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The map label for this gene is rnr

Identifier: 51594784

GI number: 51594784

Start: 516271

End: 518805

Strand: Direct

Name: rnr

Synonym: YPTB0432

Alternate gene names: 51594784

Gene position: 516271-518805 (Clockwise)

Preceding gene: 51594783

Following gene: 51594785

Centisome position: 10.88

GC content: 52.31

Gene sequence:

>2535_bases
ATGTCACAAGATCCATTCCTGGAACGAGAAGCAGAGAAATATGAGTCACCAATCCCTAGCCGGGAATTTATTTTGGCTCA
TCTCGCGAAGCGCGAGACACCTGCCAGCCGTGAAGAGCTGGCCAATGAACTTAATTTAACCGGTGAAGAGCCTTTAGAGG
CGCTACGCCGTCGTTTGCGTGCGATGGAACGTGATGGGCAATTGGTCTTCACCCGTCGTCAGTGCTACGCCTTGCCAGAG
CGTCTGGATTTACTGCGCGGTACGGTTATTGGTCACCGTGATGGCTATGGCTTTTTGCGGGTTGAAGGCAGTAAAGATGA
TCTGTATCTCTCCGCAGAGCAGATGAAAATGGCGATCCATGGTGATGTCGTCTTGGCACAAGTGGTCGGGGCTGATCGTA
AAGGCCGCCGTGAAGCGCGTATCGTGCGTGTATTGGTCCCAAAAACCAGCCAGATCGTGGGTCGCTACTTTACCGATGCA
GGTACGGGCTTTGTCGTGCCGGATGACAGTCGTCTTAGCTTTGATATCTTGATCCCAGCAGAGGCGACCTGTGGTGCGCG
GATGGGCTTTGTGGTCGTAGTCGAATTGACTCAGCGGCCAACTCGCCGTACTAAAGCGGTTGGTAAGATTGTTGAAGTAC
TTGGTGAGAATATGGGCACCAGCATGGCGGTGGATATCGCATTGCGGACCCATGAGATCCCGCACACCTGGCCGCCTCAA
GTTGAAAAACAAGTCGCAGATCTGAAAGAACAGGTACCGGAAGAAGCGAAAAAGGGGCGGGTAGATTTGCGCGATCTGCC
TCTGGTTACGATTGATGGTGAAGATGCCCGCGACTTCGATGATGCCGTGTATTGCGAGAAGAAACGTGGCGGCGGTTGGC
GGTTGTGGGTAGCGATTGCGGATGTCAGTTATTATGTGCGTCCTCAAACCGCATTGGATGACGAAGCCCGGAGCCGTGGT
AACTCGGTCTACTTCCCATCGCAAGTGATACCGATGCTGCCGGAAGTGCTATCAAACGGCCTTTGCTCCCTTAATCCACA
GGTAGACCGCCTGTGTATGGTGTGCGAGATGACCATCTCTTCGCAGGGCAAACTCTCGTCTTATAAGTTCTACGAAGCGG
TAATGAGCTCCCATGCTCGTCTGACCTACACTAAGGTGTGGCGGATTATAGATGGTGAGGAATCGCTGCGTGAGCAATAT
AAGCCGCTGGTGCCACATCTGGAAGAGCTGCACGCGATGTATAAAGTGCTGGATCAGGCGCGCGCAGAGCGGGGAGGGAT
TGCTTTCGAAACAGAAGAAGCCAAGTTTATCTTTAATGCTGAACGGCGCATTGAACGTATCGAACCCACGGTACGTAATG
ATGCCCATAAGCTAATTGAAGAGTGCATGATTCTGGCGAATATCGCGGCGGCGCGTTTTGTGGAAAAACACGAAGAACCG
GCGTTGTTCCGAGTGCATGATCGCCCAAGCGATGACCATATTGTGGCATTGCGCAGTGTGTTGAATGAGTTGGGGCTAAC
ACTCGGGGGCGGGCTGAAGCCGCAACCAAAAGATTATTCAGTGTTGATGGATGAAATTTCTGATCGCCCCGATCATGAAA
TGCTGCAAACCATGTTGCTACGCTCCATGAAACAAGCGGTTTATGATCCAGAAAACCGGGGTCACTTTGGTTTGGCGCTG
GCTTCTTATGGCCACTTCACCTCACCTATTCGTCGTTACCCTGATTTGGCGATGCATCGGGCTATTAAGTATCAGTTAGC
CAAAGAGCACGGTAATTTAAAAGATCGCTGGACACCTACGGGCGGCTGGCACAGCGATTTCGAAGATATGCTGCAATTGG
GCCAACACTGTTCGATGACCGAGCGCCGAGCGGATGAAGCAACCCGCGATGTCGCTGACTGGCTGAAGTGTGACTTCATG
CTAGATCAGGTCGGTAATGTCTTCACCGGTATTATTGCCAGTGTGACCGGTTTTGGCTTCTTCGTGCGTCTGGATGACCT
CTTTATCGATGGTCTGGTGCATGTCTCCAGCCTGGATAACGATTACTACCGTTACGACAACATTGGTCAGCGTCTGATCG
GTGAATCTTCCGGTGTAGTTTATCGGCTGGGTGATACCGTGGAGATTCGAGTCGATGCGGTTCATATGGATGAGCGTAAA
ATTGACTTTGCTCTGGTCTCCAGTACCCGCAAGCCACGTGGTGAAGGCAAGACCGCCCGTGATAAGGCGAAAAATAACGG
CCAGCGTACATTACGCAGTAATTCTGCAGGTCGTGGCTCTTCATCCGGCTCATCGCGCCGTGATGGTGCGCCAACTGCGG
GTGGACAAAAACGCCCACGTCGGGCGAAAAAACCGGTAAACTTCGAGCCGGACAGTGCGTTCCGTCCAGATGCTGCCGCG
GCTAAGCCAGACGATAAAGCCTTAGCTGAGAAGAAAGCCAAGGCGAAGGCAAAAAGAGCCTCGGCTAAGACCAAAAAAAT
TGCTGCGGCGACCAAAGCCAAGCGAGCAAAGAAAAAAACCACTAGCGATCAGTAA

