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The map label for this gene is moeZ [H]

Identifier: 51594912

GI number: 51594912

Start: 662305

End: 663531

Strand: Direct

Name: moeZ [H]

Synonym: YPTB0561

Alternate gene names: 51594912

Gene position: 662305-663531 (Clockwise)

Preceding gene: 51594911

Following gene: 51594914

Centisome position: 13.96

GC content: 41.16

Gene sequence:

>1227_bases
ATGAGTAAATTAGCTAATGACATTGAATTTATAAGCCTTAGTCCGGCGGAAATAGGGTTATATTCAAGGCACTTACTGAT
ACCCTCCATTGGCGTTAAAGGCCAATTGGCGCTAAAAAATGCTAGTGTATTGATGGTAGGGGCAGGTGGTCTCGGTTGCC
CCGTTTTGCTTTATTTAGCAGCAGCGGGTGTTGGGCGGATAGGTATTATTGATGCAGACCATATTGAAATTTCTAATGTG
CACCGACAGATATTATATCGGGTAGTAGATAAAGGGAAGAATAAAGCCGATGTAGCTAAATTTCGTTTACAGGCACTTAA
CCCCTATATTGAAATAGAAACCTATATTGATCGATTAAATGTAGATAATGCCGAAGCACTCATATCTCGCTACGATATTG
TGGTTGATGGGACAGATAACTTTACAACTAAATATCTTATTAATGATGCGTGTTATTTTGCCGGTAAGCCTTTGGTGTAT
GGTGCCATTATGCAATTTGAGGGACAAGTCGCAGTATTTAATGCATTGGATGAGCAGGGGGGGTATGGGGCTAATTATCG
TGACCTTTATAGCGATCCTCCTGATGCCGCATTAGCACCTAATTGTGCTGAGGCTGGAGTGCTGGGTATTTTACCTGGCA
TCATCGGCTGTTTTCAGGCTAATGAGGTAATTAAATTGATTACCGGACTCGGACGGTCTTTGTCTGAACGTCTGCTAATT
TATGATGCATTGGATGCCACGACGACAGAATTACATTTTTCTGCGTGTGCAGATAATCCGCTACGCGATCCTAATCGGCC
TCACGTATTGGAAGAAATACCGGCCATATGCAATAGCCCTGTGGTTTCTGATCAATTTGTTATCAGCCTCGATGAATTTA
ATGATCTTATGCGTGATCATGTTGTTATCCATCTAATTGATGTTCGTGAACCACATGAGCGAAAGCAAGTCTCTATTGGT
GGCATACATATTCCGCTAGCAGAGATAGACGGCGTTGAACATGAATACATTAATGATGTGCCTATTATTTTATATTGTCA
GTCTGGCGTCCGTAGCCAAAAAGCCGCCAAAATTTTGGCAGATAAATTACAGCATGCACAAATATTCAGTCTTAAGGGGG
GAATATCTGCATTTTTGGCTTCTAATTTATATCCAGAACTGATAGCCAATTTAGCCTTATGTCAGTGTATACCCAATAAA
CCTCAAGATGCAGATTTGAGCACCTGA

Upstream 100 bases:

>100_bases
TTGTCCATCATATTTTCAATATCAGCAGGGCTGATACTCTGGCTGCTGTCGTCGTCGAAAGTTTTTAATTTAATTACTGC
GTCTGGGGAGAATAAATAAT

Downstream 100 bases:

>100_bases
AAATTACCGTTAATTCTAAATAACTGAGTCTTTTACTGCTACACCTGTCCTTTTTGAGCATATGATTGCACAGTAAAAGC
TGTGTGCTACAAGCTTAATA

Product: protein involved in molybdopterin biosynthesis

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSKLANDIEFISLSPAEIGLYSRHLLIPSIGVKGQLALKNASVLMVGAGGLGCPVLLYLAAAGVGRIGIIDADHIEISNV
HRQILYRVVDKGKNKADVAKFRLQALNPYIEIETYIDRLNVDNAEALISRYDIVVDGTDNFTTKYLINDACYFAGKPLVY
GAIMQFEGQVAVFNALDEQGGYGANYRDLYSDPPDAALAPNCAEAGVLGILPGIIGCFQANEVIKLITGLGRSLSERLLI
YDALDATTTELHFSACADNPLRDPNRPHVLEEIPAICNSPVVSDQFVISLDEFNDLMRDHVVIHLIDVREPHERKQVSIG
GIHIPLAEIDGVEHEYINDVPIILYCQSGVRSQKAAKILADKLQHAQIFSLKGGISAFLASNLYPELIANLALCQCIPNK
PQDADLST

Sequences:

>Translated_408_residues
MSKLANDIEFISLSPAEIGLYSRHLLIPSIGVKGQLALKNASVLMVGAGGLGCPVLLYLAAAGVGRIGIIDADHIEISNV
HRQILYRVVDKGKNKADVAKFRLQALNPYIEIETYIDRLNVDNAEALISRYDIVVDGTDNFTTKYLINDACYFAGKPLVY
GAIMQFEGQVAVFNALDEQGGYGANYRDLYSDPPDAALAPNCAEAGVLGILPGIIGCFQANEVIKLITGLGRSLSERLLI
YDALDATTTELHFSACADNPLRDPNRPHVLEEIPAICNSPVVSDQFVISLDEFNDLMRDHVVIHLIDVREPHERKQVSIG
GIHIPLAEIDGVEHEYINDVPIILYCQSGVRSQKAAKILADKLQHAQIFSLKGGISAFLASNLYPELIANLALCQCIPNK
PQDADLST
>Mature_407_residues
SKLANDIEFISLSPAEIGLYSRHLLIPSIGVKGQLALKNASVLMVGAGGLGCPVLLYLAAAGVGRIGIIDADHIEISNVH
RQILYRVVDKGKNKADVAKFRLQALNPYIEIETYIDRLNVDNAEALISRYDIVVDGTDNFTTKYLINDACYFAGKPLVYG
AIMQFEGQVAVFNALDEQGGYGANYRDLYSDPPDAALAPNCAEAGVLGILPGIIGCFQANEVIKLITGLGRSLSERLLIY
DALDATTTELHFSACADNPLRDPNRPHVLEEIPAICNSPVVSDQFVISLDEFNDLMRDHVVIHLIDVREPHERKQVSIGG
IHIPLAEIDGVEHEYINDVPIILYCQSGVRSQKAAKILADKLQHAQIFSLKGGISAFLASNLYPELIANLALCQCIPNKP
QDADLST

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=403, Percent_Identity=36.9727047146402, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4885649, Length=137, Percent_Identity=33.5766423357664, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI38045948, Length=159, Percent_Identity=31.4465408805031, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38045944, Length=114, Percent_Identity=35.9649122807018, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI38045942, Length=114, Percent_Identity=35.9649122807018, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI23510338, Length=152, Percent_Identity=29.6052631578947, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI23510340, Length=152, Percent_Identity=29.6052631578947, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787048, Length=243, Percent_Identity=38.6831275720165, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082356, Length=256, Percent_Identity=35.546875, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17540406, Length=407, Percent_Identity=32.9238329238329, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI193203301, Length=151, Percent_Identity=31.7880794701987, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71984476, Length=112, Percent_Identity=36.6071428571429, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321903, Length=396, Percent_Identity=31.8181818181818, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6322639, Length=157, Percent_Identity=31.8471337579618, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24582879, Length=401, Percent_Identity=36.1596009975062, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24660640, Length=139, Percent_Identity=35.9712230215827, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129973, Length=108, Percent_Identity=37.037037037037, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573937, Length=182, Percent_Identity=28.021978021978, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 44401; Mature: 44270

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLANDIEFISLSPAEIGLYSRHLLIPSIGVKGQLALKNASVLMVGAGGLGCPVLLYLA
CCCCCCCCEEEEECCHHHCCEECEEEECCCCCCCEEEEECCCEEEEECCCCHHHHHHHHH
AAGVGRIGIIDADHIEISNVHRQILYRVVDKGKNKADVAKFRLQALNPYIEIETYIDRLN
HCCCCEEEEEECCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEHHHHCC
VDNAEALISRYDIVVDGTDNFTTKYLINDACYFAGKPLVYGAIMQFEGQVAVFNALDEQG
CCCHHHHHHHCEEEEECCCCCEEEEEECCHHHHCCCCHHEEHHHHCCCCEEEEECHHHCC
GYGANYRDLYSDPPDAALAPNCAEAGVLGILPGIIGCFQANEVIKLITGLGRSLSERLLI
CCCCCCHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEE
YDALDATTTELHFSACADNPLRDPNRPHVLEEIPAICNSPVVSDQFVISLDEFNDLMRDH
EECCCCCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCC
VVIHLIDVREPHERKQVSIGGIHIPLAEIDGVEHEYINDVPIILYCQSGVRSQKAAKILA
EEEEEEECCCCCCCCEEEECCEEEEHHHHCCCCHHHHCCCCEEEEECCCCCHHHHHHHHH
DKLQHAQIFSLKGGISAFLASNLYPELIANLALCQCIPNKPQDADLST
HHHHHHEEEEECCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SKLANDIEFISLSPAEIGLYSRHLLIPSIGVKGQLALKNASVLMVGAGGLGCPVLLYLA
CCCCCCCEEEEECCHHHCCEECEEEECCCCCCCEEEEECCCEEEEECCCCHHHHHHHHH
AAGVGRIGIIDADHIEISNVHRQILYRVVDKGKNKADVAKFRLQALNPYIEIETYIDRLN
HCCCCEEEEEECCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEHHHHCC
VDNAEALISRYDIVVDGTDNFTTKYLINDACYFAGKPLVYGAIMQFEGQVAVFNALDEQG
CCCHHHHHHHCEEEEECCCCCEEEEEECCHHHHCCCCHHEEHHHHCCCCEEEEECHHHCC
GYGANYRDLYSDPPDAALAPNCAEAGVLGILPGIIGCFQANEVIKLITGLGRSLSERLLI
CCCCCCHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEE
YDALDATTTELHFSACADNPLRDPNRPHVLEEIPAICNSPVVSDQFVISLDEFNDLMRDH
EECCCCCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCC
VVIHLIDVREPHERKQVSIGGIHIPLAEIDGVEHEYINDVPIILYCQSGVRSQKAAKILA
EEEEEEECCCCCCCCEEEECCEEEEHHHHCCCCHHHHCCCCEEEEECCCCCHHHHHHHHH
DKLQHAQIFSLKGGISAFLASNLYPELIANLALCQCIPNKPQDADLST
HHHHHHEEEEECCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]