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The map label for this gene is glyA

Identifier: 50841854

GI number: 50841854

Start: 416665

End: 418140

Strand: Reverse

Name: glyA

Synonym: PPA0369

Alternate gene names: 50841854

Gene position: 418140-416665 (Counterclockwise)

Preceding gene: 50841855

Following gene: 50841853

Centisome position: 16.33

GC content: 62.94

Gene sequence:

>1476_bases
GTGAGTGATCCCCGTGCCGTCGATCCCACTGCCCGTGACATTGCCGAGAAGCTAGCCCCGGCCTACCGCACCATGCTCGA
CGCGATCGCACAGGTCGAGCCGCGGATCGCGGAGGCCACCCGTGCTGAACTCACCGACCAGCGTCATTCCCTCAAACTTA
TTGCTTCCGAAAACTACGCATCCTTGCCAGTTCTGGCGACCATGGGTACCTGGTTCTCTGATAAGTACGCCGAAGGTACT
GCCGGCCACCGCTTCTACGCCGGTTGCCAAAACGTTGACACCGTCGAGACGATCGCCGCCGAGCATGCCTGCGCTCTGTT
CGGCGCTGAGCACGCTTACGTACAGCCCCACTCCGGCATTGACGCCAACCTCACCGCCTACTGGACGATCCTGGCCCACC
ATATCGAGACCCCAGCCCTGTCAGAATTTGGCGCCCGCACTGTCAATGACCTCACTCAAGTTGACTGGGACACCCTGCGT
CATCGTTTCAATGACCAGCGGGCGATCGGCATGAGCCTCGATGCTGGTGGCCACCTTACCCACGGTTTCCGCCCCAATAT
CTCCGGAAAGATGTTCGACCAGCGCTCCTACGGCACCGATCCGCAAACGGGCCTGCTCGACTACGACAAGGTCGCTGAGC
TGGCCCGCGAGTTTAAGCCGCTTGTCATCGTCGCCGGATACTCCGCCTACCCGCGCCGCGTTAATTTCGCAAAGATGCGC
GAGATTGCCGACGAAGTCGGTGCTGTGCTCATGGTCGATATGGCCCACTTCGCTGGCCTGGTAGCTGGCAAAGTCTTCAC
TGGTGACGAGAACCCCATCCCCCACGCCCAGGTCGTGACGACGACGACCCACAAGTCGCTACGCGGACCGCGCGGCGGCA
TGGTGCTGACGACTAAGGACTACGCCGACGACGTCGACCGCGGCTGCCCAATGGTGCTCGGCGGCCCGCTGTCCCACGTC
ATGGCTGCCAAGGCCGTCGCTCTGGCAGAAGCGCGCACCCAGACCTTCCGCGACTACGCTCAGCGCGTCGCCAATAACGC
GAAGGCCCTAGCCGAAGGACTCATGAAACGTGGCGTCAAGCTCGTCACCGATGGGACTGACAACCACATCAACCTGCTCG
ACGTCACGACGAGCTTCGGGCTGACCGGTCGTCAGGCCGAGGCCGCGCTGCTGGACGCCGGTGTGGTCACCAACCGCAAC
TCCATTCCGACTGACCCGAACGGCGCCTGGTACACCTCTGGCATACGCATCGGCACCCCGGCACTGACCTCCCGCGGATT
CGGACCCGACGAATTCGATCAGGTCGCCGAGCTCATCGTCACTACCTTGGAGGCCACCACCCCGATGACGGCCTCCACCG
GCAAGCCCGGCAAGGCCAAATACCAAATTGCCGACGGTGTGGCGCAGAAGGTCCATGACGCCGCCGACGAGCTGCTGGGC
AACTTCCCCCTCTACCCAGGGCTGGATTTGGCCTGA

Upstream 100 bases:

>100_bases
AGGACGGCGAGCCGTTCGCCGTCCTTTCAGGCTATAGCCCCAAGTGGCTCCCGGGACGAGTAGATTTGTGCTTACCGTCC
CGTCATGACAGGAGCCATCC

Downstream 100 bases:

>100_bases
CGGGGCTCAATCCCCCTTGATTCCTAGTTCGGGGATTCTCACCAAGTATCTACTCACGAAATTTCCGCACCGTTTCGATC
GGCGGTCCACGTTCTGCAAA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MSDPRAVDPTARDIAEKLAPAYRTMLDAIAQVEPRIAEATRAELTDQRHSLKLIASENYASLPVLATMGTWFSDKYAEGT
AGHRFYAGCQNVDTVETIAAEHACALFGAEHAYVQPHSGIDANLTAYWTILAHHIETPALSEFGARTVNDLTQVDWDTLR
HRFNDQRAIGMSLDAGGHLTHGFRPNISGKMFDQRSYGTDPQTGLLDYDKVAELAREFKPLVIVAGYSAYPRRVNFAKMR
EIADEVGAVLMVDMAHFAGLVAGKVFTGDENPIPHAQVVTTTTHKSLRGPRGGMVLTTKDYADDVDRGCPMVLGGPLSHV
MAAKAVALAEARTQTFRDYAQRVANNAKALAEGLMKRGVKLVTDGTDNHINLLDVTTSFGLTGRQAEAALLDAGVVTNRN
SIPTDPNGAWYTSGIRIGTPALTSRGFGPDEFDQVAELIVTTLEATTPMTASTGKPGKAKYQIADGVAQKVHDAADELLG
NFPLYPGLDLA

Sequences:

>Translated_491_residues
MSDPRAVDPTARDIAEKLAPAYRTMLDAIAQVEPRIAEATRAELTDQRHSLKLIASENYASLPVLATMGTWFSDKYAEGT
AGHRFYAGCQNVDTVETIAAEHACALFGAEHAYVQPHSGIDANLTAYWTILAHHIETPALSEFGARTVNDLTQVDWDTLR
HRFNDQRAIGMSLDAGGHLTHGFRPNISGKMFDQRSYGTDPQTGLLDYDKVAELAREFKPLVIVAGYSAYPRRVNFAKMR
EIADEVGAVLMVDMAHFAGLVAGKVFTGDENPIPHAQVVTTTTHKSLRGPRGGMVLTTKDYADDVDRGCPMVLGGPLSHV
MAAKAVALAEARTQTFRDYAQRVANNAKALAEGLMKRGVKLVTDGTDNHINLLDVTTSFGLTGRQAEAALLDAGVVTNRN
SIPTDPNGAWYTSGIRIGTPALTSRGFGPDEFDQVAELIVTTLEATTPMTASTGKPGKAKYQIADGVAQKVHDAADELLG
NFPLYPGLDLA
>Mature_490_residues
SDPRAVDPTARDIAEKLAPAYRTMLDAIAQVEPRIAEATRAELTDQRHSLKLIASENYASLPVLATMGTWFSDKYAEGTA
GHRFYAGCQNVDTVETIAAEHACALFGAEHAYVQPHSGIDANLTAYWTILAHHIETPALSEFGARTVNDLTQVDWDTLRH
RFNDQRAIGMSLDAGGHLTHGFRPNISGKMFDQRSYGTDPQTGLLDYDKVAELAREFKPLVIVAGYSAYPRRVNFAKMRE
IADEVGAVLMVDMAHFAGLVAGKVFTGDENPIPHAQVVTTTTHKSLRGPRGGMVLTTKDYADDVDRGCPMVLGGPLSHVM
AAKAVALAEARTQTFRDYAQRVANNAKALAEGLMKRGVKLVTDGTDNHINLLDVTTSFGLTGRQAEAALLDAGVVTNRNS
IPTDPNGAWYTSGIRIGTPALTSRGFGPDEFDQVAELIVTTLEATTPMTASTGKPGKAKYQIADGVAQKVHDAADELLGN
FPLYPGLDLA

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=36.5638766519824, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=36.5638766519824, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=36.5638766519824, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=36.5638766519824, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI261862346, Length=454, Percent_Identity=35.2422907488987, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI22547186, Length=483, Percent_Identity=36.4389233954451, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI22547189, Length=467, Percent_Identity=35.9743040685225, Blast_Score=238, Evalue=8e-63,
Organism=Escherichia coli, GI1788902, Length=423, Percent_Identity=45.1536643026005, Blast_Score=314, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI25144729, Length=479, Percent_Identity=35.0730688935282, Blast_Score=275, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI25144732, Length=479, Percent_Identity=35.0730688935282, Blast_Score=274, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6319739, Length=489, Percent_Identity=35.5828220858896, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6323087, Length=494, Percent_Identity=33.4008097165992, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24640005, Length=494, Percent_Identity=35.82995951417, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI221329721, Length=494, Percent_Identity=35.82995951417, Blast_Score=292, Evalue=4e-79,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_PROAC (Q6AAU3)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055081.1
- ProteinModelPortal:   Q6AAU3
- SMR:   Q6AAU3
- GeneID:   2932089
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0369
- NMPDR:   fig|267747.1.peg.358
- HOGENOM:   HBG301263
- OMA:   SGIVTNR
- ProtClustDB:   PRK13580
- BioCyc:   PACN267747:PPA0369-MONOMER
- BRENDA:   2.1.2.1
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 52936; Mature: 52805

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00096 SHMT; PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPRAVDPTARDIAEKLAPAYRTMLDAIAQVEPRIAEATRAELTDQRHSLKLIASENYA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHCEEEEECCCCC
SLPVLATMGTWFSDKYAEGTAGHRFYAGCQNVDTVETIAAEHACALFGAEHAYVQPHSGI
CCCHHHHHCCHHCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCC
DANLTAYWTILAHHIETPALSEFGARTVNDLTQVDWDTLRHRFNDQRAIGMSLDAGGHLT
CCCHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCCC
HGFRPNISGKMFDQRSYGTDPQTGLLDYDKVAELAREFKPLVIVAGYSAYPRRVNFAKMR
CCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHH
EIADEVGAVLMVDMAHFAGLVAGKVFTGDENPIPHAQVVTTTTHKSLRGPRGGMVLTTKD
HHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCEEEEEECHHHHCCCCCCEEEEECH
YADDVDRGCPMVLGGPLSHVMAAKAVALAEARTQTFRDYAQRVANNAKALAEGLMKRGVK
HHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LVTDGTDNHINLLDVTTSFGLTGRQAEAALLDAGVVTNRNSIPTDPNGAWYTSGIRIGTP
EEECCCCCEEEEEEEECCCCCCCCCHHHHHHHCCEEECCCCCCCCCCCCEEECCEEECCC
ALTSRGFGPDEFDQVAELIVTTLEATTPMTASTGKPGKAKYQIADGVAQKVHDAADELLG
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
NFPLYPGLDLA
CCCCCCCCCCC
>Mature Secondary Structure 
SDPRAVDPTARDIAEKLAPAYRTMLDAIAQVEPRIAEATRAELTDQRHSLKLIASENYA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHCEEEEECCCCC
SLPVLATMGTWFSDKYAEGTAGHRFYAGCQNVDTVETIAAEHACALFGAEHAYVQPHSGI
CCCHHHHHCCHHCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCC
DANLTAYWTILAHHIETPALSEFGARTVNDLTQVDWDTLRHRFNDQRAIGMSLDAGGHLT
CCCHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCCC
HGFRPNISGKMFDQRSYGTDPQTGLLDYDKVAELAREFKPLVIVAGYSAYPRRVNFAKMR
CCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHH
EIADEVGAVLMVDMAHFAGLVAGKVFTGDENPIPHAQVVTTTTHKSLRGPRGGMVLTTKD
HHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCEEEEEECHHHHCCCCCCEEEEECH
YADDVDRGCPMVLGGPLSHVMAAKAVALAEARTQTFRDYAQRVANNAKALAEGLMKRGVK
HHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LVTDGTDNHINLLDVTTSFGLTGRQAEAALLDAGVVTNRNSIPTDPNGAWYTSGIRIGTP
EEECCCCCEEEEEEEECCCCCCCCCHHHHHHHCCEEECCCCCCCCCCCCEEECCEEECCC
ALTSRGFGPDEFDQVAELIVTTLEATTPMTASTGKPGKAKYQIADGVAQKVHDAADELLG
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
NFPLYPGLDLA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA