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The map label for this gene is 50841863

Identifier: 50841863

GI number: 50841863

Start: 425934

End: 428375

Strand: Reverse

Name: 50841863

Synonym: PPA0380

Alternate gene names: NA

Gene position: 428375-425934 (Counterclockwise)

Preceding gene: 50841866

Following gene: 50841861

Centisome position: 16.73

GC content: 64.95

Gene sequence:

>2442_bases
TTGTTCGGCACCCCATCTCGACGAACCTTCCTCACCGCATCTGCGCTGTCAGCCATGGCGCTCGCCGCTTCTCCCACAGT
GACGGACGCCATTGCCGCCCCCGGGCCCGACAGCTGGTCGGCGCTGTGCGAGCGATGGATCGACATCATCACCGGACGCA
GAGCCGCCCGGACCTCTGACCCACGTGCCCGAGCGATCATCGCCAAGACCGACCGGAAGGTCGCCGAGATCCTCACCGAC
CTCGTATCCGGCTCGAGCCGTCAGACCGTTCTGATCTCGGCAGACCTCCGCAAGGAGCAGTCGCCCTTCATCACCAAGAC
AGCCCGAGCCATCGAGTCGATGGCCTGCGCCTGGGCCACACCCGGGTCCAGCTACCACAAGGATCCCGAAATCCTCTCCG
CGTGCATCGAGGGGCTCAGGGACTTCTGCCGACTTCGGTACAACCCCTCCCAGGACGAGTATGGGAACTGGTGGGACTGG
GAGGACGGCGCGTCAAGAGCTGTCGCCGATGTCATGTGCATCCTGCACGACGTCCTGCCGCCCGAGGTCATGTCCGCAGC
GGCAGCCGGCATCGACCACTTCATCCCCGACCCCTGGTTCCAGCAGCCGGCGTCGGTCAAGCCCACTGCCAACCCCGTTC
AGCCCGTGGTCTCGACAGGCGCGAATCGCATGGACCTGACCCGTGCCGTCATGTGCCGTTCCATCGCGACCGGCGACGAG
AAGAGGCTGCGTCATGCCGTTGACGGATTGCCTGACGCCTGGCGCGTCACCACCGAAGGTGACGGTTTCCGTGCCGACGG
CGGATTCATCCAGCACTCCCACATCCCCTACACCGGCGGCTACGGCGACGTCCTGTTCAGCGGACTGGCAATGCTCTTCC
CGCTGGTCTCCGGGATGAGGTTCGACATCGTCGAATCGGCTCGTAAGGCTTTCCACGACCAGGTCGAACGCGGCTTCATC
CCCGTCATGTACAACGGCCAGATCCTCGACGACGTGCGCGGCCGATCCATCTCGCGCATCAACGAGTCTGCCGCCATGCA
CGGCATCTCGATCGCCCGTGCCATGCTCATGATGGCTGATGCCCTGCCGACACACCGCGCCGAACAGTGGCGAGGGATCG
TGCACGGTTGGATGGCTCGAAACACCTTCGATCACCTGTCCGAGCCGTCCACCCTTGTCGACATCTCCCTGTTCGACGCC
GCCGCCAAGGCGCGCCCCGTCCCGGAGTCGTCGACGCCGAGCTACTTCGCGTCCATGGACCGTCTCGTCCACCGCACCGC
GGACTGGCTAATCACCGTCTCCAACTGTTCGGATCGCATTGCCTGGTACGAGTACGGCAACGGGGAGAACGAATGGGCGT
CCAGGACCAGCCAGGGAATGCGTTACCTCCTGCTGCCCGGAGACATGGGACAGTACGAGGACGGGTACTGGGCCACCGTC
GACTACTCAGCACCGACGGGGACGACGGTGGACTCCACTCCGCTCAAACGCGCCGTCGGAGCCTCGTGGGCGGCCAAGAC
CCCGACCAACGAATGGTCCGGGGGCCTCGCATCGGGGTCGTGGTCTGCCGCCGCGTCCCACATCACCTCCCAGGACTCCG
CCCTCAAGGCACGCCGCCTATGGGTGGGTCTGAAGGACGCCATGGTAGAGCTGACGACCGACGTGACCACCGACGCATCG
CGGGCCATAACCGTCGTCGAGCACCGCAAGGTGGCCAGCTCGTCGACGAAACTCCTCGTCGACGGCAACCGGGTCTCATC
CGCGACCTCCTTCCAGAACCCCCGGTGGGCCCATCTGGACGGAGTCGGCGGTTACGTCTTCGCCACTGACACCGATCTCT
CCGCAGATGTGGCGACGAGAAAGGGAACGTGGATCGACGTCAATCCCTCCCGCAAGGTCAAGGGGGCTGACGAGGTCATC
GAGCGCGCCTACGCATCCCTGCACGTCACCCACCACGATCGTCCAGTCGCGTGGGCGCTGCTTCCCACTGCCAGCCGTTC
CCACACGATGGCCCTGGCCACGCGCCCAGGAGTCGAGCCGTTCACCGTGCTCCGGAATGACGCAACCGTCCAGGCCGTCC
GCTCTGCGGGTGCCCTCTTGACGAAGGACCCCACTGTCGTCACCACCTTGGCTTTTTGGAAGCCAGCTACCTGCGGCGGC
GTGGCAGTTAACCGTCCTGCGCTGGTGCAGACTCGGGAGAGCGCAAACCAAATGGAGGTCGTCATCGTCGAACCCACCCA
GAAGAGGGGATCACTTACCGTAACTATTGAGGGAAGCTGGAAGGTCAAAACCGCAGATAGCCACGTTGATGTCAGCTGCG
AAAACGCGGCCGGGACTCTGCATGTCGACACGGCGGGGCTAGGCGGCCAGTCCGTGCGAGTAACGCTGGCACGCCAGGTA
ACTCAAACTCCCTCCGGCGGCGGCCGCCACGACCGAGCCTGA

Upstream 100 bases:

>100_bases
GTCCAACTGGTGACAATGGTAACCGCTTTCCTGTAATGTTTCTGGACAACAAACCTGTACGTGTGGCAGTGCTGCCACCC
TCTCCCGAGGAGCGTGACCC

Downstream 100 bases:

>100_bases
TGTGCCGCCTCACCTAACTAGATTGCCGCTAACCCAAGTCACGTCCCGCTTCATCAGGCACGCCCCGCGTACTGACCGAC
CGGGAATTCCCCGGCCACGG

Product: hyalorunate lyase

Products: NA

Alternate protein names: Hyaluronidase; HYase

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MFGTPSRRTFLTASALSAMALAASPTVTDAIAAPGPDSWSALCERWIDIITGRRAARTSDPRARAIIAKTDRKVAEILTD
LVSGSSRQTVLISADLRKEQSPFITKTARAIESMACAWATPGSSYHKDPEILSACIEGLRDFCRLRYNPSQDEYGNWWDW
EDGASRAVADVMCILHDVLPPEVMSAAAAGIDHFIPDPWFQQPASVKPTANPVQPVVSTGANRMDLTRAVMCRSIATGDE
KRLRHAVDGLPDAWRVTTEGDGFRADGGFIQHSHIPYTGGYGDVLFSGLAMLFPLVSGMRFDIVESARKAFHDQVERGFI
PVMYNGQILDDVRGRSISRINESAAMHGISIARAMLMMADALPTHRAEQWRGIVHGWMARNTFDHLSEPSTLVDISLFDA
AAKARPVPESSTPSYFASMDRLVHRTADWLITVSNCSDRIAWYEYGNGENEWASRTSQGMRYLLLPGDMGQYEDGYWATV
DYSAPTGTTVDSTPLKRAVGASWAAKTPTNEWSGGLASGSWSAAASHITSQDSALKARRLWVGLKDAMVELTTDVTTDAS
RAITVVEHRKVASSSTKLLVDGNRVSSATSFQNPRWAHLDGVGGYVFATDTDLSADVATRKGTWIDVNPSRKVKGADEVI
ERAYASLHVTHHDRPVAWALLPTASRSHTMALATRPGVEPFTVLRNDATVQAVRSAGALLTKDPTVVTTLAFWKPATCGG
VAVNRPALVQTRESANQMEVVIVEPTQKRGSLTVTIEGSWKVKTADSHVDVSCENAAGTLHVDTAGLGGQSVRVTLARQV
TQTPSGGGRHDRA

Sequences:

>Translated_813_residues
MFGTPSRRTFLTASALSAMALAASPTVTDAIAAPGPDSWSALCERWIDIITGRRAARTSDPRARAIIAKTDRKVAEILTD
LVSGSSRQTVLISADLRKEQSPFITKTARAIESMACAWATPGSSYHKDPEILSACIEGLRDFCRLRYNPSQDEYGNWWDW
EDGASRAVADVMCILHDVLPPEVMSAAAAGIDHFIPDPWFQQPASVKPTANPVQPVVSTGANRMDLTRAVMCRSIATGDE
KRLRHAVDGLPDAWRVTTEGDGFRADGGFIQHSHIPYTGGYGDVLFSGLAMLFPLVSGMRFDIVESARKAFHDQVERGFI
PVMYNGQILDDVRGRSISRINESAAMHGISIARAMLMMADALPTHRAEQWRGIVHGWMARNTFDHLSEPSTLVDISLFDA
AAKARPVPESSTPSYFASMDRLVHRTADWLITVSNCSDRIAWYEYGNGENEWASRTSQGMRYLLLPGDMGQYEDGYWATV
DYSAPTGTTVDSTPLKRAVGASWAAKTPTNEWSGGLASGSWSAAASHITSQDSALKARRLWVGLKDAMVELTTDVTTDAS
RAITVVEHRKVASSSTKLLVDGNRVSSATSFQNPRWAHLDGVGGYVFATDTDLSADVATRKGTWIDVNPSRKVKGADEVI
ERAYASLHVTHHDRPVAWALLPTASRSHTMALATRPGVEPFTVLRNDATVQAVRSAGALLTKDPTVVTTLAFWKPATCGG
VAVNRPALVQTRESANQMEVVIVEPTQKRGSLTVTIEGSWKVKTADSHVDVSCENAAGTLHVDTAGLGGQSVRVTLARQV
TQTPSGGGRHDRA
>Mature_813_residues
MFGTPSRRTFLTASALSAMALAASPTVTDAIAAPGPDSWSALCERWIDIITGRRAARTSDPRARAIIAKTDRKVAEILTD
LVSGSSRQTVLISADLRKEQSPFITKTARAIESMACAWATPGSSYHKDPEILSACIEGLRDFCRLRYNPSQDEYGNWWDW
EDGASRAVADVMCILHDVLPPEVMSAAAAGIDHFIPDPWFQQPASVKPTANPVQPVVSTGANRMDLTRAVMCRSIATGDE
KRLRHAVDGLPDAWRVTTEGDGFRADGGFIQHSHIPYTGGYGDVLFSGLAMLFPLVSGMRFDIVESARKAFHDQVERGFI
PVMYNGQILDDVRGRSISRINESAAMHGISIARAMLMMADALPTHRAEQWRGIVHGWMARNTFDHLSEPSTLVDISLFDA
AAKARPVPESSTPSYFASMDRLVHRTADWLITVSNCSDRIAWYEYGNGENEWASRTSQGMRYLLLPGDMGQYEDGYWATV
DYSAPTGTTVDSTPLKRAVGASWAAKTPTNEWSGGLASGSWSAAASHITSQDSALKARRLWVGLKDAMVELTTDVTTDAS
RAITVVEHRKVASSSTKLLVDGNRVSSATSFQNPRWAHLDGVGGYVFATDTDLSADVATRKGTWIDVNPSRKVKGADEVI
ERAYASLHVTHHDRPVAWALLPTASRSHTMALATRPGVEPFTVLRNDATVQAVRSAGALLTKDPTVVTTLAFWKPATCGG
VAVNRPALVQTRESANQMEVVIVEPTQKRGSLTVTIEGSWKVKTADSHVDVSCENAAGTLHVDTAGLGGQSVRVTLARQV
TQTPSGGGRHDRA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide lyase 8 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HYSA_PROAC (Q59634)

Other databases:

- EMBL:   U15927
- EMBL:   AE017283
- RefSeq:   YP_055090.1
- ProteinModelPortal:   Q59634
- GeneID:   2932015
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0380
- NMPDR:   fig|267747.1.peg.367
- HOGENOM:   HBG699337
- OMA:   SRINESA
- ProtClustDB:   CLSK2763251
- BioCyc:   PACN267747:PPA0380-MONOMER
- BRENDA:   4.2.2.1
- InterPro:   IPR008929
- InterPro:   IPR011013
- InterPro:   IPR014718
- InterPro:   IPR011071
- InterPro:   IPR012970
- InterPro:   IPR004103
- InterPro:   IPR003159
- InterPro:   IPR012329
- InterPro:   IPR006311
- Gene3D:   G3DSA:2.70.98.10
- Gene3D:   G3DSA:2.60.220.10
- Gene3D:   G3DSA:1.50.10.100
- TIGRFAMs:   TIGR01409

Pfam domain/function: PF02278 Lyase_8; PF02884 Lyase_8_C; PF08124 Lyase_8_N; SSF48230 Chondroitin_lyas; SSF74650 Gal_mut_like; SSF49863 Lyase_like_C

EC number: =4.2.2.1

Molecular weight: Translated: 88131; Mature: 88131

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS51318 TAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGTPSRRTFLTASALSAMALAASPTVTDAIAAPGPDSWSALCERWIDIITGRRAARTSD
CCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
PRARAIIAKTDRKVAEILTDLVSGSSRQTVLISADLRKEQSPFITKTARAIESMACAWAT
CCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
PGSSYHKDPEILSACIEGLRDFCRLRYNPSQDEYGNWWDWEDGASRAVADVMCILHDVLP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
PEVMSAAAAGIDHFIPDPWFQQPASVKPTANPVQPVVSTGANRMDLTRAVMCRSIATGDE
HHHHHHHHHCHHHCCCCHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCHH
KRLRHAVDGLPDAWRVTTEGDGFRADGGFIQHSHIPYTGGYGDVLFSGLAMLFPLVSGMR
HHHHHHHCCCCCCEEEEECCCCEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCH
FDIVESARKAFHDQVERGFIPVMYNGQILDDVRGRSISRINESAAMHGISIARAMLMMAD
HHHHHHHHHHHHHHHHCCCEEEEECCEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALPTHRAEQWRGIVHGWMARNTFDHLSEPSTLVDISLFDAAAKARPVPESSTPSYFASMD
CCCCHHHHHHHHHHHHHHHHCHHHHHCCCCEEEEEEHHHHHHHCCCCCCCCCCHHHHHHH
RLVHRTADWLITVSNCSDRIAWYEYGNGENEWASRTSQGMRYLLLPGDMGQYEDGYWATV
HHHHHCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCEEEEECCCCCCCCCCEEEEE
DYSAPTGTTVDSTPLKRAVGASWAAKTPTNEWSGGLASGSWSAAASHITSQDSALKARRL
ECCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHH
WVGLKDAMVELTTDVTTDASRAITVVEHRKVASSSTKLLVDGNRVSSATSFQNPRWAHLD
HHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEC
GVGGYVFATDTDLSADVATRKGTWIDVNPSRKVKGADEVIERAYASLHVTHHDRPVAWAL
CCCCEEEEECCCCCCCHHCCCCCEEECCCCCCCCCHHHHHHHHHHHEEEEECCCCEEEEE
LPTASRSHTMALATRPGVEPFTVLRNDATVQAVRSAGALLTKDPTVVTTLAFWKPATCGG
ECCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCC
VAVNRPALVQTRESANQMEVVIVEPTQKRGSLTVTIEGSWKVKTADSHVDVSCENAAGTL
EEECCCHHEEECCCCCCEEEEEECCCCCCCCEEEEEECCEEEEECCCCEEEEECCCCCEE
HVDTAGLGGQSVRVTLARQVTQTPSGGGRHDRA
EEECCCCCCCEEEEEEEHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MFGTPSRRTFLTASALSAMALAASPTVTDAIAAPGPDSWSALCERWIDIITGRRAARTSD
CCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
PRARAIIAKTDRKVAEILTDLVSGSSRQTVLISADLRKEQSPFITKTARAIESMACAWAT
CCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
PGSSYHKDPEILSACIEGLRDFCRLRYNPSQDEYGNWWDWEDGASRAVADVMCILHDVLP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
PEVMSAAAAGIDHFIPDPWFQQPASVKPTANPVQPVVSTGANRMDLTRAVMCRSIATGDE
HHHHHHHHHCHHHCCCCHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCHH
KRLRHAVDGLPDAWRVTTEGDGFRADGGFIQHSHIPYTGGYGDVLFSGLAMLFPLVSGMR
HHHHHHHCCCCCCEEEEECCCCEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCH
FDIVESARKAFHDQVERGFIPVMYNGQILDDVRGRSISRINESAAMHGISIARAMLMMAD
HHHHHHHHHHHHHHHHCCCEEEEECCEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALPTHRAEQWRGIVHGWMARNTFDHLSEPSTLVDISLFDAAAKARPVPESSTPSYFASMD
CCCCHHHHHHHHHHHHHHHHCHHHHHCCCCEEEEEEHHHHHHHCCCCCCCCCCHHHHHHH
RLVHRTADWLITVSNCSDRIAWYEYGNGENEWASRTSQGMRYLLLPGDMGQYEDGYWATV
HHHHHCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCEEEEECCCCCCCCCCEEEEE
DYSAPTGTTVDSTPLKRAVGASWAAKTPTNEWSGGLASGSWSAAASHITSQDSALKARRL
ECCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHH
WVGLKDAMVELTTDVTTDASRAITVVEHRKVASSSTKLLVDGNRVSSATSFQNPRWAHLD
HHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEC
GVGGYVFATDTDLSADVATRKGTWIDVNPSRKVKGADEVIERAYASLHVTHHDRPVAWAL
CCCCEEEEECCCCCCCHHCCCCCEEECCCCCCCCCHHHHHHHHHHHEEEEECCCCEEEEE
LPTASRSHTMALATRPGVEPFTVLRNDATVQAVRSAGALLTKDPTVVTTLAFWKPATCGG
ECCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCC
VAVNRPALVQTRESANQMEVVIVEPTQKRGSLTVTIEGSWKVKTADSHVDVSCENAAGTL
EEECCCHHEEECCCCCCEEEEEECCCCCCCCEEEEEECCEEEEECCCCEEEEECCCCCEE
HVDTAGLGGQSVRVTLARQVTQTPSGGGRHDRA
EEECCCCCCCEEEEEEEHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9115089