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The map label for this gene is murB

Identifier: 49187925

GI number: 49187925

Start: 4820407

End: 4821324

Strand: Reverse

Name: murB

Synonym: BAS4937

Alternate gene names: 49187925

Gene position: 4821324-4820407 (Counterclockwise)

Preceding gene: 49187926

Following gene: 49187924

Centisome position: 92.21

GC content: 36.17

Gene sequence:

>918_bases
ATGAATATGCAAGAGGTTTATGAATATTTAAGTACGGTATTGCCTGAAGGTCATGTGAAACAAGATGAAATGTTAAAGAA
TCATACGCATATTAAAGTTGGTGGAAAAGCAGATGTGTTCGTTGCGCCGACAAATTATGATGAAATTCAAGAAGTTATTA
AATATGCTAACAAATATAATATTCCAGTTACGTTTTTAGGAAACGGATCGAATGTCATTATTAAAGACGGTGGAATTCGC
GGGATTACAGTAAGTTTAATTCATATTACAGGTGTTACTGTAACAGGAACGACAATTGTAGCACAGTGCGGTGCAGCAAT
TATTGACGTATCACGTATTGCGTTAGACCATAACTTAACGGGTCTTGAGTTCGCTTGTGGTATTCCAGGTTCAGTTGGCG
GAGCATTATATATGAATGCAGGTGCATACGGCGGTGAAATTTCGTTTGTATTAACAGAAGCTGTCGTAATGACAGGTGAT
GGAGAGCTACGTACTTTGACGAAAGAAGCATTTGAATTTGGATATCGTAAGAGTGTATTTGCGAACAATCATTACATTAT
TCTTGAAGCGAGATTTGAACTTGAAGAAGGTGTATATGAAGAAATTAAAGCAAAAATGGATGATTTAACGTTTAAACGTG
AGTCAAAACAACCTCTAGAATATCCTTCATGTGGTAGCGTATTTAAACGCCCACCAAATAACTTTGCTGGTAAATTGATT
CAAGAATCAGGGTTACAAGGTAAGCGAATTGGTGGAGTGGAAGTTTCTTTAAAACACGCTGGATTTATGGTAAATGTTGA
TAACGGAACAGCACAAGATTACATCGATTTAATTCACTTCGTACAAAAAACAGTTGAAGAGAAATTTGGCGTGAAGTTAG
AGCGTGAAGTAAGGATTATTGGAGAAGATAAAGAATAA

Upstream 100 bases:

>100_bases
GGTACACTGTATCCACCACTTTAGGTTCGTTCATGTATGTGGGGATATTATGGGCCCGTATAACGGGATAAAAAGAATAT
AGAAATAGAGGAATCGTAAA

Downstream 100 bases:

>100_bases
CATATACGTATGAAGTTGCGAATTATTTTAAAATAATATTTGGGTATTGTTGACAATTTGTTTTCAATTCAATATAATGG
CTAATAATTTAACAAATAAC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase 2

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNMQEVYEYLSTVLPEGHVKQDEMLKNHTHIKVGGKADVFVAPTNYDEIQEVIKYANKYNIPVTFLGNGSNVIIKDGGIR
GITVSLIHITGVTVTGTTIVAQCGAAIIDVSRIALDHNLTGLEFACGIPGSVGGALYMNAGAYGGEISFVLTEAVVMTGD
GELRTLTKEAFEFGYRKSVFANNHYIILEARFELEEGVYEEIKAKMDDLTFKRESKQPLEYPSCGSVFKRPPNNFAGKLI
QESGLQGKRIGGVEVSLKHAGFMVNVDNGTAQDYIDLIHFVQKTVEEKFGVKLEREVRIIGEDKE

Sequences:

