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The map label for this gene is hemA

Identifier: 50841795

GI number: 50841795

Start: 357887

End: 359221

Strand: Direct

Name: hemA

Synonym: PPA0307

Alternate gene names: 50841795

Gene position: 357887-359221 (Clockwise)

Preceding gene: 50841780

Following gene: 50841796

Centisome position: 13.98

GC content: 62.4

Gene sequence:

>1335_bases
TTGACCGTGGATCATGCCGAGCAGGGGCTTGGCGTCGTTTCCGAGGCGGCCGCGCAGGTTGACGGACTTGGCCTGGCATT
GACCGATCATCCCCAGATCCGGGGCGCCCTTGTGCTGTCAACGTGCAACCGGGTGTGCCTGATCGTTGAAACCTCCCCTG
AAGCCGTCGCGCAAGGGTTCGACGAGGCCGCGTTACGCAGGTGCATTGCCGATCACGGAGCAAACGTGTTAGCTGAATCT
GCCCAGCTCGTCTGTGAGAACGACGCCGTTTGGCGTTTGTTCCGTGTGGCTGCGGGCATGGAGTCGATGGTTTTTGGGGA
ACGTGAGGTCGCCGGACAGATGAAGCGTGCTCTCAGTGAGGCGCGCCGTGAACAGACCGTCTCCTACACCATTGGTCACG
TCGTTGAGGAAGCTCTCAAGACGTCACGTCATGTCGCTACCGAGACTGCGTTGGCTGCTGAGGGACGCACCGTTGTCGCG
GTCGGGCTTGACCTCGTTGCCCAGCGGATGGACTTGGATGGCGCTCGGGTGCTCGTTATGGGGACTGGCTCCTATGCCGG
TGCGTCGTGCGCCCAGCTGAGTTCTCGGGGAGTCGCCGAGATTCAAGTCCATTCAGCTTCCGGACGTGCCGCCGGATTCG
CTCGACGCCACCGGGTCAGTGAGGCTCTCGACATCGACGCCGCGCTGGCACAAGCTGATCTTGTCGTCACCTGCCGTGGG
TCGGGAGTTCCTGCGTTGTCTGCTGAGGCTGCTCGGCGCGCGGTCGACGCTCGAAGGGGCCGCGATCTCATGGTGCTCGA
TTTAGCAATCAGCGGGGACGTTGAGGAGCCTGTCCCCGCTGGGGTAGAGGTCATCGACCTTGAGACGATCCGGCAGGCTG
TTCCCGCCTCTGCGGAAGCTGAGCGGGCCGCCGCCGAACACATCATCGCTACGGGAGTCCGTCACTTTGCCGTAGACCTC
GAACGTCGTCGGATGGCCCCGGCTGTCGTCGCTCTGCGCGACGTCATTTCAGATCTCGTTACTGCTGAACTGGAGCGTCT
GCCCGAAGAAGGCTCGGTCCCTGTCGATGAGGTAGCGGCGTCTCTTCGACGACTCGCTGCATCTATGGCGCACATCCCGT
CGGCTCGAGCCAGGATGGCCTCTGAGCAGGGCTTGGGCGATCGCTGGCTTAACTCATTGTCGGATGTATTGGGAATTGAC
GTGGATATCGCGGCACCCGTCATCGACATGTCCAGCTTCGCCAATGCTGACTGCATGACGTGTCCGGTTACCGGCCTGCG
GGTGGAGGACCTTGCCACAGATGCGGCACCCCGAGGTGAGGAGAGGACATCGTGA

Upstream 100 bases:

>100_bases
TGCCGCCCACAGGACGGTTATTGGGCGAGTTATGAGCTTCGTATGTACTGGGGTTCGTCGTTACAGCATGGTTGAATAAC
GCTTCGTGGGATTGTGTGTC

Downstream 100 bases:

>100_bases
CCGCTAATCCCTACGCTGCTCCCACGGACCCGTTGGCCCCTTATAGCGCCGTGCTTGTCGTTTCTTTTGGCGGTCCGCGT
TCCCCTGAAGAGGTCATGCC

Product: glutamyl-tRNA reductase, HemA

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTVDHAEQGLGVVSEAAAQVDGLGLALTDHPQIRGALVLSTCNRVCLIVETSPEAVAQGFDEAALRRCIADHGANVLAES
AQLVCENDAVWRLFRVAAGMESMVFGEREVAGQMKRALSEARREQTVSYTIGHVVEEALKTSRHVATETALAAEGRTVVA
VGLDLVAQRMDLDGARVLVMGTGSYAGASCAQLSSRGVAEIQVHSASGRAAGFARRHRVSEALDIDAALAQADLVVTCRG
SGVPALSAEAARRAVDARRGRDLMVLDLAISGDVEEPVPAGVEVIDLETIRQAVPASAEAERAAAEHIIATGVRHFAVDL
ERRRMAPAVVALRDVISDLVTAELERLPEEGSVPVDEVAASLRRLAASMAHIPSARARMASEQGLGDRWLNSLSDVLGID
VDIAAPVIDMSSFANADCMTCPVTGLRVEDLATDAAPRGEERTS

Sequences:

>Translated_444_residues
MTVDHAEQGLGVVSEAAAQVDGLGLALTDHPQIRGALVLSTCNRVCLIVETSPEAVAQGFDEAALRRCIADHGANVLAES
AQLVCENDAVWRLFRVAAGMESMVFGEREVAGQMKRALSEARREQTVSYTIGHVVEEALKTSRHVATETALAAEGRTVVA
VGLDLVAQRMDLDGARVLVMGTGSYAGASCAQLSSRGVAEIQVHSASGRAAGFARRHRVSEALDIDAALAQADLVVTCRG
SGVPALSAEAARRAVDARRGRDLMVLDLAISGDVEEPVPAGVEVIDLETIRQAVPASAEAERAAAEHIIATGVRHFAVDL
ERRRMAPAVVALRDVISDLVTAELERLPEEGSVPVDEVAASLRRLAASMAHIPSARARMASEQGLGDRWLNSLSDVLGID
VDIAAPVIDMSSFANADCMTCPVTGLRVEDLATDAAPRGEERTS
>Mature_443_residues
TVDHAEQGLGVVSEAAAQVDGLGLALTDHPQIRGALVLSTCNRVCLIVETSPEAVAQGFDEAALRRCIADHGANVLAESA
QLVCENDAVWRLFRVAAGMESMVFGEREVAGQMKRALSEARREQTVSYTIGHVVEEALKTSRHVATETALAAEGRTVVAV
GLDLVAQRMDLDGARVLVMGTGSYAGASCAQLSSRGVAEIQVHSASGRAAGFARRHRVSEALDIDAALAQADLVVTCRGS
GVPALSAEAARRAVDARRGRDLMVLDLAISGDVEEPVPAGVEVIDLETIRQAVPASAEAERAAAEHIIATGVRHFAVDLE
RRRMAPAVVALRDVISDLVTAELERLPEEGSVPVDEVAASLRRLAASMAHIPSARARMASEQGLGDRWLNSLSDVLGIDV
DIAAPVIDMSSFANADCMTCPVTGLRVEDLATDAAPRGEERTS

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=389, Percent_Identity=25.706940874036, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_PROAC (Q6AB02)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055022.1
- ProteinModelPortal:   Q6AB02
- SMR:   Q6AB02
- GeneID:   2932189
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0307
- NMPDR:   fig|267747.1.peg.299
- OMA:   RIELYAD
- ProtClustDB:   CLSK2763204
- BioCyc:   PACN267747:PPA0307-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46740; Mature: 46609

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 42-42 BINDING 102-102 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDHAEQGLGVVSEAAAQVDGLGLALTDHPQIRGALVLSTCNRVCLIVETSPEAVAQGF
CCCCCCHHCCCHHHHHHHHHCCCEEEECCCCCCCHHEEEECCCCEEEEEECCHHHHHCCC
DEAALRRCIADHGANVLAESAQLVCENDAVWRLFRVAAGMESMVFGEREVAGQMKRALSE
HHHHHHHHHHHCCHHHHHHHHHHEECCHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHH
ARREQTVSYTIGHVVEEALKTSRHVATETALAAEGRTVVAVGLDLVAQRMDLDGARVLVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCEEEEE
GTGSYAGASCAQLSSRGVAEIQVHSASGRAAGFARRHRVSEALDIDAALAQADLVVTCRG
ECCCCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
SGVPALSAEAARRAVDARRGRDLMVLDLAISGDVEEPVPAGVEVIDLETIRQAVPASAEA
CCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEEHHHHHHHCCCCCHH
ERAAAEHIIATGVRHFAVDLERRRMAPAVVALRDVISDLVTAELERLPEEGSVPVDEVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SLRRLAASMAHIPSARARMASEQGLGDRWLNSLSDVLGIDVDIAAPVIDMSSFANADCMT
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHCCHHHHHHCCCCCCEE
CPVTGLRVEDLATDAAPRGEERTS
CCCCCCCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TVDHAEQGLGVVSEAAAQVDGLGLALTDHPQIRGALVLSTCNRVCLIVETSPEAVAQGF
CCCCCHHCCCHHHHHHHHHCCCEEEECCCCCCCHHEEEECCCCEEEEEECCHHHHHCCC
DEAALRRCIADHGANVLAESAQLVCENDAVWRLFRVAAGMESMVFGEREVAGQMKRALSE
HHHHHHHHHHHCCHHHHHHHHHHEECCHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHH
ARREQTVSYTIGHVVEEALKTSRHVATETALAAEGRTVVAVGLDLVAQRMDLDGARVLVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCEEEEE
GTGSYAGASCAQLSSRGVAEIQVHSASGRAAGFARRHRVSEALDIDAALAQADLVVTCRG
ECCCCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
SGVPALSAEAARRAVDARRGRDLMVLDLAISGDVEEPVPAGVEVIDLETIRQAVPASAEA
CCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEEHHHHHHHCCCCCHH
ERAAAEHIIATGVRHFAVDLERRRMAPAVVALRDVISDLVTAELERLPEEGSVPVDEVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SLRRLAASMAHIPSARARMASEQGLGDRWLNSLSDVLGIDVDIAAPVIDMSSFANADCMT
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHCCHHHHHHCCCCCCEE
CPVTGLRVEDLATDAAPRGEERTS
CCCCCCCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA