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The map label for this gene is ffh [H]

Identifier: 50365296

GI number: 50365296

Start: 563275

End: 564627

Strand: Reverse

Name: ffh [H]

Synonym: Mfl479

Alternate gene names: 50365296

Gene position: 564627-563275 (Counterclockwise)

Preceding gene: 50365297

Following gene: 50365295

Centisome position: 71.18

GC content: 29.56

Gene sequence:

>1353_bases
ATGGCATTTGGAGATTTTTTAACTAAACGAATGAAAAAATCAATGGAGAAAAATATCAAAAAATCTACATTGACTGATGA
AAACATTCAAGAAACACTTCGTGAGATACGTTTAGCTTTATTAGAAGCTGACGTTAACGTTGAAGTTGTAAAAGAATTAA
TAAGTAAAATAAAAGAAAAAACAGTTGGTGAATATATTCAAGAAGGTGTTACTTCACACCAACAAATGTTGAAAATTGTT
CATGAAGAATTAATTGACATTTTAGGAACTGAAAAAGCACCTTTAAATCTTTCTAAAAAACCTTCTGTTGTTATGATGGT
TGGGTTACAAGGATCAGGGAAAACTACTTCATCATCTAAACTAGCTCATTATTTAGCAAAAAAAGAAGCTAAAAAGCCTT
TACTAGTTGGTTTAGATATTTATAGACCAGGGGCTATTGACCAATTGGTTGAATTAGGAAATAAAAATAACATACCAGTT
TTTGAGCAAGGAAAACAATCACCTTTAAAAACAGCAAAACAAGCATTAGAATTTGCTGAAAAAAATGGACATGATGTTGT
TATTTTAGATACAGCAGGTCGTTTACAAATTGATAAAGATTTAATGAATGAATTAAATGACTTAAGAAAGATTACATCAC
CAAATGAAACTTTATTAGTTGTTGATGGAATGATTGGTCAAGAAATTATTAATGTAACTAATGAATTTAACAATCAATTA
AAATTAACAGGGGTTATTGTAACTAAATTAGATGGGGATGCTCGTGGGGGAGCTACACTATCAATTAGATACATGACTAA
ATTACCAATTAAATTTATTGGTGAAGGAGAAGGAGTTTCAGCTCTTGCTCCATTCTATCCAAAAAGAATGGCTGATAGAA
TTCTTGGAATGGGAGATATTGAAACTCTTTTTGAAAAAGTTGTTGATAATATTGATGAACGTTCAATGCAAAAAACTATG
AAACGTATGTTCATGGGACAATTTGATTTAGAAGATTTAAGAAACCAATTAGTTCAAGTATCTAAAATGGGTAATATTGG
TGGAATTATGAAAATGATGCCAAATGCTAAAATATCAGATAATCAAATTTCAGATGCACAAAGAAAATTAGTTGTATTCT
CAATTTTAATGGATTCAATGACATTAAAAGAAAGAAGAGAACCTAAACTATTAAAATCACTTACTAGAAAAAATAGAATT
ATTAGTGGTTCAGGTCGTACAGAAAAAGAATTAAATGAGTTAATTAACTCATTTGAAAAAGGTAAAAAACAAGTTCTTGA
AATGGCTAAAATGATGAAAAGCGGACGTATGCCAGGAATGCCTGGAATGGGTAAAGGAGGATTTGGTTTTTAA

Upstream 100 bases:

>100_bases
TGTATTAATATATAAATATATTCAAAAATGCCTTGCGGCATTTTTATTTTGAATATTAAGTTTGGTATAATAAATAAAGA
TTAAAACTGGAGGTATGCAT

Downstream 100 bases:

>100_bases
TCAAATCTCATCATGAATATCAAAATAGTTTGTTTTGGTAAATTAGATAAGAAATTCTTTATTGATTCATTTAATGAATA
CGCAAATAGAATATCAAAAT

Product: signal recognition particle (signal binding protein)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MAFGDFLTKRMKKSMEKNIKKSTLTDENIQETLREIRLALLEADVNVEVVKELISKIKEKTVGEYIQEGVTSHQQMLKIV
HEELIDILGTEKAPLNLSKKPSVVMMVGLQGSGKTTSSSKLAHYLAKKEAKKPLLVGLDIYRPGAIDQLVELGNKNNIPV
FEQGKQSPLKTAKQALEFAEKNGHDVVILDTAGRLQIDKDLMNELNDLRKITSPNETLLVVDGMIGQEIINVTNEFNNQL
KLTGVIVTKLDGDARGGATLSIRYMTKLPIKFIGEGEGVSALAPFYPKRMADRILGMGDIETLFEKVVDNIDERSMQKTM
KRMFMGQFDLEDLRNQLVQVSKMGNIGGIMKMMPNAKISDNQISDAQRKLVVFSILMDSMTLKERREPKLLKSLTRKNRI
ISGSGRTEKELNELINSFEKGKKQVLEMAKMMKSGRMPGMPGMGKGGFGF

Sequences:

