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The map label for this gene is lon-2 [H]

Identifier: 51598865

GI number: 51598865

Start: 641769

End: 644177

Strand: Direct

Name: lon-2 [H]

Synonym: BG0629

Alternate gene names: 51598865

Gene position: 641769-644177 (Clockwise)

Preceding gene: 51598864

Following gene: 51598866

Centisome position: 70.97

GC content: 29.68

Gene sequence:

>2409_bases
ATGAAATCAATCTTAAATATGATAAAAAATAGAAAAGAAGATCTTCCAATTGTTATTTTAAAAGAAAATGTTCTTTTCCC
TAATATTACATTGTGGGTAACCTTTGATAATGAATATGTAATTAATTCCATAGCCCAATCTATGTTAGAGGGAAGGTTGA
TTCTTTTTGCATATCCAAATGAATCTAATTATGACGAATTTGGTAAAGGAGGGATTAAAAACCTATGTTCTGTAGGCACT
TATTCTAAACTTATCCAGGTTATAAAGGTCAGTAAAGACGTAGTAAAAGTTTTGGTTGAGTGTCAAAGCAGAGTTCTTAT
AGACAGTGTTTCAAAAAAAAATGATTATTTAAGAGCCAAAGTTACTTTTGTGCCTGATGTTAGTGGATTAAACAGAGAGC
TTTTTACTTATTCTAAATTTTTAAAAGAAACTTACGAAGTTTATAGAAATTCTTTATCTTTAAAATCTTATGATAGTGAT
AATGAGCCAATTGATTATTTTGAGAATCCAAGCAAGCTTGTTGATATTATAGCTTCTAATTCAAACTTAGAGAATAGTAT
AAAATTAGAGCTTTTGCAAGAGTTAAATGTTAAAACCAGAATAGAAAAGTTAATTGTTAATTTAAACATTGAAATTGACC
TTTTAGATCTTAAAAAAGATATTAATTCTAAAGTTAGAGCTAAGCTGGATAAAGGACAAAGAGATTATTTTCTTTCTGAG
CAAGTTAAAGAGATACAAAAAAGATTAGGTAAAGATGAGAACGACTATATTGACAGATTAAATTCCAAAGATATTTCAGA
AGATGTTAAATCTAAGATTGAAAAAGAAATTTCTAGATTATCTAAAATGCAGATGAATTCTCCCGATGCTAATATTATTA
GAAGCTATATAGAATTAATATTAGATCTTCCTTGGAATGAAAATACTCTTATGAAAAATCATTTAAGCGAGATTGAGTTT
ATCTTAAGAAATTCTCATTATGGTATGGATGAAGCAAAAGAAAAGATAATAAATTTTTTAGCTGTTTATCAAATTAATTC
TAAGGTTAAAGCTCCTATTTTATGCCTTGTAGGACCTCCCGGTATTGGCAAAACATCTCTTGTAGAATCTGTTGCAAGAT
CGTTGTCTAGAGAATTTGTTAAAATATCTCTAGGTGGCTTAAGAGATGAGGCAGAAATTAGGGGACACAGAAGAACCTAT
GTTGGTTCTCTTCCAGGTGTTTTTATTAGTGCAATGAAAAGAGCAGGCAAATCTAATCCCGTTATTCTTCTCGATGAAAT
AGATAAAATTAATAATAGTTATAAAGGAAATCCCGAATCTGCCCTTTTAGAAGTTTTAGATCCCGAGCAAAATTATAAAT
TTATAGATCATTATTTAGAAATTCCTTATGATCTTTCTAATGTTTTATTTGTTACAACAGCCAATTCTCTTAATAGTATG
TCAAAGCCACTTCTTGATAGGATGGAAATAATTAAAGTTGAGGGTTATTCTTATATTGAAAAGTTAGAGATTGCTAAGAT
TTTTTTGATTCCAAGCATAATTAAAGAGAGTTTTTTAGACAAAGTTTATATAAGAATAGAAGACGAGGTTATTTTTAATT
TAATTAGAAAGTATACTATGGAATCTGGTGTAAGGGGACTAAAGAGAGTTTTAACTAATTTAATTAGAAAACTCGTAAGG
GAGCTGCTTTATAAGTATTCTAAAGATCAAATCATCAAAGGCAATTTTTATTCACCAAGTTCTTTAATACATGGAAACAA
TTCACTTTTTACTCATGATCCTGATATTCCAGGTATTTATAAAATAATAAATATTAATAATTATTGTAATTATGTTGATA
CTGAGTATAACTTGGATTTAATTAAGATTGACTCTTCTGGATTTGTTTATGGACTTGCTTGGACAAATTATGGTGGCGCA
GTTCTTCCTGTTGAGGCAACTAAGTTTGAGAAAACAGGAGACATTATTCTAACAGGAAGTCTTGGGGCTATTATGAAAGA
GAGTGCACAGCTTGCATATTCTATAGTTAAGACCTATTCTTCTAAGCTTAATTTTGACATAAAAGAAAGTCCCGAAATTC
ATTTACACTTTCCAGAAGGGGCAACGCCAAAAGATGGACCTTCTGCAGGTATTACCATTGCAACAGCAATTGCTTCAATA
CTGTCTGACAAGAAGGTCCCCTTGGATCTTGCAATGACTGGTGAGGTGACTTTAAAAGGTTTTGTTCTTCCTGTGGGCGG
CATTAAAGAAAAAGTTTTAGCAGCCTATAGAAATGGTATAAACAAAGTTATTTTACCTAAAGATAATAAAAAAGATTATT
TTAAGCTTCCAGAAGAAGTTAAGGATAATATAGATGTTAAGTTTGTCTCTAGTTTGGAAGAAGTTTTTGATTATTTGAAT
ATTATTTAA

Upstream 100 bases:

>100_bases
AAGAAGGTTATTGTTACAAAAGAATCTGTTTTAAATACAGATATTAACCCATTAATTTTGGTGGGAAATGCAATTAAAAA
GCCTTGGGCAAAAGAGTTAT

Downstream 100 bases:

>100_bases
AAGTTTATATATTTATATTTTAGGAGTAGATATATGAAAGATGGAGTTAGAAGGCCCACAAGCAGTAGGACGTCTTTTAG
TGTTCAGCCTTATGCTAAAA

Product: ATP-dependent protease LA

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 802; Mature: 802

Protein sequence:

>802_residues
MKSILNMIKNRKEDLPIVILKENVLFPNITLWVTFDNEYVINSIAQSMLEGRLILFAYPNESNYDEFGKGGIKNLCSVGT
YSKLIQVIKVSKDVVKVLVECQSRVLIDSVSKKNDYLRAKVTFVPDVSGLNRELFTYSKFLKETYEVYRNSLSLKSYDSD
NEPIDYFENPSKLVDIIASNSNLENSIKLELLQELNVKTRIEKLIVNLNIEIDLLDLKKDINSKVRAKLDKGQRDYFLSE
QVKEIQKRLGKDENDYIDRLNSKDISEDVKSKIEKEISRLSKMQMNSPDANIIRSYIELILDLPWNENTLMKNHLSEIEF
ILRNSHYGMDEAKEKIINFLAVYQINSKVKAPILCLVGPPGIGKTSLVESVARSLSREFVKISLGGLRDEAEIRGHRRTY
VGSLPGVFISAMKRAGKSNPVILLDEIDKINNSYKGNPESALLEVLDPEQNYKFIDHYLEIPYDLSNVLFVTTANSLNSM
SKPLLDRMEIIKVEGYSYIEKLEIAKIFLIPSIIKESFLDKVYIRIEDEVIFNLIRKYTMESGVRGLKRVLTNLIRKLVR
ELLYKYSKDQIIKGNFYSPSSLIHGNNSLFTHDPDIPGIYKIININNYCNYVDTEYNLDLIKIDSSGFVYGLAWTNYGGA
VLPVEATKFEKTGDIILTGSLGAIMKESAQLAYSIVKTYSSKLNFDIKESPEIHLHFPEGATPKDGPSAGITIATAIASI
LSDKKVPLDLAMTGEVTLKGFVLPVGGIKEKVLAAYRNGINKVILPKDNKKDYFKLPEEVKDNIDVKFVSSLEEVFDYLN
II

Sequences:

>Translated_802_residues
MKSILNMIKNRKEDLPIVILKENVLFPNITLWVTFDNEYVINSIAQSMLEGRLILFAYPNESNYDEFGKGGIKNLCSVGT
YSKLIQVIKVSKDVVKVLVECQSRVLIDSVSKKNDYLRAKVTFVPDVSGLNRELFTYSKFLKETYEVYRNSLSLKSYDSD
NEPIDYFENPSKLVDIIASNSNLENSIKLELLQELNVKTRIEKLIVNLNIEIDLLDLKKDINSKVRAKLDKGQRDYFLSE
QVKEIQKRLGKDENDYIDRLNSKDISEDVKSKIEKEISRLSKMQMNSPDANIIRSYIELILDLPWNENTLMKNHLSEIEF
ILRNSHYGMDEAKEKIINFLAVYQINSKVKAPILCLVGPPGIGKTSLVESVARSLSREFVKISLGGLRDEAEIRGHRRTY
VGSLPGVFISAMKRAGKSNPVILLDEIDKINNSYKGNPESALLEVLDPEQNYKFIDHYLEIPYDLSNVLFVTTANSLNSM
SKPLLDRMEIIKVEGYSYIEKLEIAKIFLIPSIIKESFLDKVYIRIEDEVIFNLIRKYTMESGVRGLKRVLTNLIRKLVR
ELLYKYSKDQIIKGNFYSPSSLIHGNNSLFTHDPDIPGIYKIININNYCNYVDTEYNLDLIKIDSSGFVYGLAWTNYGGA
VLPVEATKFEKTGDIILTGSLGAIMKESAQLAYSIVKTYSSKLNFDIKESPEIHLHFPEGATPKDGPSAGITIATAIASI
LSDKKVPLDLAMTGEVTLKGFVLPVGGIKEKVLAAYRNGINKVILPKDNKKDYFKLPEEVKDNIDVKFVSSLEEVFDYLN
II
>Mature_802_residues
MKSILNMIKNRKEDLPIVILKENVLFPNITLWVTFDNEYVINSIAQSMLEGRLILFAYPNESNYDEFGKGGIKNLCSVGT
YSKLIQVIKVSKDVVKVLVECQSRVLIDSVSKKNDYLRAKVTFVPDVSGLNRELFTYSKFLKETYEVYRNSLSLKSYDSD
NEPIDYFENPSKLVDIIASNSNLENSIKLELLQELNVKTRIEKLIVNLNIEIDLLDLKKDINSKVRAKLDKGQRDYFLSE
QVKEIQKRLGKDENDYIDRLNSKDISEDVKSKIEKEISRLSKMQMNSPDANIIRSYIELILDLPWNENTLMKNHLSEIEF
ILRNSHYGMDEAKEKIINFLAVYQINSKVKAPILCLVGPPGIGKTSLVESVARSLSREFVKISLGGLRDEAEIRGHRRTY
VGSLPGVFISAMKRAGKSNPVILLDEIDKINNSYKGNPESALLEVLDPEQNYKFIDHYLEIPYDLSNVLFVTTANSLNSM
SKPLLDRMEIIKVEGYSYIEKLEIAKIFLIPSIIKESFLDKVYIRIEDEVIFNLIRKYTMESGVRGLKRVLTNLIRKLVR
ELLYKYSKDQIIKGNFYSPSSLIHGNNSLFTHDPDIPGIYKIININNYCNYVDTEYNLDLIKIDSSGFVYGLAWTNYGGA
VLPVEATKFEKTGDIILTGSLGAIMKESAQLAYSIVKTYSSKLNFDIKESPEIHLHFPEGATPKDGPSAGITIATAIASI
LSDKKVPLDLAMTGEVTLKGFVLPVGGIKEKVLAAYRNGINKVILPKDNKKDYFKLPEEVKDNIDVKFVSSLEEVFDYLN
II

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=830, Percent_Identity=35.1807228915663, Blast_Score=468, Evalue=1e-131,
Organism=Homo sapiens, GI21396489, Length=673, Percent_Identity=38.038632986627, Blast_Score=464, Evalue=1e-130,
Organism=Escherichia coli, GI1786643, Length=800, Percent_Identity=39.875, Blast_Score=572, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17505831, Length=663, Percent_Identity=38.1598793363499, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17556486, Length=637, Percent_Identity=36.4207221350078, Blast_Score=427, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=715, Percent_Identity=38.041958041958, Blast_Score=470, Evalue=1e-133,
Organism=Drosophila melanogaster, GI221513036, Length=693, Percent_Identity=38.6724386724387, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24666867, Length=693, Percent_Identity=38.6724386724387, Blast_Score=473, Evalue=1e-133,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 91074; Mature: 91074

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSILNMIKNRKEDLPIVILKENVLFPNITLWVTFDNEYVINSIAQSMLEGRLILFAYPN
CHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEECCC
ESNYDEFGKGGIKNLCSVGTYSKLIQVIKVSKDVVKVLVECQSRVLIDSVSKKNDYLRAK
CCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VTFVPDVSGLNRELFTYSKFLKETYEVYRNSLSLKSYDSDNEPIDYFENPSKLVDIIASN
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCC
SNLENSIKLELLQELNVKTRIEKLIVNLNIEIDLLDLKKDINSKVRAKLDKGQRDYFLSE
CCCCHHHHHHHHHHCCHHHHHHHHHEEECEEEEEEHHHHHHCHHHHHHHCCCCCCHHHHH
QVKEIQKRLGKDENDYIDRLNSKDISEDVKSKIEKEISRLSKMQMNSPDANIIRSYIELI
HHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LDLPWNENTLMKNHLSEIEFILRNSHYGMDEAKEKIINFLAVYQINSKVKAPILCLVGPP
HCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCCEEEEECCC
GIGKTSLVESVARSLSREFVKISLGGLRDEAEIRGHRRTYVGSLPGVFISAMKRAGKSNP
CCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHCCCCHHHHCCCHHHHHHHHHHCCCCCC
VILLDEIDKINNSYKGNPESALLEVLDPEQNYKFIDHYLEIPYDLSNVLFVTTANSLNSM
EEEEECHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEEECHHHHHH
SKPLLDRMEIIKVEGYSYIEKLEIAKIFLIPSIIKESFLDKVYIRIEDEVIFNLIRKYTM
HHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHH
ESGVRGLKRVLTNLIRKLVRELLYKYSKDQIIKGNFYSPSSLIHGNNSLFTHDPDIPGIY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEECCCCEEECCCCCCCEE
KIININNYCNYVDTEYNLDLIKIDSSGFVYGLAWTNYGGAVLPVEATKFEKTGDIILTGS
EEEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEECCCCCCCCCEEEECC
LGAIMKESAQLAYSIVKTYSSKLNFDIKESPEIHLHFPEGATPKDGPSAGITIATAIASI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
LSDKKVPLDLAMTGEVTLKGFVLPVGGIKEKVLAAYRNGINKVILPKDNKKDYFKLPEEV
HCCCCCCEEEEEECCEEEEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCHHHCCCHHH
KDNIDVKFVSSLEEVFDYLNII
HCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSILNMIKNRKEDLPIVILKENVLFPNITLWVTFDNEYVINSIAQSMLEGRLILFAYPN
CHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEECCC
ESNYDEFGKGGIKNLCSVGTYSKLIQVIKVSKDVVKVLVECQSRVLIDSVSKKNDYLRAK
CCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VTFVPDVSGLNRELFTYSKFLKETYEVYRNSLSLKSYDSDNEPIDYFENPSKLVDIIASN
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCC
SNLENSIKLELLQELNVKTRIEKLIVNLNIEIDLLDLKKDINSKVRAKLDKGQRDYFLSE
CCCCHHHHHHHHHHCCHHHHHHHHHEEECEEEEEEHHHHHHCHHHHHHHCCCCCCHHHHH
QVKEIQKRLGKDENDYIDRLNSKDISEDVKSKIEKEISRLSKMQMNSPDANIIRSYIELI
HHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LDLPWNENTLMKNHLSEIEFILRNSHYGMDEAKEKIINFLAVYQINSKVKAPILCLVGPP
HCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCCEEEEECCC
GIGKTSLVESVARSLSREFVKISLGGLRDEAEIRGHRRTYVGSLPGVFISAMKRAGKSNP
CCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHCCCCHHHHCCCHHHHHHHHHHCCCCCC
VILLDEIDKINNSYKGNPESALLEVLDPEQNYKFIDHYLEIPYDLSNVLFVTTANSLNSM
EEEEECHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEEECHHHHHH
SKPLLDRMEIIKVEGYSYIEKLEIAKIFLIPSIIKESFLDKVYIRIEDEVIFNLIRKYTM
HHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHH
ESGVRGLKRVLTNLIRKLVRELLYKYSKDQIIKGNFYSPSSLIHGNNSLFTHDPDIPGIY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEECCCCEEECCCCCCCEE
KIININNYCNYVDTEYNLDLIKIDSSGFVYGLAWTNYGGAVLPVEATKFEKTGDIILTGS
EEEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEECCCCCCCCCEEEECC
LGAIMKESAQLAYSIVKTYSSKLNFDIKESPEIHLHFPEGATPKDGPSAGITIATAIASI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
LSDKKVPLDLAMTGEVTLKGFVLPVGGIKEKVLAAYRNGINKVILPKDNKKDYFKLPEEV
HCCCCCCEEEEEECCEEEEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCHHHCCCHHH
KDNIDVKFVSSLEEVFDYLNII
HCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]