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The map label for this gene is clpP [H]

Identifier: 51598863

GI number: 51598863

Start: 639900

End: 640484

Strand: Direct

Name: clpP [H]

Synonym: BG0627

Alternate gene names: 51598863

Gene position: 639900-640484 (Clockwise)

Preceding gene: 51598862

Following gene: 51598864

Centisome position: 70.77

GC content: 33.16

Gene sequence:

>585_bases
ATGCATAATTTAATACCCACTGTGATAGAGCATACGGGAAATTATGAGAGAGTATTTGATATATATTCAAGATTACTTAG
AGAGCGTATAATATTTTTGAGTGGTGAGATTAATGATCTTAAGGCAGACACTGTTATTGCTCAACTTTTGTTTTTAGAAT
CAGAAGATTCAAATAAAGATATTTATCTCTATTTGAATTCTCCAGGAGGCAGTATTACTGCAGGTCTTGCAATTTATGAT
ACTATGCAGTATATAAAACCTGATGTAAGGACAATTTGCATTGGGCAAGCTGCTTCAATGGGAGCTTTTTTGCTTGCTGG
TGGCGCTAAGGGTAAAAGAGAATCTCTGGCTTATTCTAGAATAATGATTCATCAGCCTTGGGGAGGAATAAGTGGTCAGG
CTAGTGATATTAATATACAAGCTAATGAAATTTTAAGACTTAAAAAGTTAATAATAGATATTATGTCTAATCAGATAGGG
ATTGATAAGGAAAAACTGGCTCTTGATATGGAAAGAGATTATTTTATGACTTCAAATGATGCTCTTAAATATGGTCTTAT
TGATAGTATCTTAGTACGGGAGTAG

Upstream 100 bases:

>100_bases
AGAAAAAAATTTTAGCAAATCTTAAAGAGTTAAAAGGCAAGCAAGTTTCTTTTAAAGATTTTGTTAATTATAAAATTTGT
GAGTAAGAAAAATGGAGTTT

Downstream 100 bases:

>100_bases
TTTTATTTTTGGTAAAAATTTTTATGGCAAGATTAAAAGGTCAAAAAGTAAAAGAATGTTCTTTTTGTGGACTTAGCGTT
GCTGAGCTTGGGGGCAATGT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MHNLIPTVIEHTGNYERVFDIYSRLLRERIIFLSGEINDLKADTVIAQLLFLESEDSNKDIYLYLNSPGGSITAGLAIYD
TMQYIKPDVRTICIGQAASMGAFLLAGGAKGKRESLAYSRIMIHQPWGGISGQASDINIQANEILRLKKLIIDIMSNQIG
IDKEKLALDMERDYFMTSNDALKYGLIDSILVRE

Sequences:

>Translated_194_residues
MHNLIPTVIEHTGNYERVFDIYSRLLRERIIFLSGEINDLKADTVIAQLLFLESEDSNKDIYLYLNSPGGSITAGLAIYD
TMQYIKPDVRTICIGQAASMGAFLLAGGAKGKRESLAYSRIMIHQPWGGISGQASDINIQANEILRLKKLIIDIMSNQIG
IDKEKLALDMERDYFMTSNDALKYGLIDSILVRE
>Mature_194_residues
MHNLIPTVIEHTGNYERVFDIYSRLLRERIIFLSGEINDLKADTVIAQLLFLESEDSNKDIYLYLNSPGGSITAGLAIYD
TMQYIKPDVRTICIGQAASMGAFLLAGGAKGKRESLAYSRIMIHQPWGGISGQASDINIQANEILRLKKLIIDIMSNQIG
IDKEKLALDMERDYFMTSNDALKYGLIDSILVRE

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=189, Percent_Identity=56.0846560846561, Blast_Score=216, Evalue=7e-57,
Organism=Escherichia coli, GI1786641, Length=189, Percent_Identity=60.3174603174603, Blast_Score=245, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.6881720430108, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI20129427, Length=189, Percent_Identity=57.1428571428571, Blast_Score=224, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21734; Mature: 21734

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNLIPTVIEHTGNYERVFDIYSRLLRERIIFLSGEINDLKADTVIAQLLFLESEDSNKD
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCCCCCE
IYLYLNSPGGSITAGLAIYDTMQYIKPDVRTICIGQAASMGAFLLAGGAKGKRESLAYSR
EEEEEECCCCCEEEHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCHHHHHEEE
IMIHQPWGGISGQASDINIQANEILRLKKLIIDIMSNQIGIDKEKLALDMERDYFMTSND
EEEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCEEECCCC
ALKYGLIDSILVRE
CEEHHHHHHHHHCC
>Mature Secondary Structure
MHNLIPTVIEHTGNYERVFDIYSRLLRERIIFLSGEINDLKADTVIAQLLFLESEDSNKD
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCCCCCE
IYLYLNSPGGSITAGLAIYDTMQYIKPDVRTICIGQAASMGAFLLAGGAKGKRESLAYSR
EEEEEECCCCCEEEHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCHHHHHEEE
IMIHQPWGGISGQASDINIQANEILRLKKLIIDIMSNQIGIDKEKLALDMERDYFMTSND
EEEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCEEECCCC
ALKYGLIDSILVRE
CEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]