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The map label for this gene is map [H]

Identifier: 50085124

GI number: 50085124

Start: 1977554

End: 1978351

Strand: Reverse

Name: map [H]

Synonym: ACIAD1987

Alternate gene names: 50085124

Gene position: 1978351-1977554 (Counterclockwise)

Preceding gene: 50085131

Following gene: 50085123

Centisome position: 54.98

GC content: 39.97

Gene sequence:

>798_bases
ATGCGAGCATCAACCGTCACAATTAAAAATGAACAAGATATAGAACATTTACGTGTATCTGGACGTTTGGCGGCTCAGGT
TTTGGAAATGATTATTCCATATGTAAAACCTGGTGTATCTACGGAATATTTAGATGATATTTGCCATGAATTTATTGTTG
ATACATTAAAAGTAATTCCTGCAAATGTTGGATATCATGGTTTTACAAAAACGACCTGTACTTCGGTGAATGAAGTGGTG
TGTCATGGTATACCATCACCCAATAAAATTTTACAGGATGGCGATATACTCAATATTGATGTTGCGATTATCAAGGACGG
TTATTTTGGTGATACTAGTCGAATGTATCTGGTTGGAGAGGTTGCTCCAGAAGCCAAAAAACTAGTTAAAACCACTTATG
AGGCGATGCTTGCAGGCATTCAGGTGGTTAAACCAGGTGCAACATTGGGTGATATTGGTCATGCCATTCAAACCACAGCT
CAGCGTGAAGGTTATAGCATTGTCAAGGAGTACTGTGGTCATGGTATTGGTAAAGTTTATCATGAGCAGCCAAACATTCT
TCACTATGGTCAACCTGGGCATGGCATGGTGCTTGAAAAGGGAATGGTTTTTACCATTGAACCAATGGTGAATGCTGGAA
AATCACAAGTAAAAGAGTTAAATGATGGCTGGACAGTGGTCACTACCGACAAATCTTTATCTGCGCAGTGGGAGCATATG
GTCGCAGTAACAGAAACGGGTTTTGAATTACTCACGCCTTGGCCTACTGGTACAGGTGAATACCCAGAAATTATTTAA

Upstream 100 bases:

>100_bases
CATTTTTTCGAATTCATCAAACCTATGAAAAAGGCTTGATTGATTGTACGTATGATTTTTAAAAATAGTATAATGTGATT
TGGTCAATGAGGATAATTTC

Downstream 100 bases:

>100_bases
TGTGTATGTGCTGCAACTATGTTTTGTTTAACTTAAATTGAGATATCATGAGTTGAATTTTTAATCATTTGTGTAGCCAG
AATCATTAAGCTTCATAACA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MRASTVTIKNEQDIEHLRVSGRLAAQVLEMIIPYVKPGVSTEYLDDICHEFIVDTLKVIPANVGYHGFTKTTCTSVNEVV
CHGIPSPNKILQDGDILNIDVAIIKDGYFGDTSRMYLVGEVAPEAKKLVKTTYEAMLAGIQVVKPGATLGDIGHAIQTTA
QREGYSIVKEYCGHGIGKVYHEQPNILHYGQPGHGMVLEKGMVFTIEPMVNAGKSQVKELNDGWTVVTTDKSLSAQWEHM
VAVTETGFELLTPWPTGTGEYPEII

Sequences:

>Translated_265_residues
MRASTVTIKNEQDIEHLRVSGRLAAQVLEMIIPYVKPGVSTEYLDDICHEFIVDTLKVIPANVGYHGFTKTTCTSVNEVV
CHGIPSPNKILQDGDILNIDVAIIKDGYFGDTSRMYLVGEVAPEAKKLVKTTYEAMLAGIQVVKPGATLGDIGHAIQTTA
QREGYSIVKEYCGHGIGKVYHEQPNILHYGQPGHGMVLEKGMVFTIEPMVNAGKSQVKELNDGWTVVTTDKSLSAQWEHM
VAVTETGFELLTPWPTGTGEYPEII
>Mature_265_residues
MRASTVTIKNEQDIEHLRVSGRLAAQVLEMIIPYVKPGVSTEYLDDICHEFIVDTLKVIPANVGYHGFTKTTCTSVNEVV
CHGIPSPNKILQDGDILNIDVAIIKDGYFGDTSRMYLVGEVAPEAKKLVKTTYEAMLAGIQVVKPGATLGDIGHAIQTTA
QREGYSIVKEYCGHGIGKVYHEQPNILHYGQPGHGMVLEKGMVFTIEPMVNAGKSQVKELNDGWTVVTTDKSLSAQWEHM
VAVTETGFELLTPWPTGTGEYPEII

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=249, Percent_Identity=44.9799196787149, Blast_Score=228, Evalue=4e-60,
Organism=Homo sapiens, GI40385867, Length=251, Percent_Identity=39.8406374501992, Blast_Score=190, Evalue=9e-49,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=55.0607287449393, Blast_Score=300, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI71996291, Length=256, Percent_Identity=41.40625, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6323273, Length=254, Percent_Identity=40.1574803149606, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI21355531, Length=260, Percent_Identity=40.3846153846154, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24583427, Length=247, Percent_Identity=39.2712550607287, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29029; Mature: 29029

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRASTVTIKNEQDIEHLRVSGRLAAQVLEMIIPYVKPGVSTEYLDDICHEFIVDTLKVIP
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
ANVGYHGFTKTTCTSVNEVVCHGIPSPNKILQDGDILNIDVAIIKDGYFGDTSRMYLVGE
CCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEEEEEECCCCCCCCCEEEEEC
VAPEAKKLVKTTYEAMLAGIQVVKPGATLGDIGHAIQTTAQREGYSIVKEYCGHGIGKVY
CCHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHH
HEQPNILHYGQPGHGMVLEKGMVFTIEPMVNAGKSQVKELNDGWTVVTTDKSLSAQWEHM
CCCCCEEEECCCCCCEEEECCEEEEECHHHCCCHHHHHHCCCCEEEEEECCCCCCCHHHE
VAVTETGFELLTPWPTGTGEYPEII
EEEECCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MRASTVTIKNEQDIEHLRVSGRLAAQVLEMIIPYVKPGVSTEYLDDICHEFIVDTLKVIP
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
ANVGYHGFTKTTCTSVNEVVCHGIPSPNKILQDGDILNIDVAIIKDGYFGDTSRMYLVGE
CCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEEEEEECCCCCCCCCEEEEEC
VAPEAKKLVKTTYEAMLAGIQVVKPGATLGDIGHAIQTTAQREGYSIVKEYCGHGIGKVY
CCHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHH
HEQPNILHYGQPGHGMVLEKGMVFTIEPMVNAGKSQVKELNDGWTVVTTDKSLSAQWEHM
CCCCCEEEECCCCCCEEEECCEEEEECHHHCCCHHHHHHCCCCEEEEEECCCCCCCHHHE
VAVTETGFELLTPWPTGTGEYPEII
EEEECCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]