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The map label for this gene is mtr [H]

Identifier: 50841819

GI number: 50841819

Start: 383235

End: 384635

Strand: Direct

Name: mtr [H]

Synonym: PPA0333

Alternate gene names: 50841819

Gene position: 383235-384635 (Clockwise)

Preceding gene: 50841815

Following gene: 50841831

Centisome position: 14.97

GC content: 60.46

Gene sequence:

>1401_bases
ATGGAGCATTACGACATCGTCGTCATCGGTTCGGGGTCGGGAAACACGATCCTGGATGAAGACTTCGCAGATCGACGCGC
CGCGATCATCGATTCTGGTGCGTTTGGGGGCACCTGCCTCAACGTCGGCTGCATACCTACGAAGATGTTCGTGCTCCCGG
CGGACTTTGCGTCCTCGCCGTCCGAGGCTGTCCGAGTGGGAGTCGACCTGCAGTTCCGCGGAGCATCCTTTGCCTCGATC
CGTGACCGGATCTTTGGCCGAATCGACTCCATATCTAAGGCCGGGCTTTCGTACCGACAGGGACTAGACAATATTGACGT
TTATACCGGCGAGGCGGCATTTATCGATGCACACACCCTTGAGGTGGGAGGCAGGTGTATTACTGCTGACCAGATTGTCC
TGGCGGCTGGATCGCGTCCGCGAGTGCCTGATGTGCCTGGTCTCGACGATCCCAGCATGGCTGGGTTGATTCACACTTCC
GACACCATCATGAGGCTAGCGGAGCTTCCGCAGCGTCTGGTGATCCTTGGTGGCGGGCTTATCGCGGCGGAGTTCGCTCA
CATCTTCTCTGGGCTCGGGTCCCAGGTGACCGTTATCAACCGTTCTGGCCGGATGCTGCGTCACGAGGATCGCGAGATCT
CGCAGCGCTTCACTGAACAGATGGGACGTCGGGTGCGTCTGCGGATGGCGGAGGGGCTGGTGGGTGTTGACCGTGACCCC
GGCGGTCACCTGGTGGTGCTGACCGTCGACGGTGATGGGGTCGACTACGACTATCCGGCAGATGTCGTTCTCAATGCCAC
CGGTCGGGTCTCCAACGGGGATCGCCTTAACCTGCCGGCGGCCGGTGTTGACGTTGACGACGACGGGTTCGTGGTGGTCG
ATAAGCACCAGCGCACCAACGTTGAGCATATCTGGGCCCTAGGCGACGTGTGCTCCCCCTGGGAGCTCAAACACGTGGCC
AATCATGAGGCGCGTGTGGTCCGTCACAACCTGTTGCATCCTGACGATCTGGCTAGTTCTAATCATTGCTTCGTGCCGCA
CGCGGTGTTTTCGAATCCGCAGGTGGCGTCGGTTGGTGCCACGGAGCAGGGACTGTTGCAATCCGACACTCCTTACGCGG
CGTACCTTCAGGAGTACGCGGACGTCGCCTATGGGTGGGCCATGGAGGACGAGGGGCACTGCGTCAAGCTGCTGGGAGAT
CCGCAGACGAGGACTTTGCTGGGGGCGCACATCATTGGGCCCCAAGCGTCCACCCTCATTCAGACCTGTATTCAGGGGAT
GAGCGTTGGGCAGACGGTCGACGAAATGGCGCGTGGGCAGTACTGGATCCATCCTGCCCTCTCTGAAGTCGTCGAAAGTG
CCCTGCTGGGGCTTGGCAAGGAAATGGATACCACGAGGTGA

Upstream 100 bases:

>100_bases
GGCTGGCGATCACCCTACATGGCATTGCTCGACATCACTGGATCCGCGCCTGCAGCAGGTTGACGGGATCCGCGTGGGCC
CGGGATGACACACTGGTGAC

Downstream 100 bases:

>100_bases
CGGGTCGCCGCCCGCATCCCCGAATGCTCCGCTGCGGGCACTCGGGGATGAGAGACGGTGCGCCCTCATGAACTCATCGT
GGTCACTTCTTGTCCTTGAT

Product: mycothione reductase

Products: NA

Alternate protein names: Mycothiol-disulfide reductase; NADPH-dependent mycothione reductase [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MEHYDIVVIGSGSGNTILDEDFADRRAAIIDSGAFGGTCLNVGCIPTKMFVLPADFASSPSEAVRVGVDLQFRGASFASI
RDRIFGRIDSISKAGLSYRQGLDNIDVYTGEAAFIDAHTLEVGGRCITADQIVLAAGSRPRVPDVPGLDDPSMAGLIHTS
DTIMRLAELPQRLVILGGGLIAAEFAHIFSGLGSQVTVINRSGRMLRHEDREISQRFTEQMGRRVRLRMAEGLVGVDRDP
GGHLVVLTVDGDGVDYDYPADVVLNATGRVSNGDRLNLPAAGVDVDDDGFVVVDKHQRTNVEHIWALGDVCSPWELKHVA
NHEARVVRHNLLHPDDLASSNHCFVPHAVFSNPQVASVGATEQGLLQSDTPYAAYLQEYADVAYGWAMEDEGHCVKLLGD
PQTRTLLGAHIIGPQASTLIQTCIQGMSVGQTVDEMARGQYWIHPALSEVVESALLGLGKEMDTTR

Sequences:

>Translated_466_residues
MEHYDIVVIGSGSGNTILDEDFADRRAAIIDSGAFGGTCLNVGCIPTKMFVLPADFASSPSEAVRVGVDLQFRGASFASI
RDRIFGRIDSISKAGLSYRQGLDNIDVYTGEAAFIDAHTLEVGGRCITADQIVLAAGSRPRVPDVPGLDDPSMAGLIHTS
DTIMRLAELPQRLVILGGGLIAAEFAHIFSGLGSQVTVINRSGRMLRHEDREISQRFTEQMGRRVRLRMAEGLVGVDRDP
GGHLVVLTVDGDGVDYDYPADVVLNATGRVSNGDRLNLPAAGVDVDDDGFVVVDKHQRTNVEHIWALGDVCSPWELKHVA
NHEARVVRHNLLHPDDLASSNHCFVPHAVFSNPQVASVGATEQGLLQSDTPYAAYLQEYADVAYGWAMEDEGHCVKLLGD
PQTRTLLGAHIIGPQASTLIQTCIQGMSVGQTVDEMARGQYWIHPALSEVVESALLGLGKEMDTTR
>Mature_466_residues
MEHYDIVVIGSGSGNTILDEDFADRRAAIIDSGAFGGTCLNVGCIPTKMFVLPADFASSPSEAVRVGVDLQFRGASFASI
RDRIFGRIDSISKAGLSYRQGLDNIDVYTGEAAFIDAHTLEVGGRCITADQIVLAAGSRPRVPDVPGLDDPSMAGLIHTS
DTIMRLAELPQRLVILGGGLIAAEFAHIFSGLGSQVTVINRSGRMLRHEDREISQRFTEQMGRRVRLRMAEGLVGVDRDP
GGHLVVLTVDGDGVDYDYPADVVLNATGRVSNGDRLNLPAAGVDVDDDGFVVVDKHQRTNVEHIWALGDVCSPWELKHVA
NHEARVVRHNLLHPDDLASSNHCFVPHAVFSNPQVASVGATEQGLLQSDTPYAAYLQEYADVAYGWAMEDEGHCVKLLGD
PQTRTLLGAHIIGPQASTLIQTCIQGMSVGQTVDEMARGQYWIHPALSEVVESALLGLGKEMDTTR

Specific function: Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=451, Percent_Identity=29.9334811529933, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI91199540, Length=489, Percent_Identity=26.1758691206544, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI22035672, Length=455, Percent_Identity=29.6703296703297, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI291045266, Length=461, Percent_Identity=24.9457700650759, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI148277071, Length=443, Percent_Identity=24.1534988713318, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI33519430, Length=443, Percent_Identity=24.1534988713318, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI33519428, Length=443, Percent_Identity=24.1534988713318, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI33519426, Length=443, Percent_Identity=24.1534988713318, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI148277065, Length=443, Percent_Identity=24.1534988713318, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI291045268, Length=451, Percent_Identity=25.4988913525499, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=30.5747126436782, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1786307, Length=427, Percent_Identity=29.9765807962529, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI87081717, Length=462, Percent_Identity=28.5714285714286, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI87082354, Length=481, Percent_Identity=26.8191268191268, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI32565766, Length=478, Percent_Identity=26.7782426778243, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=340, Percent_Identity=27.9411764705882, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=340, Percent_Identity=27.9411764705882, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17557007, Length=482, Percent_Identity=28.0082987551867, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71982272, Length=419, Percent_Identity=24.8210023866348, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6325166, Length=459, Percent_Identity=26.5795206971678, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=27.3684210526316, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=492, Percent_Identity=26.8292682926829, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21358499, Length=475, Percent_Identity=27.5789473684211, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24640549, Length=475, Percent_Identity=28.6315789473684, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24640553, Length=475, Percent_Identity=28.6315789473684, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=28.4810126582279, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17737741, Length=483, Percent_Identity=28.9855072463768, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017817
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.15 [H]

Molecular weight: Translated: 50228; Mature: 50228

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHYDIVVIGSGSGNTILDEDFADRRAAIIDSGAFGGTCLNVGCIPTKMFVLPADFASSP
CCCEEEEEEECCCCCCEECCCHHCCCEEEEECCCCCCEEEECCCCCEEEEEEECCCCCCC
SEAVRVGVDLQFRGASFASIRDRIFGRIDSISKAGLSYRQGLDNIDVYTGEAAFIDAHTL
CHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEEECCEEEEEEEEE
EVGGRCITADQIVLAAGSRPRVPDVPGLDDPSMAGLIHTSDTIMRLAELPQRLVILGGGL
ECCCEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHCCCEEEEECCCH
IAAEFAHIFSGLGSQVTVINRSGRMLRHEDREISQRFTEQMGRRVRLRMAEGLVGVDRDP
HHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEHHHHCCCEECCCCC
GGHLVVLTVDGDGVDYDYPADVVLNATGRVSNGDRLNLPAAGVDVDDDGFVVVDKHQRTN
CCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCEECCCCCCCCCCCCCEEEEECCCCCC
VEHIWALGDVCSPWELKHVANHEARVVRHNLLHPDDLASSNHCFVPHAVFSNPQVASVGA
HHHEEEECCCCCCHHHHHHCCCHHHHHHHHCCCCHHCCCCCCEEECHHHCCCCCEEECCC
TEQGLLQSDTPYAAYLQEYADVAYGWAMEDEGHCVKLLGDPQTRTLLGAHIIGPQASTLI
CCCCCCCCCCCHHHHHHHHHHHHHCEEECCCCCEEEEECCCCHHEEEEEEEECCCHHHHH
QTCIQGMSVGQTVDEMARGQYWIHPALSEVVESALLGLGKEMDTTR
HHHHHCCCCCCHHHHHHCCCEEECHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEHYDIVVIGSGSGNTILDEDFADRRAAIIDSGAFGGTCLNVGCIPTKMFVLPADFASSP
CCCEEEEEEECCCCCCEECCCHHCCCEEEEECCCCCCEEEECCCCCEEEEEEECCCCCCC
SEAVRVGVDLQFRGASFASIRDRIFGRIDSISKAGLSYRQGLDNIDVYTGEAAFIDAHTL
CHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEEECCEEEEEEEEE
EVGGRCITADQIVLAAGSRPRVPDVPGLDDPSMAGLIHTSDTIMRLAELPQRLVILGGGL
ECCCEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHCCCEEEEECCCH
IAAEFAHIFSGLGSQVTVINRSGRMLRHEDREISQRFTEQMGRRVRLRMAEGLVGVDRDP
HHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEHHHHCCCEECCCCC
GGHLVVLTVDGDGVDYDYPADVVLNATGRVSNGDRLNLPAAGVDVDDDGFVVVDKHQRTN
CCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCEECCCCCCCCCCCCCEEEEECCCCCC
VEHIWALGDVCSPWELKHVANHEARVVRHNLLHPDDLASSNHCFVPHAVFSNPQVASVGA
HHHEEEECCCCCCHHHHHHCCCHHHHHHHHCCCCHHCCCCCCEEECHHHCCCCCEEECCC
TEQGLLQSDTPYAAYLQEYADVAYGWAMEDEGHCVKLLGDPQTRTLLGAHIIGPQASTLI
CCCCCCCCCCCHHHHHHHHHHHHHCEEECCCCCEEEEECCCCHHEEEEEEEECCCHHHHH
QTCIQGMSVGQTVDEMARGQYWIHPALSEVVESALLGLGKEMDTTR
HHHHHCCCCCCHHHHHHCCCEEECHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]