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The map label for this gene is cobH

Identifier: 50841913

GI number: 50841913

Start: 475278

End: 475931

Strand: Reverse

Name: cobH

Synonym: PPA0429

Alternate gene names: 50841913

Gene position: 475931-475278 (Counterclockwise)

Preceding gene: 50841919

Following gene: 50841912

Centisome position: 18.59

GC content: 60.09

Gene sequence:

>654_bases
GTGGCCCACGAATACATCAACAACGGATCCGACATTTACCGCGAGTCCTTCCGTATCATTCGCTCTGAGGCGAACCTGGA
TCGCTTCCCCACCGACGTTGAGGGGGTTGTCGTCCGCATGATCCACGCCGCTGCCGATCCGGCCATCGCCGATGACATCG
CTTTTACCCCGGCAGTAGTGACGGCAGCTCGCAGGGCTTTAGGTGACGGTGCACCAATTCTGTGTGATTCCTCCATGACG
GCCACCGGCATTATCCGATCCCGACTGCCTCGCGACAACGAAACGATCTGCTACATCAAAGACCCTCGCTTGGCCGATAT
CGCTCAGGCGAAAGATATGACGAAGACCTGCGCCGCGGTGGACTTGTGGACCGAGGAAGGCAAACTCGACGGAGCCATTG
TCGCTATCGGCAATGCCCCCACCGCGCTGTTTCGAGTGCTTGAGGTGTGCGAAGAGACCGGCGCTCGCCCAGCAGCCGTC
GTTGGTATCCCGGTCGGGTTCGTCGGTGCAGCAGAGTCCAAGCAGGCCCTCGTCGACTCAAAACTGGGCTTGGAGTACCT
CACCTTGCTGGGACGCCGCGGTGGATCAGCGATCGCAGTGGCCGCCGTTAACGCCATCGCATCGACCGACGAGTTGACCA
ATAGTCATCGCTGA

Upstream 100 bases:

>100_bases
TGCCTAAGCTTGGTTGCGCACCCGTTACAGCACAATGGTCCGGTGTTACGCTTCCAAACAATCACCACCACAAGTGTTCG
CCGTCGTCAGGAGCAGCATC

Downstream 100 bases:

>100_bases
CGGCAGCAAACCGCTCTTTCCAGGACAGCGAATCGTCATTCTAGGCACGGCGTTTTGCTGATTCAGCGGTAGCAAACTGC
TACTGTCTTAGCATGCAGCT

Product: precorrin-8X methylmutase

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MAHEYINNGSDIYRESFRIIRSEANLDRFPTDVEGVVVRMIHAAADPAIADDIAFTPAVVTAARRALGDGAPILCDSSMT
ATGIIRSRLPRDNETICYIKDPRLADIAQAKDMTKTCAAVDLWTEEGKLDGAIVAIGNAPTALFRVLEVCEETGARPAAV
VGIPVGFVGAAESKQALVDSKLGLEYLTLLGRRGGSAIAVAAVNAIASTDELTNSHR

Sequences:

>Translated_217_residues
MAHEYINNGSDIYRESFRIIRSEANLDRFPTDVEGVVVRMIHAAADPAIADDIAFTPAVVTAARRALGDGAPILCDSSMT
ATGIIRSRLPRDNETICYIKDPRLADIAQAKDMTKTCAAVDLWTEEGKLDGAIVAIGNAPTALFRVLEVCEETGARPAAV
VGIPVGFVGAAESKQALVDSKLGLEYLTLLGRRGGSAIAVAAVNAIASTDELTNSHR
>Mature_216_residues
AHEYINNGSDIYRESFRIIRSEANLDRFPTDVEGVVVRMIHAAADPAIADDIAFTPAVVTAARRALGDGAPILCDSSMTA
TGIIRSRLPRDNETICYIKDPRLADIAQAKDMTKTCAAVDLWTEEGKLDGAIVAIGNAPTALFRVLEVCEETGARPAAVV
GIPVGFVGAAESKQALVDSKLGLEYLTLLGRRGGSAIAVAAVNAIASTDELTNSHR

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: =5.4.1.2 [H]

Molecular weight: Translated: 22965; Mature: 22834

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHEYINNGSDIYRESFRIIRSEANLDRFPTDVEGVVVRMIHAAADPAIADDIAFTPAVV
CCCCHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TAARRALGDGAPILCDSSMTATGIIRSRLPRDNETICYIKDPRLADIAQAKDMTKTCAAV
HHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
DLWTEEGKLDGAIVAIGNAPTALFRVLEVCEETGARPAAVVGIPVGFVGAAESKQALVDS
EEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHH
KLGLEYLTLLGRRGGSAIAVAAVNAIASTDELTNSHR
HCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AHEYINNGSDIYRESFRIIRSEANLDRFPTDVEGVVVRMIHAAADPAIADDIAFTPAVV
CCCHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TAARRALGDGAPILCDSSMTATGIIRSRLPRDNETICYIKDPRLADIAQAKDMTKTCAAV
HHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
DLWTEEGKLDGAIVAIGNAPTALFRVLEVCEETGARPAAVVGIPVGFVGAAESKQALVDS
EEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHH
KLGLEYLTLLGRRGGSAIAVAAVNAIASTDELTNSHR
HCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 1732194 [H]