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The map label for this gene is guaC [H]

Identifier: 50364986

GI number: 50364986

Start: 199471

End: 200433

Strand: Direct

Name: guaC [H]

Synonym: Mfl170

Alternate gene names: 50364986

Gene position: 199471-200433 (Clockwise)

Preceding gene: 50364985

Following gene: 50364987

Centisome position: 25.15

GC content: 30.11

Gene sequence:

>963_bases
ATGTACGCTTTTGATTATGAAGATATTCAACTTATACCAAACATGTGTGTTGTAAATTCAAGGAGTGAATGTAACACTTC
TGTAACACTAGGGAAACATACTTTTAAAATGCCTGTTGTTCCCGCAAATATGGCAACAGTTATAAATGAAGAATTGTCTA
TTATGTTAGCAGAAAAAAACTATTTTTATGTAATGCATAGATTTGATTTTGATGCTGTTTCATTTATAAAAAAAATGAAA
GAAAAGAAATTAATATCATCAATTAGTGTTGGTGTTAAAGAACAAGATTTTAAAATGATTAATGAATTAACTGAATTAAA
CTTAATACCAGATTATATAACTATTGATATTGCTCATGGACATGCAAATAGTGTAAAAGAAATGATTGAACACATTAGAA
CTAAAATGGGAGATCAAACTTTTATTATTGCTGGTAATGTTGCAACTCCACAAGCAGTAAGAGATTTAGAACATTGAGGA
GCAGATGCAACAAAAGTTGGTGTAGGTCCAGGTAAAGTTTGCATCACTAAATTAAAAACAGGTTTTGGAACAGGTGGATG
ACAACTTGGAGCAATTAAATGATGTAGTAAAGCTGCAACAAAGCCAATCATTGCAGACGGTGGTTTAAGAGTTAATGGTG
ATATTGCTAAATCAATTAGATTTGGAGCAACAATGTGCATGATAGGAAGTTTATTTGCGGCTCATGAAGAATCACCAGGA
AAAAATGTAACAGTTGATAATGTTTTATTTAAAGAGTATTATGGAAGTGCAAGTGAATATAACAAAGGTGAAAAAAGATA
CGTAGAAGGGAAAAAGGAACTTATTAAAGTACGTGGAAAATTAATGGACACTTACAAAGAAATGGAAGAAGATTTACAAT
CATCTATTTCATATGCAGGTGGTAAAACATTAAAAGCTATTAAAAAAGTAGACTACGTAATTTTAAAAACAAGTAACTTT
TAA

Upstream 100 bases:

>100_bases
TTAAATAGTGGGTAAATCATATATATTAGAAATACTTATTTTGTAAAAAATAGGTATTTTTATTTATAATAGAACTATAG
AGAATTTAAGAGGAAAAAAT

Downstream 100 bases:

>100_bases
TTTTAAAAATGAATAATTTAACAAATAGTGAAAGATTAAATGAAAATATAAAAGTAATTACAAAACAAAAATTAAGTATT
AAAGAAATAGCAACTATATT

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MYAFDYEDIQLIPNMCVVNSRSECNTSVTLGKHTFKMPVVPANMATVINEELSIMLAEKNYFYVMHRFDFDAVSFIKKMK
EKKLISSISVGVKEQDFKMINELTELNLIPDYITIDIAHGHANSVKEMIEHIRTKMGDQTFIIAGNVATPQAVRDLEHWG
ADATKVGVGPGKVCITKLKTGFGTGGWQLGAIKWCSKAATKPIIADGGLRVNGDIAKSIRFGATMCMIGSLFAAHEESPG
KNVTVDNVLFKEYYGSASEYNKGEKRYVEGKKELIKVRGKLMDTYKEMEEDLQSSISYAGGKTLKAIKKVDYVILKTSNF

Sequences:

