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The map label for this gene is panF [H]

Identifier: 51599065

GI number: 51599065

Start: 862327

End: 863661

Strand: Direct

Name: panF [H]

Synonym: BG0839

Alternate gene names: 51599065

Gene position: 862327-863661 (Clockwise)

Preceding gene: 51599063

Following gene: 51599066

Centisome position: 95.36

GC content: 25.02

Gene sequence:

>1335_bases
TTGTTATTAAATAAATACTTTCTTGCAAATCGAAATATTAATTTTATTGTTATGGCCTTGCTATTTTCTTCCAACTATAT
TAGTGCTAGTAGTTTTATTTCTGGTCCTTCTGCTGTTTATAAGTATGGGCTATCTTTTATATTATTAGCTGTTATACAAA
TTCCTACAACTTTAATTGCTTTTATTATTGTTGGTGAGAGATTAAATCGTGAATCGAAAAAAATTAATGCAATAAATATT
ATTGATTATATTAGATATAGATATGAAAGTGATTTTTTGGCGTTAATAAGTGGATGTGTATTAATTTTTTTTTTAATGTT
TTTGATTTCTGCCCAATTAATAGGTGGTGCCAAGCTTATAGAAGTTTTTTGGGATATTAATTATGCAGTTGGTCTTTTAC
TTTTTGCCCTATTAGTTTTTATTTATGTATTTTTTGGTGGATTTAAGGCAGTAGCTTATACGGACTTGATTCAAGGATTT
TTAATGCTCGTTTCATCTGTTATTTTGTTTTCCAAAATGTTGGATTTGGGAGGTGGTATTAATAATTTGTTCAAGACAGC
AGCGTCTAGTTTAGATAAAAACCTATTACTACCTTCGAATATTGATATAAAACCACAATATATAATTTCTTTTTGGATAT
TAATAGGGATAGGAATATTAGGACAACCTCAGATTATTAATAATTTTATAGCATTTAAAGATGGGAATGCTATAAAATTA
TCGCTTCCCATTTCTACTTTTATTATCAGCTTTTTAATTGTTTTGATGCATTTAATAGGGTTTTTTGCGATTATTCTTTT
TCCAGATTTAAATCCAAATGATAAAGTTGTTTTAAATGTAGCTTTAAAAGTTTTAAATCCTTTTTCTTGTTTTATTTTTT
TTATGGGACTTTTATCTGCAATAATGTCCACAGTAGATTCAAATTTATTATTAATAACATCTGTTTTAATAAAGTCAATA
TTTATTTATAAAAAAGATTTAAAAGAAGATTTAAAGGTTGGTAGAGTGATAATGATTTCCAATGTTTTTTTTATTTTAAT
AATACTTGTATTTTCTTTCCTTCCTCCCAATTTTTTATTCTTTGTTAATATTTTTGCTTTTGGAGCTTTAGAAGTTTCAT
TTTTTCCCATCATTGTTTTTGGACTTTATTTAAATTTTGCAAGCAAAATAGCAGCATTTACTTCTATGTTTTTAGGTTTG
ATATTTTATTTGTGTATTTTATGCTTTGGTTTTAATATTTGGTTTTTTCACCCTGTTTTTCCATCATTTTTTGTCTCTAT
ATTTACATTTTTAATAGTTAATTTTTTTTGTAAAAAATATAGCAAAGTTTATTAG

Upstream 100 bases:

>100_bases
TTTTTTGGTTTGTTTTTTTATTTTAGTAATTAGCAAGACTTGATACATTATTAATAATTTTTTATTTTTATATTTTTAAA
AAAGAAATAGAGGTAATTTC

Downstream 100 bases:

>100_bases
GATGATTATTTTTTGCGTTTAGATAAGTATATTTTTTTAGAAGTTCTTGCTAATGATAATGGCAAGCGATTAGATTCAAT
TTTAATTAAAATTTTAAATT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MLLNKYFLANRNINFIVMALLFSSNYISASSFISGPSAVYKYGLSFILLAVIQIPTTLIAFIIVGERLNRESKKINAINI
IDYIRYRYESDFLALISGCVLIFFLMFLISAQLIGGAKLIEVFWDINYAVGLLLFALLVFIYVFFGGFKAVAYTDLIQGF
LMLVSSVILFSKMLDLGGGINNLFKTAASSLDKNLLLPSNIDIKPQYIISFWILIGIGILGQPQIINNFIAFKDGNAIKL
SLPISTFIISFLIVLMHLIGFFAIILFPDLNPNDKVVLNVALKVLNPFSCFIFFMGLLSAIMSTVDSNLLLITSVLIKSI
FIYKKDLKEDLKVGRVIMISNVFFILIILVFSFLPPNFLFFVNIFAFGALEVSFFPIIVFGLYLNFASKIAAFTSMFLGL
IFYLCILCFGFNIWFFHPVFPSFFVSIFTFLIVNFFCKKYSKVY

Sequences:

>Translated_444_residues
MLLNKYFLANRNINFIVMALLFSSNYISASSFISGPSAVYKYGLSFILLAVIQIPTTLIAFIIVGERLNRESKKINAINI
IDYIRYRYESDFLALISGCVLIFFLMFLISAQLIGGAKLIEVFWDINYAVGLLLFALLVFIYVFFGGFKAVAYTDLIQGF
LMLVSSVILFSKMLDLGGGINNLFKTAASSLDKNLLLPSNIDIKPQYIISFWILIGIGILGQPQIINNFIAFKDGNAIKL
SLPISTFIISFLIVLMHLIGFFAIILFPDLNPNDKVVLNVALKVLNPFSCFIFFMGLLSAIMSTVDSNLLLITSVLIKSI
FIYKKDLKEDLKVGRVIMISNVFFILIILVFSFLPPNFLFFVNIFAFGALEVSFFPIIVFGLYLNFASKIAAFTSMFLGL
IFYLCILCFGFNIWFFHPVFPSFFVSIFTFLIVNFFCKKYSKVY
>Mature_444_residues
MLLNKYFLANRNINFIVMALLFSSNYISASSFISGPSAVYKYGLSFILLAVIQIPTTLIAFIIVGERLNRESKKINAINI
IDYIRYRYESDFLALISGCVLIFFLMFLISAQLIGGAKLIEVFWDINYAVGLLLFALLVFIYVFFGGFKAVAYTDLIQGF
LMLVSSVILFSKMLDLGGGINNLFKTAASSLDKNLLLPSNIDIKPQYIISFWILIGIGILGQPQIINNFIAFKDGNAIKL
SLPISTFIISFLIVLMHLIGFFAIILFPDLNPNDKVVLNVALKVLNPFSCFIFFMGLLSAIMSTVDSNLLLITSVLIKSI
FIYKKDLKEDLKVGRVIMISNVFFILIILVFSFLPPNFLFFVNIFAFGALEVSFFPIIVFGLYLNFASKIAAFTSMFLGL
IFYLCILCFGFNIWFFHPVFPSFFVSIFTFLIVNFFCKKYSKVY

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=475, Percent_Identity=29.2631578947368, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI87082237, Length=444, Percent_Identity=32.8828828828829, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI1787251, Length=430, Percent_Identity=25.3488372093023, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1790503, Length=464, Percent_Identity=25.6465517241379, Blast_Score=108, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 50172; Mature: 50172

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLNKYFLANRNINFIVMALLFSSNYISASSFISGPSAVYKYGLSFILLAVIQIPTTLIA
CCCCCHHHCCCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FIIVGERLNRESKKINAINIIDYIRYRYESDFLALISGCVLIFFLMFLISAQLIGGAKLI
HHHHHHHHCCHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EVFWDINYAVGLLLFALLVFIYVFFGGFKAVAYTDLIQGFLMLVSSVILFSKMLDLGGGI
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
NNLFKTAASSLDKNLLLPSNIDIKPQYIISFWILIGIGILGQPQIINNFIAFKDGNAIKL
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHEEECCCEEEE
SLPISTFIISFLIVLMHLIGFFAIILFPDLNPNDKVVLNVALKVLNPFSCFIFFMGLLSA
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IMSTVDSNLLLITSVLIKSIFIYKKDLKEDLKVGRVIMISNVFFILIILVFSFLPPNFLF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHH
FVNIFAFGALEVSFFPIIVFGLYLNFASKIAAFTSMFLGLIFYLCILCFGFNIWFFHPVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
PSFFVSIFTFLIVNFFCKKYSKVY
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLLNKYFLANRNINFIVMALLFSSNYISASSFISGPSAVYKYGLSFILLAVIQIPTTLIA
CCCCCHHHCCCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FIIVGERLNRESKKINAINIIDYIRYRYESDFLALISGCVLIFFLMFLISAQLIGGAKLI
HHHHHHHHCCHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EVFWDINYAVGLLLFALLVFIYVFFGGFKAVAYTDLIQGFLMLVSSVILFSKMLDLGGGI
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
NNLFKTAASSLDKNLLLPSNIDIKPQYIISFWILIGIGILGQPQIINNFIAFKDGNAIKL
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHEEECCCEEEE
SLPISTFIISFLIVLMHLIGFFAIILFPDLNPNDKVVLNVALKVLNPFSCFIFFMGLLSA
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IMSTVDSNLLLITSVLIKSIFIYKKDLKEDLKVGRVIMISNVFFILIILVFSFLPPNFLF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHH
FVNIFAFGALEVSFFPIIVFGLYLNFASKIAAFTSMFLGLIFYLCILCFGFNIWFFHPVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
PSFFVSIFTFLIVNFFCKKYSKVY
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]