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The map label for this gene is tkt [H]

Identifier: 50085168

GI number: 50085168

Start: 2024042

End: 2026030

Strand: Reverse

Name: tkt [H]

Synonym: ACIAD2035

Alternate gene names: 50085168

Gene position: 2026030-2024042 (Counterclockwise)

Preceding gene: 50085170

Following gene: 50085167

Centisome position: 56.3

GC content: 43.64

Gene sequence:

>1989_bases
ATGACGACCCCTTTAAACGAACGTCGTATTGCAAACGCAATTCGTGTATTGGCTATGGATGCTGTGCAACAAGCAAACTC
AGGGCATCCTGGTGCTCCAATGGGGATGGCAGATATTGCTGATGTGGTTTGGCGTGAATTTCTAAATCACAATCCAACAA
ATCCACAATGGGCGAATCGTGACCGTTTTGTGCTTTCTAATGGTCATGGTTCAATGCTGCATTATGCATTACTTCATTTA
AGTGGTTATGATCTTTCCATTGAAGACCTTAAGCAGTTCCGTCAGCTGCATTCAAAAACACCAGGTCATCCAGAGCTAGG
TTATGCGCCAGGTATTGAAACAACAACAGGTCCATTGGGTCAAGGGATCGCAAATGCTATAGGTTTTGCTTTGGCAGAAA
GAACCTTGGCAGCTCAATTTAATAAAGATGATTTGAAAGTCGTTGATCATTATACTTACTGTTTCCTGGGCGATGGTTGC
TTGATGGAAGGTATTTCTCACGAAGTATGTTCACTGGCAGGTACGTTAGGTCTAGGTAAGTTGATTGCTTATTATGATGA
TAATGGCATTTCAATTGATGGCGAAGTTGAAGGCTGGTTCAGTGATGACACTGAACAACGTTTTAAAGCATATGGCTGGC
AAGTTCTGCGTGTAGATGGTCATGACACAGATGCGATTCGTCAGGCGACTGTTGAAGCAAAAGCACAAACTGCTCAGCCA
ACGATCATTATTTGTAAGACGATTATCGGTTTAGGTTCGCCAAACAAACAGGGTAAAGAAGATTGTCATGGTGCTCCATT
GGGTACAGATGAAATCAAACTTACTCGTGAAGCACTAGGCTGGGAAGAAGAAGCATTTGTTATTCCAAAAGATGTTTATT
CTGCTTGGAATGCAAAAGATAAGGGGCAAGCTGCAGAGTCTGCATGGAATGATGTATTTGCTCAGTATCAAGCGAAGTAT
CCGTCAGAAGCAGCAGAATTACTCCGCCGTGTTCAAGGCGACTTGCCTGCAGAATTTCTTGCGCAAGCAGATGCCTTTAT
TGCTGAAACCAATGCAAAAGCTGAAACAATTGCAACGCGTAAAGCAAGCCAAAATACTTTACAGGCATTTGGTCCTTTAT
TACCAGAATTGCTTGGTGGTTCGGCAGATCTTGCTGGTTCCAACCTAACACTTTGGAAAGGGTGTGAAGGCGTACAGGAT
AATCCAGCGGGTAACTATGTGTACTACGGTGTACGTGAGTTTGGTATGACTGCCATCGCCAATGGTGTTGCATTGCATGG
CGGTTTTATTCCTTACGTTGCGACTTTCTTAATGTTTATGGAATATGCGCGTAATGCAGTACGTATGTCTGCCTTAATGA
AACAGCGTGTAATTCACGTATATACGCATGATTCAATTGGTTTAGGCGAAGATGGCCCAACGCATCAACCCATTGAACAG
ATTGCTTCATTGCGTGGTACGCCAAACCTCAACACATGGCGTCCAGCCGATACGGTAGAAACAGCGATTGCATGGAAATC
TGCGCTTGAGCGTAAAGATGGTCCAACAGCGCTGATCTTGTCTCGTCAGAATTTGCCATTCCAATCACGTTCTGAAGCTC
AAATTCAGGATGCTGCAAAAGGTGGTTATGTTTTGGCTCAAGAAAAGGGTGAGTTAAAAGCAATTATTATCGCGACTGGA
TCTGAAATTTCAGTGGCAATGGATGCTTATGTACAGCTTGAAGGTGTACGTGTGGTATCGATGCCGTGTGCTGAAGAGTT
TATGAAACAAGATGCAGCATATCGTGAGTCAGTATTGCCTTCACAGATTCGTGCTCGTGTTGCTGTAGAAGCTGCTCACG
TCGATTACTGGTGGAAGTTTGTTGGTTTAGACGGTAAAGTCATTGGTATGACAACGTATGGCGAATCTGCCCCAGCGAAA
GACTTGTTTAAGCATTTTGGTATTACCAGTGATGCAGTTGTAGAAGCAGTGAAGAGTCTAACAGCTTAA

Upstream 100 bases:

>100_bases
TCTAGGCTTTACCCATCACACTTTTTTTAAGACAATAGACGCTGTTTGAATTCTGATTCATTTTCTTCTTCCTAATCAGC
TTTAATTTGGATACTGATCT

Downstream 100 bases:

>100_bases
TTGTTTTTATATAAAAAAGCCCTTTAAAGGGCTTTTTTATATTTTACCCTTTAGATTCGATGTTGAATAAATGTTGTTTT
TTGTGGATTTCCTGTCTAAA

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MTTPLNERRIANAIRVLAMDAVQQANSGHPGAPMGMADIADVVWREFLNHNPTNPQWANRDRFVLSNGHGSMLHYALLHL
SGYDLSIEDLKQFRQLHSKTPGHPELGYAPGIETTTGPLGQGIANAIGFALAERTLAAQFNKDDLKVVDHYTYCFLGDGC
LMEGISHEVCSLAGTLGLGKLIAYYDDNGISIDGEVEGWFSDDTEQRFKAYGWQVLRVDGHDTDAIRQATVEAKAQTAQP
TIIICKTIIGLGSPNKQGKEDCHGAPLGTDEIKLTREALGWEEEAFVIPKDVYSAWNAKDKGQAAESAWNDVFAQYQAKY
PSEAAELLRRVQGDLPAEFLAQADAFIAETNAKAETIATRKASQNTLQAFGPLLPELLGGSADLAGSNLTLWKGCEGVQD
NPAGNYVYYGVREFGMTAIANGVALHGGFIPYVATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIGLGEDGPTHQPIEQ
IASLRGTPNLNTWRPADTVETAIAWKSALERKDGPTALILSRQNLPFQSRSEAQIQDAAKGGYVLAQEKGELKAIIIATG
SEISVAMDAYVQLEGVRVVSMPCAEEFMKQDAAYRESVLPSQIRARVAVEAAHVDYWWKFVGLDGKVIGMTTYGESAPAK
DLFKHFGITSDAVVEAVKSLTA

Sequences:

>Translated_662_residues
MTTPLNERRIANAIRVLAMDAVQQANSGHPGAPMGMADIADVVWREFLNHNPTNPQWANRDRFVLSNGHGSMLHYALLHL
SGYDLSIEDLKQFRQLHSKTPGHPELGYAPGIETTTGPLGQGIANAIGFALAERTLAAQFNKDDLKVVDHYTYCFLGDGC
LMEGISHEVCSLAGTLGLGKLIAYYDDNGISIDGEVEGWFSDDTEQRFKAYGWQVLRVDGHDTDAIRQATVEAKAQTAQP
TIIICKTIIGLGSPNKQGKEDCHGAPLGTDEIKLTREALGWEEEAFVIPKDVYSAWNAKDKGQAAESAWNDVFAQYQAKY
PSEAAELLRRVQGDLPAEFLAQADAFIAETNAKAETIATRKASQNTLQAFGPLLPELLGGSADLAGSNLTLWKGCEGVQD
NPAGNYVYYGVREFGMTAIANGVALHGGFIPYVATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIGLGEDGPTHQPIEQ
IASLRGTPNLNTWRPADTVETAIAWKSALERKDGPTALILSRQNLPFQSRSEAQIQDAAKGGYVLAQEKGELKAIIIATG
SEISVAMDAYVQLEGVRVVSMPCAEEFMKQDAAYRESVLPSQIRARVAVEAAHVDYWWKFVGLDGKVIGMTTYGESAPAK
DLFKHFGITSDAVVEAVKSLTA
>Mature_661_residues
TTPLNERRIANAIRVLAMDAVQQANSGHPGAPMGMADIADVVWREFLNHNPTNPQWANRDRFVLSNGHGSMLHYALLHLS
GYDLSIEDLKQFRQLHSKTPGHPELGYAPGIETTTGPLGQGIANAIGFALAERTLAAQFNKDDLKVVDHYTYCFLGDGCL
MEGISHEVCSLAGTLGLGKLIAYYDDNGISIDGEVEGWFSDDTEQRFKAYGWQVLRVDGHDTDAIRQATVEAKAQTAQPT
IIICKTIIGLGSPNKQGKEDCHGAPLGTDEIKLTREALGWEEEAFVIPKDVYSAWNAKDKGQAAESAWNDVFAQYQAKYP
SEAAELLRRVQGDLPAEFLAQADAFIAETNAKAETIATRKASQNTLQAFGPLLPELLGGSADLAGSNLTLWKGCEGVQDN
PAGNYVYYGVREFGMTAIANGVALHGGFIPYVATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIGLGEDGPTHQPIEQI
ASLRGTPNLNTWRPADTVETAIAWKSALERKDGPTALILSRQNLPFQSRSEAQIQDAAKGGYVLAQEKGELKAIIIATGS
EISVAMDAYVQLEGVRVVSMPCAEEFMKQDAAYRESVLPSQIRARVAVEAAHVDYWWKFVGLDGKVIGMTTYGESAPAKD
LFKHFGITSDAVVEAVKSLTA