>Translated_320_residues
MYAFDYEDIQLIPNMCVVNSRSECNTSVTLGKHTFKMPVVPANMATVINEELSIMLAEKNYFYVMHRFDFDAVSFIKKMK
EKKLISSISVGVKEQDFKMINELTELNLIPDYITIDIAHGHANSVKEMIEHIRTKMGDQTFIIAGNVATPQAVRDLEH*G
ADATKVGVGPGKVCITKLKTGFGTGG*QLGAIK*CSKAATKPIIADGGLRVNGDIAKSIRFGATMCMIGSLFAAHEESPG
KNVTVDNVLFKEYYGSASEYNKGEKRYVEGKKELIKVRGKLMDTYKEMEEDLQSSISYAGGKTLKAIKKVDYVILKTSNF
>Mature_320_residues
MYAFDYEDIQLIPNMCVVNSRSECNTSVTLGKHTFKMPVVPANMATVINEELSIMLAEKNYFYVMHRFDFDAVSFIKKMK
EKKLISSISVGVKEQDFKMINELTELNLIPDYITIDIAHGHANSVKEMIEHIRTKMGDQTFIIAGNVATPQAVRDLEH*G
ADATKVGVGPGKVCITKLKTGFGTGG*QLGAIK*CSKAATKPIIADGGLRVNGDIAKSIRFGATMCMIGSLFAAHEESPG
KNVTVDNVLFKEYYGSASEYNKGEKRYVEGKKELIKVRGKLMDTYKEMEEDLQSSISYAGGKTLKAIKKVDYVILKTSNF

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=322, Percent_Identity=31.055900621118, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI50541954, Length=322, Percent_Identity=31.055900621118, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI50541952, Length=322, Percent_Identity=31.055900621118, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI50541948, Length=322, Percent_Identity=31.055900621118, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI156104880, Length=321, Percent_Identity=30.2180685358255, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI217035148, Length=215, Percent_Identity=32.5581395348837, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI217035150, Length=215, Percent_Identity=32.5581395348837, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI217035146, Length=215, Percent_Identity=32.5581395348837, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI156616279, Length=215, Percent_Identity=32.5581395348837, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI34328928, Length=215, Percent_Identity=32.5581395348837, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI34328930, Length=215, Percent_Identity=32.5581395348837, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI217035152, Length=215, Percent_Identity=32.5581395348837, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI66933016, Length=250, Percent_Identity=28, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1786293, Length=322, Percent_Identity=30.7453416149068, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788855, Length=220, Percent_Identity=35, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560440, Length=323, Percent_Identity=31.8885448916409, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71994385, Length=259, Percent_Identity=27.7992277992278, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994389, Length=207, Percent_Identity=28.9855072463768, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323585, Length=183, Percent_Identity=31.6939890710383, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323464, Length=183, Percent_Identity=31.1475409836066, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322012, Length=187, Percent_Identity=28.3422459893048, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641071, Length=254, Percent_Identity=27.5590551181102, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641073, Length=254, Percent_Identity=27.5590551181102, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571163, Length=254, Percent_Identity=27.5590551181102, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 34973; Mature: 34973

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYAFDYEDIQLIPNMCVVNSRSECNTSVTLGKHTFKMPVVPANMATVINEELSIMLAEKN
CCCCCCCHHHHCCCEEEECCCCCCCCEEEECCEEEECCCCCCHHHHHHHHCEEEEEECCC
YFYVMHRFDFDAVSFIKKMKEKKLISSISVGVKEQDFKMINELTELNLIPDYITIDIAHG
EEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEECC
HANSVKEMIEHIRTKMGDQTFIIAGNVATPQAVRDLEHGADATKVGVGPGKVCITKLKTG
CHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCHHHHEEHHCC
FGTGGQLGAIKCSKAATKPIIADGGLRVNGDIAKSIRFGATMCMIGSLFAAHEESPGKNV
CCCCCCCCEEEECCCCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TVDNVLFKEYYGSASEYNKGEKRYVEGKKELIKVRGKLMDTYKEMEEDLQSSISYAGGKT
CHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LKAIKKVDYVILKTSNF
HHHHHHCCEEEEEECCC
>Mature Secondary Structure
MYAFDYEDIQLIPNMCVVNSRSECNTSVTLGKHTFKMPVVPANMATVINEELSIMLAEKN
CCCCCCCHHHHCCCEEEECCCCCCCCEEEECCEEEECCCCCCHHHHHHHHCEEEEEECCC
YFYVMHRFDFDAVSFIKKMKEKKLISSISVGVKEQDFKMINELTELNLIPDYITIDIAHG
EEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEECC
HANSVKEMIEHIRTKMGDQTFIIAGNVATPQAVRDLEHGADATKVGVGPGKVCITKLKTG
CHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCHHHHEEHHCC
FGTGGQLGAIKCSKAATKPIIADGGLRVNGDIAKSIRFGATMCMIGSLFAAHEESPGKNV
CCCCCCCCEEEECCCCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TVDNVLFKEYYGSASEYNKGEKRYVEGKKELIKVRGKLMDTYKEMEEDLQSSISYAGGKT
CHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LKAIKKVDYVILKTSNF
HHHHHHCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA