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The map label for this gene is hemH [H]

Identifier: 50841796

GI number: 50841796

Start: 359218

End: 361269

Strand: Direct

Name: hemH [H]

Synonym: PPA0308

Alternate gene names: 50841796

Gene position: 359218-361269 (Clockwise)

Preceding gene: 50841795

Following gene: 50841797

Centisome position: 14.03

GC content: 61.94

Gene sequence:

>2052_bases
GTGACCGCTAATCCCTACGCTGCTCCCACGGACCCGTTGGCCCCTTATAGCGCCGTGCTTGTCGTTTCTTTTGGCGGTCC
GCGTTCCCCTGAAGAGGTCATGCCTTTTCTGAGAAGGGTCTCCCACGGTCGCATTCCTGAAGAACGCTTGGCTGATGTCG
CCCGACACTATGACCGTTTCGGCGGTGTCAGCCCGATTAACGATGCGACGGACGTTTTCGTCAACGCGATTGGGAATGAA
CTGCGCCGTCACGGAGTACGAGTTCCAGTGCTGTTAGGGAACCGCAACGGCACCCCCTTCCTTGAGGAAGCGCTGACTGA
CATGCACGCGCACGGGGTGCGTCGGGTGTTAGCGGTTGTCACCTCTGCCTACGCCAGTTACTCCGGGTGCCGTCAGTATC
GCGAGGAGATCGCGACTGCCCTGGCTCACGCCGGTATCACCGATATGCAGGTCGACAAGGTACCTCCCTTTAACGAGGCG
CCGGGATTCATTCGCGCTAACGCGGAAGCTCTGATGCAGGCGTTTATGCGGATCCCGCCTACTCCTCTTGAGGCTACCCG
CGTCGTTTTCGTCACTCACTCCATCCCTGACTCTATGCAGGACGCATCTGGCGCTGGGCAGCCGGGGACGGATTACATTT
CTCAGCACAAGGCGGTTTGTGAGAGGGTCGCTGGTCAGGTGCGCCAGGTCTTCGGGAATATGCCGCAGTGGGACTTGGCC
TATTGCTCGAGGTCGGGGCGACCCAGCGACCCGTGGCTTGAACCGGACATTATCGATCACCTCCGCAGTCTTCCCGAACA
GGGCGTGCAATCTGTTGTCGTCGCTCCAATTGGCTTCGTTGCTGACCACATGGAGGTCGTTAATGACCTTGATTACGAGG
CCGCCGAGGCAGCTAAGGAGTCCGGGCTCGCCTTCACGCGGGCGGCGACCGCTGGTACCCATTCCGCCTTTATCGCTGAT
CTCGCCGGGCTCATCTTGTCCCAGGCCGCGGCGGCTCGTGGTGAGGGTGGCAATCTAACGTCGTGGCCGGCTCCTTGCGT
CGCCGGTTGTTGCCGACGCTACCCGGACGCTCAGGACATTCCAGCCGTCTCCGGTGGTGATGTCGAGTCCGTAGCTGCCG
GTGCCGATGTAGTCGATGCTGAACCAGGAGGTGTGGATTTTGTGCCAAGCGGCTCAGCGAGTGCAGTCGATCGCCCGGGG
CCAGAGGCGGTCGAACTGGAGACTCCTCCTTCCCCCTACAACCCGTTGACTAAGGAGACCCCCATGTCTGATCATTCGAG
TGCTGATTCGGTGATTGAGGGACCACGCGACGACGAAGTTCCCGCCGGCTCCTACACCGCACCGACCGATCCCCGCGATA
CCCCGGTCATTCCCGAGGAGGTCAACGCCTCCAGCAAGTGGGCGATGTACTCGGTATTCCGCGTCGCGACCGCGCTTCCT
GCCGAGGATGACGAGCGTCGCCGCCTTGTTGAGGGCTCCGACGAGTGGGCGGGACAGTCCGGTGTCGACACCCGAGGATG
GTACGACCTGTCGGGCCTGCGCGCTAACGCCGACCTGCTGGTGTGGTGGGTTAGCGACGATCCGGCGGTGCTGCAGGATG
CCTACCATCGTTTCCGCGCATCTGGGCTGGGGCGCCACCTGGAACCGGTGTGGTCGAACGTAGGAGTTCATCGTCCTGCG
GAGTTCAACAAGTCTCACCTGCCCTCATGCTTTGCCGGCATCGCCCCGAGGCGTTGGGCTGCGTTCTACCCCTTCATTCG
CTCCAAGGAGTGGTACCTCCTTCCGGCGGCTGATCGTTCCCGCATGCTGCGCGAACACGGCATCGTCGGCGCGGCCAGCT
CCGACGTCAAAGCGTCGACGTTGGCGGCATTCGCGCTCGGGGACTACGAGTGGATTCTCGCGTTGGAGGGTGACGACCTC
GCCCGTATTGTCGATGTCATGAAGGACCTTCGTTACGTTGAAGCCCGTCGTTATGTCGACGTGGATACCCCCTTCTTCAC
CGGCGAGCGCGTTTCTCCGGTGGTGTGGGCCGACCGTCAGATGAGAGCCTGA

Upstream 100 bases:

>100_bases
CCAGCTTCGCCAATGCTGACTGCATGACGTGTCCGGTTACCGGCCTGCGGGTGGAGGACCTTGCCACAGATGCGGCACCC
CGAGGTGAGGAGAGGACATC

Downstream 100 bases:

>100_bases
TGACGTCATTGCGTGGTCTGACTGACCCAGTGGGGCCAGAATCTCCGCAAACATATTGGGTGCGCCGACTGATGTTGTTG
GTTGTCGTGGTCGTCGTCGT

Product: ferrochelatase, HemH

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 683; Mature: 682

Protein sequence:

>683_residues
MTANPYAAPTDPLAPYSAVLVVSFGGPRSPEEVMPFLRRVSHGRIPEERLADVARHYDRFGGVSPINDATDVFVNAIGNE
LRRHGVRVPVLLGNRNGTPFLEEALTDMHAHGVRRVLAVVTSAYASYSGCRQYREEIATALAHAGITDMQVDKVPPFNEA
PGFIRANAEALMQAFMRIPPTPLEATRVVFVTHSIPDSMQDASGAGQPGTDYISQHKAVCERVAGQVRQVFGNMPQWDLA
YCSRSGRPSDPWLEPDIIDHLRSLPEQGVQSVVVAPIGFVADHMEVVNDLDYEAAEAAKESGLAFTRAATAGTHSAFIAD
LAGLILSQAAAARGEGGNLTSWPAPCVAGCCRRYPDAQDIPAVSGGDVESVAAGADVVDAEPGGVDFVPSGSASAVDRPG
PEAVELETPPSPYNPLTKETPMSDHSSADSVIEGPRDDEVPAGSYTAPTDPRDTPVIPEEVNASSKWAMYSVFRVATALP
AEDDERRRLVEGSDEWAGQSGVDTRGWYDLSGLRANADLLVWWVSDDPAVLQDAYHRFRASGLGRHLEPVWSNVGVHRPA
EFNKSHLPSCFAGIAPRRWAAFYPFIRSKEWYLLPAADRSRMLREHGIVGAASSDVKASTLAAFALGDYEWILALEGDDL
ARIVDVMKDLRYVEARRYVDVDTPFFTGERVSPVVWADRQMRA

Sequences:

>Translated_683_residues
MTANPYAAPTDPLAPYSAVLVVSFGGPRSPEEVMPFLRRVSHGRIPEERLADVARHYDRFGGVSPINDATDVFVNAIGNE
LRRHGVRVPVLLGNRNGTPFLEEALTDMHAHGVRRVLAVVTSAYASYSGCRQYREEIATALAHAGITDMQVDKVPPFNEA
PGFIRANAEALMQAFMRIPPTPLEATRVVFVTHSIPDSMQDASGAGQPGTDYISQHKAVCERVAGQVRQVFGNMPQWDLA
YCSRSGRPSDPWLEPDIIDHLRSLPEQGVQSVVVAPIGFVADHMEVVNDLDYEAAEAAKESGLAFTRAATAGTHSAFIAD
LAGLILSQAAAARGEGGNLTSWPAPCVAGCCRRYPDAQDIPAVSGGDVESVAAGADVVDAEPGGVDFVPSGSASAVDRPG
PEAVELETPPSPYNPLTKETPMSDHSSADSVIEGPRDDEVPAGSYTAPTDPRDTPVIPEEVNASSKWAMYSVFRVATALP
AEDDERRRLVEGSDEWAGQSGVDTRGWYDLSGLRANADLLVWWVSDDPAVLQDAYHRFRASGLGRHLEPVWSNVGVHRPA
EFNKSHLPSCFAGIAPRRWAAFYPFIRSKEWYLLPAADRSRMLREHGIVGAASSDVKASTLAAFALGDYEWILALEGDDL
ARIVDVMKDLRYVEARRYVDVDTPFFTGERVSPVVWADRQMRA
>Mature_682_residues
TANPYAAPTDPLAPYSAVLVVSFGGPRSPEEVMPFLRRVSHGRIPEERLADVARHYDRFGGVSPINDATDVFVNAIGNEL
RRHGVRVPVLLGNRNGTPFLEEALTDMHAHGVRRVLAVVTSAYASYSGCRQYREEIATALAHAGITDMQVDKVPPFNEAP
GFIRANAEALMQAFMRIPPTPLEATRVVFVTHSIPDSMQDASGAGQPGTDYISQHKAVCERVAGQVRQVFGNMPQWDLAY
CSRSGRPSDPWLEPDIIDHLRSLPEQGVQSVVVAPIGFVADHMEVVNDLDYEAAEAAKESGLAFTRAATAGTHSAFIADL
AGLILSQAAAARGEGGNLTSWPAPCVAGCCRRYPDAQDIPAVSGGDVESVAAGADVVDAEPGGVDFVPSGSASAVDRPGP
EAVELETPPSPYNPLTKETPMSDHSSADSVIEGPRDDEVPAGSYTAPTDPRDTPVIPEEVNASSKWAMYSVFRVATALPA
EDDERRRLVEGSDEWAGQSGVDTRGWYDLSGLRANADLLVWWVSDDPAVLQDAYHRFRASGLGRHLEPVWSNVGVHRPAE
FNKSHLPSCFAGIAPRRWAAFYPFIRSKEWYLLPAADRSRMLREHGIVGAASSDVKASTLAAFALGDYEWILALEGDDLA
RIVDVMKDLRYVEARRYVDVDTPFFTGERVSPVVWADRQMRA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=377, Percent_Identity=22.8116710875332, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI60499025, Length=365, Percent_Identity=22.7397260273973, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17864156, Length=334, Percent_Identity=25.4491017964072, Blast_Score=90, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 74065; Mature: 73934

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANPYAAPTDPLAPYSAVLVVSFGGPRSPEEVMPFLRRVSHGRIPEERLADVARHYDRF
CCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GGVSPINDATDVFVNAIGNELRRHGVRVPVLLGNRNGTPFLEEALTDMHAHGVRRVLAVV
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
TSAYASYSGCRQYREEIATALAHAGITDMQVDKVPPFNEAPGFIRANAEALMQAFMRIPP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHCCC
TPLEATRVVFVTHSIPDSMQDASGAGQPGTDYISQHKAVCERVAGQVRQVFGNMPQWDLA
CCCCCCEEEEEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
YCSRSGRPSDPWLEPDIIDHLRSLPEQGVQSVVVAPIGFVADHMEVVNDLDYEAAEAAKE
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SGLAFTRAATAGTHSAFIADLAGLILSQAAAARGEGGNLTSWPAPCVAGCCRRYPDAQDI
CCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCC
PAVSGGDVESVAAGADVVDAEPGGVDFVPSGSASAVDRPGPEAVELETPPSPYNPLTKET
CCCCCCCHHHHHCCCCEECCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
PMSDHSSADSVIEGPRDDEVPAGSYTAPTDPRDTPVIPEEVNASSKWAMYSVFRVATALP
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCC
AEDDERRRLVEGSDEWAGQSGVDTRGWYDLSGLRANADLLVWWVSDDPAVLQDAYHRFRA
CCCHHHHHHHCCCHHHCCCCCCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
SGLGRHLEPVWSNVGVHRPAEFNKSHLPSCFAGIAPRRWAAFYPFIRSKEWYLLPAADRS
HHCCCHHHHHHHCCCCCCCCCCCHHCCCHHHHCCCCHHHHHHHHHHCCCCEEEEECHHHH
RMLREHGIVGAASSDVKASTLAAFALGDYEWILALEGDDLARIVDVMKDLRYVEARRYVD
HHHHHCCCCCCCCCCCHHHHHHHHEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHEEE
VDTPFFTGERVSPVVWADRQMRA
CCCCCCCCCCCCCEEECCHHCCC
>Mature Secondary Structure 
TANPYAAPTDPLAPYSAVLVVSFGGPRSPEEVMPFLRRVSHGRIPEERLADVARHYDRF
CCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GGVSPINDATDVFVNAIGNELRRHGVRVPVLLGNRNGTPFLEEALTDMHAHGVRRVLAVV
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
TSAYASYSGCRQYREEIATALAHAGITDMQVDKVPPFNEAPGFIRANAEALMQAFMRIPP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHCCC
TPLEATRVVFVTHSIPDSMQDASGAGQPGTDYISQHKAVCERVAGQVRQVFGNMPQWDLA
CCCCCCEEEEEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
YCSRSGRPSDPWLEPDIIDHLRSLPEQGVQSVVVAPIGFVADHMEVVNDLDYEAAEAAKE
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SGLAFTRAATAGTHSAFIADLAGLILSQAAAARGEGGNLTSWPAPCVAGCCRRYPDAQDI
CCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCC
PAVSGGDVESVAAGADVVDAEPGGVDFVPSGSASAVDRPGPEAVELETPPSPYNPLTKET
CCCCCCCHHHHHCCCCEECCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
PMSDHSSADSVIEGPRDDEVPAGSYTAPTDPRDTPVIPEEVNASSKWAMYSVFRVATALP
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCC
AEDDERRRLVEGSDEWAGQSGVDTRGWYDLSGLRANADLLVWWVSDDPAVLQDAYHRFRA
CCCHHHHHHHCCCHHHCCCCCCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
SGLGRHLEPVWSNVGVHRPAEFNKSHLPSCFAGIAPRRWAAFYPFIRSKEWYLLPAADRS
HHCCCHHHHHHHCCCCCCCCCCCHHCCCHHHHCCCCHHHHHHHHHHCCCCEEEEECHHHH
RMLREHGIVGAASSDVKASTLAAFALGDYEWILALEGDDLARIVDVMKDLRYVEARRYVD
HHHHHCCCCCCCCCCCHHHHHHHHEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHEEE
VDTPFFTGERVSPVVWADRQMRA
CCCCCCCCCCCCCEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]