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The map label for this gene is argH2 [H]

Identifier: 51893888

GI number: 51893888

Start: 2967100

End: 2968716

Strand: Reverse

Name: argH2 [H]

Synonym: STH2750

Alternate gene names: 51893888

Gene position: 2968716-2967100 (Counterclockwise)

Preceding gene: 51893889

Following gene: 51893887

Centisome position: 83.25

GC content: 72.85

Gene sequence:

>1617_bases
TTGACCCGCAATCCGAACCCGGCCGGGGCCGCCAACGACCCGTGCCGGAACGAATCCGCCGCACCGCACGCAGGGGCCGC
ATCCACCCACGCCCCGACCCGCGCTGAGATCGCGGCCGAGGACGGCCGCTGCTTCCCCGGGCGCAGCTACGCGGAGGCCG
TGCTCAGCCCCATCTACGACAGCGCCAAGCACGAGCTGCTCGAGCCCATGATGGCGATCCACCGGGCGCACCTGGTGATG
CTGGTGGAGCAGGGGCTGGTCGACGCCGGGACGGCCAGGAAGATCCTCGCCGGGCTGGCATCCATCGACCTCGGGGAAGT
GGCCGCGTCGCGGTACGACGGCCGCTACGAGGACCTGTTCTTCTACGTGGAGGACCTGACGCTGAAGGCCGCGGGCGAGG
AGGCGGGCAACCTGCACATCGCCCGCAGCCGCAACGACATGGGCGTCACCATGTACCGCATGGTGCTGCGCAAGCACCTG
CTGGACGCGATCGAGGCCGCCCAGCTGCTGCACCGGGTGCTGCTCCGCTTCGCCGCGGAGGAGGCTGACACGGTGATGCT
CGCCCACACGCACACGCAGCAGGCGCAGCCCACCACGCTGGGCCACTGGCTCACCGCCGCGGCGGACGTGCTGGAGCGGG
ACATCGCCCGGATGCAGGCCGCCTACGAGCGGGCCAACCGCTCGCCGATGGGCGCCGCGGCCCTGTCCACCTCGGGCTTC
CCCATCTCGCGGGAGCGGGTGGCCGAGCTCCTGGGCTTCGACGGCCTGGTGGAGAACAGCTACGACGCCATCGCCGGGGC
GGACTACGTGAGCGAGGCCGCCGCCGCCGTGCAGCTGACCGCCCTTCACACCGGCCGCATGGTGCAGGACCTGCTCCTCT
GGTGCACCCAGGAGTACGGGGCGCTGCGGGTCGCAGATCCGTACGTGCAGACCAGCTCCATCATGCCCCAGAAGCGGAAC
CCCGTTTCGCTGGAGCACGCCCGCACGCTGCTCAGCTACACCGCCGGCCGGGCGCAGACCGTGCTGCAGATGCTGCACAA
CACGCCCTTCGGCGACATCGTCGACACCGAGGACGAGATGCAGCCCAACCTGTGGGCCGCGCTCTCCACCCTGCGGTCCG
TCTTCCGGCTGCTGGCCAACGTGGTCGGCACGGCCGAGGTCAACCGGGATCTGCTGCTGGAGCGTGCCCGGGCCAGCTTC
GCCAACGTTACGGAGCTGGCTGACCTGCTGGTGCGGGAGGCCGGGCTGCCGTTCCGCACCGCCCACGGGGTCGTGGCGGC
CCTGGTCAAGGCGGCTGAGGCCCGGGGCATCCGGGACGTGCGGGACGTGGACCCCGGGATGGTCGAGGAGGCCGCGCAGA
AGGTGCTGGGGCGCCCCCTGGGTGTGCCGGCCGAAAAGCTGCGGCTGGCGCTGGATCCCGTGCACTTCGTCGCCGTCCGC
ACCGTGCGGGGCGGCGTGGCCCCCGCCGAGGTCCGGCGCATGCTGGCCGAGCGGGAGGCGCGCGCCGCGGCGATGGCCGG
CTGGCTGGACGCTGCCCGGGCGCGGCTGGCGGCGGCCGCTCAGCGGCTGAACTCGGCCTGCCTGGCCCTGTCCGGGGAGG
AGGGGGGCCGGGGATGA

Upstream 100 bases:

>100_bases
GCCGCCTACGGTTTGCTGCAGATGCTCCTGATCCTGGTCGCCATCTACATCTCCAACCGCCTGGAACAGAGGCAGAACCT
CGCCTAAGGAAGTGATCGCG

Downstream 100 bases:

>100_bases
CGTACTACCTTGCGGTGGACGGCGGCGGCACGAAGTGCCTGGCGGTGCTGGTCCACCCGGATCAGGGCATCGTGGGCAGC
GGCCGTTCCGGCGGCAGCAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 2; Arginosuccinase [H]

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MTRNPNPAGAANDPCRNESAAPHAGAASTHAPTRAEIAAEDGRCFPGRSYAEAVLSPIYDSAKHELLEPMMAIHRAHLVM
LVEQGLVDAGTARKILAGLASIDLGEVAASRYDGRYEDLFFYVEDLTLKAAGEEAGNLHIARSRNDMGVTMYRMVLRKHL
LDAIEAAQLLHRVLLRFAAEEADTVMLAHTHTQQAQPTTLGHWLTAAADVLERDIARMQAAYERANRSPMGAAALSTSGF
PISRERVAELLGFDGLVENSYDAIAGADYVSEAAAAVQLTALHTGRMVQDLLLWCTQEYGALRVADPYVQTSSIMPQKRN
PVSLEHARTLLSYTAGRAQTVLQMLHNTPFGDIVDTEDEMQPNLWAALSTLRSVFRLLANVVGTAEVNRDLLLERARASF
ANVTELADLLVREAGLPFRTAHGVVAALVKAAEARGIRDVRDVDPGMVEEAAQKVLGRPLGVPAEKLRLALDPVHFVAVR
TVRGGVAPAEVRRMLAEREARAAAMAGWLDAARARLAAAAQRLNSACLALSGEEGGRG

Sequences:

>Translated_538_residues
MTRNPNPAGAANDPCRNESAAPHAGAASTHAPTRAEIAAEDGRCFPGRSYAEAVLSPIYDSAKHELLEPMMAIHRAHLVM
LVEQGLVDAGTARKILAGLASIDLGEVAASRYDGRYEDLFFYVEDLTLKAAGEEAGNLHIARSRNDMGVTMYRMVLRKHL
LDAIEAAQLLHRVLLRFAAEEADTVMLAHTHTQQAQPTTLGHWLTAAADVLERDIARMQAAYERANRSPMGAAALSTSGF
PISRERVAELLGFDGLVENSYDAIAGADYVSEAAAAVQLTALHTGRMVQDLLLWCTQEYGALRVADPYVQTSSIMPQKRN
PVSLEHARTLLSYTAGRAQTVLQMLHNTPFGDIVDTEDEMQPNLWAALSTLRSVFRLLANVVGTAEVNRDLLLERARASF
ANVTELADLLVREAGLPFRTAHGVVAALVKAAEARGIRDVRDVDPGMVEEAAQKVLGRPLGVPAEKLRLALDPVHFVAVR
TVRGGVAPAEVRRMLAEREARAAAMAGWLDAARARLAAAAQRLNSACLALSGEEGGRG
>Mature_537_residues
TRNPNPAGAANDPCRNESAAPHAGAASTHAPTRAEIAAEDGRCFPGRSYAEAVLSPIYDSAKHELLEPMMAIHRAHLVML
VEQGLVDAGTARKILAGLASIDLGEVAASRYDGRYEDLFFYVEDLTLKAAGEEAGNLHIARSRNDMGVTMYRMVLRKHLL
DAIEAAQLLHRVLLRFAAEEADTVMLAHTHTQQAQPTTLGHWLTAAADVLERDIARMQAAYERANRSPMGAAALSTSGFP
ISRERVAELLGFDGLVENSYDAIAGADYVSEAAAAVQLTALHTGRMVQDLLLWCTQEYGALRVADPYVQTSSIMPQKRNP
VSLEHARTLLSYTAGRAQTVLQMLHNTPFGDIVDTEDEMQPNLWAALSTLRSVFRLLANVVGTAEVNRDLLLERARASFA
NVTELADLLVREAGLPFRTAHGVVAALVKAAEARGIRDVRDVDPGMVEEAAQKVLGRPLGVPAEKLRLALDPVHFVAVRT
VRGGVAPAEVRRMLAEREARAAAMAGWLDAARARLAAAAQRLNSACLALSGEEGGRG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=408, Percent_Identity=29.656862745098, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI68303542, Length=408, Percent_Identity=29.656862745098, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI68303547, Length=408, Percent_Identity=29.656862745098, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI68303549, Length=408, Percent_Identity=28.4313725490196, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1790398, Length=385, Percent_Identity=32.2077922077922, Blast_Score=185, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6321806, Length=362, Percent_Identity=32.8729281767956, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI221473854, Length=435, Percent_Identity=29.1954022988506, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI78706858, Length=435, Percent_Identity=29.1954022988506, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 58002; Mature: 57871

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRNPNPAGAANDPCRNESAAPHAGAASTHAPTRAEIAAEDGRCFPGRSYAEAVLSPIYD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCCCHHHHHHHHHHHH
SAKHELLEPMMAIHRAHLVMLVEQGLVDAGTARKILAGLASIDLGEVAASRYDGRYEDLF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCHHHHH
FYVEDLTLKAAGEEAGNLHIARSRNDMGVTMYRMVLRKHLLDAIEAAQLLHRVLLRFAAE
HHHHHHHHEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EADTVMLAHTHTQQAQPTTLGHWLTAAADVLERDIARMQAAYERANRSPMGAAALSTSGF
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCC
PISRERVAELLGFDGLVENSYDAIAGADYVSEAAAAVQLTALHTGRMVQDLLLWCTQEYG
CCCHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ALRVADPYVQTSSIMPQKRNPVSLEHARTLLSYTAGRAQTVLQMLHNTPFGDIVDTEDEM
CEEECCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
QPNLWAALSTLRSVFRLLANVVGTAEVNRDLLLERARASFANVTELADLLVREAGLPFRT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AHGVVAALVKAAEARGIRDVRDVDPGMVEEAAQKVLGRPLGVPAEKLRLALDPVHFVAVR
HHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHH
TVRGGVAPAEVRRMLAEREARAAAMAGWLDAARARLAAAAQRLNSACLALSGEEGGRG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
>Mature Secondary Structure 
TRNPNPAGAANDPCRNESAAPHAGAASTHAPTRAEIAAEDGRCFPGRSYAEAVLSPIYD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCCCHHHHHHHHHHHH
SAKHELLEPMMAIHRAHLVMLVEQGLVDAGTARKILAGLASIDLGEVAASRYDGRYEDLF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCHHHHH
FYVEDLTLKAAGEEAGNLHIARSRNDMGVTMYRMVLRKHLLDAIEAAQLLHRVLLRFAAE
HHHHHHHHEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EADTVMLAHTHTQQAQPTTLGHWLTAAADVLERDIARMQAAYERANRSPMGAAALSTSGF
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCC
PISRERVAELLGFDGLVENSYDAIAGADYVSEAAAAVQLTALHTGRMVQDLLLWCTQEYG
CCCHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ALRVADPYVQTSSIMPQKRNPVSLEHARTLLSYTAGRAQTVLQMLHNTPFGDIVDTEDEM
CEEECCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
QPNLWAALSTLRSVFRLLANVVGTAEVNRDLLLERARASFANVTELADLLVREAGLPFRT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AHGVVAALVKAAEARGIRDVRDVDPGMVEEAAQKVLGRPLGVPAEKLRLALDPVHFVAVR
HHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHH
TVRGGVAPAEVRRMLAEREARAAAMAGWLDAARARLAAAAQRLNSACLALSGEEGGRG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]