>Translated_305_residues
MNMQEVYEYLSTVLPEGHVKQDEMLKNHTHIKVGGKADVFVAPTNYDEIQEVIKYANKYNIPVTFLGNGSNVIIKDGGIR
GITVSLIHITGVTVTGTTIVAQCGAAIIDVSRIALDHNLTGLEFACGIPGSVGGALYMNAGAYGGEISFVLTEAVVMTGD
GELRTLTKEAFEFGYRKSVFANNHYIILEARFELEEGVYEEIKAKMDDLTFKRESKQPLEYPSCGSVFKRPPNNFAGKLI
QESGLQGKRIGGVEVSLKHAGFMVNVDNGTAQDYIDLIHFVQKTVEEKFGVKLEREVRIIGEDKE
>Mature_305_residues
MNMQEVYEYLSTVLPEGHVKQDEMLKNHTHIKVGGKADVFVAPTNYDEIQEVIKYANKYNIPVTFLGNGSNVIIKDGGIR
GITVSLIHITGVTVTGTTIVAQCGAAIIDVSRIALDHNLTGLEFACGIPGSVGGALYMNAGAYGGEISFVLTEAVVMTGD
GELRTLTKEAFEFGYRKSVFANNHYIILEARFELEEGVYEEIKAKMDDLTFKRESKQPLEYPSCGSVFKRPPNNFAGKLI
QESGLQGKRIGGVEVSLKHAGFMVNVDNGTAQDYIDLIHFVQKTVEEKFGVKLEREVRIIGEDKE

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB2_BACAN (Q81XC5)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_847491.1
- RefSeq:   YP_021973.1
- RefSeq:   YP_031178.1
- ProteinModelPortal:   Q81XC5
- SMR:   Q81XC5
- EnsemblBacteria:   EBBACT00000011437
- EnsemblBacteria:   EBBACT00000014869
- EnsemblBacteria:   EBBACT00000024057
- GeneID:   1084813
- GeneID:   2817665
- GeneID:   2850049
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_5315
- KEGG:   bar:GBAA_5315
- KEGG:   bat:BAS4937
- TIGR:   BA_5315
- TIGR:   GBAA_5315
- GeneTree:   EBGT00050000001391
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK12436
- BioCyc:   BANT260799:BAS4937-MONOMER
- BioCyc:   BANT261594:GBAA5315-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 33547; Mature: 33547

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 176-176 ACT_SITE 226-226 ACT_SITE 296-296

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMQEVYEYLSTVLPEGHVKQDEMLKNHTHIKVGGKADVFVAPTNYDEIQEVIKYANKYN
CCHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCEEEEEECCCHHHHHHHHHHHHCCC
IPVTFLGNGSNVIIKDGGIRGITVSLIHITGVTVTGTTIVAQCGAAIIDVSRIALDHNLT
CEEEEEECCCEEEEECCCCCEEEEEEEEEEEEEEECHHHHHHCCHHHHHHHHHHCCCCCC
GLEFACGIPGSVGGALYMNAGAYGGEISFVLTEAVVMTGDGELRTLTKEAFEFGYRKSVF
CEEEECCCCCCCCCEEEEECCCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHCCCCCEEE
ANNHYIILEARFELEEGVYEEIKAKMDDLTFKRESKQPLEYPSCGSVFKRPPNNFAGKLI
ECCCEEEEEEEECHHCCHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHCCCCCHHHHHHH
QESGLQGKRIGGVEVSLKHAGFMVNVDNGTAQDYIDLIHFVQKTVEEKFGVKLEREVRII
HHCCCCCCCCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEE
GEDKE
ECCCC
>Mature Secondary Structure
MNMQEVYEYLSTVLPEGHVKQDEMLKNHTHIKVGGKADVFVAPTNYDEIQEVIKYANKYN
CCHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCEEEEEECCCHHHHHHHHHHHHCCC
IPVTFLGNGSNVIIKDGGIRGITVSLIHITGVTVTGTTIVAQCGAAIIDVSRIALDHNLT
CEEEEEECCCEEEEECCCCCEEEEEEEEEEEEEEECHHHHHHCCHHHHHHHHHHCCCCCC
GLEFACGIPGSVGGALYMNAGAYGGEISFVLTEAVVMTGDGELRTLTKEAFEFGYRKSVF
CEEEECCCCCCCCCEEEEECCCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHCCCCCEEE
ANNHYIILEARFELEEGVYEEIKAKMDDLTFKRESKQPLEYPSCGSVFKRPPNNFAGKLI
ECCCEEEEEEEECHHCCHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHCCCCCHHHHHHH
QESGLQGKRIGGVEVSLKHAGFMVNVDNGTAQDYIDLIHFVQKTVEEKFGVKLEREVRII
HHCCCCCCCCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEE
GEDKE
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629