYRARTEEDEAAPLPDAYGITKLEQERLALSYQERGLEVVVVRPSAVFGPGDP
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCC
DGMNTLIWMVKNGRLPFYLGSGQAVVNLVFVRDVVRGTVAAMERGRPGEVYHLVGPNLTQ
CCCCEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCH
EQLFGLLAQVSGGRSPRWAMPVPVLMGAARLATIGARLTFRRRSLVHPHEIRNWTAPWIM
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEE
SDDKARRELGLVPTDTAAAFRETLQWLQAYKARQAEASRTGN
CCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]