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The map label for this gene is pepD [H]

Identifier: 51598861

GI number: 51598861

Start: 636526

End: 637956

Strand: Direct

Name: pepD [H]

Synonym: BG0621

Alternate gene names: 51598861

Gene position: 636526-637956 (Clockwise)

Preceding gene: 51598860

Following gene: 51598862

Centisome position: 70.39

GC content: 30.26

Gene sequence:

>1431_bases
ATGAGTATTGTAATTGATTCTTTTAAAGAGATATCAAAAATTCCAAGATGTTCAAAAAATGTTAAAGGAATTATTAATTT
TATTAAGGAGAGATCCAAAAAATTTGGTTATTCTTTTAAAGAAGATAGTGTTGGAAATCTTGTTGTGCAGATAAAATCCA
ATAGTAATATTAATATGCACCCTATCATTTTACAATCTCATGTTGATATGGTTTGTGAAAAAAATGAATCCAGTTTACAT
AATTTTGAAACAGATCCAATTGAAATTGTTGAAGAGGATGGGTATCTAAAAGGAGTGGGGACTACCCTTGGAGCTGATAA
TGGGATTGGAGTAGCTATGATGTTGAGCATTATGAGTGAGGCCAATAGCTTCTCTCATCCTGATTTAGAACTTCTTTTTA
CCGTTGATGAAGAAATAGGCCTAATAGGTGCTCTTAGTCTTGATTCTAAGCTATGTAGTGGCAAAAGCCTTATTAATCTT
GATGGGGAGGAAGAGGGTTATTTTTTAGTTGGTTGTGCGGGATCAAGACTTGTTGAGATTGTTTTTTCTCCTCAGTATAG
TCTTGCAACAAAAAAAACAAAAGTAGAAATTTTGCTTAAAGGGCTTAAAGGCGGCCATTCTGGAGCAGATATTCATTTAG
ATTTGGCAAATTCTTTAAAATTAATGTTTTTTGCTCTTTTCGAAATTAAATCAAATATTGATTTTGAGATTGAAAGTATT
TTTGGTGGAGACAGCAGTAATGCAATTCCAAATGAAGCCAAGGCTTTAATCTTTATTAATGATAGTGATTATGATTTATT
AAGTAAAGAACTTAAACTTTTCGTATTTAAAGTTAAAAGTGTATATTCTCTTGAGGATGAATTTGACATTGTTGTTAATA
AAAAAGAATTTTCATCAGTTAAAGTTCTTGATGAAAATAGCAAAAGCAAGCTTTTAAATATGGGAATGGGATTTTTACAT
GGAGTTCAAAAAGTAGAAAATTATGAAAATAAGCTCATCAAGACTTCTTTAAATTTTTCAAGTCTTTTCAAAATTAAAGA
CGACTATATTTTTACTTTTTTAATAAGATCTTTATTTGATTCAGATAAAGAGTATGTTTTTAATCATTTACAATCAATAG
GCGGTTTATCAGGAGCTAATTTGCGTGTAATTTATGACTATCCTTCTTGGAAGTCTAACAAGAATAGTAATCTTTTAAAA
CATCTTAAAGAGGTGTATAAAGAGATGTATCTTGAAGATGCTAATGTTTCTTTAATACATGCGGGGCTTGAAACAGGTAT
AATATCTTCGAGGTTGGGGGGCATAGAATCTGTTACTCTTGGGCCTTGGATTGAATCGCCTCATACTACTAGAGAAAGGG
TAAATATTTCTTCAACTATTAGAGTTTATGATTTCTTGAAAAAAAGTTTAGAAAGATTTCAAAAATTTTAG

Upstream 100 bases:

>100_bases
TAAATTTTAATATTGATTTAGTATATTATATTATTAATTATAATTAAGTCTAAGTATTTTTATGGATTTAATATAATCAC
ATAATTAAAGGAAATTTATT

Downstream 100 bases:

>100_bases
TTTTAAAAATTTAATGTTTTAATATAAATTTTTGAATAAAGGTCTTATAGCTTTTATTATCCTTATCTTTTGTTGACTTA
GAAATTAAATATTTATAAAA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSIVIDSFKEISKIPRCSKNVKGIINFIKERSKKFGYSFKEDSVGNLVVQIKSNSNINMHPIILQSHVDMVCEKNESSLH
NFETDPIEIVEEDGYLKGVGTTLGADNGIGVAMMLSIMSEANSFSHPDLELLFTVDEEIGLIGALSLDSKLCSGKSLINL
DGEEEGYFLVGCAGSRLVEIVFSPQYSLATKKTKVEILLKGLKGGHSGADIHLDLANSLKLMFFALFEIKSNIDFEIESI
FGGDSSNAIPNEAKALIFINDSDYDLLSKELKLFVFKVKSVYSLEDEFDIVVNKKEFSSVKVLDENSKSKLLNMGMGFLH
GVQKVENYENKLIKTSLNFSSLFKIKDDYIFTFLIRSLFDSDKEYVFNHLQSIGGLSGANLRVIYDYPSWKSNKNSNLLK
HLKEVYKEMYLEDANVSLIHAGLETGIISSRLGGIESVTLGPWIESPHTTRERVNISSTIRVYDFLKKSLERFQKF

Sequences:

>Translated_476_residues
MSIVIDSFKEISKIPRCSKNVKGIINFIKERSKKFGYSFKEDSVGNLVVQIKSNSNINMHPIILQSHVDMVCEKNESSLH
NFETDPIEIVEEDGYLKGVGTTLGADNGIGVAMMLSIMSEANSFSHPDLELLFTVDEEIGLIGALSLDSKLCSGKSLINL
DGEEEGYFLVGCAGSRLVEIVFSPQYSLATKKTKVEILLKGLKGGHSGADIHLDLANSLKLMFFALFEIKSNIDFEIESI
FGGDSSNAIPNEAKALIFINDSDYDLLSKELKLFVFKVKSVYSLEDEFDIVVNKKEFSSVKVLDENSKSKLLNMGMGFLH
GVQKVENYENKLIKTSLNFSSLFKIKDDYIFTFLIRSLFDSDKEYVFNHLQSIGGLSGANLRVIYDYPSWKSNKNSNLLK
HLKEVYKEMYLEDANVSLIHAGLETGIISSRLGGIESVTLGPWIESPHTTRERVNISSTIRVYDFLKKSLERFQKF
>Mature_475_residues
SIVIDSFKEISKIPRCSKNVKGIINFIKERSKKFGYSFKEDSVGNLVVQIKSNSNINMHPIILQSHVDMVCEKNESSLHN
FETDPIEIVEEDGYLKGVGTTLGADNGIGVAMMLSIMSEANSFSHPDLELLFTVDEEIGLIGALSLDSKLCSGKSLINLD
GEEEGYFLVGCAGSRLVEIVFSPQYSLATKKTKVEILLKGLKGGHSGADIHLDLANSLKLMFFALFEIKSNIDFEIESIF
GGDSSNAIPNEAKALIFINDSDYDLLSKELKLFVFKVKSVYSLEDEFDIVVNKKEFSSVKVLDENSKSKLLNMGMGFLHG
VQKVENYENKLIKTSLNFSSLFKIKDDYIFTFLIRSLFDSDKEYVFNHLQSIGGLSGANLRVIYDYPSWKSNKNSNLLKH
LKEVYKEMYLEDANVSLIHAGLETGIISSRLGGIESVTLGPWIESPHTTRERVNISSTIRVYDFLKKSLERFQKF

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=479, Percent_Identity=32.3590814196242, Blast_Score=253, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53333; Mature: 53202

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVIDSFKEISKIPRCSKNVKGIINFIKERSKKFGYSFKEDSVGNLVVQIKSNSNINMH
CCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCEE
PIILQSHVDMVCEKNESSLHNFETDPIEIVEEDGYLKGVGTTLGADNGIGVAMMLSIMSE
EEEEHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHH
ANSFSHPDLELLFTVDEEIGLIGALSLDSKLCSGKSLINLDGEEEGYFLVGCAGSRLVEI
CCCCCCCCEEEEEEECCCCCEEEEEECCHHHCCCCCEEECCCCCCCEEEEEECCCEEEEE
VFSPQYSLATKKTKVEILLKGLKGGHSGADIHLDLANSLKLMFFALFEIKSNIDFEIESI
EECCCCHHHCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEE
FGGDSSNAIPNEAKALIFINDSDYDLLSKELKLFVFKVKSVYSLEDEFDIVVNKKEFSSV
ECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHEEHHHHHCCCCCEEEEEECCCCCEE
KVLDENSKSKLLNMGMGFLHGVQKVENYENKLIKTSLNFSSLFKIKDDYIFTFLIRSLFD
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHEEECCHHHHHHHHHHHHC
SDKEYVFNHLQSIGGLSGANLRVIYDYPSWKSNKNSNLLKHLKEVYKEMYLEDANVSLIH
CCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
AGLETGIISSRLGGIESVTLGPWIESPHTTRERVNISSTIRVYDFLKKSLERFQKF
CCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIVIDSFKEISKIPRCSKNVKGIINFIKERSKKFGYSFKEDSVGNLVVQIKSNSNINMH
CEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCEE
PIILQSHVDMVCEKNESSLHNFETDPIEIVEEDGYLKGVGTTLGADNGIGVAMMLSIMSE
EEEEHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHH
ANSFSHPDLELLFTVDEEIGLIGALSLDSKLCSGKSLINLDGEEEGYFLVGCAGSRLVEI
CCCCCCCCEEEEEEECCCCCEEEEEECCHHHCCCCCEEECCCCCCCEEEEEECCCEEEEE
VFSPQYSLATKKTKVEILLKGLKGGHSGADIHLDLANSLKLMFFALFEIKSNIDFEIESI
EECCCCHHHCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEE
FGGDSSNAIPNEAKALIFINDSDYDLLSKELKLFVFKVKSVYSLEDEFDIVVNKKEFSSV
ECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHEEHHHHHCCCCCEEEEEECCCCCEE
KVLDENSKSKLLNMGMGFLHGVQKVENYENKLIKTSLNFSSLFKIKDDYIFTFLIRSLFD
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHEEECCHHHHHHHHHHHHC
SDKEYVFNHLQSIGGLSGANLRVIYDYPSWKSNKNSNLLKHLKEVYKEMYLEDANVSLIH
CCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
AGLETGIISSRLGGIESVTLGPWIESPHTTRERVNISSTIRVYDFLKKSLERFQKF
CCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]