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=664, Percent_Identity=25.6024096385542, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI4507521, Length=664, Percent_Identity=25.6024096385542, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI133778974, Length=499, Percent_Identity=26.25250501002, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI225637459, Length=259, Percent_Identity=24.7104247104247, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI225637463, Length=157, Percent_Identity=29.2993630573248, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI225637461, Length=157, Percent_Identity=29.2993630573248, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI48994911, Length=660, Percent_Identity=67.4242424242424, Blast_Score=954, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=655, Percent_Identity=63.8167938931298, Blast_Score=907, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=574, Percent_Identity=24.7386759581882, Blast_Score=156, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=672, Percent_Identity=47.4702380952381, Blast_Score=582, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6319593, Length=664, Percent_Identity=44.2771084337349, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45551847, Length=683, Percent_Identity=26.207906295754, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI45550715, Length=683, Percent_Identity=26.207906295754, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24666278, Length=514, Percent_Identity=25.875486381323, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24645119, Length=649, Percent_Identity=26.040061633282, Blast_Score=139, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72086; Mature: 71955

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLNERRIANAIRVLAMDAVQQANSGHPGAPMGMADIADVVWREFLNHNPTNPQWANR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
DRFVLSNGHGSMLHYALLHLSGYDLSIEDLKQFRQLHSKTPGHPELGYAPGIETTTGPLG
CEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
QGIANAIGFALAERTLAAQFNKDDLKVVDHYTYCFLGDGCLMEGISHEVCSLAGTLGLGK
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCHHH
LIAYYDDNGISIDGEVEGWFSDDTEQRFKAYGWQVLRVDGHDTDAIRQATVEAKAQTAQP
EEEEECCCCEEECCCCCCCCCCCHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHCCCC
TIIICKTIIGLGSPNKQGKEDCHGAPLGTDEIKLTREALGWEEEAFVIPKDVYSAWNAKD
CEEEEHHHHCCCCCCCCCCHHCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHCCCCC
KGQAAESAWNDVFAQYQAKYPSEAAELLRRVQGDLPAEFLAQADAFIAETNAKAETIATR
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHH
KASQNTLQAFGPLLPELLGGSADLAGSNLTLWKGCEGVQDNPAGNYVYYGVREFGMTAIA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHH
NGVALHGGFIPYVATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIGLGEDGPTHQPIEQ
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCHHHHHH
IASLRGTPNLNTWRPADTVETAIAWKSALERKDGPTALILSRQNLPFQSRSEAQIQDAAK
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHCC
GGYVLAQEKGELKAIIIATGSEISVAMDAYVQLEGVRVVSMPCAEEFMKQDAAYRESVLP
CCEEEEECCCCEEEEEEEECCCEEEEEEEEEEECCEEEEECHHHHHHHHHHHHHHHHCCH
SQIRARVAVEAAHVDYWWKFVGLDGKVIGMTTYGESAPAKDLFKHFGITSDAVVEAVKSL
HHHHHHHHHHHHHHEEEEEEECCCCEEEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHH
TA
CC
>Mature Secondary Structure 
TTPLNERRIANAIRVLAMDAVQQANSGHPGAPMGMADIADVVWREFLNHNPTNPQWANR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
DRFVLSNGHGSMLHYALLHLSGYDLSIEDLKQFRQLHSKTPGHPELGYAPGIETTTGPLG
CEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
QGIANAIGFALAERTLAAQFNKDDLKVVDHYTYCFLGDGCLMEGISHEVCSLAGTLGLGK
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCHHH
LIAYYDDNGISIDGEVEGWFSDDTEQRFKAYGWQVLRVDGHDTDAIRQATVEAKAQTAQP
EEEEECCCCEEECCCCCCCCCCCHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHCCCC
TIIICKTIIGLGSPNKQGKEDCHGAPLGTDEIKLTREALGWEEEAFVIPKDVYSAWNAKD
CEEEEHHHHCCCCCCCCCCHHCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHCCCCC
KGQAAESAWNDVFAQYQAKYPSEAAELLRRVQGDLPAEFLAQADAFIAETNAKAETIATR
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHH
KASQNTLQAFGPLLPELLGGSADLAGSNLTLWKGCEGVQDNPAGNYVYYGVREFGMTAIA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHH
NGVALHGGFIPYVATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIGLGEDGPTHQPIEQ
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCHHHHHH
IASLRGTPNLNTWRPADTVETAIAWKSALERKDGPTALILSRQNLPFQSRSEAQIQDAAK
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHCC
GGYVLAQEKGELKAIIIATGSEISVAMDAYVQLEGVRVVSMPCAEEFMKQDAAYRESVLP
CCEEEEECCCCEEEEEEEECCCEEEEEEEEEEECCEEEEECHHHHHHHHHHHHHHHHCCH
SQIRARVAVEAAHVDYWWKFVGLDGKVIGMTTYGESAPAKDLFKHFGITSDAVVEAVKSL
HHHHHHHHHHHHHHEEEEEEECCCCEEEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHH
TA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]