Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 49188176

GI number: 49188176

Start: 5070204

End: 5071343

Strand: Reverse

Name: acdA [H]

Synonym: BAS5190

Alternate gene names: 49188176

Gene position: 5071343-5070204 (Counterclockwise)

Preceding gene: 49188177

Following gene: 49188175

Centisome position: 96.99

GC content: 43.68

Gene sequence:

>1140_bases
ATGCATTTTAAACTATCAGAAGAACATGAAATGATAAGAAAAATGGTTCGAGACTTTGCTAAGAATGAAGTAGCACCGAC
GGCAGCTGAGCGTGATGAAGAAGAGAGATTTGATCGTGCAATATTTGATCAAATGGCCGAGCTTGGTTTAACTGGTATTC
CGTGGCCTGAAGAATACGGCGGAATTGGAAGCGATTACTTAGCGTATGTAATTGCTATTGAAGAATTATCGCGTGTATGT
GCTTCTACAGGTGTAACATTGTCTGCACATACTTCGCTTGCTGGTTGGCCAATTTTTAAATTTGGAACAGAAGAGCAAAA
GCAAACGTTTTTACGACCGATGGCTGAAGGGAAGAAAATTGGTGCGTACGGCTTAACGGAGCCAGGATCTGGATCGGATG
CTGGTGGAATGAAGACGATTGCTAAAAGAGATGGAGACCATTATGTATTAAATGGATCAAAAATATTTATCACTAATGGT
GGTATTGCTGATATTTATGTTGTCTTTGCGTTAACTGATCCTGAATCGAAGCAGCGTGGCACGAGTGCATTTATAGTGGA
AAGTGATACACCAGGATTTTCAGTTGGGAAGAAGGAAAGTAAGTTAGGGATTCGCTCTTCACCAACAACTGAAATTATGT
TCGAAGATTGCCGCATTCCTGTAGAAAATTTACTGGGGGAAGAAGGGCAAGGGTTTAAGATAGCGATGCAAACATTAGAT
GGCGGCCGTAACGGTATTGCGGCGCAAGCGGTCGGTATTGCACAAGGGGCTTTAGATGCTTCCGTAGCATATGCAAGAGA
GCGCTATCAGTTTGGGAAGCCAATTGCGGCGCAACAAGGAATTGGCTTTAAACTTGCAGATATGGCAACGGATGTGGAGG
CGGCGCGCCTTCTAACATACCAAGCAGCTTGGCTTGAATCGGAAGGGCTTCCGTATGGGAAAGAGTCAGCGATGTCAAAA
GTATTTGCAGGCGATGCAGCGATGAAGGTGACGACGGAAGCGGTACAAGTATTTGGTGGTTACGGTTATACGAAAGATTA
TCCAGTAGAGCGTTATATGCGGGATGCAAAGATTACACAGATATATGAAGGAACGCAAGAGATTCAAAGGCTCGTAATTT
CTCGTATGTTAACGAAGTAG

Upstream 100 bases:

>100_bases
TTTCCGTGATGCGAAAATCACGCAAATATATGAAGGAACGAGCGAAATACAGAAACTTGTTATTAGCCGAGCTTTGTAAA
AGCACAAGGGGGAGACGGGT

Downstream 100 bases:

>100_bases
GATCGAAGGCGTAGGTATTTTCCTACGCTTTTTCCTTCCAAAAAATAATAGAGGGGTGAAGGGGATGGTTAAACATAATG
TGCACGCATCAGTGAAAGAT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRAIFDQMAELGLTGIPWPEEYGGIGSDYLAYVIAIEELSRVC
ASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNG
GIADIYVVFALTDPESKQRGTSAFIVESDTPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQGALDASVAYARERYQFGKPIAAQQGIGFKLADMATDVEAARLLTYQAAWLESEGLPYGKESAMSK
VFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLTK

Sequences:

>Translated_379_residues
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRAIFDQMAELGLTGIPWPEEYGGIGSDYLAYVIAIEELSRVC
ASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNG
GIADIYVVFALTDPESKQRGTSAFIVESDTPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQGALDASVAYARERYQFGKPIAAQQGIGFKLADMATDVEAARLLTYQAAWLESEGLPYGKESAMSK
VFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLTK
>Mature_379_residues
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRAIFDQMAELGLTGIPWPEEYGGIGSDYLAYVIAIEELSRVC
ASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNG
GIADIYVVFALTDPESKQRGTSAFIVESDTPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQGALDASVAYARERYQFGKPIAAQQGIGFKLADMATDVEAARLLTYQAAWLESEGLPYGKESAMSK
VFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLTK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=53.9893617021277, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI4501859, Length=381, Percent_Identity=43.0446194225722, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=43.3510638297872, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=43.5013262599469, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=43.5013262599469, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=40.5835543766578, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=40.8695652173913, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI21361497, Length=351, Percent_Identity=42.7350427350427, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=36.3636363636364, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI76496475, Length=377, Percent_Identity=37.4005305039788, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI4557235, Length=377, Percent_Identity=37.4005305039788, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=32.2751322751323, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=31.9672131147541, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI211971008, Length=295, Percent_Identity=31.5254237288136, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI48976061, Length=295, Percent_Identity=31.5254237288136, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI38505218, Length=384, Percent_Identity=27.6041666666667, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI218563752, Length=228, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=30.9711286089239, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=30.2083333333333, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI87081702, Length=315, Percent_Identity=27.6190476190476, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87082384, Length=271, Percent_Identity=28.4132841328413, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=45.6692913385827, Blast_Score=317, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=42.7807486631016, Blast_Score=316, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=45.6919060052219, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=41.0187667560322, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=41.8421052631579, Blast_Score=304, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=39.3139841688654, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=39.9470899470899, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71990804, Length=292, Percent_Identity=43.4931506849315, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71985184, Length=367, Percent_Identity=39.5095367847411, Blast_Score=240, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=32.6259946949602, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI71982178, Length=268, Percent_Identity=36.9402985074627, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=43.0434782608696, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI71985192, Length=314, Percent_Identity=39.4904458598726, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17551932, Length=383, Percent_Identity=30.5483028720627, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17505929, Length=379, Percent_Identity=31.1345646437995, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=34.8547717842324, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17562446, Length=291, Percent_Identity=29.2096219931272, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17531913, Length=179, Percent_Identity=29.608938547486, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=310, Percent_Identity=26.4516129032258, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=310, Percent_Identity=26.4516129032258, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=52.8, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=47.2, Blast_Score=352, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24666513, Length=375, Percent_Identity=41.8666666666667, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=43.6507936507937, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=38.5826771653543, Blast_Score=264, Evalue=7e-71,
Organism=Drosophila melanogaster, GI281363737, Length=386, Percent_Identity=38.60103626943, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=34.5549738219895, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24652780, Length=324, Percent_Identity=24.6913580246914, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41398; Mature: 41398

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRAIFDQMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GIGSDYLAYVIAIEELSRVCASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCHHHHHHHHHHHHCCCEE
GAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNGGIADIYVVFALTDPESKQRG
CCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCEEEEECCCCEEEEEEEEECCCCHHHCC
TSAFIVESDTPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
CEEEEEECCCCCCCCCCCHHCCCCCCCCCHHEEHHCCCCCHHHHCCCCCCCEEEEEEECC
GGRNGIAAQAVGIAQGALDASVAYARERYQFGKPIAAQQGIGFKLADMATDVEAARLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHH
QAAWLESEGLPYGKESAMSKVFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQ
HHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLTK
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRAIFDQMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GIGSDYLAYVIAIEELSRVCASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCHHHHHHHHHHHHCCCEE
GAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNGGIADIYVVFALTDPESKQRG
CCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCEEEEECCCCEEEEEEEEECCCCHHHCC
TSAFIVESDTPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
CEEEEEECCCCCCCCCCCHHCCCCCCCCCHHEEHHCCCCCHHHHCCCCCCCEEEEEEECC
GGRNGIAAQAVGIAQGALDASVAYARERYQFGKPIAAQQGIGFKLADMATDVEAARLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHH
QAAWLESEGLPYGKESAMSKVFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQ
HHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLTK
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]