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The map label for this gene is cytR [H]

Identifier: 50841945

GI number: 50841945

Start: 509037

End: 510017

Strand: Direct

Name: cytR [H]

Synonym: PPA0462

Alternate gene names: 50841945

Gene position: 509037-510017 (Clockwise)

Preceding gene: 50841944

Following gene: 50841946

Centisome position: 19.88

GC content: 62.59

Gene sequence:

>981_bases
ATGCGCAACCCAACTCAGACCGATGTTGCACGCATGGCTGGGGTCTCTCGTGGTCTGGTATCCCTGGCCCTGGCGGGACG
CCCCGGAGTCTCGTCAGCCACTCGTCGGCGCATCCAAGACGCAGCCGATAGGCTTGGTTACAGCCGGGATCTGTCAGCCG
CCAGCTTGGCGACAGGGAGCTCTCCGGTATTGGGAATAATCCTTCCCAACTTGCGTAATCCCTTTTTCGAGACGGTCGTC
TCGTATCTTTCCGTCGCGGCGGAGCGTGTTGGGTGGTTACCGCTCGTGGGCACCGCCTCGGACGACACTCGCCATGAAGA
GGCGGTGCTGCGCCGGTTTCGCGAGTTCCGAGCTGTTGGAGTCATTGTCGTTTCGCCAGTGGGGGACCTCGAGTCGCTTG
CCGCACTCAGCGGCCCCACATCACCCCTGGTTCTGCTGGGAGCCGAGAACCAATCTGGCGTCGTCCCCTGTGTCCACGTC
GACGAGGACACCGCGGCACAACTCATCGTTGAGCACCTGGGCTCACAGGGAGTGCGTCGCGTTGTCTCTCTGGCTGAGGA
ATGCGGATCGGGGATGGTGTGGGTGCTACGGCGACGCGCAGCCCTTATTGCAGCATGTCAGTCTGCTGGAATCGAGTGTG
TACCCGCAATAGTGGAACGAGGTGAGGCGGTCGCTCCCATTCTGGCGCGCTTCATTGACGACGCGCAGACCGATGTCGGT
GTCGTGGCGCACAATGATGTCGTCGCGCTCGATGCCCTGTCGGTACTGCGCTCCGTGGGGCTGGAGTCTCGGCGGTGGAT
TCCCGTTGTGGGTTTCGACGACACTCATCTGGCCTCGCGCCCGGAGTTTGATCTGACGTCGGTGAACCAGCAACCCGGCG
CGTTAGTAGACGTCGCGCTCGACATGGTGGCAGGTGCGGTCCGAGGTCTCGATCACACCGTTGAGCCTCGCCTGGTCGTC
AGATCCTCCTCGAAGCGCTGA

Upstream 100 bases:

>100_bases
AGTGACACGGCGTATGTAGATCGAGGCGGTCAGGACCTGTTCCTGGCCGCCTCGTTACCCTTGTGCCGATGTCACCATGC
CGACGGGAAGGGGCACGTCG

Downstream 100 bases:

>100_bases
TGACCGGTGGGCCTGCAATGATGCAGCTCCGCATATTCCTTGACAGGACAAACTGCCCATGAGATCCTGGAACCAGGATT
TAACGCGCGTTAAATCATGC

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MRNPTQTDVARMAGVSRGLVSLALAGRPGVSSATRRRIQDAADRLGYSRDLSAASLATGSSPVLGIILPNLRNPFFETVV
SYLSVAAERVGWLPLVGTASDDTRHEEAVLRRFREFRAVGVIVVSPVGDLESLAALSGPTSPLVLLGAENQSGVVPCVHV
DEDTAAQLIVEHLGSQGVRRVVSLAEECGSGMVWVLRRRAALIAACQSAGIECVPAIVERGEAVAPILARFIDDAQTDVG
VVAHNDVVALDALSVLRSVGLESRRWIPVVGFDDTHLASRPEFDLTSVNQQPGALVDVALDMVAGAVRGLDHTVEPRLVV
RSSSKR

