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The map label for this gene is msrA [H]

Identifier: 50842042

GI number: 50842042

Start: 615706

End: 616338

Strand: Reverse

Name: msrA [H]

Synonym: PPA0556

Alternate gene names: 50842042

Gene position: 616338-615706 (Counterclockwise)

Preceding gene: 50842044

Following gene: 50842041

Centisome position: 24.07

GC content: 59.56

Gene sequence:

>633_bases
ATGAATAAAACCGAGATGGTCTCATCGGAGAACGCACTACCAGGGGGTCATACCCCAGTGCTGGCGATGCCGTTCTTCCA
CCGAGTGACCGGAGACCGGCTCGATCGTCCCTTCCCAAGCTCAGAGACGATCTACCTAGCCATGGGCTGTTTTTGGGGAG
CCGAAAAGCTGTTTTGGAACACTGACGGAGTACTGCAGACCGCCGTCGGGTACATGGGCGGTCTCACCCCTAACCCCACC
TACCGCGAGGTGTACACGGGATGCACCGGACACGCCGAAACCGTTCGAGTAACCTACGACCCCACTCAGGTCTCGACCGA
GGCGATCCTCACTATCTTCCTGGAAAACCATGACCCTACTCAGGGAATGCGCCAGGGCAACGACGTGGGCACACAGTACC
GTTCGGCGATCTGGTGCACCACCACCGAACAGTTCATGACGGCCACCACTGTCAAGGGCTCTTACCAAGCCAACCTACTC
AACGCGGGCTATGGAGCCATCACGACCGCGATCTCCATGGCCAACGGCGTCGAGTTTTACCTGGCGGAGGCCGAGCACCA
GCAGTATCTCGAAGACAACCCCTTCGGTTACTGCCCCGTTCACGCCACCGGGGTATGCCTCGCCGGCTCGTGA

Upstream 100 bases:

>100_bases
AGACCGGATCATGGACCATCCACTGAGATAGGCAGGAATGGATCGCTGACGTGATTCGTTGAACCCGTAACGAGAGAGCT
GGCCTGCGAGGAGACAGCAC

Downstream 100 bases:

>100_bases
GCGAAGTAGATCTCTCCCACGTCCTACGATCAATGCACTTGGTCGCGACTCAGGGCACGATGTAGTTGCCACACCACCGG
AGCATCATGGATACGACCAC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MNKTEMVSSENALPGGHTPVLAMPFFHRVTGDRLDRPFPSSETIYLAMGCFWGAEKLFWNTDGVLQTAVGYMGGLTPNPT
YREVYTGCTGHAETVRVTYDPTQVSTEAILTIFLENHDPTQGMRQGNDVGTQYRSAIWCTTTEQFMTATTVKGSYQANLL
NAGYGAITTAISMANGVEFYLAEAEHQQYLEDNPFGYCPVHATGVCLAGS

Sequences:

>Translated_210_residues
MNKTEMVSSENALPGGHTPVLAMPFFHRVTGDRLDRPFPSSETIYLAMGCFWGAEKLFWNTDGVLQTAVGYMGGLTPNPT
YREVYTGCTGHAETVRVTYDPTQVSTEAILTIFLENHDPTQGMRQGNDVGTQYRSAIWCTTTEQFMTATTVKGSYQANLL
NAGYGAITTAISMANGVEFYLAEAEHQQYLEDNPFGYCPVHATGVCLAGS
>Mature_210_residues
MNKTEMVSSENALPGGHTPVLAMPFFHRVTGDRLDRPFPSSETIYLAMGCFWGAEKLFWNTDGVLQTAVGYMGGLTPNPT
YREVYTGCTGHAETVRVTYDPTQVSTEAILTIFLENHDPTQGMRQGNDVGTQYRSAIWCTTTEQFMTATTVKGSYQANLL
NAGYGAITTAISMANGVEFYLAEAEHQQYLEDNPFGYCPVHATGVCLAGS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=205, Percent_Identity=52.6829268292683, Blast_Score=200, Evalue=9e-52,
Organism=Homo sapiens, GI208609995, Length=180, Percent_Identity=54.4444444444444, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI208609993, Length=209, Percent_Identity=43.0622009569378, Blast_Score=134, Evalue=7e-32,
Organism=Escherichia coli, GI1790665, Length=208, Percent_Identity=52.4038461538462, Blast_Score=193, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=31.0810810810811, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=171, Percent_Identity=33.9181286549708, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=39.5833333333333, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=40.1408450704225, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=38.1944444444444, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 22950; Mature: 22950

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTEMVSSENALPGGHTPVLAMPFFHRVTGDRLDRPFPSSETIYLAMGCFWGAEKLFWN
CCCCCCCCCCCCCCCCCCCEEECHHHHHHCCHHCCCCCCCCCEEEEEEECHHCCCEEEEC
TDGVLQTAVGYMGGLTPNPTYREVYTGCTGHAETVRVTYDPTQVSTEAILTIFLENHDPT
CCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCH
QGMRQGNDVGTQYRSAIWCTTTEQFMTATTVKGSYQANLLNAGYGAITTAISMANGVEFY
HHHHCCCHHCHHHHCEEEEECHHHHEEEEEECCCCEEEEEECCCHHHHHHHHHHCCEEEE
LAEAEHQQYLEDNPFGYCPVHATGVCLAGS
EECCHHHHHHCCCCCEECCCCCCCEEEECC
>Mature Secondary Structure
MNKTEMVSSENALPGGHTPVLAMPFFHRVTGDRLDRPFPSSETIYLAMGCFWGAEKLFWN
CCCCCCCCCCCCCCCCCCCEEECHHHHHHCCHHCCCCCCCCCEEEEEEECHHCCCEEEEC
TDGVLQTAVGYMGGLTPNPTYREVYTGCTGHAETVRVTYDPTQVSTEAILTIFLENHDPT
CCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCH
QGMRQGNDVGTQYRSAIWCTTTEQFMTATTVKGSYQANLLNAGYGAITTAISMANGVEFY
HHHHCCCHHCHHHHCEEEEECHHHHEEEEEECCCCEEEEEECCCHHHHHHHHHHCCEEEE
LAEAEHQQYLEDNPFGYCPVHATGVCLAGS
EECCHHHHHHCCCCCEECCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA