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The map label for this gene is yrbE [H]

Identifier: 50841946

GI number: 50841946

Start: 510154

End: 511368

Strand: Direct

Name: yrbE [H]

Synonym: PPA0463

Alternate gene names: 50841946

Gene position: 510154-511368 (Clockwise)

Preceding gene: 50841945

Following gene: 50841947

Centisome position: 19.93

GC content: 58.77

Gene sequence:

>1215_bases
ATGTCGGCATTATCACAACCAGCCACGTCGCAGCGGCATCCCTTGTCGGTGGCCGTCATCGGAGCCGGTATGGCTGGTCG
AACGCACGCCAACGCCTGGCGCCAGGTCGGGACCGTGTTCGGATCCGAGGGGATACCCCCTATACGGCTCGCTGCCATCT
GTGACTCTTACGAGCCCTTCGCCCGTAGTGCCCGCGACAGTTATGGCTACGAAAGAGCAGTAACTGACTGGCATGACATC
GTGGACGCTGACGATATAGACGTCGTGTCGGTCGTCGTGTCGAACGCACTGCATCGTCAGGTCGCCGAGGACCTGGTCCG
GGCTGGCAAACATGTCCTGTGTGAGAAGCCACTGTCTGACAGCTTGAAGAATGCCAGGGCGATGGCTGAGCTGGAAGCTA
ATTCCCAGGTCGTCACCGGCGTCGGCTTCAGTTACCGACGCCACCCCTCAGTCGCTGCAATAGCCGAACTGGTGCGACAA
GGCCGTCTAGGTGATGTTACGACGTTTTCTGGGCGGTATTGGTGTGGGTACGGCGTCGATCCCACCGTGCCGATGGCATG
GCGCTATCGAGGCCCTCAGGGCTCGGGCGCCCTGGGGGACCTTGGTTCGCACATCATCGATGTGGCCGAGTTCGTCTGTG
GTCCGATACGAAGCGTCCGTGGTGGGGCTTTTGCCACGATTATCGATAAGCGTCCGCCCGCGCTGGAGGGAGTTGCAGGA
GGACGTGGGATGACGGTGTCGGCGCAGGCCATCGAAACCGTGGAAAATGACGACATTGCAGTATTCAATATGACCTTCGA
GTCCGGGGCCATTGGTACGATTGTCGTTTCCCGTGTTGCATTTGGCCTGCCCAATTCGATGGAGTTCGACGTCTTCGGTA
CCCAGGGGCGGGCCTCATTCGATCTGGCCCGCTCCGGTGAGATCATTGTGGACGACACATCAACCCCAGAAGGATTCAGC
GGGCCTCGTCAAGTATTGTCCAATCCAACTTTCCCCTATTACAAGGGTGGATCATCCATGGATTTTGCTGGTGTTGGCAG
CACTCAGATCGAACAATTTACCTATCAAGCGAGGGCTTTCCTCGACCAGGTCTTGGGGTTGGACGAAGGGTTTCCTCTGG
TGCCGTCCTTCGCGCACGGGTACCGAACAATGTGTATCGCCGATGCCGTCGCTCGATCTGCGGCGGCCGGTGGGAAAACC
ATTGATCTCACCTGA

Upstream 100 bases:

>100_bases
TCCTTGACAGGACAAACTGCCCATGAGATCCTGGAACCAGGATTTAACGCGCGTTAAATCATGCTGTGAAACCTACTGAC
ATCGTCGTCGAGGAGAGCAC

Downstream 100 bases:

>100_bases
CACCACCGTGATCACATATCCGTTACAGAAACTAGGAGTCCGACATGTCCATGAATATCGGGGCCTACACCGCCTGTCTC
CATAACTACGATCTCGCCGA

Product: dehydrogenase, putative myo-inositol 2-dehydrogenase

Products: 2,4,6/3,5-pentahydroxycyclohexanone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSALSQPATSQRHPLSVAVIGAGMAGRTHANAWRQVGTVFGSEGIPPIRLAAICDSYEPFARSARDSYGYERAVTDWHDI
VDADDIDVVSVVVSNALHRQVAEDLVRAGKHVLCEKPLSDSLKNARAMAELEANSQVVTGVGFSYRRHPSVAAIAELVRQ
GRLGDVTTFSGRYWCGYGVDPTVPMAWRYRGPQGSGALGDLGSHIIDVAEFVCGPIRSVRGGAFATIIDKRPPALEGVAG
GRGMTVSAQAIETVENDDIAVFNMTFESGAIGTIVVSRVAFGLPNSMEFDVFGTQGRASFDLARSGEIIVDDTSTPEGFS
GPRQVLSNPTFPYYKGGSSMDFAGVGSTQIEQFTYQARAFLDQVLGLDEGFPLVPSFAHGYRTMCIADAVARSAAAGGKT
IDLT

Sequences:

>Translated_404_residues
MSALSQPATSQRHPLSVAVIGAGMAGRTHANAWRQVGTVFGSEGIPPIRLAAICDSYEPFARSARDSYGYERAVTDWHDI
VDADDIDVVSVVVSNALHRQVAEDLVRAGKHVLCEKPLSDSLKNARAMAELEANSQVVTGVGFSYRRHPSVAAIAELVRQ
GRLGDVTTFSGRYWCGYGVDPTVPMAWRYRGPQGSGALGDLGSHIIDVAEFVCGPIRSVRGGAFATIIDKRPPALEGVAG
GRGMTVSAQAIETVENDDIAVFNMTFESGAIGTIVVSRVAFGLPNSMEFDVFGTQGRASFDLARSGEIIVDDTSTPEGFS
GPRQVLSNPTFPYYKGGSSMDFAGVGSTQIEQFTYQARAFLDQVLGLDEGFPLVPSFAHGYRTMCIADAVARSAAAGGKT
IDLT
>Mature_403_residues
SALSQPATSQRHPLSVAVIGAGMAGRTHANAWRQVGTVFGSEGIPPIRLAAICDSYEPFARSARDSYGYERAVTDWHDIV
DADDIDVVSVVVSNALHRQVAEDLVRAGKHVLCEKPLSDSLKNARAMAELEANSQVVTGVGFSYRRHPSVAAIAELVRQG
RLGDVTTFSGRYWCGYGVDPTVPMAWRYRGPQGSGALGDLGSHIIDVAEFVCGPIRSVRGGAFATIIDKRPPALEGVAGG
RGMTVSAQAIETVENDDIAVFNMTFESGAIGTIVVSRVAFGLPNSMEFDVFGTQGRASFDLARSGEIIVDDTSTPEGFSG
PRQVLSNPTFPYYKGGSSMDFAGVGSTQIEQFTYQARAFLDQVLGLDEGFPLVPSFAHGYRTMCIADAVARSAAAGGKTI
DLT

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI1787574, Length=222, Percent_Identity=31.0810810810811, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: 1.1.1.18

Molecular weight: Translated: 42937; Mature: 42805

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALSQPATSQRHPLSVAVIGAGMAGRTHANAWRQVGTVFGSEGIPPIRLAAICDSYEPF
CCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEHHHHHCCCCHH
ARSARDSYGYERAVTDWHDIVDADDIDVVSVVVSNALHRQVAEDLVRAGKHVLCEKPLSD
HHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHH
SLKNARAMAELEANSQVVTGVGFSYRRHPSVAAIAELVRQGRLGDVTTFSGRYWCGYGVD
HHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCEEECCCCC
PTVPMAWRYRGPQGSGALGDLGSHIIDVAEFVCGPIRSVRGGAFATIIDKRPPALEGVAG
CCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
GRGMTVSAQAIETVENDDIAVFNMTFESGAIGTIVVSRVAFGLPNSMEFDVFGTQGRASF
CCCCEEEHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCE
DLARSGEIIVDDTSTPEGFSGPRQVLSNPTFPYYKGGSSMDFAGVGSTQIEQFTYQARAF
ECCCCCCEEEECCCCCCCCCCHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHH
LDQVLGLDEGFPLVPSFAHGYRTMCIADAVARSAAAGGKTIDLT
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECC
>Mature Secondary Structure 
SALSQPATSQRHPLSVAVIGAGMAGRTHANAWRQVGTVFGSEGIPPIRLAAICDSYEPF
CCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEHHHHHCCCCHH
ARSARDSYGYERAVTDWHDIVDADDIDVVSVVVSNALHRQVAEDLVRAGKHVLCEKPLSD
HHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHH
SLKNARAMAELEANSQVVTGVGFSYRRHPSVAAIAELVRQGRLGDVTTFSGRYWCGYGVD
HHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCEEECCCCC
PTVPMAWRYRGPQGSGALGDLGSHIIDVAEFVCGPIRSVRGGAFATIIDKRPPALEGVAG
CCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
GRGMTVSAQAIETVENDDIAVFNMTFESGAIGTIVVSRVAFGLPNSMEFDVFGTQGRASF
CCCCEEEHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCE
DLARSGEIIVDDTSTPEGFSGPRQVLSNPTFPYYKGGSSMDFAGVGSTQIEQFTYQARAF
ECCCCCCEEEECCCCCCCCCCHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHH
LDQVLGLDEGFPLVPSFAHGYRTMCIADAVARSAAAGGKTIDLT
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: myo-inositol; NAD+

Specific reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]