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The map label for this gene is ung [H]

Identifier: 50842044

GI number: 50842044

Start: 618243

End: 618959

Strand: Reverse

Name: ung [H]

Synonym: PPA0558

Alternate gene names: 50842044

Gene position: 618959-618243 (Counterclockwise)

Preceding gene: 50842047

Following gene: 50842042

Centisome position: 24.18

GC content: 58.86

Gene sequence:

>717_bases
ATGTCATCCGTATGTATTCTCTTGGAGGCCACCGTGGTTGCTCATCCCGTTGCTGAACTCGTCACCCCCGACTGGGCAGA
GGCATTAACAGGAGTGGAACCCCGGATCCACGAGATGGGCGACTTCCTACGAGCGGAGACAGCTGCCGGGAGAGGCTTTT
TACCTCATGGTGACCGTATTCTACGTGCTTTCTCCCGTCCGATGGCTGATGTTCGCGTACTTATCGTCGGTCAGGACCCC
TACCCGACGCCCGGGCATCCGGTGGGTTTGAGTTTTTCAGTGGAGCGGGATGTCCGACCGCTGCCGCGGTCCTTGCAAAA
CATCTACACCGAGTTGCAGTCAGATCTCGGTATTGCCCCATGTGAGCACGGTGATCTCACCGGCTGGTTTGAACAGGGCG
TACTGCTTCTCAACAGGTGTCTAACAGTCCAGCCGGGGCGGCCAGCATCCCATCGAGGCAAGGGATGGGAGGAGGTCACC
CAGACGGCGATCGAAGCTTTGGTGGCGCGCGGCGGTCCGCTGGTGGCGATCCTGTGGGGACGCGATGCGCAGTCCCTAGA
GCCCATGCTGGGCAAAGTTCCTATTGTAAAGTCCTCGCACCCCTCCCCCATGTCAGCCCGGTACGGTTTTTTCGGATCTC
GACCGTTTAGTCGCACGAATGAATTGCTCGTACAGCAAGGGGCCGACCCCATCAACTGGGATTTGTCGTCCCACTAA

Upstream 100 bases:

>100_bases
GGGGTCTTCCTACCCGAGCTAAAGAGCTTCATGGGTTCCTTCCAGAATAGCGTGGTGGGGCTGCGGTCTCAAAAGGCGCG
ATCACAGGGTAGCGTCATGC

Downstream 100 bases:

>100_bases
TCGACTCGGCTCATGGCATCTTTCACGTCAGTCCTGTTCAGGATGTCGGAAGAGCGAGATGGCCGACGCAGCTAGTCCGC
CCCACACCGTGACCATCGCA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSSVCILLEATVVAHPVAELVTPDWAEALTGVEPRIHEMGDFLRAETAAGRGFLPHGDRILRAFSRPMADVRVLIVGQDP
YPTPGHPVGLSFSVERDVRPLPRSLQNIYTELQSDLGIAPCEHGDLTGWFEQGVLLLNRCLTVQPGRPASHRGKGWEEVT
QTAIEALVARGGPLVAILWGRDAQSLEPMLGKVPIVKSSHPSPMSARYGFFGSRPFSRTNELLVQQGADPINWDLSSH

Sequences:

>Translated_238_residues
MSSVCILLEATVVAHPVAELVTPDWAEALTGVEPRIHEMGDFLRAETAAGRGFLPHGDRILRAFSRPMADVRVLIVGQDP
YPTPGHPVGLSFSVERDVRPLPRSLQNIYTELQSDLGIAPCEHGDLTGWFEQGVLLLNRCLTVQPGRPASHRGKGWEEVT
QTAIEALVARGGPLVAILWGRDAQSLEPMLGKVPIVKSSHPSPMSARYGFFGSRPFSRTNELLVQQGADPINWDLSSH
>Mature_237_residues
SSVCILLEATVVAHPVAELVTPDWAEALTGVEPRIHEMGDFLRAETAAGRGFLPHGDRILRAFSRPMADVRVLIVGQDPY
PTPGHPVGLSFSVERDVRPLPRSLQNIYTELQSDLGIAPCEHGDLTGWFEQGVLLLNRCLTVQPGRPASHRGKGWEEVTQ
TAIEALVARGGPLVAILWGRDAQSLEPMLGKVPIVKSSHPSPMSARYGFFGSRPFSRTNELLVQQGADPINWDLSSH

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=169, Percent_Identity=46.1538461538462, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI6224979, Length=170, Percent_Identity=45.8823529411765, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI1788934, Length=193, Percent_Identity=39.8963730569948, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17556304, Length=233, Percent_Identity=36.480686695279, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323620, Length=222, Percent_Identity=36.9369369369369, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25981; Mature: 25850

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVCILLEATVVAHPVAELVTPDWAEALTGVEPRIHEMGDFLRAETAAGRGFLPHGDRI
CCCEEEEEHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
LRAFSRPMADVRVLIVGQDPYPTPGHPVGLSFSVERDVRPLPRSLQNIYTELQSDLGIAP
HHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCC
CEHGDLTGWFEQGVLLLNRCLTVQPGRPASHRGKGWEEVTQTAIEALVARGGPLVAILWG
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
RDAQSLEPMLGKVPIVKSSHPSPMSARYGFFGSRPFSRTNELLVQQGADPINWDLSSH
CCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SSVCILLEATVVAHPVAELVTPDWAEALTGVEPRIHEMGDFLRAETAAGRGFLPHGDRI
CCEEEEEHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
LRAFSRPMADVRVLIVGQDPYPTPGHPVGLSFSVERDVRPLPRSLQNIYTELQSDLGIAP
HHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCC
CEHGDLTGWFEQGVLLLNRCLTVQPGRPASHRGKGWEEVTQTAIEALVARGGPLVAILWG
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
RDAQSLEPMLGKVPIVKSSHPSPMSARYGFFGSRPFSRTNELLVQQGADPINWDLSSH
CCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA