Click here to switch to the map view.

The map label for this gene is trkA

Identifier: 51597958

GI number: 51597958

Start: 4380651

End: 4382027

Strand: Direct

Name: trkA

Synonym: YPTB3668

Alternate gene names: 51597958

Gene position: 4380651-4382027 (Clockwise)

Preceding gene: 51597957

Following gene: 51597959

Centisome position: 92.33

GC content: 43.65

Gene sequence:

>1377_bases
ATGAAAATAATTATTCTTGGGGCAGGGCAAGTTGGCGGGACCCTGGCAGAAAACTTGGTGGGTGAAAATAACGATATCAC
TGTAGTCGATATCGACTCTGGTCGACTACGCCAACTGCAGGATAAGTTTGATTTACGTGTAGTACAAGGGTATGGCTCAC
ACCCTAGAGTTCTACGAGAGGCAGGAGCTGAGGATGCCGATATGCTGGTAGCCGTGACTAATTCTGATGAAACCAATATG
ATTGCCTGCCAAATCGCTTACTCATTATTCAATACACCAAATCGCATTGCTCGCATTCGATCAACTGAATATATACGTGA
AGCAGATAAACTCTTTCTGCCCGAAGCTGTACCGATTGACCATTTAATCTCACCTGAACAACTAGTCATTGACTATATCT
ATAAGTTAATCGAATACCCTGGAGCACTACAGGTCGTTAACTTTGCTGAAGGTAAAGTTAGCATCGCAGCAGTCAAAGCC
TACTATGGCGGCCCATTGGTAGGGAATGCATTGTCATCCTTACGTGAACATATGCCACATATTGATACTAGAGTCGCGGC
TATATTTCGCCAAGATCGACCAATCCGTCCACAGGGATCAACAATTATTGAAGCTGGTGATGAAGTCTTTTTTGTAGCGG
CCTCTCAGCATATACGAGCGGTAATGAGTGAGTTACAGCGCCTGGAAAAACCGTATAAACGCATTATGATTGTCGGTGGT
GGTAATGTCGGTGCAGGTCTGGCACTGCGTCTGGAAAAAGACTACAGCGTAAAGTTAATTGAACGTGACCAACAGCGGGC
AGCTGAATTAGCTGAAATGCTACACGATACTATCGTATTTTATGGTGATGCATCAGACCAAGAATTACTTGCAGAAGAAC
ATATTGAACAGGTTGATGTATTTATCGCCATTACAAATGATGATGAAGCCAATATTATGTCGGCTATGCTGGCAAAACGG
ATGGGTGCGAAAAAAGCGATGGTACTTATCCAACGCAGTGCTTACGTCGATTTGGTTCAGGGAAGCGTTATTGATATTGT
TATATCACCGCAGCAAGCCACTATTTCAGCACTATTAGGTCATGTCCGTAAAGCAGATATCGTTAGTGTATCCTCGCTGA
GACGTGGCGTTGCTGAGGCAATAGAAGCTATTGCTCATGGTGATGAAAGCACTTCAAAAGTTGTCGGCCGGATGGTTGAA
GACATAAAGTTACCACCAGGAACAACTATTGGAGCTATCGTTCGGGGGGATGAGGTTATTATTGCAAACAGTAACTCCAT
AATTAAGCAAGGGGACCATGTAATAATGTTCATTACCCACAAAAAATTTGTACCCGATGTGGAACGGTTGTTCCAACCAA
GCCCATTCTTCCTATAA

Upstream 100 bases:

>100_bases
GAGGACGGTGATGGTTTCTTCTACGCAAAGATAATCAAAAAATAGTCTGTGGCTTTTGCTATGCCTCAAAACCTAATTTC
AGTGTGAAACAGAGAACGCT

Downstream 100 bases:

>100_bases
CTAATAATCATTAATTTCTGGCATCCTTATAAAAAGCCATGCTCATGAGGAAATAATTAAAATTTCCCTATAATTTTAGT
GATAATAGGCATTATTTAGC

Product: potassium transporter peripheral membrane component

Products: NA

Alternate protein names: K(+)-uptake protein trkA [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKIIILGAGQVGGTLAENLVGENNDITVVDIDSGRLRQLQDKFDLRVVQGYGSHPRVLREAGAEDADMLVAVTNSDETNM
IACQIAYSLFNTPNRIARIRSTEYIREADKLFLPEAVPIDHLISPEQLVIDYIYKLIEYPGALQVVNFAEGKVSIAAVKA
YYGGPLVGNALSSLREHMPHIDTRVAAIFRQDRPIRPQGSTIIEAGDEVFFVAASQHIRAVMSELQRLEKPYKRIMIVGG
GNVGAGLALRLEKDYSVKLIERDQQRAAELAEMLHDTIVFYGDASDQELLAEEHIEQVDVFIAITNDDEANIMSAMLAKR
MGAKKAMVLIQRSAYVDLVQGSVIDIVISPQQATISALLGHVRKADIVSVSSLRRGVAEAIEAIAHGDESTSKVVGRMVE
DIKLPPGTTIGAIVRGDEVIIANSNSIIKQGDHVIMFITHKKFVPDVERLFQPSPFFL

Sequences:

>Translated_458_residues
MKIIILGAGQVGGTLAENLVGENNDITVVDIDSGRLRQLQDKFDLRVVQGYGSHPRVLREAGAEDADMLVAVTNSDETNM
IACQIAYSLFNTPNRIARIRSTEYIREADKLFLPEAVPIDHLISPEQLVIDYIYKLIEYPGALQVVNFAEGKVSIAAVKA
YYGGPLVGNALSSLREHMPHIDTRVAAIFRQDRPIRPQGSTIIEAGDEVFFVAASQHIRAVMSELQRLEKPYKRIMIVGG
GNVGAGLALRLEKDYSVKLIERDQQRAAELAEMLHDTIVFYGDASDQELLAEEHIEQVDVFIAITNDDEANIMSAMLAKR
MGAKKAMVLIQRSAYVDLVQGSVIDIVISPQQATISALLGHVRKADIVSVSSLRRGVAEAIEAIAHGDESTSKVVGRMVE
DIKLPPGTTIGAIVRGDEVIIANSNSIIKQGDHVIMFITHKKFVPDVERLFQPSPFFL
>Mature_458_residues
MKIIILGAGQVGGTLAENLVGENNDITVVDIDSGRLRQLQDKFDLRVVQGYGSHPRVLREAGAEDADMLVAVTNSDETNM
IACQIAYSLFNTPNRIARIRSTEYIREADKLFLPEAVPIDHLISPEQLVIDYIYKLIEYPGALQVVNFAEGKVSIAAVKA
YYGGPLVGNALSSLREHMPHIDTRVAAIFRQDRPIRPQGSTIIEAGDEVFFVAASQHIRAVMSELQRLEKPYKRIMIVGG
GNVGAGLALRLEKDYSVKLIERDQQRAAELAEMLHDTIVFYGDASDQELLAEEHIEQVDVFIAITNDDEANIMSAMLAKR
MGAKKAMVLIQRSAYVDLVQGSVIDIVISPQQATISALLGHVRKADIVSVSSLRRGVAEAIEAIAHGDESTSKVVGRMVE
DIKLPPGTTIGAIVRGDEVIIANSNSIIKQGDHVIMFITHKKFVPDVERLFQPSPFFL

Specific function: Part of the constitutive potassium transport systems trkG and trkH. May regulate the transport activity of trkG and trkH systems. Binds to NAD+ and NADH [H]

COG id: COG0569

COG function: function code P; K+ transport systems, NAD-binding component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripherally bound to the inner side of the inner membrane via the trkG and trkH proteins (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 RCK N-terminal domains [H]

Homologues:

Organism=Escherichia coli, GI1789685, Length=458, Percent_Identity=86.2445414847162, Blast_Score=818, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR006037
- InterPro:   IPR003148 [H]

Pfam domain/function: PF02080 TrkA_C; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 50289; Mature: 50289

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIILGAGQVGGTLAENLVGENNDITVVDIDSGRLRQLQDKFDLRVVQGYGSHPRVLRE
CEEEEEECCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCEEEEECCCCCCHHHHH
AGAEDADMLVAVTNSDETNMIACQIAYSLFNTPNRIARIRSTEYIREADKLFLPEAVPID
CCCCCCCEEEEEECCCCCCEEEHEEHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHH
HLISPEQLVIDYIYKLIEYPGALQVVNFAEGKVSIAAVKAYYGGPLVGNALSSLREHMPH
HCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHCCC
IDTRVAAIFRQDRPIRPQGSTIIEAGDEVFFVAASQHIRAVMSELQRLEKPYKRIMIVGG
HHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHCHHHEEEEEEC
GNVGAGLALRLEKDYSVKLIERDQQRAAELAEMLHDTIVFYGDASDQELLAEEHIEQVDV
CCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCEEEE
FIAITNDDEANIMSAMLAKRMGAKKAMVLIQRSAYVDLVQGSVIDIVISPQQATISALLG
EEEEECCCHHHHHHHHHHHHHCCCHHEEEEEHHHHHHHHCCCEEEEEECCCHHHHHHHHH
HVRKADIVSVSSLRRGVAEAIEAIAHGDESTSKVVGRMVEDIKLPPGTTIGAIVRGDEVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCEEE
IANSNSIIKQGDHVIMFITHKKFVPDVERLFQPSPFFL
EECCCCCEECCCEEEEEEECCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MKIIILGAGQVGGTLAENLVGENNDITVVDIDSGRLRQLQDKFDLRVVQGYGSHPRVLRE
CEEEEEECCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCEEEEECCCCCCHHHHH
AGAEDADMLVAVTNSDETNMIACQIAYSLFNTPNRIARIRSTEYIREADKLFLPEAVPID
CCCCCCCEEEEEECCCCCCEEEHEEHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHH
HLISPEQLVIDYIYKLIEYPGALQVVNFAEGKVSIAAVKAYYGGPLVGNALSSLREHMPH
HCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHCCC
IDTRVAAIFRQDRPIRPQGSTIIEAGDEVFFVAASQHIRAVMSELQRLEKPYKRIMIVGG
HHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHCHHHEEEEEEC
GNVGAGLALRLEKDYSVKLIERDQQRAAELAEMLHDTIVFYGDASDQELLAEEHIEQVDV
CCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCEEEE
FIAITNDDEANIMSAMLAKRMGAKKAMVLIQRSAYVDLVQGSVIDIVISPQQATISALLG
EEEEECCCHHHHHHHHHHHHHCCCHHEEEEEHHHHHHHHCCCEEEEEECCCHHHHHHHHH
HVRKADIVSVSSLRRGVAEAIEAIAHGDESTSKVVGRMVEDIKLPPGTTIGAIVRGDEVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCEEE
IANSNSIIKQGDHVIMFITHKKFVPDVERLFQPSPFFL
EECCCCCEECCCEEEEEEECCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]