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The map label for this gene is dnaX [H]

Identifier: 50085108

GI number: 50085108

Start: 1957924

End: 1960059

Strand: Reverse

Name: dnaX [H]

Synonym: ACIAD1970

Alternate gene names: 50085108

Gene position: 1960059-1957924 (Counterclockwise)

Preceding gene: 50085109

Following gene: 50085107

Centisome position: 54.47

GC content: 40.22

Gene sequence:

>2136_bases
ATGTATCAAGTATTGGCAAGAAAATATCGACCACGAAATTTTATTGAGCTGGTTGGGCAAAATCATGTATCAAGAGCACT
GACCAGTGCATTGGAACGTGGTCGTTTGCATCATGCCTATTTGTTTACAGGAACACGCGGTGTTGGTAAAACGACCATTG
CCCGTATTTTGGCGAAATGTCTAAATTGTGAGACAGGAATTACCTCAACGCCGTGTGAAGTTTGTGCAACCTGTAAAGCT
GTGAATGAAGGTCGCTTTATTGATTTAATTGAGATTGATGCAGCTTCACGAACCAAAGTCGAAGATACACGCGAGTTATT
AGACAATGTACCTTATGCACCCACCCAAGGTCGCTTTAAAGTCTATCTGATCGATGAAGTACATATGCTTTCGACGCACT
CATTCAATGCGTTACTCAAAACGCTTGAAGAGCCGCCTGAGCATGTTAAGTTTTTGTTTGCCACCACCGATCCGCAAAAG
CTTCCGATCACGGTAATATCTCGTTGTTTACAATTTACCTTGCGCCCACTTGCTGTAGATGAAATCACTTCTCATCTAAC
GACTATTTTAGCTAAAGAGCAAATAGAAGCGGATAAAGACGCGATTTGGCAGATTGCTGAATCGGCTCAAGGTTCTTTGC
GTGATGCTTTGTCTTTGACAGATCAGGCGATTGCCTATGGACAAGGGGCAGTCCATCATCAAGATGTTAAAGAAATGCTA
GGTCTGATTGATCGAACCATTATTTATGATTTGATTTTAGCGATTCATCAAAATCAGACTGCCAGAGTCAGTCAATTGTT
GATGCAATTTCGTCAGCAGGCCTTAGATGTATCTCTGGTACTTGATCAATTGATTTCAACCTTGCATGAGCTGGCACTAT
TACAATATCTGCCTGAACTCAGCTTAAAATATAGCGAAGAAATCAATCAAAAAATTCTTAAGTTAGCAAAGATCGTTTCT
GCTCAGGATTTACAGCTTTATTATCAGATCGCCTGTAAAGGTCGTTCTGAATTACAGCTGTCAGTGACTCAAGAGCAAGG
TTTTGAAATGTGCGTGCTTAGATTGTTGGCATTTCGACCTCTTTCAATTGATGAGGTAACAGTACATGCATCTTCTCAAC
CGTCAGAATTACAAATCAATCAACTTCCGCCTGCTGCTGATTCAGAAACGGACTCATCCTCTCGTTCAGAACTTCAACAC
ACAAACAATCGTATTGAACCCGATTTGGAGGGAAGTGTCGTTATTTCTGTCATTTCTCAAGAGGCCGAATCTTTTGAAGC
AGAACAGGTTGTAAATCATACTACAGATGATTGCCAGACTGCTAAGACTCGTCAGAATAAAGATGTTTCCTCAGCAGTAG
TTGAAGCCGAGCAAGAAAATATCCTGGTTTTTAATGCCAATTCAGATGATATTGTCGGAATTGAACAAAACAAGACTGCT
GTTGTTTTAGCGGCTCAAGATATGCCATTTTTTCCTGTCGAGGAAGAAAGACAAATTGCTAATCATCAACATATCGCTTT
GCCTGCGGAGCGAGTTGAGCAAGCTGACACTTACCAGCCTGAACCTCATCAAGTTACTCAACCTATATCTGACAGCTCTT
CAGAAGAGAGTTCTTTGGACGCATTAGCTGATGATGAAAGTACACCATTAATTGATCTTTCTATTGATACCAATGAACAT
AAAGTTCAAGTTACATCTGCCGCAAATGATCTTGAAGTCATGCCTCAGGATATTCTTAAGCTTGCAGAGCAAGAGCTAGA
AGGTGAGTGGACACTAGAAAAATGGGAATACTGGTTTAGAACGAGTCAACTTTCACCTGCCGTTCAGGAGTTGGCTCAAT
ATGGATTAATGTCTGGAAATATTGATGGCATATGTACTTTTAATATTCCTCAACAATATGAGGGAATGTTGTCACAGCTC
CAACATGCACTTGAATCTGAGGTTAAATCGCGCTGGCCGAATACACAATTTACGGTGAAATATGGAAAAGTAAATGAAAT
TACGCCTTATATCAAACAAATAGAGCGTAAAGAAAAGGCTTTCCAGCGTGCGATTGATTTGCTTCAGCAAAATCCTGTGG
TCAAAGACTTATTAAATACTTTTGATGGTCAATTACAGAATATTCAATTGAAGTAA

Upstream 100 bases:

>100_bases
AAAATGGTTGTGTTTAAGACAACCTGAAAATGATCATGTGCTTATTCATTCACTAATCATCAAAAAGACAGTATGCTTAT
GCGGGTAACAAGGAGCATTC

Downstream 100 bases:

>100_bases
ATACTATTATTTTTAGAATAGGCTTACGGGCCTATTTTTGTAAATATTTAATTAAAATCTGTGTTTAATATAGGGGTATT
CCAATCAATTAACAGCTAGG

Product: DNA polymerase III subunits tau and gamma

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 711; Mature: 711

Protein sequence:

>711_residues
MYQVLARKYRPRNFIELVGQNHVSRALTSALERGRLHHAYLFTGTRGVGKTTIARILAKCLNCETGITSTPCEVCATCKA
VNEGRFIDLIEIDAASRTKVEDTRELLDNVPYAPTQGRFKVYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFATTDPQK
LPITVISRCLQFTLRPLAVDEITSHLTTILAKEQIEADKDAIWQIAESAQGSLRDALSLTDQAIAYGQGAVHHQDVKEML
GLIDRTIIYDLILAIHQNQTARVSQLLMQFRQQALDVSLVLDQLISTLHELALLQYLPELSLKYSEEINQKILKLAKIVS
AQDLQLYYQIACKGRSELQLSVTQEQGFEMCVLRLLAFRPLSIDEVTVHASSQPSELQINQLPPAADSETDSSSRSELQH
TNNRIEPDLEGSVVISVISQEAESFEAEQVVNHTTDDCQTAKTRQNKDVSSAVVEAEQENILVFNANSDDIVGIEQNKTA
VVLAAQDMPFFPVEEERQIANHQHIALPAERVEQADTYQPEPHQVTQPISDSSSEESSLDALADDESTPLIDLSIDTNEH
KVQVTSAANDLEVMPQDILKLAEQELEGEWTLEKWEYWFRTSQLSPAVQELAQYGLMSGNIDGICTFNIPQQYEGMLSQL
QHALESEVKSRWPNTQFTVKYGKVNEITPYIKQIERKEKAFQRAIDLLQQNPVVKDLLNTFDGQLQNIQLK

Sequences:

>Translated_711_residues
MYQVLARKYRPRNFIELVGQNHVSRALTSALERGRLHHAYLFTGTRGVGKTTIARILAKCLNCETGITSTPCEVCATCKA
VNEGRFIDLIEIDAASRTKVEDTRELLDNVPYAPTQGRFKVYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFATTDPQK
LPITVISRCLQFTLRPLAVDEITSHLTTILAKEQIEADKDAIWQIAESAQGSLRDALSLTDQAIAYGQGAVHHQDVKEML
GLIDRTIIYDLILAIHQNQTARVSQLLMQFRQQALDVSLVLDQLISTLHELALLQYLPELSLKYSEEINQKILKLAKIVS
AQDLQLYYQIACKGRSELQLSVTQEQGFEMCVLRLLAFRPLSIDEVTVHASSQPSELQINQLPPAADSETDSSSRSELQH
TNNRIEPDLEGSVVISVISQEAESFEAEQVVNHTTDDCQTAKTRQNKDVSSAVVEAEQENILVFNANSDDIVGIEQNKTA
VVLAAQDMPFFPVEEERQIANHQHIALPAERVEQADTYQPEPHQVTQPISDSSSEESSLDALADDESTPLIDLSIDTNEH
KVQVTSAANDLEVMPQDILKLAEQELEGEWTLEKWEYWFRTSQLSPAVQELAQYGLMSGNIDGICTFNIPQQYEGMLSQL
QHALESEVKSRWPNTQFTVKYGKVNEITPYIKQIERKEKAFQRAIDLLQQNPVVKDLLNTFDGQLQNIQLK
>Mature_711_residues
MYQVLARKYRPRNFIELVGQNHVSRALTSALERGRLHHAYLFTGTRGVGKTTIARILAKCLNCETGITSTPCEVCATCKA
VNEGRFIDLIEIDAASRTKVEDTRELLDNVPYAPTQGRFKVYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFATTDPQK
LPITVISRCLQFTLRPLAVDEITSHLTTILAKEQIEADKDAIWQIAESAQGSLRDALSLTDQAIAYGQGAVHHQDVKEML
GLIDRTIIYDLILAIHQNQTARVSQLLMQFRQQALDVSLVLDQLISTLHELALLQYLPELSLKYSEEINQKILKLAKIVS
AQDLQLYYQIACKGRSELQLSVTQEQGFEMCVLRLLAFRPLSIDEVTVHASSQPSELQINQLPPAADSETDSSSRSELQH
TNNRIEPDLEGSVVISVISQEAESFEAEQVVNHTTDDCQTAKTRQNKDVSSAVVEAEQENILVFNANSDDIVGIEQNKTA
VVLAAQDMPFFPVEEERQIANHQHIALPAERVEQADTYQPEPHQVTQPISDSSSEESSLDALADDESTPLIDLSIDTNEH
KVQVTSAANDLEVMPQDILKLAEQELEGEWTLEKWEYWFRTSQLSPAVQELAQYGLMSGNIDGICTFNIPQQYEGMLSQL
QHALESEVKSRWPNTQFTVKYGKVNEITPYIKQIERKEKAFQRAIDLLQQNPVVKDLLNTFDGQLQNIQLK