>Translated_450_residues
MAFGDFLTKRMKKSMEKNIKKSTLTDENIQETLREIRLALLEADVNVEVVKELISKIKEKTVGEYIQEGVTSHQQMLKIV
HEELIDILGTEKAPLNLSKKPSVVMMVGLQGSGKTTSSSKLAHYLAKKEAKKPLLVGLDIYRPGAIDQLVELGNKNNIPV
FEQGKQSPLKTAKQALEFAEKNGHDVVILDTAGRLQIDKDLMNELNDLRKITSPNETLLVVDGMIGQEIINVTNEFNNQL
KLTGVIVTKLDGDARGGATLSIRYMTKLPIKFIGEGEGVSALAPFYPKRMADRILGMGDIETLFEKVVDNIDERSMQKTM
KRMFMGQFDLEDLRNQLVQVSKMGNIGGIMKMMPNAKISDNQISDAQRKLVVFSILMDSMTLKERREPKLLKSLTRKNRI
ISGSGRTEKELNELINSFEKGKKQVLEMAKMMKSGRMPGMPGMGKGGFGF
>Mature_449_residues
AFGDFLTKRMKKSMEKNIKKSTLTDENIQETLREIRLALLEADVNVEVVKELISKIKEKTVGEYIQEGVTSHQQMLKIVH
EELIDILGTEKAPLNLSKKPSVVMMVGLQGSGKTTSSSKLAHYLAKKEAKKPLLVGLDIYRPGAIDQLVELGNKNNIPVF
EQGKQSPLKTAKQALEFAEKNGHDVVILDTAGRLQIDKDLMNELNDLRKITSPNETLLVVDGMIGQEIINVTNEFNNQLK
LTGVIVTKLDGDARGGATLSIRYMTKLPIKFIGEGEGVSALAPFYPKRMADRILGMGDIETLFEKVVDNIDERSMQKTMK
RMFMGQFDLEDLRNQLVQVSKMGNIGGIMKMMPNAKISDNQISDAQRKLVVFSILMDSMTLKERREPKLLKSLTRKNRII
SGSGRTEKELNELINSFEKGKKQVLEMAKMMKSGRMPGMPGMGKGGFGF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=442, Percent_Identity=32.1266968325792, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI226371618, Length=394, Percent_Identity=31.9796954314721, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI23308697, Length=293, Percent_Identity=26.6211604095563, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI295424842, Length=293, Percent_Identity=26.6211604095563, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI89061728, Length=148, Percent_Identity=34.4594594594595, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1788963, Length=451, Percent_Identity=41.4634146341463, Blast_Score=334, Evalue=8e-93,
Organism=Escherichia coli, GI1789874, Length=252, Percent_Identity=34.9206349206349, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=423, Percent_Identity=31.2056737588652, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=287, Percent_Identity=27.5261324041812, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=431, Percent_Identity=33.6426914153132, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=339, Percent_Identity=25.6637168141593, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17647949, Length=427, Percent_Identity=31.3817330210773, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24641198, Length=294, Percent_Identity=25.5102040816327, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50250; Mature: 50119

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFGDFLTKRMKKSMEKNIKKSTLTDENIQETLREIRLALLEADVNVEVVKELISKIKEK
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TVGEYIQEGVTSHQQMLKIVHEELIDILGTEKAPLNLSKKPSVVMMVGLQGSGKTTSSSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHH
LAHYLAKKEAKKPLLVGLDIYRPGAIDQLVELGNKNNIPVFEQGKQSPLKTAKQALEFAE
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KNGHDVVILDTAGRLQIDKDLMNELNDLRKITSPNETLLVVDGMIGQEIINVTNEFNNQL
CCCCEEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCEE
KLTGVIVTKLDGDARGGATLSIRYMTKLPIKFIGEGEGVSALAPFYPKRMADRILGMGDI
EEEEEEEEEECCCCCCCCEEEEEEEECCCHHEECCCCCCCHHCCHHHHHHHHHHCCCCCH
ETLFEKVVDNIDERSMQKTMKRMFMGQFDLEDLRNQLVQVSKMGNIGGIMKMMPNAKISD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
NQISDAQRKLVVFSILMDSMTLKERREPKLLKSLTRKNRIISGSGRTEKELNELINSFEK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHH
GKKQVLEMAKMMKSGRMPGMPGMGKGGFGF
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AFGDFLTKRMKKSMEKNIKKSTLTDENIQETLREIRLALLEADVNVEVVKELISKIKEK
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TVGEYIQEGVTSHQQMLKIVHEELIDILGTEKAPLNLSKKPSVVMMVGLQGSGKTTSSSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHH
LAHYLAKKEAKKPLLVGLDIYRPGAIDQLVELGNKNNIPVFEQGKQSPLKTAKQALEFAE
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KNGHDVVILDTAGRLQIDKDLMNELNDLRKITSPNETLLVVDGMIGQEIINVTNEFNNQL
CCCCEEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCEE
KLTGVIVTKLDGDARGGATLSIRYMTKLPIKFIGEGEGVSALAPFYPKRMADRILGMGDI
EEEEEEEEEECCCCCCCCEEEEEEEECCCHHEECCCCCCCHHCCHHHHHHHHHHCCCCCH
ETLFEKVVDNIDERSMQKTMKRMFMGQFDLEDLRNQLVQVSKMGNIGGIMKMMPNAKISD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
NQISDAQRKLVVFSILMDSMTLKERREPKLLKSLTRKNRIISGSGRTEKELNELINSFEK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHH
GKKQVLEMAKMMKSGRMPGMPGMGKGGFGF
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1280809 [H]