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The map label for this gene is galE [C]

Identifier: 51893853

GI number: 51893853

Start: 2913069

End: 2914034

Strand: Reverse

Name: galE [C]

Synonym: STH2715

Alternate gene names: 51893853

Gene position: 2914034-2913069 (Counterclockwise)

Preceding gene: 51893854

Following gene: 51893851

Centisome position: 81.71

GC content: 53.42

Gene sequence:

>966_bases
ATGGGGTGTGTGATGAGGACTGTTCTTATTACAGGCGGAGCTGGGTTCGTTGGTTCACATGTAGTTGAGCGGTTTCTAGC
TGAAGGCCTTCGGGTCGTTGTGGTGGACAATCTGACTACCGGTGTTCGTGAGCACGTACCTCCAGGTGCAGAGTTCCATA
ATATCGATATCCTGACCCCTGAGTTTACTTCATTGGTTGGGAAAGTAAAGCCCGATACCATTGTACATCTAGCCGCCCAG
GTGAGCGTGGCGGTATCGGTCAGAGATCCCGTGTTGGATGCGGATGTAAACGTAGGTGGTACACTGCGTGTTCTTGAAGC
GGCGCGGGAACACCAGGTGCCGAACTTTGTCTTTTCCTCCTCAGCAGCCGTTTATGGAATACCTAGTTCACTCCCTGTTA
CGGAGGACGCTCCGTTCAGCCCCTTAAGCCCCTACGGAATAGCTAAGGTAGCGGCCGAAGGGTATATCCGAGCGTACTGT
TTCTTGCATGGATTGAAAGCTGTCGTGATGCGGTATTCAAACGTATTTGGTCCACGCCAAAAGGCGGCTGGCGACGGCGG
AGTCGTGGCCAACTTTGTTGAGGCAATCTTGCGAGGTCATCCACCGGTCTTCTTCGGAGATGGTGGGCAGACGCGTGACT
TCATTTACGTGAAGGATGTCGCTGATGCTACCCTGAAAGCGATCGACTACCTTGATAAGTCGGGCACATCGGAGTACCTC
GTTGTAAACATAAGCAGCGGTGTTGAAACCAGTCTGCGTACGCTTTATACCCTCCTTTGTGAGCTTGTGAAGCAGGCCCC
GGAACCCATTCTTACACCTCCAAGAGAAGGGGACATTCGGCACAGTTGTCTTGACAACCGAAAAGCACGTGAGTACCTAG
GTTGGTTGCCCGGATACTCACTGGAACAAGGGATCCTGGAGACCGTGACTGCTGCGCGGCTCGCAGGGCAGGGAGCGAGG
TTGTGA

Upstream 100 bases:

>100_bases
CTGGAGTTGAGGCTAGCCCAACGCCACAGCGGATGAGAGCCGAGCGACTGGTGTTGGACCGTTCGGGGCGTGTACCGTGA
TTGTCAAGTATGGTCTCGGT

Downstream 100 bases:

>100_bases
CTGGGCATGCCGCATCTAGCTCAAGTTTCACGCGAACAACTCGACATTCGTGGTGTTAAAAGGGCGTATGGGTAGGGAGT
GGCCCGGTTCAGGGTAATCT

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MGCVMRTVLITGGAGFVGSHVVERFLAEGLRVVVVDNLTTGVREHVPPGAEFHNIDILTPEFTSLVGKVKPDTIVHLAAQ
VSVAVSVRDPVLDADVNVGGTLRVLEAAREHQVPNFVFSSSAAVYGIPSSLPVTEDAPFSPLSPYGIAKVAAEGYIRAYC
FLHGLKAVVMRYSNVFGPRQKAAGDGGVVANFVEAILRGHPPVFFGDGGQTRDFIYVKDVADATLKAIDYLDKSGTSEYL
VVNISSGVETSLRTLYTLLCELVKQAPEPILTPPREGDIRHSCLDNRKAREYLGWLPGYSLEQGILETVTAARLAGQGAR
L

Sequences:

>Translated_321_residues
MGCVMRTVLITGGAGFVGSHVVERFLAEGLRVVVVDNLTTGVREHVPPGAEFHNIDILTPEFTSLVGKVKPDTIVHLAAQ
VSVAVSVRDPVLDADVNVGGTLRVLEAAREHQVPNFVFSSSAAVYGIPSSLPVTEDAPFSPLSPYGIAKVAAEGYIRAYC
FLHGLKAVVMRYSNVFGPRQKAAGDGGVVANFVEAILRGHPPVFFGDGGQTRDFIYVKDVADATLKAIDYLDKSGTSEYL
VVNISSGVETSLRTLYTLLCELVKQAPEPILTPPREGDIRHSCLDNRKAREYLGWLPGYSLEQGILETVTAARLAGQGAR
L
>Mature_320_residues
GCVMRTVLITGGAGFVGSHVVERFLAEGLRVVVVDNLTTGVREHVPPGAEFHNIDILTPEFTSLVGKVKPDTIVHLAAQV
SVAVSVRDPVLDADVNVGGTLRVLEAAREHQVPNFVFSSSAAVYGIPSSLPVTEDAPFSPLSPYGIAKVAAEGYIRAYCF
LHGLKAVVMRYSNVFGPRQKAAGDGGVVANFVEAILRGHPPVFFGDGGQTRDFIYVKDVADATLKAIDYLDKSGTSEYLV
VNISSGVETSLRTLYTLLCELVKQAPEPILTPPREGDIRHSCLDNRKAREYLGWLPGYSLEQGILETVTAARLAGQGARL

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=318, Percent_Identity=31.7610062893082, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI7657641, Length=332, Percent_Identity=28.3132530120482, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI56237023, Length=327, Percent_Identity=31.4984709480122, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI56118217, Length=327, Percent_Identity=31.4984709480122, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI189083684, Length=327, Percent_Identity=31.4984709480122, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4504031, Length=240, Percent_Identity=30, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI48994969, Length=337, Percent_Identity=32.0474777448071, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=30.6547619047619, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788353, Length=333, Percent_Identity=30.6306306306306, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1790049, Length=224, Percent_Identity=29.4642857142857, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788366, Length=266, Percent_Identity=27.4436090225564, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788589, Length=334, Percent_Identity=23.6526946107784, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539532, Length=320, Percent_Identity=31.875, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71982035, Length=332, Percent_Identity=30.421686746988, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71982038, Length=334, Percent_Identity=30.2395209580838, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI115532424, Length=333, Percent_Identity=29.4294294294294, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17568069, Length=342, Percent_Identity=26.6081871345029, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17507723, Length=274, Percent_Identity=26.6423357664234, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133901790, Length=246, Percent_Identity=24.7967479674797, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133901788, Length=246, Percent_Identity=24.7967479674797, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539422, Length=246, Percent_Identity=24.7967479674797, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133901786, Length=246, Percent_Identity=24.7967479674797, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=246, Percent_Identity=24.7967479674797, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=324, Percent_Identity=28.7037037037037, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21356223, Length=320, Percent_Identity=31.5625, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19923002, Length=329, Percent_Identity=31.306990881459, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34418; Mature: 34287

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCVMRTVLITGGAGFVGSHVVERFLAEGLRVVVVDNLTTGVREHVPPGAEFHNIDILTP
CCHHHEEHHEECCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCCCCEEEEECH
EFTSLVGKVKPDTIVHLAAQVSVAVSVRDPVLDADVNVGGTLRVLEAAREHQVPNFVFSS
HHHHHHHCCCCHHHHHHHHHHEEEEEECCCCEECCCCCCCHHHHHHHHHHCCCCCEEECC
SAAVYGIPSSLPVTEDAPFSPLSPYGIAKVAAEGYIRAYCFLHGLKAVVMRYSNVFGPRQ
CCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
KAAGDGGVVANFVEAILRGHPPVFFGDGGQTRDFIYVKDVADATLKAIDYLDKSGTSEYL
HCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCEE
VVNISSGVETSLRTLYTLLCELVKQAPEPILTPPREGDIRHSCLDNRKAREYLGWLPGYS
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCC
LEQGILETVTAARLAGQGARL
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GCVMRTVLITGGAGFVGSHVVERFLAEGLRVVVVDNLTTGVREHVPPGAEFHNIDILTP
CHHHEEHHEECCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCCCCEEEEECH
EFTSLVGKVKPDTIVHLAAQVSVAVSVRDPVLDADVNVGGTLRVLEAAREHQVPNFVFSS
HHHHHHHCCCCHHHHHHHHHHEEEEEECCCCEECCCCCCCHHHHHHHHHHCCCCCEEECC
SAAVYGIPSSLPVTEDAPFSPLSPYGIAKVAAEGYIRAYCFLHGLKAVVMRYSNVFGPRQ
CCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
KAAGDGGVVANFVEAILRGHPPVFFGDGGQTRDFIYVKDVADATLKAIDYLDKSGTSEYL
HCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCEE
VVNISSGVETSLRTLYTLLCELVKQAPEPILTPPREGDIRHSCLDNRKAREYLGWLPGYS
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCC
LEQGILETVTAARLAGQGARL
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]