Upstream 100 bases:

>100_bases
GCTTCAAGTCAATGATTCGGGTGATTGAGAGCAGCCAACACACCTGCACTTTGAAAGACGATGGGTATAGCAACCTGCTG
CTGACAACGGAGGAACCTCA

Downstream 100 bases:

>100_bases
TTAGCGATCAGTAAGTAATGGTGGTGTGCTACTTGCCGGGCGGCTTTTGTCGCCCGCATATAATTTAATTATTGGTGGGT
AAGTCATATTGTCTGCCAAC

Product: exoribonuclease R

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 844; Mature: 843

Protein sequence:

>844_residues
MSQDPFLEREAEKYESPIPSREFILAHLAKRETPASREELANELNLTGEEPLEALRRRLRAMERDGQLVFTRRQCYALPE
RLDLLRGTVIGHRDGYGFLRVEGSKDDLYLSAEQMKMAIHGDVVLAQVVGADRKGRREARIVRVLVPKTSQIVGRYFTDA
GTGFVVPDDSRLSFDILIPAEATCGARMGFVVVVELTQRPTRRTKAVGKIVEVLGENMGTSMAVDIALRTHEIPHTWPPQ
VEKQVADLKEQVPEEAKKGRVDLRDLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPQTALDDEARSRG
NSVYFPSQVIPMLPEVLSNGLCSLNPQVDRLCMVCEMTISSQGKLSSYKFYEAVMSSHARLTYTKVWRIIDGEESLREQY
KPLVPHLEELHAMYKVLDQARAERGGIAFETEEAKFIFNAERRIERIEPTVRNDAHKLIEECMILANIAAARFVEKHEEP
ALFRVHDRPSDDHIVALRSVLNELGLTLGGGLKPQPKDYSVLMDEISDRPDHEMLQTMLLRSMKQAVYDPENRGHFGLAL
ASYGHFTSPIRRYPDLAMHRAIKYQLAKEHGNLKDRWTPTGGWHSDFEDMLQLGQHCSMTERRADEATRDVADWLKCDFM
LDQVGNVFTGIIASVTGFGFFVRLDDLFIDGLVHVSSLDNDYYRYDNIGQRLIGESSGVVYRLGDTVEIRVDAVHMDERK
IDFALVSSTRKPRGEGKTARDKAKNNGQRTLRSNSAGRGSSSGSSRRDGAPTAGGQKRPRRAKKPVNFEPDSAFRPDAAA
AKPDDKALAEKKAKAKAKRASAKTKKIAAATKAKRAKKKTTSDQ