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=359, Percent_Identity=56.2674094707521, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1787119, Length=229, Percent_Identity=26.6375545851528, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=236, Percent_Identity=26.6949152542373, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=293, Percent_Identity=23.2081911262799, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324039, Length=215, Percent_Identity=26.046511627907, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859927, Length=295, Percent_Identity=24.0677966101695, Blast_Score=80, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19921076, Length=314, Percent_Identity=24.203821656051, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 79994; Mature: 79994

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQVLARKYRPRNFIELVGQNHVSRALTSALERGRLHHAYLFTGTRGVGKTTIARILAKC
CCHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHH
LNCETGITSTPCEVCATCKAVNEGRFIDLIEIDAASRTKVEDTRELLDNVPYAPTQGRFK
HCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEE
VYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFATTDPQKLPITVISRCLQFTLRPLAVD
EEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCHHHHH
EITSHLTTILAKEQIEADKDAIWQIAESAQGSLRDALSLTDQAIAYGQGAVHHQDVKEML
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
GLIDRTIIYDLILAIHQNQTARVSQLLMQFRQQALDVSLVLDQLISTLHELALLQYLPEL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLKYSEEINQKILKLAKIVSAQDLQLYYQIACKGRSELQLSVTQEQGFEMCVLRLLAFRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEHHCCHHHHHHHHHHCCC
LSIDEVTVHASSQPSELQINQLPPAADSETDSSSRSELQHTNNRIEPDLEGSVVISVISQ
CCCCEEEEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEHHHHHH
EAESFEAEQVVNHTTDDCQTAKTRQNKDVSSAVVEAEQENILVFNANSDDIVGIEQNKTA
HHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHCCCCCEEEEECCCCCEEEEECCCEE
VVLAAQDMPFFPVEEERQIANHQHIALPAERVEQADTYQPEPHQVTQPISDSSSEESSLD
EEEEECCCCCCCCCHHHHHHCCCEEECCHHHHHHCCCCCCCCCHHCCCCCCCCCCHHHHH
ALADDESTPLIDLSIDTNEHKVQVTSAANDLEVMPQDILKLAEQELEGEWTLEKWEYWFR
HHCCCCCCCEEEEEECCCCCEEEEECCCCCHHHCHHHHHHHHHHHCCCCCCHHHHHHHHH
TSQLSPAVQELAQYGLMSGNIDGICTFNIPQQYEGMLSQLQHALESEVKSRWPNTQFTVK
HCCCCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
YGKVNEITPYIKQIERKEKAFQRAIDLLQQNPVVKDLLNTFDGQLQNIQLK
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECC
>Mature Secondary Structure
MYQVLARKYRPRNFIELVGQNHVSRALTSALERGRLHHAYLFTGTRGVGKTTIARILAKC
CCHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHH
LNCETGITSTPCEVCATCKAVNEGRFIDLIEIDAASRTKVEDTRELLDNVPYAPTQGRFK
HCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEE
VYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFATTDPQKLPITVISRCLQFTLRPLAVD
EEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCHHHHH
EITSHLTTILAKEQIEADKDAIWQIAESAQGSLRDALSLTDQAIAYGQGAVHHQDVKEML
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
GLIDRTIIYDLILAIHQNQTARVSQLLMQFRQQALDVSLVLDQLISTLHELALLQYLPEL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLKYSEEINQKILKLAKIVSAQDLQLYYQIACKGRSELQLSVTQEQGFEMCVLRLLAFRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEHHCCHHHHHHHHHHCCC
LSIDEVTVHASSQPSELQINQLPPAADSETDSSSRSELQHTNNRIEPDLEGSVVISVISQ
CCCCEEEEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEHHHHHH
EAESFEAEQVVNHTTDDCQTAKTRQNKDVSSAVVEAEQENILVFNANSDDIVGIEQNKTA
HHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHCCCCCEEEEECCCCCEEEEECCCEE
VVLAAQDMPFFPVEEERQIANHQHIALPAERVEQADTYQPEPHQVTQPISDSSSEESSLD
EEEEECCCCCCCCCHHHHHHCCCEEECCHHHHHHCCCCCCCCCHHCCCCCCCCCCHHHHH
ALADDESTPLIDLSIDTNEHKVQVTSAANDLEVMPQDILKLAEQELEGEWTLEKWEYWFR
HHCCCCCCCEEEEEECCCCCEEEEECCCCCHHHCHHHHHHHHHHHCCCCCCHHHHHHHHH
TSQLSPAVQELAQYGLMSGNIDGICTFNIPQQYEGMLSQLQHALESEVKSRWPNTQFTVK
HCCCCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
YGKVNEITPYIKQIERKEKAFQRAIDLLQQNPVVKDLLNTFDGQLQNIQLK
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]