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The map label for this gene is gltC [H]

Identifier: 49187542

GI number: 49187542

Start: 4455432

End: 4456274

Strand: Reverse

Name: gltC [H]

Synonym: BAS4548

Alternate gene names: 49187542

Gene position: 4456274-4455432 (Counterclockwise)

Preceding gene: 49187544

Following gene: 49187541

Centisome position: 85.23

GC content: 37.49

Gene sequence:

>843_bases
ATGGATTTGGAGGCAGTACGATCGTTTATTGAAGTGAAGAATACGCGAAGTTTATCAAAGGCGAGTAAGATTTTACATAT
TTCTCAGCCGGCGCTTAGTAAACAAATTCAAAGGTTAGAAGCGGATTTAGAGGTTACTTTATTGAAGCGTTCCGCGCAAG
GAGTAGAATTAACAAGTGCTGGAGAGTTATTTATAAAAAGAATGTTACCGGTTTTGGAACACATACATGAAGTGAAAGCT
GAAATGAAGAAGTTTCAAGAGAAGAGGAACATTTCGATAGGCATATTGCCAAGTTTAGCAGCACATTACATATCAAAATG
TAAAGATATATTAGGTGACGGGTTTGAAGTAGAATGGAAAATTGAGCATACAAAAGTACTGATGGGACTGTTTAAAGAAC
GGAAGATTGAAGCGATCTTCATCGATTCAGTAGTAGAAGGCGCTACGTGTATAAAAGAAATACGAGAAGAAAAAATTGTT
TGTGTCGTTTCAAATGATCATCTTTATAAAGAGAAAACAGTAATCCGAATGGAAGATTTGCAAAATGAAAAGTTAATCGT
ATACCCAGAAATCTGTGATGTTAGGAAAATGATTACGCATATGTTTCAAGGGATAGGTGCGAAACCGATCATTGCATTTG
AAACTTCTTATGCAGAACCGATGCTTGCAATGGTTGGTGCTGGACTTGGTATCACGTTACTTCCAGAAATGTCAGTAGAG
CAAGCGGTAAAGCAAGGGAATGTGCATGCGATTTCTATTGAACCGCCACTTGTGCGCAAAATTTATTTCGTATCTCATAT
GGAAGAAGGCCCTTTGTTGCATTCATTTGATGATGAGAGGTAA

Upstream 100 bases:

>100_bases
GTTATAGTAAGTTGATGAAATAAGTATAAAGAGTAATTGTTTATAGAAGGAAATACTGATTTTTTATGACAGTTATAACT
TTTTGTTAGAGGTGTGTACG

Downstream 100 bases:

>100_bases
TCCAAACGGAATATTGAGAAAGATTACAATTGCATTGAAAGAAACATGAAATTTTAAAAAAAACTAGGTCAAAAACAAGC
CATTACATGGTATGATTAGT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MDLEAVRSFIEVKNTRSLSKASKILHISQPALSKQIQRLEADLEVTLLKRSAQGVELTSAGELFIKRMLPVLEHIHEVKA
EMKKFQEKRNISIGILPSLAAHYISKCKDILGDGFEVEWKIEHTKVLMGLFKERKIEAIFIDSVVEGATCIKEIREEKIV
CVVSNDHLYKEKTVIRMEDLQNEKLIVYPEICDVRKMITHMFQGIGAKPIIAFETSYAEPMLAMVGAGLGITLLPEMSVE
QAVKQGNVHAISIEPPLVRKIYFVSHMEEGPLLHSFDDER

Sequences:

>Translated_280_residues
MDLEAVRSFIEVKNTRSLSKASKILHISQPALSKQIQRLEADLEVTLLKRSAQGVELTSAGELFIKRMLPVLEHIHEVKA
EMKKFQEKRNISIGILPSLAAHYISKCKDILGDGFEVEWKIEHTKVLMGLFKERKIEAIFIDSVVEGATCIKEIREEKIV
CVVSNDHLYKEKTVIRMEDLQNEKLIVYPEICDVRKMITHMFQGIGAKPIIAFETSYAEPMLAMVGAGLGITLLPEMSVE
QAVKQGNVHAISIEPPLVRKIYFVSHMEEGPLLHSFDDER
>Mature_280_residues
MDLEAVRSFIEVKNTRSLSKASKILHISQPALSKQIQRLEADLEVTLLKRSAQGVELTSAGELFIKRMLPVLEHIHEVKA
EMKKFQEKRNISIGILPSLAAHYISKCKDILGDGFEVEWKIEHTKVLMGLFKERKIEAIFIDSVVEGATCIKEIREEKIV
CVVSNDHLYKEKTVIRMEDLQNEKLIVYPEICDVRKMITHMFQGIGAKPIIAFETSYAEPMLAMVGAGLGITLLPEMSVE
QAVKQGNVHAISIEPPLVRKIYFVSHMEEGPLLHSFDDER

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=272, Percent_Identity=27.2058823529412, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788887, Length=276, Percent_Identity=27.1739130434783, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI157672245, Length=267, Percent_Identity=22.8464419475655, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693105, Length=276, Percent_Identity=23.5507246376812, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI2367136, Length=243, Percent_Identity=23.0452674897119, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787879, Length=251, Percent_Identity=23.9043824701195, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787601, Length=97, Percent_Identity=38.1443298969072, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790262, Length=266, Percent_Identity=22.9323308270677, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788297, Length=107, Percent_Identity=30.8411214953271, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31720; Mature: 31720

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLEAVRSFIEVKNTRSLSKASKILHISQPALSKQIQRLEADLEVTLLKRSAQGVELTSA
CCHHHHHHHHHHHHCHHHHHHHHHEECCCHHHHHHHHHHHCCHHHEEEHHCCCCCEECCH
GELFIKRMLPVLEHIHEVKAEMKKFQEKRNISIGILPSLAAHYISKCKDILGDGFEVEWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEE
IEHTKVLMGLFKERKIEAIFIDSVVEGATCIKEIREEKIVCVVSNDHLYKEKTVIRMEDL
EHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCEEEEEECCCEEHHHHEEEECCC
QNEKLIVYPEICDVRKMITHMFQGIGAKPIIAFETSYAEPMLAMVGAGLGITLLPEMSVE
CCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHCCCCCEEECCCCCHH
QAVKQGNVHAISIEPPLVRKIYFVSHMEEGPLLHSFDDER
HHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MDLEAVRSFIEVKNTRSLSKASKILHISQPALSKQIQRLEADLEVTLLKRSAQGVELTSA
CCHHHHHHHHHHHHCHHHHHHHHHEECCCHHHHHHHHHHHCCHHHEEEHHCCCCCEECCH
GELFIKRMLPVLEHIHEVKAEMKKFQEKRNISIGILPSLAAHYISKCKDILGDGFEVEWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEE
IEHTKVLMGLFKERKIEAIFIDSVVEGATCIKEIREEKIVCVVSNDHLYKEKTVIRMEDL
EHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCEEEEEECCCEEHHHHEEEECCC
QNEKLIVYPEICDVRKMITHMFQGIGAKPIIAFETSYAEPMLAMVGAGLGITLLPEMSVE
CCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHCCCCCEEECCCCCHH
QAVKQGNVHAISIEPPLVRKIYFVSHMEEGPLLHSFDDER
HHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]