Sequences:

>Translated_326_residues
MRNPTQTDVARMAGVSRGLVSLALAGRPGVSSATRRRIQDAADRLGYSRDLSAASLATGSSPVLGIILPNLRNPFFETVV
SYLSVAAERVGWLPLVGTASDDTRHEEAVLRRFREFRAVGVIVVSPVGDLESLAALSGPTSPLVLLGAENQSGVVPCVHV
DEDTAAQLIVEHLGSQGVRRVVSLAEECGSGMVWVLRRRAALIAACQSAGIECVPAIVERGEAVAPILARFIDDAQTDVG
VVAHNDVVALDALSVLRSVGLESRRWIPVVGFDDTHLASRPEFDLTSVNQQPGALVDVALDMVAGAVRGLDHTVEPRLVV
RSSSKR
>Mature_326_residues
MRNPTQTDVARMAGVSRGLVSLALAGRPGVSSATRRRIQDAADRLGYSRDLSAASLATGSSPVLGIILPNLRNPFFETVV
SYLSVAAERVGWLPLVGTASDDTRHEEAVLRRFREFRAVGVIVVSPVGDLESLAALSGPTSPLVLLGAENQSGVVPCVHV
DEDTAAQLIVEHLGSQGVRRVVSLAEECGSGMVWVLRRRAALIAACQSAGIECVPAIVERGEAVAPILARFIDDAQTDVG
VVAHNDVVALDALSVLRSVGLESRRWIPVVGFDDTHLASRPEFDLTSVNQQPGALVDVALDMVAGAVRGLDHTVEPRLVV
RSSSKR

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=292, Percent_Identity=28.0821917808219, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789202, Length=284, Percent_Identity=26.4084507042254, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788474, Length=338, Percent_Identity=26.3313609467456, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787906, Length=274, Percent_Identity=27.3722627737226, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789068, Length=298, Percent_Identity=22.8187919463087, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 34512; Mature: 34512

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50932 HTH_LACI_2 ; PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPTQTDVARMAGVSRGLVSLALAGRPGVSSATRRRIQDAADRLGYSRDLSAASLATGS
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCC
SPVLGIILPNLRNPFFETVVSYLSVAAERVGWLPLVGTASDDTRHEEAVLRRFREFRAVG
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHEE
VIVVSPVGDLESLAALSGPTSPLVLLGAENQSGVVPCVHVDEDTAAQLIVEHLGSQGVRR
EEEEECCCCHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHCCHHHHH
VVSLAEECGSGMVWVLRRRAALIAACQSAGIECVPAIVERGEAVAPILARFIDDAQTDVG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCE
VVAHNDVVALDALSVLRSVGLESRRWIPVVGFDDTHLASRPEFDLTSVNQQPGALVDVAL
EEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
DMVAGAVRGLDHTVEPRLVVRSSSKR
HHHHHHHHCCCCCCCCEEEECCCCCC
>Mature Secondary Structure
MRNPTQTDVARMAGVSRGLVSLALAGRPGVSSATRRRIQDAADRLGYSRDLSAASLATGS
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCC
SPVLGIILPNLRNPFFETVVSYLSVAAERVGWLPLVGTASDDTRHEEAVLRRFREFRAVG
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHEE
VIVVSPVGDLESLAALSGPTSPLVLLGAENQSGVVPCVHVDEDTAAQLIVEHLGSQGVRR
EEEEECCCCHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHCCHHHHH
VVSLAEECGSGMVWVLRRRAALIAACQSAGIECVPAIVERGEAVAPILARFIDDAQTDVG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCE
VVAHNDVVALDALSVLRSVGLESRRWIPVVGFDDTHLASRPEFDLTSVNQQPGALVDVAL
EEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
DMVAGAVRGLDHTVEPRLVVRSSSKR
HHHHHHHHCCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]