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The map label for this gene is pksG [H]

Identifier: 51598938

GI number: 51598938

Start: 726143

End: 727366

Strand: Direct

Name: pksG [H]

Synonym: BG0706

Alternate gene names: 51598938

Gene position: 726143-727366 (Clockwise)

Preceding gene: 51598936

Following gene: 51598939

Centisome position: 80.3

GC content: 30.72

Gene sequence:

>1224_bases
ATGAAAATAGGTATTAGTGATATTAGGATTTTTTTACCTTTAAATTATTTAGACTTTTCTGTTCTTTTGGAAAATCCTTT
ATATTCTTCCAATGAAGTTTTTTTAAAAAAAATCAATAGAGCGATAGATGCAACTCTGCAAAAAGGTTTTAGGTTTACCA
GTCCCAATGAGGATAGTGTAACAATGGCAAGTTCGGCTGTTAAGCTTATTTTTGACAACAATAATCTTGATTTAAACAAA
ATTAGAATGCTTTTAGGTGGAACTGAGACAGGTGTTGATCATTCAAAGGCAATTTCTTCTTATGTTTTTGGGGCTTTAAA
GCAGTCTGGTATTTGTCTGGGGAATAATTTTCTAACCTTCCAAGTTCAGCATGCGTGCGCTGGTGCTGCTATTTCTTTAC
ACAGTGTAGCAAGTGTTTTAAGCCATTCTAATAATTCTGAATATGGTATAGTTTTTTCTTCAGATATTGCGCATTATAGC
AATCTTACTACAGCTGAGATTACCCAAGGAGCTGGTGCAACTGCAATTCTGGTTGAAAAAAATCCAAAGCTACTCTCTAT
TAATTTATCTGAATTCGGAGTTTATACTGATGATGTTGATGATTTTTTTAGACCTTTTGGAAGTGTTGAAGCTAAGGTGC
GGGGTCAATATTCAGTTGAATGTTACAATAATGCCAATGAAAATGCTTTAAAAGATTTTGCTGCCAAAAAGCAACTTAGT
ATTAAAGATTTGTTTTCTAATTATAGGTTTATTTTGCATGTTCCTTTTGCTAAAATGCCGATAGATTCAATGCATCATAT
TTTAAAAAAATATTATAGTGATGATGAATCTGTTAGGAATGCTTATTTAGAATCAATAGATTTTTACGATGGAGTTGAAG
CTGCTATGGAAGTGGGGAATTTGTATACGGGTTCAATTTTTCTATCTTTAGCATTTTATTTAAAAAAAGTTTTTTCCAAG
AAAGATATTACAGGAGAAAAGATATTGTTTTGTTCTTATGGATCTGGCAATATTATGATTATTTATGAATTTACCATTGA
AAAAGGTGCTTTTGATGTTGTTAAATTATGGGATCTTGATGGACTTATAAAAAATAGAAATAATGCAAATTTTGAAGAAT
ATAAAGATTTCTTTCAGAATAAAATAGTTCCTGGTGAATCCAAAGGATTTTATTTAAAAGAATTAAGGAATGATAAATAC
CGAGTTTATGGGTATCGAGCCTAA

Upstream 100 bases:

>100_bases
TTTTCATAAACTTCCCTTTTTAGGTTTCATTATATAAGATTTTGATAATTTTTGTAAATTATAATATAATACTTAAATCC
ATTAATGCACCGAGGAATAT

Downstream 100 bases:

>100_bases
TATACTAGAAAATAAAAAAAGGCATATTGAAATTTGTTTAAATAAAAACGATGTTAAAGGTGGCTGCAATTTTTTAAAGT
TTATTAAGCTAAAACATAAT

Product: 3-hydroxy-3-methylglutaryl-CoA synthase

Products: NA

Alternate protein names: HMG synthase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKIGISDIRIFLPLNYLDFSVLLENPLYSSNEVFLKKINRAIDATLQKGFRFTSPNEDSVTMASSAVKLIFDNNNLDLNK
IRMLLGGTETGVDHSKAISSYVFGALKQSGICLGNNFLTFQVQHACAGAAISLHSVASVLSHSNNSEYGIVFSSDIAHYS
NLTTAEITQGAGATAILVEKNPKLLSINLSEFGVYTDDVDDFFRPFGSVEAKVRGQYSVECYNNANENALKDFAAKKQLS
IKDLFSNYRFILHVPFAKMPIDSMHHILKKYYSDDESVRNAYLESIDFYDGVEAAMEVGNLYTGSIFLSLAFYLKKVFSK
KDITGEKILFCSYGSGNIMIIYEFTIEKGAFDVVKLWDLDGLIKNRNNANFEEYKDFFQNKIVPGESKGFYLKELRNDKY
RVYGYRA

Sequences:

>Translated_407_residues
MKIGISDIRIFLPLNYLDFSVLLENPLYSSNEVFLKKINRAIDATLQKGFRFTSPNEDSVTMASSAVKLIFDNNNLDLNK
IRMLLGGTETGVDHSKAISSYVFGALKQSGICLGNNFLTFQVQHACAGAAISLHSVASVLSHSNNSEYGIVFSSDIAHYS
NLTTAEITQGAGATAILVEKNPKLLSINLSEFGVYTDDVDDFFRPFGSVEAKVRGQYSVECYNNANENALKDFAAKKQLS
IKDLFSNYRFILHVPFAKMPIDSMHHILKKYYSDDESVRNAYLESIDFYDGVEAAMEVGNLYTGSIFLSLAFYLKKVFSK
KDITGEKILFCSYGSGNIMIIYEFTIEKGAFDVVKLWDLDGLIKNRNNANFEEYKDFFQNKIVPGESKGFYLKELRNDKY
RVYGYRA
>Mature_407_residues
MKIGISDIRIFLPLNYLDFSVLLENPLYSSNEVFLKKINRAIDATLQKGFRFTSPNEDSVTMASSAVKLIFDNNNLDLNK
IRMLLGGTETGVDHSKAISSYVFGALKQSGICLGNNFLTFQVQHACAGAAISLHSVASVLSHSNNSEYGIVFSSDIAHYS
NLTTAEITQGAGATAILVEKNPKLLSINLSEFGVYTDDVDDFFRPFGSVEAKVRGQYSVECYNNANENALKDFAAKKQLS
IKDLFSNYRFILHVPFAKMPIDSMHHILKKYYSDDESVRNAYLESIDFYDGVEAAMEVGNLYTGSIFLSLAFYLKKVFSK
KDITGEKILFCSYGSGNIMIIYEFTIEKGAFDVVKLWDLDGLIKNRNNANFEEYKDFFQNKIVPGESKGFYLKELRNDKY
RVYGYRA

Specific function: Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac- AcpK) and

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA synthase family [H]

Homologues:

Organism=Homo sapiens, GI5031751, Length=468, Percent_Identity=24.7863247863248, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI148298764, Length=390, Percent_Identity=25.6410256410256, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI148298677, Length=390, Percent_Identity=25.6410256410256, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560126, Length=416, Percent_Identity=25.4807692307692, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323509, Length=421, Percent_Identity=24.4655581947743, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24654139, Length=460, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24654137, Length=460, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24654133, Length=460, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24654135, Length=460, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17933694, Length=460, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013746
- InterPro:   IPR013528
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08540 HMG_CoA_synt_C; PF01154 HMG_CoA_synt_N [H]

EC number: NA

Molecular weight: Translated: 45749; Mature: 45749

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGISDIRIFLPLNYLDFSVLLENPLYSSNEVFLKKINRAIDATLQKGFRFTSPNEDSV
CCCCCCEEEEEEEECHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEECCCCCCCE
TMASSAVKLIFDNNNLDLNKIRMLLGGTETGVDHSKAISSYVFGALKQSGICLGNNFLTF
EEECCEEEEEEECCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCCEEECCCEEEE
QVQHACAGAAISLHSVASVLSHSNNSEYGIVFSSDIAHYSNLTTAEITQGAGATAILVEK
EEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCHHHHCCCCCCEEEEEEC
NPKLLSINLSEFGVYTDDVDDFFRPFGSVEAKVRGQYSVECYNNANENALKDFAAKKQLS
CCCEEEEEHHHCCCCCCCHHHHHCCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHCCC
IKDLFSNYRFILHVPFAKMPIDSMHHILKKYYSDDESVRNAYLESIDFYDGVEAAMEVGN
HHHHHCCCEEEEECCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCC
LYTGSIFLSLAFYLKKVFSKKDITGEKILFCSYGSGNIMIIYEFTIEKGAFDVVKLWDLD
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCEEEEEEECCC
GLIKNRNNANFEEYKDFFQNKIVPGESKGFYLKELRNDKYRVYGYRA
HHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MKIGISDIRIFLPLNYLDFSVLLENPLYSSNEVFLKKINRAIDATLQKGFRFTSPNEDSV
CCCCCCEEEEEEEECHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEECCCCCCCE
TMASSAVKLIFDNNNLDLNKIRMLLGGTETGVDHSKAISSYVFGALKQSGICLGNNFLTF
EEECCEEEEEEECCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCCEEECCCEEEE
QVQHACAGAAISLHSVASVLSHSNNSEYGIVFSSDIAHYSNLTTAEITQGAGATAILVEK
EEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCHHHHCCCCCCEEEEEEC
NPKLLSINLSEFGVYTDDVDDFFRPFGSVEAKVRGQYSVECYNNANENALKDFAAKKQLS
CCCEEEEEHHHCCCCCCCHHHHHCCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHCCC
IKDLFSNYRFILHVPFAKMPIDSMHHILKKYYSDDESVRNAYLESIDFYDGVEAAMEVGN
HHHHHCCCEEEEECCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCC
LYTGSIFLSLAFYLKKVFSKKDITGEKILFCSYGSGNIMIIYEFTIEKGAFDVVKLWDLD
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCEEEEEEECCC
GLIKNRNNANFEEYKDFFQNKIVPGESKGFYLKELRNDKYRVYGYRA
HHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7704258; 9384377 [H]