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The map label for this gene is kdsA

Identifier: 50085137

GI number: 50085137

Start: 1992734

End: 1993591

Strand: Reverse

Name: kdsA

Synonym: ACIAD2002

Alternate gene names: 50085137

Gene position: 1993591-1992734 (Counterclockwise)

Preceding gene: 50085138

Following gene: 50085136

Centisome position: 55.4

GC content: 41.84

Gene sequence:

>858_bases
ATGTCACAATTAAAACCCCAAGAGATTGTACGTTTAGGCGATATACAAATGGCAAATCATTTGCCATTTGTATTATTTGG
CGGAATGAATGTACTTGAGTCGAAAGATCTTGCATTTGAAATTGCAGAAACCTATGTAGATATCTGCAAACGCCTTGAAA
TCCCTTACGTTTTCAAAGCAAGTTTTGATAAAGCAAACCGTTCAAGCCTACATTCGTTTCGTGGTCCTGGCCTCGAAAAA
GGCATTGAATGGCTCGGTGAAATTAAAAAACATTTTAATGTTCCAATTATTACCGATGTGCATGAACCGTATCAGGCTGC
TCCTGTTGCAGAGGTTGCCGATATTATTCAATTGCCTGCATTTTTGAGCCGTCAAACGGATCTGGTTGAGGCAATGGCAA
AAACTCAAGCCATTATTAATATTAAAAAAGCACAATTCTTGTCGCCGCGTGAAATGAATCATATCTTGAACAAGTGTCTT
GAAGCGGGCAATGACAAGCTGATTTTATGTGAGCGTGGAACCTCTTTTGGCTACAACAATCTTGTGGTCGATATGCTTGG
TTTTGACACCATGAAAGAGATGAATGTGCCGGTATTCTTTGATGTCACGCATGCACTTCAAACACCTGGTGGTCGAGCTG
ACTCGGCAGGTGGACGCCGTGCACAAATTACGACATTAGCTCGCGCAGGGATGGCGACTGGATTGGCTGGATTGTTCTTG
GAAGCACATCCTGATCCTGAAAAAGCCAAATGTGATGGTCCTTGTGCGTTACGCCTATCACAGCTTGAGCCGTTCTTGGC
ACAATTAAAAGAATTGGATGCTTTAGTTAAAGGATTCAAAAAGTTAGATACTCATTGA

Upstream 100 bases:

>100_bases
GCCACGTGATGGACATCCATTATTTGCTAGCTTTATCGATGCTGCGAAAAAACAGCACCTTAAAACGAAATAATACGACG
CATAAACTAGGACTGTTTAA

Downstream 100 bases:

>100_bases
TGCAAATGATTGCATCTTATTTTTCATTCAATTGAGGAATTGTTCATGAGCCAAATCGTTGACATTCGTGCACGTGAAAT
TTTGGACTCTCGTGGTAACC

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSQLKPQEIVRLGDIQMANHLPFVLFGGMNVLESKDLAFEIAETYVDICKRLEIPYVFKASFDKANRSSLHSFRGPGLEK
GIEWLGEIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLSPREMNHILNKCL
EAGNDKLILCERGTSFGYNNLVVDMLGFDTMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFL
EAHPDPEKAKCDGPCALRLSQLEPFLAQLKELDALVKGFKKLDTH

Sequences:

>Translated_285_residues
MSQLKPQEIVRLGDIQMANHLPFVLFGGMNVLESKDLAFEIAETYVDICKRLEIPYVFKASFDKANRSSLHSFRGPGLEK
GIEWLGEIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLSPREMNHILNKCL
EAGNDKLILCERGTSFGYNNLVVDMLGFDTMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFL
EAHPDPEKAKCDGPCALRLSQLEPFLAQLKELDALVKGFKKLDTH
>Mature_284_residues
SQLKPQEIVRLGDIQMANHLPFVLFGGMNVLESKDLAFEIAETYVDICKRLEIPYVFKASFDKANRSSLHSFRGPGLEKG
IEWLGEIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLSPREMNHILNKCLE
AGNDKLILCERGTSFGYNNLVVDMLGFDTMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFLE
AHPDPEKAKCDGPCALRLSQLEPFLAQLKELDALVKGFKKLDTH

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=280, Percent_Identity=67.5, Blast_Score=394, Evalue=1e-111,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_ACIAD (Q6FAT8)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_046647.1
- ProteinModelPortal:   Q6FAT8
- SMR:   Q6FAT8
- STRING:   Q6FAT8
- GeneID:   2879978
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2002
- NMPDR:   fig|62977.3.peg.1909
- eggNOG:   COG2877
- HOGENOM:   HBG575990
- OMA:   VHEPHQA
- PhylomeDB:   Q6FAT8
- ProtClustDB:   PRK05198
- BioCyc:   ASP62977:ACIAD2002-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 31534; Mature: 31403

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLKPQEIVRLGDIQMANHLPFVLFGGMNVLESKDLAFEIAETYVDICKRLEIPYVFKA
CCCCCHHHHHHHCCCHHHCCCCEEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEC
SFDKANRSSLHSFRGPGLEKGIEWLGEIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPA
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHCCCHHHHHHHHHHHH
FLSRQTDLVEAMAKTQAIINIKKAQFLSPREMNHILNKCLEAGNDKLILCERGTSFGYNN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCH
LVVDMLGFDTMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFL
HHHHHHCCHHHHHCCCCEEEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHE
EAHPDPEKAKCDGPCALRLSQLEPFLAQLKELDALVKGFKKLDTH
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQLKPQEIVRLGDIQMANHLPFVLFGGMNVLESKDLAFEIAETYVDICKRLEIPYVFKA
CCCCHHHHHHHCCCHHHCCCCEEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEC
SFDKANRSSLHSFRGPGLEKGIEWLGEIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPA
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHCCCHHHHHHHHHHHH
FLSRQTDLVEAMAKTQAIINIKKAQFLSPREMNHILNKCLEAGNDKLILCERGTSFGYNN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCH
LVVDMLGFDTMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFL
HHHHHHCCHHHHHCCCCEEEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHE
EAHPDPEKAKCDGPCALRLSQLEPFLAQLKELDALVKGFKKLDTH
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA