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The map label for this gene is smvA [H]

Identifier: 50085109

GI number: 50085109

Start: 1960201

End: 1961700

Strand: Reverse

Name: smvA [H]

Synonym: ACIAD1971

Alternate gene names: 50085109

Gene position: 1961700-1960201 (Counterclockwise)

Preceding gene: 50085111

Following gene: 50085108

Centisome position: 54.51

GC content: 41.67

Gene sequence:

>1500_bases
ATGTACCGTAAATGGATGGTCTTGGCGATCATCGTTTTAATCTATTTACCAGTTTCAATTGATGCGACTGTTTTGCATGT
CGCTATTCCGACATTGAGTGCTTCACTTTCTTTAAGTGCAAACCAAATGTTGTGGGTGATTGATATTTATTCATTGGTCA
TGGCTGGTTTAATATTGCCCATGGGAGCACTTGGTGACCGAATAGGATTTAAGCGTTTAATGCTGGTTGGAGCCAGTATT
TTTGGAGGCGCTTCATTCATGGCGGCATTTGCAAATTCAGCCTTGCTCTTGATTATTGCCCGAGCATTTTTAGGATTGGG
TGCAGCCATGATATTGCCCGCAACACTAGCAGGGCTACGTCATACTTTTCTGGATGAAAAACAACGTAATTATGCACTTG
GAATATGGGGAACTGTGGGCGGTGGTGGTGCAGCTTTTGGTCCGTTACTGGGTGGATTTATTCTTGAACATTTTTCATGG
GGAACCGTGTTTTTGATTAATGTTCCCATTATTTTAGTGGTGATTGTTTTAACTGCTTGGATTGTGCCTCAACAAAAATC
TGATCGTCAGCAAGCATTGAATTTAACGCAAGCTTTGGTATTGGTCACTGCAATTCTATTGGTGACTTATGCAATTAAAA
CCGCCATGCATGATTTTAGTATCATGATGATTTTGTTATTTATTGTTGGATTGGGAATGTTGATTGGATTTGTACGACAT
CAACTGACAAGCACAAGTCCTATGATTGATTTTAATTTATTTAAGCATCCTGTGATTTCCACCAGTATCATTATGGCGAT
GGTCGCAATGATTGCACTTGTCGGTTTTGAGTTATTGCTGTCACAGGAATTGCAGTTTGTTTATGGATATACGCCTTTAG
AAGCAGGCTTGTTTATTTTACCGTTTATGATTGCAATCAGTATTGGTGGGCCATTTGCCAGTTTTTTGATGAACCGTTTT
GGATTAAAACCCGTTGCAACTTTGGGTATGCTGATGTGTGCTGTAAGCTTTTTTGGGTTGGCAACCACCCATTTTGATAC
ACAGCATTTACAGGCATGGTCGTGGATGGCAATCATGGGGGTAAGTGTTGAAATTGCGTTGTTATCTTCAACAGCAGCCA
TTATGTCTGCGGTTCCTCCACACAAAGCGACAGCAGCGGGAGCAATTGAAGGAATGGCTTATGAGCTCGGCGCAGGATTG
GGAATTGCTATATTTGGATTACTGTTGTCATTTTTCTATGCAAGATCAATACTGGTTCCAACTCATTTACCCTCAGATTT
GATTGGAACAGCAAGTTCTTCGGTAGGAGAGGCGGTTCAGCTCAGTCGCCAATTAGATCCCTCACTGGCGCATCATCTGC
TAGATGCAGCATCCATCGCCTTTACACAGTCTCATAGTGTTGTGCTGGGTATTGCGGGATCAATGTTTCTGATTCTATCT
GTATTTGTCTGGTGGGCATTGTCAAATCAAACAGATGGGAATAGACGTAAATCGGTATAG

Upstream 100 bases:

>100_bases
TCAATTACAGAAGACATATTAAACAAAGTTGGACATCTGTTCAAGTTTGAATATAATGTCCTCAACTTGAACAAGTGTCC
AACTTTAATTTGGGTGTGTT

Downstream 100 bases:

>100_bases
CTGGTAATGCAAAAGCAATAAAAACTGTTTTGGATGTAGCTAAAATGGTTGTGTTTAAGACAACCTGAAAATGATCATGT
GCTTATTCATTCACTAATCA

Product: major facilitator superfamily methyl viologen resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MYRKWMVLAIIVLIYLPVSIDATVLHVAIPTLSASLSLSANQMLWVIDIYSLVMAGLILPMGALGDRIGFKRLMLVGASI
FGGASFMAAFANSALLLIIARAFLGLGAAMILPATLAGLRHTFLDEKQRNYALGIWGTVGGGGAAFGPLLGGFILEHFSW
GTVFLINVPIILVVIVLTAWIVPQQKSDRQQALNLTQALVLVTAILLVTYAIKTAMHDFSIMMILLFIVGLGMLIGFVRH
QLTSTSPMIDFNLFKHPVISTSIIMAMVAMIALVGFELLLSQELQFVYGYTPLEAGLFILPFMIAISIGGPFASFLMNRF
GLKPVATLGMLMCAVSFFGLATTHFDTQHLQAWSWMAIMGVSVEIALLSSTAAIMSAVPPHKATAAGAIEGMAYELGAGL
GIAIFGLLLSFFYARSILVPTHLPSDLIGTASSSVGEAVQLSRQLDPSLAHHLLDAASIAFTQSHSVVLGIAGSMFLILS
VFVWWALSNQTDGNRRKSV

Sequences:

>Translated_499_residues
MYRKWMVLAIIVLIYLPVSIDATVLHVAIPTLSASLSLSANQMLWVIDIYSLVMAGLILPMGALGDRIGFKRLMLVGASI
FGGASFMAAFANSALLLIIARAFLGLGAAMILPATLAGLRHTFLDEKQRNYALGIWGTVGGGGAAFGPLLGGFILEHFSW
GTVFLINVPIILVVIVLTAWIVPQQKSDRQQALNLTQALVLVTAILLVTYAIKTAMHDFSIMMILLFIVGLGMLIGFVRH
QLTSTSPMIDFNLFKHPVISTSIIMAMVAMIALVGFELLLSQELQFVYGYTPLEAGLFILPFMIAISIGGPFASFLMNRF
GLKPVATLGMLMCAVSFFGLATTHFDTQHLQAWSWMAIMGVSVEIALLSSTAAIMSAVPPHKATAAGAIEGMAYELGAGL
GIAIFGLLLSFFYARSILVPTHLPSDLIGTASSSVGEAVQLSRQLDPSLAHHLLDAASIAFTQSHSVVLGIAGSMFLILS
VFVWWALSNQTDGNRRKSV
>Mature_499_residues
MYRKWMVLAIIVLIYLPVSIDATVLHVAIPTLSASLSLSANQMLWVIDIYSLVMAGLILPMGALGDRIGFKRLMLVGASI
FGGASFMAAFANSALLLIIARAFLGLGAAMILPATLAGLRHTFLDEKQRNYALGIWGTVGGGGAAFGPLLGGFILEHFSW
GTVFLINVPIILVVIVLTAWIVPQQKSDRQQALNLTQALVLVTAILLVTYAIKTAMHDFSIMMILLFIVGLGMLIGFVRH
QLTSTSPMIDFNLFKHPVISTSIIMAMVAMIALVGFELLLSQELQFVYGYTPLEAGLFILPFMIAISIGGPFASFLMNRF
GLKPVATLGMLMCAVSFFGLATTHFDTQHLQAWSWMAIMGVSVEIALLSSTAAIMSAVPPHKATAAGAIEGMAYELGAGL
GIAIFGLLLSFFYARSILVPTHLPSDLIGTASSSVGEAVQLSRQLDPSLAHHLLDAASIAFTQSHSVVLGIAGSMFLILS
VFVWWALSNQTDGNRRKSV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=484, Percent_Identity=27.2727272727273, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789042, Length=390, Percent_Identity=27.4358974358974, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI87081983, Length=418, Percent_Identity=25.1196172248804, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790195, Length=404, Percent_Identity=24.2574257425743, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788392, Length=433, Percent_Identity=24.0184757505774, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790146, Length=194, Percent_Identity=25.7731958762887, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53462; Mature: 53462

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRKWMVLAIIVLIYLPVSIDATVLHVAIPTLSASLSLSANQMLWVIDIYSLVMAGLILP
CCCHHHHHHHHHHHHHCCCCCHHHHHEEHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHH
MGALGDRIGFKRLMLVGASIFGGASFMAAFANSALLLIIARAFLGLGAAMILPATLAGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
HTFLDEKQRNYALGIWGTVGGGGAAFGPLLGGFILEHFSWGTVFLINVPIILVVIVLTAW
HHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHH
IVPQQKSDRQQALNLTQALVLVTAILLVTYAIKTAMHDFSIMMILLFIVGLGMLIGFVRH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLTSTSPMIDFNLFKHPVISTSIIMAMVAMIALVGFELLLSQELQFVYGYTPLEAGLFIL
HHCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
PFMIAISIGGPFASFLMNRFGLKPVATLGMLMCAVSFFGLATTHFDTQHLQAWSWMAIMG
HHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
VSVEIALLSSTAAIMSAVPPHKATAAGAIEGMAYELGAGLGIAIFGLLLSFFYARSILVP
CEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
THLPSDLIGTASSSVGEAVQLSRQLDPSLAHHLLDAASIAFTQSHSVVLGIAGSMFLILS
CCCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHH
VFVWWALSNQTDGNRRKSV
HHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MYRKWMVLAIIVLIYLPVSIDATVLHVAIPTLSASLSLSANQMLWVIDIYSLVMAGLILP
CCCHHHHHHHHHHHHHCCCCCHHHHHEEHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHH
MGALGDRIGFKRLMLVGASIFGGASFMAAFANSALLLIIARAFLGLGAAMILPATLAGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
HTFLDEKQRNYALGIWGTVGGGGAAFGPLLGGFILEHFSWGTVFLINVPIILVVIVLTAW
HHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHH
IVPQQKSDRQQALNLTQALVLVTAILLVTYAIKTAMHDFSIMMILLFIVGLGMLIGFVRH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLTSTSPMIDFNLFKHPVISTSIIMAMVAMIALVGFELLLSQELQFVYGYTPLEAGLFIL
HHCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
PFMIAISIGGPFASFLMNRFGLKPVATLGMLMCAVSFFGLATTHFDTQHLQAWSWMAIMG
HHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
VSVEIALLSSTAAIMSAVPPHKATAAGAIEGMAYELGAGLGIAIFGLLLSFFYARSILVP
CEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
THLPSDLIGTASSSVGEAVQLSRQLDPSLAHHLLDAASIAFTQSHSVVLGIAGSMFLILS
CCCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHH
VFVWWALSNQTDGNRRKSV
HHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7926834; 11677609 [H]