Sequences:

>Translated_844_residues
MSQDPFLEREAEKYESPIPSREFILAHLAKRETPASREELANELNLTGEEPLEALRRRLRAMERDGQLVFTRRQCYALPE
RLDLLRGTVIGHRDGYGFLRVEGSKDDLYLSAEQMKMAIHGDVVLAQVVGADRKGRREARIVRVLVPKTSQIVGRYFTDA
GTGFVVPDDSRLSFDILIPAEATCGARMGFVVVVELTQRPTRRTKAVGKIVEVLGENMGTSMAVDIALRTHEIPHTWPPQ
VEKQVADLKEQVPEEAKKGRVDLRDLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPQTALDDEARSRG
NSVYFPSQVIPMLPEVLSNGLCSLNPQVDRLCMVCEMTISSQGKLSSYKFYEAVMSSHARLTYTKVWRIIDGEESLREQY
KPLVPHLEELHAMYKVLDQARAERGGIAFETEEAKFIFNAERRIERIEPTVRNDAHKLIEECMILANIAAARFVEKHEEP
ALFRVHDRPSDDHIVALRSVLNELGLTLGGGLKPQPKDYSVLMDEISDRPDHEMLQTMLLRSMKQAVYDPENRGHFGLAL
ASYGHFTSPIRRYPDLAMHRAIKYQLAKEHGNLKDRWTPTGGWHSDFEDMLQLGQHCSMTERRADEATRDVADWLKCDFM
LDQVGNVFTGIIASVTGFGFFVRLDDLFIDGLVHVSSLDNDYYRYDNIGQRLIGESSGVVYRLGDTVEIRVDAVHMDERK
IDFALVSSTRKPRGEGKTARDKAKNNGQRTLRSNSAGRGSSSGSSRRDGAPTAGGQKRPRRAKKPVNFEPDSAFRPDAAA
AKPDDKALAEKKAKAKAKRASAKTKKIAAATKAKRAKKKTTSDQ
>Mature_843_residues
SQDPFLEREAEKYESPIPSREFILAHLAKRETPASREELANELNLTGEEPLEALRRRLRAMERDGQLVFTRRQCYALPER
LDLLRGTVIGHRDGYGFLRVEGSKDDLYLSAEQMKMAIHGDVVLAQVVGADRKGRREARIVRVLVPKTSQIVGRYFTDAG
TGFVVPDDSRLSFDILIPAEATCGARMGFVVVVELTQRPTRRTKAVGKIVEVLGENMGTSMAVDIALRTHEIPHTWPPQV
EKQVADLKEQVPEEAKKGRVDLRDLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPQTALDDEARSRGN
SVYFPSQVIPMLPEVLSNGLCSLNPQVDRLCMVCEMTISSQGKLSSYKFYEAVMSSHARLTYTKVWRIIDGEESLREQYK
PLVPHLEELHAMYKVLDQARAERGGIAFETEEAKFIFNAERRIERIEPTVRNDAHKLIEECMILANIAAARFVEKHEEPA
LFRVHDRPSDDHIVALRSVLNELGLTLGGGLKPQPKDYSVLMDEISDRPDHEMLQTMLLRSMKQAVYDPENRGHFGLALA
SYGHFTSPIRRYPDLAMHRAIKYQLAKEHGNLKDRWTPTGGWHSDFEDMLQLGQHCSMTERRADEATRDVADWLKCDFML
DQVGNVFTGIIASVTGFGFFVRLDDLFIDGLVHVSSLDNDYYRYDNIGQRLIGESSGVVYRLGDTVEIRVDAVHMDERKI
DFALVSSTRKPRGEGKTARDKAKNNGQRTLRSNSAGRGSSSGSSRRDGAPTAGGQKRPRRAKKPVNFEPDSAFRPDAAAA
KPDDKALAEKKAKAKAKRASAKTKKIAAATKAKRAKKKTTSDQ

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=403, Percent_Identity=30.7692307692308, Blast_Score=175, Evalue=2e-43,
Organism=Homo sapiens, GI190014625, Length=403, Percent_Identity=30.7692307692308, Blast_Score=175, Evalue=2e-43,
Organism=Homo sapiens, GI134288890, Length=409, Percent_Identity=30.5623471882641, Blast_Score=160, Evalue=6e-39,
Organism=Homo sapiens, GI19115966, Length=578, Percent_Identity=26.2975778546713, Blast_Score=141, Evalue=3e-33,
Organism=Homo sapiens, GI219521928, Length=578, Percent_Identity=26.2975778546713, Blast_Score=141, Evalue=3e-33,
Organism=Escherichia coli, GI87082383, Length=795, Percent_Identity=78.7421383647799, Blast_Score=1285, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=650, Percent_Identity=26.3076923076923, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI212645896, Length=421, Percent_Identity=31.5914489311164, Blast_Score=185, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17553506, Length=539, Percent_Identity=27.6437847866419, Blast_Score=163, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324552, Length=519, Percent_Identity=27.9383429672447, Blast_Score=160, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6323943, Length=357, Percent_Identity=25.7703081232493, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24649634, Length=496, Percent_Identity=29.2338709677419, Blast_Score=182, Evalue=8e-46,
Organism=Drosophila melanogaster, GI19922976, Length=375, Percent_Identity=29.6, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24654597, Length=375, Percent_Identity=29.6, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24654592, Length=375, Percent_Identity=29.6, Blast_Score=140, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 94925; Mature: 94794

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDPFLEREAEKYESPIPSREFILAHLAKRETPASREELANELNLTGEEPLEALRRRLR
CCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
AMERDGQLVFTRRQCYALPERLDLLRGTVIGHRDGYGFLRVEGSKDDLYLSAEQMKMAIH
HHCCCCCEEEEHHHHHHCHHHHHHHHHHEEECCCCCEEEEEECCCCCEEEEHHHHHHHHH
GDVVLAQVVGADRKGRREARIVRVLVPKTSQIVGRYFTDAGTGFVVPDDSRLSFDILIPA
CHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCEEEEEEECC
EATCGARMGFVVVVELTQRPTRRTKAVGKIVEVLGENMGTSMAVDIALRTHEIPHTWPPQ
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCHH
VEKQVADLKEQVPEEAKKGRVDLRDLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIA
HHHHHHHHHHHCCHHHHCCCCCCCCCCEEEECCCCCCCCCHHHEEECCCCCCEEEEEEEE
DVSYYVRPQTALDDEARSRGNSVYFPSQVIPMLPEVLSNGLCSLNPQVDRLCMVCEMTIS
CCEEEECCCCCCCHHHHHCCCEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
SQGKLSSYKFYEAVMSSHARLTYTKVWRIIDGEESLREQYKPLVPHLEELHAMYKVLDQA
CCCCCHHHHHHHHHHHCCCEEEEEHHHEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RAERGGIAFETEEAKFIFNAERRIERIEPTVRNDAHKLIEECMILANIAAARFVEKHEEP
HHHHCCCEEECCCCEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ALFRVHDRPSDDHIVALRSVLNELGLTLGGGLKPQPKDYSVLMDEISDRPDHEMLQTMLL
CEEEEECCCCCCHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHH
RSMKQAVYDPENRGHFGLALASYGHFTSPIRRYPDLAMHRAIKYQLAKEHGNLKDRWTPT
HHHHHHHCCCCCCCCEEEEEHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCC
GGWHSDFEDMLQLGQHCSMTERRADEATRDVADWLKCDFMLDQVGNVFTGIIASVTGFGF
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEE
FVRLDDLFIDGLVHVSSLDNDYYRYDNIGQRLIGESSGVVYRLGDTVEIRVDAVHMDERK
EEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEEEEEEECCCHH
IDFALVSSTRKPRGEGKTARDKAKNNGQRTLRSNSAGRGSSSGSSRRDGAPTAGGQKRPR
CCHHEECCCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
RAKKPVNFEPDSAFRPDAAAAKPDDKALAEKKAKAKAKRASAKTKKIAAATKAKRAKKKT
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TSDQ
CCCC
>Mature Secondary Structure 
SQDPFLEREAEKYESPIPSREFILAHLAKRETPASREELANELNLTGEEPLEALRRRLR
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
AMERDGQLVFTRRQCYALPERLDLLRGTVIGHRDGYGFLRVEGSKDDLYLSAEQMKMAIH
HHCCCCCEEEEHHHHHHCHHHHHHHHHHEEECCCCCEEEEEECCCCCEEEEHHHHHHHHH
GDVVLAQVVGADRKGRREARIVRVLVPKTSQIVGRYFTDAGTGFVVPDDSRLSFDILIPA
CHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCEEEEEEECC
EATCGARMGFVVVVELTQRPTRRTKAVGKIVEVLGENMGTSMAVDIALRTHEIPHTWPPQ
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCHH
VEKQVADLKEQVPEEAKKGRVDLRDLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIA
HHHHHHHHHHHCCHHHHCCCCCCCCCCEEEECCCCCCCCCHHHEEECCCCCCEEEEEEEE
DVSYYVRPQTALDDEARSRGNSVYFPSQVIPMLPEVLSNGLCSLNPQVDRLCMVCEMTIS
CCEEEECCCCCCCHHHHHCCCEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
SQGKLSSYKFYEAVMSSHARLTYTKVWRIIDGEESLREQYKPLVPHLEELHAMYKVLDQA
CCCCCHHHHHHHHHHHCCCEEEEEHHHEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RAERGGIAFETEEAKFIFNAERRIERIEPTVRNDAHKLIEECMILANIAAARFVEKHEEP
HHHHCCCEEECCCCEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ALFRVHDRPSDDHIVALRSVLNELGLTLGGGLKPQPKDYSVLMDEISDRPDHEMLQTMLL
CEEEEECCCCCCHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHH
RSMKQAVYDPENRGHFGLALASYGHFTSPIRRYPDLAMHRAIKYQLAKEHGNLKDRWTPT
HHHHHHHCCCCCCCCEEEEEHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCC
GGWHSDFEDMLQLGQHCSMTERRADEATRDVADWLKCDFMLDQVGNVFTGIIASVTGFGF
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEE
FVRLDDLFIDGLVHVSSLDNDYYRYDNIGQRLIGESSGVVYRLGDTVEIRVDAVHMDERK
EEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEEEEEEECCCHH
IDFALVSSTRKPRGEGKTARDKAKNNGQRTLRSNSAGRGSSSGSSRRDGAPTAGGQKRPR
CCHHEECCCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
RAKKPVNFEPDSAFRPDAAAAKPDDKALAEKKAKAKAKRASAKTKKIAAATKAKRAKKKT
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TSDQ
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]