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The map label for this gene is moeZ [H]

Identifier: 50842002

GI number: 50842002

Start: 571030

End: 571875

Strand: Reverse

Name: moeZ [H]

Synonym: PPA0518

Alternate gene names: 50842002

Gene position: 571875-571030 (Counterclockwise)

Preceding gene: 50842003

Following gene: 50842001

Centisome position: 22.34

GC content: 62.65

Gene sequence:

>846_bases
GTGAGCGCTCTAAACCCGATGGACGACGCGGTATCTCGTGCTACCAACGGCCACGATGCCGTAGAAGACATGGGTTCCAC
GACGTCGCTAATCAACCGTGACCTGATCCGATACGCCCGCCACATCGTCTTGCCCGGATTCGGTCAGGAGGCTCAACGCC
GACTACGAGATAGTCGGGTGCTTGTCGTCGGGGCTGGGGGCCTCGGCTCCCCGGTACTGCTATACCTGTCCGCCGCCGGG
GTTGGCTACCTCACGATCCTTGATGACGACGTCGTTGACGAGTCCAACTTGCAGCGGCAAGTGATCCACCGTCAGGCCGA
CGTGGGACGGCCCAAGGCCCTCAGCGCCAAAGATGCGGTGCAGCGACTCAATACGCATCTGGTGGCAGAGGCCGTCGTCG
CCCGGCTGGGAACTGACAATGCGCTCGACCTAGTCAAGGATCATGGCCTCATCCTCGACTGCACGGACAACTTCACCACC
CGTTACTTAGCCTCCGACGCTGCCGAGATCACCGGAACCCCGCTGGTTTGGGGAACGATTCTGCAGTACCAAGGTCAGCT
ATCAGTTTTCTGGCCCGATCGCGGGCCCATGCTACGCGATCTGTTCCCCGAGGTTCCCGCCGCTGATTCAGTGCCGTCGG
CCGTTGTTGGAGGCACATTCGGCCCGGTCGTCGGTCAGGTGGGATCGATGATGGCCACCGAAGCCGTGAAGGTGCTTACT
GGGATCGGGACGCCGGCCGTGGGAAAACTTGTCGTCGTCGACGCTCTCGGCGTCGGTGCCCGCACCCTCAGCTTCGCCGC
AGACCCGGACCGTGCTTCAGTGACGCAGCTGCCCGAAGCTGAGTGA

Upstream 100 bases:

>100_bases
CATCGGGACGCATCCCGCGTCGACGTCTGGCGCGAGCCAGCTCGCCGTTCGACGGGATCATCACTGGGCGAGTCCGTGGT
CCGAGGGAGAACGACAGTCT

Downstream 100 bases:

>100_bases
AGGTGGAGGAATTCTCGGGTGATGTAGCTGATTGATTTTTTGAATCCGAGGGCGTCGCCTCGGAGAGGTTTGAGGCGTCT
GTTGGTGACCTCGGTGGGGC

Product: putative molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MSALNPMDDAVSRATNGHDAVEDMGSTTSLINRDLIRYARHIVLPGFGQEAQRRLRDSRVLVVGAGGLGSPVLLYLSAAG
VGYLTILDDDVVDESNLQRQVIHRQADVGRPKALSAKDAVQRLNTHLVAEAVVARLGTDNALDLVKDHGLILDCTDNFTT
RYLASDAAEITGTPLVWGTILQYQGQLSVFWPDRGPMLRDLFPEVPAADSVPSAVVGGTFGPVVGQVGSMMATEAVKVLT
GIGTPAVGKLVVVDALGVGARTLSFAADPDRASVTQLPEAE

Sequences:

>Translated_281_residues
MSALNPMDDAVSRATNGHDAVEDMGSTTSLINRDLIRYARHIVLPGFGQEAQRRLRDSRVLVVGAGGLGSPVLLYLSAAG
VGYLTILDDDVVDESNLQRQVIHRQADVGRPKALSAKDAVQRLNTHLVAEAVVARLGTDNALDLVKDHGLILDCTDNFTT
RYLASDAAEITGTPLVWGTILQYQGQLSVFWPDRGPMLRDLFPEVPAADSVPSAVVGGTFGPVVGQVGSMMATEAVKVLT
GIGTPAVGKLVVVDALGVGARTLSFAADPDRASVTQLPEAE
>Mature_280_residues
SALNPMDDAVSRATNGHDAVEDMGSTTSLINRDLIRYARHIVLPGFGQEAQRRLRDSRVLVVGAGGLGSPVLLYLSAAGV
GYLTILDDDVVDESNLQRQVIHRQADVGRPKALSAKDAVQRLNTHLVAEAVVARLGTDNALDLVKDHGLILDCTDNFTTR
YLASDAAEITGTPLVWGTILQYQGQLSVFWPDRGPMLRDLFPEVPAADSVPSAVVGGTFGPVVGQVGSMMATEAVKVLTG
IGTPAVGKLVVVDALGVGARTLSFAADPDRASVTQLPEAE

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=236, Percent_Identity=41.5254237288136, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1787048, Length=245, Percent_Identity=41.2244897959184, Blast_Score=181, Evalue=3e-47,
Organism=Escherichia coli, GI87082356, Length=236, Percent_Identity=38.5593220338983, Blast_Score=134, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17540406, Length=244, Percent_Identity=37.7049180327869, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321903, Length=225, Percent_Identity=42.2222222222222, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320598, Length=174, Percent_Identity=28.1609195402299, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24582879, Length=260, Percent_Identity=39.6153846153846, Blast_Score=193, Evalue=9e-50,
Organism=Drosophila melanogaster, GI28573937, Length=164, Percent_Identity=30.4878048780488, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24660640, Length=139, Percent_Identity=31.6546762589928, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 29648; Mature: 29517

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALNPMDDAVSRATNGHDAVEDMGSTTSLINRDLIRYARHIVLPGFGQEAQRRLRDSRV
CCCCCHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCE
LVVGAGGLGSPVLLYLSAAGVGYLTILDDDVVDESNLQRQVIHRQADVGRPKALSAKDAV
EEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
QRLNTHLVAEAVVARLGTDNALDLVKDHGLILDCTDNFTTRYLASDAAEITGTPLVWGTI
HHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCHHHHHHHCHHHHCCCCHHHHHH
LQYQGQLSVFWPDRGPMLRDLFPEVPAADSVPSAVVGGTFGPVVGQVGSMMATEAVKVLT
HHHCCCEEEEECCCCCHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHH
GIGTPAVGKLVVVDALGVGARTLSFAADPDRASVTQLPEAE
CCCCCCCCCEEEEEECCCCCCEEEECCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SALNPMDDAVSRATNGHDAVEDMGSTTSLINRDLIRYARHIVLPGFGQEAQRRLRDSRV
CCCCHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCE
LVVGAGGLGSPVLLYLSAAGVGYLTILDDDVVDESNLQRQVIHRQADVGRPKALSAKDAV
EEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
QRLNTHLVAEAVVARLGTDNALDLVKDHGLILDCTDNFTTRYLASDAAEITGTPLVWGTI
HHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCHHHHHHHCHHHHCCCCHHHHHH
LQYQGQLSVFWPDRGPMLRDLFPEVPAADSVPSAVVGGTFGPVVGQVGSMMATEAVKVLT
HHHCCCEEEEECCCCCHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHH
GIGTPAVGKLVVVDALGVGARTLSFAADPDRASVTQLPEAE
CCCCCCCCCEEEEEECCCCCCEEEECCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]